Sulfonic acid groups were grafted onto three different types of synthesized magnetic nanoparticles, namely Fe3O4, Fe3O4@SiO2, and Fe3O4@MCM-48. The sulfonic acid-functionalized nanoparticles were evaluated as catalyst...Sulfonic acid groups were grafted onto three different types of synthesized magnetic nanoparticles, namely Fe3O4, Fe3O4@SiO2, and Fe3O4@MCM-48. The sulfonic acid-functionalized nanoparticles were evaluated as catalysts for the synthesis of 5-aryl-1H-benzo[f]chromeno[2,3-d]pyrimidine-2,4(3H,5H)-dione derivatives in terms of activity and recyclability. Their catalytic activities were compared with that of the homogeneous acid catalyst 1-methylimidazolium hydrogen sulfate([HMIm][HSO4]). The activity of Fe3O4@MCM-48–SO3H was comparable to those of the other heter-ogeneous and homogeneous catalysts.展开更多
The present paper covers a novel technology for the concentration of trace amounts of target oligonucleotide from the solution. This technique is based on a super-paramagnetic DNA nano-enricher constructed with a sing...The present paper covers a novel technology for the concentration of trace amounts of target oligonucleotide from the solution. This technique is based on a super-paramagnetic DNA nano-enricher constructed with a single strand DNA probe immobilized onto the surface of the super-paramagnetic nanoparticles prepared by using the water-in-oil microemulsion technique, employing silica as the shell and iron oxide as the core of the super-paramagnetic nanoparticles. The silica coated magnetic nanoparticles are (40±4) nm in size. And the magnetic nanoparticle is super-paramagnetic. Biotin labeled ssDNA(Biotin-5-(A)10-GAT-TCA-CGA-GGC-CCT-AGT-CG-3) was immobilized on the surface of silica coated magnetic nanoparticles. The complementary ssDNA could be enriched effectively and the characteristics of the enriched ssDNA have not changed, which will provide a novel technique and measurement for gene transfection, mutation detection, gene diagnosis, gene therapy and so on.展开更多
利用干细胞的多潜能特性进行移植和替代研究是再生医学的重要内容,利用磁性纳米颗粒对干细胞进行标记并进行磁共振实时动态监测是一种非常有前景的干细胞示踪方法[1-3],我们试图通过对超小型超顺磁性纳米铁颗粒（ultrasmall superparama...利用干细胞的多潜能特性进行移植和替代研究是再生医学的重要内容,利用磁性纳米颗粒对干细胞进行标记并进行磁共振实时动态监测是一种非常有前景的干细胞示踪方法[1-3],我们试图通过对超小型超顺磁性纳米铁颗粒（ultrasmall superparamagnetic iron oxide,USPIO）进行表面修饰后连接Tat穿膜肽,探讨这种方法能否将USPIO带人干细胞内,旨在为干细胞的磁共振示踪寻找一条新途径.展开更多
基金supported by Islamic Azad University, Rasht Branch
文摘Sulfonic acid groups were grafted onto three different types of synthesized magnetic nanoparticles, namely Fe3O4, Fe3O4@SiO2, and Fe3O4@MCM-48. The sulfonic acid-functionalized nanoparticles were evaluated as catalysts for the synthesis of 5-aryl-1H-benzo[f]chromeno[2,3-d]pyrimidine-2,4(3H,5H)-dione derivatives in terms of activity and recyclability. Their catalytic activities were compared with that of the homogeneous acid catalyst 1-methylimidazolium hydrogen sulfate([HMIm][HSO4]). The activity of Fe3O4@MCM-48–SO3H was comparable to those of the other heter-ogeneous and homogeneous catalysts.
文摘The present paper covers a novel technology for the concentration of trace amounts of target oligonucleotide from the solution. This technique is based on a super-paramagnetic DNA nano-enricher constructed with a single strand DNA probe immobilized onto the surface of the super-paramagnetic nanoparticles prepared by using the water-in-oil microemulsion technique, employing silica as the shell and iron oxide as the core of the super-paramagnetic nanoparticles. The silica coated magnetic nanoparticles are (40±4) nm in size. And the magnetic nanoparticle is super-paramagnetic. Biotin labeled ssDNA(Biotin-5-(A)10-GAT-TCA-CGA-GGC-CCT-AGT-CG-3) was immobilized on the surface of silica coated magnetic nanoparticles. The complementary ssDNA could be enriched effectively and the characteristics of the enriched ssDNA have not changed, which will provide a novel technique and measurement for gene transfection, mutation detection, gene diagnosis, gene therapy and so on.
文摘利用干细胞的多潜能特性进行移植和替代研究是再生医学的重要内容,利用磁性纳米颗粒对干细胞进行标记并进行磁共振实时动态监测是一种非常有前景的干细胞示踪方法[1-3],我们试图通过对超小型超顺磁性纳米铁颗粒（ultrasmall superparamagnetic iron oxide,USPIO）进行表面修饰后连接Tat穿膜肽,探讨这种方法能否将USPIO带人干细胞内,旨在为干细胞的磁共振示踪寻找一条新途径.
