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载顺铂超顺磁γ-Fe2O3纳米粒子的制备与表征 被引量:3
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作者 邱嘉旋 雷水金 +1 位作者 何远桥 毛宗福 《中国组织工程研究》 CAS CSCD 2012年第12期2137-2140,共4页
背景:将化疗药物联接在磁性纳米载体上,在外加磁场的引导下使所载药物定向集中于靶向治疗部位,在增强疗效同时还可降低毒性不良反应。目的:制备海藻酸钠改性的磁性纳米粒子及其负载顺铂药物,分析产物的磁学性质。方法:通过Fe2+在乙醇胺... 背景:将化疗药物联接在磁性纳米载体上,在外加磁场的引导下使所载药物定向集中于靶向治疗部位,在增强疗效同时还可降低毒性不良反应。目的:制备海藻酸钠改性的磁性纳米粒子及其负载顺铂药物,分析产物的磁学性质。方法:通过Fe2+在乙醇胺水溶液中一步合成磁性纳米粒子,用海藻酸钠作偶联剂使磁性纳米粒子与顺铂相连,制备磁性纳米粒子药物。结果与结论:X射线衍射花样证明产物为γ-Fe2O3纯相,透射电子显微镜表明磁性纳米粒子直径平均约10nm,载顺铂后药物包覆于纳米粒子周围,磁化曲线显示纳米粒子为超顺磁性,核磁共振得到纳米粒子的弛豫率为0.11602mmol/ms。表明所制备磁性纳米粒子及其载顺铂超顺磁性纳米粒子药物性质稳定,具有作为磁性纳米粒子药物的特性。 展开更多
关键词 磁性纳米粒子药物 顺铂 超顺磁性 FE2O3 生物材料与药物控释
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Preparation and Analysis of Fe3O4 Magnetic Nanoparticles Used as Targeted-drug Carriers 被引量:32
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作者 赵原壁 邱祖民 黄佳英 《Chinese Journal of Chemical Engineering》 SCIE EI CAS CSCD 2008年第3期451-455,共5页
Fe3O4 magnetic nanoparticles were prepared by the aqueous co-precipitation of FeCl3-6H2O and FeCl2-4H2O with addition of ammonium hydroxide. The conditions for the preparation of Fe3O4 magnetic nanoparticles were opti... Fe3O4 magnetic nanoparticles were prepared by the aqueous co-precipitation of FeCl3-6H2O and FeCl2-4H2O with addition of ammonium hydroxide. The conditions for the preparation of Fe3O4 magnetic nanoparticles were optimized, and Fe3O4 magnetic nanoparticles obtained were characterized systematically by means of transmission electron microscope (TEM), dynamic laser scattering analyzer (DLS) and X-ray diffraction (XRD). The results revealed that the magnetic nanoparticles were cubic shaped and dispersive, with narrow size distribution and average diameter of 11.4 nm. It was found that the homogeneous variation of pH value in the solution via the control on the dropping rate of aqueous ammonia played a critical role in size distribution. The magnetic response of the product in the magnetic field was also analyzed and evaluated carefully. A 32.6 mT magnetic field which is produced by four ferromagnets was found to be sufficient to excite the dipole moments of 0.05 g Fe3O4 powder 2 cm far away from the ferromagnets. In conclusion, the Fe3O4 magnetic nanoparticles with excellent properties were competent for the magnetic carders of targeted-drug in future application. 展开更多
关键词 targeted--drug FE3O4 magnetic particle nanometre
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