AIM:To investigate glucose homeostasis and in particular gluconeogenesis in a large animal model of acute liver failure(ALF).METHODS:Six pigs with paracetamol induced ALF under general anaesthesia were studied over 25...AIM:To investigate glucose homeostasis and in particular gluconeogenesis in a large animal model of acute liver failure(ALF).METHODS:Six pigs with paracetamol induced ALF under general anaesthesia were studied over 25 h.Plasma samples were withdrawn every five hours from a central vein.Three animals were used as controls and were maintained under anaesthesia only.Using 1 H NMR spectroscopy we identified most gluconeogenic amino acids along with lactate and pyruvate in the animal plasma samples.RESULTS:No significant changes were observed in the concentrations of the amino acids studied in the animals maintained under anaesthesia only.If we look at the ALF animals,we observed a statistically significant rise of lactate(P<0.003)and pyruvate(P<0.018) at the end of the experiments.We also observed statistically significant rises in the concentrations of alanine(P<0.002),glycine(P<0.005),threonine(P< 0.048),tyrosine(P<0.000),phenylalanine(P<0.000) and isoleucine(P<0.01).Valine levels decreased significantly(P<0.05).CONCLUSION:Our pig model of ALF is characterized by an altered gluconeogenetic capacity,an impaired tricarboxylic acid(TCA)cycle and a glycolytic state.展开更多
Magnetic induction tomography(MIT) is one of the newest industrial process imaging techniques.Main industrial applications of the MIT imaging are in high conductive flow imaging.However,recently it has been shown that...Magnetic induction tomography(MIT) is one of the newest industrial process imaging techniques.Main industrial applications of the MIT imaging are in high conductive flow imaging.However,recently it has been shown that the MIT may be useful for low conductive process imaging.This paper presents a cost effective hardware design for MIT in industrial applications,called Bath-MKI industrial MIT system.The system comprises 8 inductor coils and has the possibility of expansion to 16 coils.The excitation signals and the measured voltages are generated and measured using a LabView based system.Two 16 by 1 multiplexers are used to select between the coils.Measurements,excitation and multiplexing are all controlled by a National Instrument(NI) USB based DAQ:USB-6259 and a signal generator.Using the same electronics,the prototype is tested with two different coil arrays;one is a small scale ferrite core coil and one larger scale air cored coil.Experimental image reconstruction results are shown using both small scale and large scale coil arrays.展开更多
The decadal variability of the North Atlantic thermohaline circulation(THC) is investigated within a three-dimensional ocean circulation model using the conditional nonlinear optimal perturbation method. The results s...The decadal variability of the North Atlantic thermohaline circulation(THC) is investigated within a three-dimensional ocean circulation model using the conditional nonlinear optimal perturbation method. The results show that the optimal initial perturbations of temperature and salinity exciting the strongest decadal THC variations have similar structures: the perturbations are mainly in the northwestern basin at a depth ranging from 1500 to 3000 m. These temperature and salinity perturbations act as the optimal precursors for future modifications of the THC, highlighting the importance of observations in the northwestern basin to monitor the variations of temperature and salinity at depth. The decadal THC variation in the nonlinear model initialized by the optimal salinity perturbations is much stronger than that caused by the optimal temperature perturbations, indicating that salinity variations might play a relatively important role in exciting the decadal THC variability. Moreover, the decadal THC variations in the tangent linear and nonlinear models show remarkably different characteristics, suggesting the importance of nonlinear processes in the decadal variability of the THC.展开更多
文摘AIM:To investigate glucose homeostasis and in particular gluconeogenesis in a large animal model of acute liver failure(ALF).METHODS:Six pigs with paracetamol induced ALF under general anaesthesia were studied over 25 h.Plasma samples were withdrawn every five hours from a central vein.Three animals were used as controls and were maintained under anaesthesia only.Using 1 H NMR spectroscopy we identified most gluconeogenic amino acids along with lactate and pyruvate in the animal plasma samples.RESULTS:No significant changes were observed in the concentrations of the amino acids studied in the animals maintained under anaesthesia only.If we look at the ALF animals,we observed a statistically significant rise of lactate(P<0.003)and pyruvate(P<0.018) at the end of the experiments.We also observed statistically significant rises in the concentrations of alanine(P<0.002),glycine(P<0.005),threonine(P< 0.048),tyrosine(P<0.000),phenylalanine(P<0.000) and isoleucine(P<0.01).Valine levels decreased significantly(P<0.05).CONCLUSION:Our pig model of ALF is characterized by an altered gluconeogenetic capacity,an impaired tricarboxylic acid(TCA)cycle and a glycolytic state.
文摘Magnetic induction tomography(MIT) is one of the newest industrial process imaging techniques.Main industrial applications of the MIT imaging are in high conductive flow imaging.However,recently it has been shown that the MIT may be useful for low conductive process imaging.This paper presents a cost effective hardware design for MIT in industrial applications,called Bath-MKI industrial MIT system.The system comprises 8 inductor coils and has the possibility of expansion to 16 coils.The excitation signals and the measured voltages are generated and measured using a LabView based system.Two 16 by 1 multiplexers are used to select between the coils.Measurements,excitation and multiplexing are all controlled by a National Instrument(NI) USB based DAQ:USB-6259 and a signal generator.Using the same electronics,the prototype is tested with two different coil arrays;one is a small scale ferrite core coil and one larger scale air cored coil.Experimental image reconstruction results are shown using both small scale and large scale coil arrays.
基金supported by the National Basic Research Program of China(973 Program,Grant No.2012CB417404)
文摘The decadal variability of the North Atlantic thermohaline circulation(THC) is investigated within a three-dimensional ocean circulation model using the conditional nonlinear optimal perturbation method. The results show that the optimal initial perturbations of temperature and salinity exciting the strongest decadal THC variations have similar structures: the perturbations are mainly in the northwestern basin at a depth ranging from 1500 to 3000 m. These temperature and salinity perturbations act as the optimal precursors for future modifications of the THC, highlighting the importance of observations in the northwestern basin to monitor the variations of temperature and salinity at depth. The decadal THC variation in the nonlinear model initialized by the optimal salinity perturbations is much stronger than that caused by the optimal temperature perturbations, indicating that salinity variations might play a relatively important role in exciting the decadal THC variability. Moreover, the decadal THC variations in the tangent linear and nonlinear models show remarkably different characteristics, suggesting the importance of nonlinear processes in the decadal variability of the THC.
