Epoxyeicosatrienoic acids(EETs)are the metabolic products of arachidonic acid(AA). They have the function of stimulating cell division, inhibiting platelet aggregation and regulating the transfer of cell calcium. In r...Epoxyeicosatrienoic acids(EETs)are the metabolic products of arachidonic acid(AA). They have the function of stimulating cell division, inhibiting platelet aggregation and regulating the transfer of cell calcium. In recent years, more and more people paid their attention to the effects of EETs on heart. This article will give a review about EETs and the relationship between EETs and heart.展开更多
Carbon fiber-reinforced polymer(CFRP)is widely used in aerospace applications.This kind of material may face the threat of high-velocity impact in the process of dedicated service,and the relevant research mainly cons...Carbon fiber-reinforced polymer(CFRP)is widely used in aerospace applications.This kind of material may face the threat of high-velocity impact in the process of dedicated service,and the relevant research mainly considers the impact resistance of the material,and lacks the high-velocity impact damage monitoring research of CFRP.To solve this problem,a real high-velocity impact damage experiment and structural health monitoring(SHM)method of CFRP plate based on piezoelectric guided wave is proposed.The results show that CFRP has obvious perforation damage and fiber breakage when high-velocity impact occurs.It is also proved that guided wave SHM technology can be effectively used in the monitoring of such damage,and the damage can be reflected by quantifying the signal changes and damage index(DI).It provides a reference for further research on guided wave structure monitoring of high/hyper-velocity impact damage of CFRP.展开更多
The aim of ＂green chemistry＂ and ＂atom economy＂ is to utilize carbon dioxide and replace harmful reactants such as CO and phosgene for the production of cyclic carbonates. In this paper, metal-free catalysts inclu...The aim of ＂green chemistry＂ and ＂atom economy＂ is to utilize carbon dioxide and replace harmful reactants such as CO and phosgene for the production of cyclic carbonates. In this paper, metal-free catalysts including organic bases, ionic liquids, supported catalysts, organic copolymers and carbon materials for the synthesis of cyclic carbonates by the cycloaddition of carbon dioxide to epoxides are reviewed. Recent advances in the design of the catalysts and the understanding of the reaction mechanism are summarized and discussed. The synergistic effects of organic bases and hydrogen bond donors, organic bases and nucleophilic anions, hydrogen bond donors and nucleophilic anions and active components and supports are highlighted. The challenge is to develop metal-free catalysts suitable for carbon dioxide capture and fixation. The ultimate goal is to synthesize cyclic carbonates in a flow reactor directly using carbon dioxide from industrial flue gas at ambient temperature and atmospheric pressure. By using synergetic effects, a multi-functional approach can meet the design strategy of metal-free catalysts for carbon dioxide adsorption and activation as well as epoxide ring opening.展开更多
目的:观察11,12-EET延迟性保护作用对缺血再灌注大鼠心肌ERK活性及磷酸化ERK表达的影响,探讨其在11,12-EET延迟性保护中的作用。方法:复制大鼠心肌缺血/再灌注模型;观察缺血/再灌注期间心脏收缩期左心室内压上升的最大变化速率(+dp/dtm ...目的:观察11,12-EET延迟性保护作用对缺血再灌注大鼠心肌ERK活性及磷酸化ERK表达的影响,探讨其在11,12-EET延迟性保护中的作用。方法:复制大鼠心肌缺血/再灌注模型;观察缺血/再灌注期间心脏收缩期左心室内压上升的最大变化速率(+dp/dtm ax)及舒张期左心室内压下降的最大变化速率(-dp/dtm ax);采用免疫共沉淀法测定大鼠心肌组织中细胞外调节激酶(ERK)的活性,采用W estern b lotting法测定大鼠心肌组织中磷酸化ERK的表达。结果:I/R组缺血60 m in及再灌注30 m in两个时段±dp/dtm ax均低于sham组(P<0.05),24 hE-ET+I/R组缺血60 m in及再灌注30 m in两个时段±dp/dtm ax明显高于I/R组(P<0.05),而24hEET+PD+I/R组缺血60 m in及再灌注30 m in两个时段±dp/dtm ax明显低于24hEET+I/R组(P<0.05)。ERK的活性24hEET+I/R高于norm al组,24hEET+I/R组低于24hEET+PD+I/R组。磷酸化ERK的表达I/R组高于norm al组和sham组,24hEET+I/R高于I/R组,24 hEET+I/R组低于24hEET+PD+I/R组。结论:外源性11,12-EET具有延迟性心脏保护作用,大量激活磷酸化的ERK参与这种保护作用。展开更多
基金supported by the Educational Science Foundation of Beijing (No. KM200510025009, KM200710025004)theNational Basic Research Development Program of China (No. 2006CB503807)
文摘Epoxyeicosatrienoic acids(EETs)are the metabolic products of arachidonic acid(AA). They have the function of stimulating cell division, inhibiting platelet aggregation and regulating the transfer of cell calcium. In recent years, more and more people paid their attention to the effects of EETs on heart. This article will give a review about EETs and the relationship between EETs and heart.
基金supported by the National Natural Science Foundation of China(Nos.51921003,52275153)the Fundamental Research Funds for the Central Universities(No.NI2023001)+2 种基金the Research Fund of State Key Laboratory of Mechanics and Control for Aero-space Structures(No.MCAS-I-0423G01)the Fund of Pro-spective Layout of Scientific Research for Nanjing University of Aeronautics and Astronauticsthe Priority Academic Program Development of Jiangsu Higher Education Institu-tions of China.
文摘Carbon fiber-reinforced polymer(CFRP)is widely used in aerospace applications.This kind of material may face the threat of high-velocity impact in the process of dedicated service,and the relevant research mainly considers the impact resistance of the material,and lacks the high-velocity impact damage monitoring research of CFRP.To solve this problem,a real high-velocity impact damage experiment and structural health monitoring(SHM)method of CFRP plate based on piezoelectric guided wave is proposed.The results show that CFRP has obvious perforation damage and fiber breakage when high-velocity impact occurs.It is also proved that guided wave SHM technology can be effectively used in the monitoring of such damage,and the damage can be reflected by quantifying the signal changes and damage index(DI).It provides a reference for further research on guided wave structure monitoring of high/hyper-velocity impact damage of CFRP.
基金supported by the National Science and Technology Support Project of China(2013BAC11B03)the National Natural Science Foundation of China(21401054,21476065,21273067)the Graduate Student Scientific Research Innovation Fund Project of Hunan Province(CX2015B082)~~
文摘The aim of ＂green chemistry＂ and ＂atom economy＂ is to utilize carbon dioxide and replace harmful reactants such as CO and phosgene for the production of cyclic carbonates. In this paper, metal-free catalysts including organic bases, ionic liquids, supported catalysts, organic copolymers and carbon materials for the synthesis of cyclic carbonates by the cycloaddition of carbon dioxide to epoxides are reviewed. Recent advances in the design of the catalysts and the understanding of the reaction mechanism are summarized and discussed. The synergistic effects of organic bases and hydrogen bond donors, organic bases and nucleophilic anions, hydrogen bond donors and nucleophilic anions and active components and supports are highlighted. The challenge is to develop metal-free catalysts suitable for carbon dioxide capture and fixation. The ultimate goal is to synthesize cyclic carbonates in a flow reactor directly using carbon dioxide from industrial flue gas at ambient temperature and atmospheric pressure. By using synergetic effects, a multi-functional approach can meet the design strategy of metal-free catalysts for carbon dioxide adsorption and activation as well as epoxide ring opening.
文摘目的:观察11,12-EET延迟性保护作用对缺血再灌注大鼠心肌ERK活性及磷酸化ERK表达的影响,探讨其在11,12-EET延迟性保护中的作用。方法:复制大鼠心肌缺血/再灌注模型;观察缺血/再灌注期间心脏收缩期左心室内压上升的最大变化速率(+dp/dtm ax)及舒张期左心室内压下降的最大变化速率(-dp/dtm ax);采用免疫共沉淀法测定大鼠心肌组织中细胞外调节激酶(ERK)的活性,采用W estern b lotting法测定大鼠心肌组织中磷酸化ERK的表达。结果:I/R组缺血60 m in及再灌注30 m in两个时段±dp/dtm ax均低于sham组(P<0.05),24 hE-ET+I/R组缺血60 m in及再灌注30 m in两个时段±dp/dtm ax明显高于I/R组(P<0.05),而24hEET+PD+I/R组缺血60 m in及再灌注30 m in两个时段±dp/dtm ax明显低于24hEET+I/R组(P<0.05)。ERK的活性24hEET+I/R高于norm al组,24hEET+I/R组低于24hEET+PD+I/R组。磷酸化ERK的表达I/R组高于norm al组和sham组,24hEET+I/R高于I/R组,24 hEET+I/R组低于24hEET+PD+I/R组。结论:外源性11,12-EET具有延迟性心脏保护作用,大量激活磷酸化的ERK参与这种保护作用。
