AIM: To evaluate the effectiveness of simethicone in enhancing visibility and efficacy during colonoscopy.METHODS: A prospective, double-blind, randomized, placebo-controlled study was conducted. One hundred and twe...AIM: To evaluate the effectiveness of simethicone in enhancing visibility and efficacy during colonoscopy.METHODS: A prospective, double-blind, randomized, placebo-controlled study was conducted. One hundred and twenty-four patients were allocated to receive 2 doses of sodium phosphate plus 240 mg of tablet simethicone or placebo as bowel preparation. Visibility was blindly assessed for the amount of air bubbles and adequacy of colon preparation. Total colonoscopic time, side effects of the medication, endoscopist and patient satisfaction were also compared.RESULTS: Sodium phosphate plus simethicone, compared to sodium phosphate plus placebo, improved visibility by diminishing air bubbles (100.00% vs 42.37%, P 〈 0.0002) but simethicone failed to demonstrate improvement in adequacy of colon preparation (90.16% vs 81.36%, P = 0.17). Endoscopist and patient satisfaction were increased significantly in the simethicone group. However, there was no difference in the total duration of colonoscopy and side effects of the medication.CONCLUSION: The addition of simethicone is of benefit for colonoscopic bowel preparation by diminishing air bubbles, which results in enhanced visibility. Endoscopist and patient satisfaction is also increased.展开更多
The effects of different application levels and species of phosphatic fertilizer on Eleocharis dulcis were studied. The results showed that the growth stage of Eleocharis dulcis was not significantly influenced by dif...The effects of different application levels and species of phosphatic fertilizer on Eleocharis dulcis were studied. The results showed that the growth stage of Eleocharis dulcis was not significantly influenced by different levels of phosphatic fertilizer application, with phosphorus level in 195-375 kg/hm^2. With increasing of the phosphorus level, starch and total soluble sugar accumulated, but the yield was not improved significantly. The analysis on the economic benefits showed that the best phosphorus level was 195 kg/hm^2. The growth stage and yield of Eleocharis dulcis were not considerably influenced by different proportions of calcium-magnesia phosphate fertilizer and ammonium dihydrogen phosphate. With increasing of ammonium dihydrogen phosphate, big-fruit rate of Eleocharis dulcis kept growing, but the accumulations of starch and total soluble sugar were decreasing.展开更多
The aim of this study was to establish a quality-control method for calcineurin subunit B(CNB) biological activity determinations. CNB enhances the p-nitrophenylphosphate(p NPP) dephosphorylating activity of calcineur...The aim of this study was to establish a quality-control method for calcineurin subunit B(CNB) biological activity determinations. CNB enhances the p-nitrophenylphosphate(p NPP) dephosphorylating activity of calcineurin subunit A Δ316 mutant(CNAΔ316). A series of CNB concentrations were fitted to a four-parameter equation to calculate the corresponding p NPP maximum dephosphorylation rates. Values were calculated based on biological activity references using a parallel line method. The method was then validated for accuracy, precision, linearity, linear range, sensitivity, specificity, and robustness. The recovery results were greater than 98%. Intra-plate precision was 6.7%, with inter-plate precision of 10.8%. The coefficient of determination was greater than 0.98. The linear range was 0.05–50 μg m L?1, with sensitivity of 50 μg m L?1. Tested cytokines did not induce CNAΔ316 dephosphorylation of p NPP. The chosen CNAΔ316 concentration range did not affect activity determinations.展开更多
基金Supported by The Gastroenterological Association of Thailand
文摘AIM: To evaluate the effectiveness of simethicone in enhancing visibility and efficacy during colonoscopy.METHODS: A prospective, double-blind, randomized, placebo-controlled study was conducted. One hundred and twenty-four patients were allocated to receive 2 doses of sodium phosphate plus 240 mg of tablet simethicone or placebo as bowel preparation. Visibility was blindly assessed for the amount of air bubbles and adequacy of colon preparation. Total colonoscopic time, side effects of the medication, endoscopist and patient satisfaction were also compared.RESULTS: Sodium phosphate plus simethicone, compared to sodium phosphate plus placebo, improved visibility by diminishing air bubbles (100.00% vs 42.37%, P 〈 0.0002) but simethicone failed to demonstrate improvement in adequacy of colon preparation (90.16% vs 81.36%, P = 0.17). Endoscopist and patient satisfaction were increased significantly in the simethicone group. However, there was no difference in the total duration of colonoscopy and side effects of the medication.CONCLUSION: The addition of simethicone is of benefit for colonoscopic bowel preparation by diminishing air bubbles, which results in enhanced visibility. Endoscopist and patient satisfaction is also increased.
基金Supported by Key Projects in Hubei Science&Technology Pillar Program in 2015(2015BBA199)Guangxi Agricultural Department Science Research ProgramHubei Agricultural S&T Innovation(2016-620-007-001)
文摘The effects of different application levels and species of phosphatic fertilizer on Eleocharis dulcis were studied. The results showed that the growth stage of Eleocharis dulcis was not significantly influenced by different levels of phosphatic fertilizer application, with phosphorus level in 195-375 kg/hm^2. With increasing of the phosphorus level, starch and total soluble sugar accumulated, but the yield was not improved significantly. The analysis on the economic benefits showed that the best phosphorus level was 195 kg/hm^2. The growth stage and yield of Eleocharis dulcis were not considerably influenced by different proportions of calcium-magnesia phosphate fertilizer and ammonium dihydrogen phosphate. With increasing of ammonium dihydrogen phosphate, big-fruit rate of Eleocharis dulcis kept growing, but the accumulations of starch and total soluble sugar were decreasing.
基金supported by the National Important Novel Medicine Research Project (2012ZX09304010, 2013ZX09102062)the National Natural Science Foundation of China (31270849)
文摘The aim of this study was to establish a quality-control method for calcineurin subunit B(CNB) biological activity determinations. CNB enhances the p-nitrophenylphosphate(p NPP) dephosphorylating activity of calcineurin subunit A Δ316 mutant(CNAΔ316). A series of CNB concentrations were fitted to a four-parameter equation to calculate the corresponding p NPP maximum dephosphorylation rates. Values were calculated based on biological activity references using a parallel line method. The method was then validated for accuracy, precision, linearity, linear range, sensitivity, specificity, and robustness. The recovery results were greater than 98%. Intra-plate precision was 6.7%, with inter-plate precision of 10.8%. The coefficient of determination was greater than 0.98. The linear range was 0.05–50 μg m L?1, with sensitivity of 50 μg m L?1. Tested cytokines did not induce CNAΔ316 dephosphorylation of p NPP. The chosen CNAΔ316 concentration range did not affect activity determinations.