Polysensitivity in fixed drug eruption is a rare finding that occurs because of chemically unrelated drugs.In cases of polysensitivity, the lesions may occur on identical or separate sites, the latter indicating the r...Polysensitivity in fixed drug eruption is a rare finding that occurs because of chemically unrelated drugs.In cases of polysensitivity, the lesions may occur on identical or separate sites, the latter indicating the role of antigen-specific mechanisms in the site-specificity of fixed drug eruption.I herein report a patient with separate site involvement induced by trimethoprim-sulfamethoxazole and tenoxicam, a drug combination that has not been reported before.Reactivation of old trimethoprim-sulfamethoxazole-specific lesions after a long resting period was another striking feature.展开更多
Background. High-dose intravenous immunoglobulin (IVIG)is emerging as a promising new therapy for treating the rare but potentially fatal drug reaction toxic epidermal necrolysis (TEN). Experimental in vitro studies s...Background. High-dose intravenous immunoglobulin (IVIG)is emerging as a promising new therapy for treating the rare but potentially fatal drug reaction toxic epidermal necrolysis (TEN). Experimental in vitro studies support that IVIG can block the Fas-FasL-mediated apoptosis in TEN. Methods. Twelve consecutive patients (7M, 5F) with TEN admitted over a 5-year period from January 1998 to December 2002 were treated with a dose of 0.5-1.0 g/kg/d of IVIG for 45 days along with standard care protocol. Clinical outcome in terms of average duration to arrest the progression, complete healing, hospital stay, side-effects and complications were determined to find the efficacy of IVIG treatment. Results. Average age was 27.16 years (7-50 years). There were four children (2M, 2F) aged 7-12 years. One patient had an underlying malignancy. No patient had HIV infection. The average total body surface area involvement was 57.5%(30-90%). An IVIG infusion was started, on average, 1.58 days (1-3 days) after admission. All patients responded well to the treatment. There was no mortality. The disease progression was arrested in a mean of 2.83 days (1-5 days). Time taken for complete healing (re-epithelialization)was 7.33 days (5-13 days). The average duration of hospital stay was 12.5 days (7-21 days). No side-effects of the IVIG treatment were observed in these patients. The drugs triggering TEN in these patients were phenytoin (four patients), followed by penicillin (three), cotrimoxazole (two), phenobarbital and furosemide (one patient each), respectively. In one patient, the offending drug could not be ascertained. Conclusion. Our experience of treating 12 patients with TEN using IVIG, in Kuwait, confirms that it is a safe and effective treatment for these patients.展开更多
Basidiobolomycosis is a chronic inflammatory disease that occurs exclusively in healthy individuals.Clinically, the infection is generally restricted to subcutaneous tissue; however, the disease has been documented to...Basidiobolomycosis is a chronic inflammatory disease that occurs exclusively in healthy individuals.Clinically, the infection is generally restricted to subcutaneous tissue; however, the disease has been documented to emerge in visceral organs but seldom spreads to cause disseminated infection We describe the first culture confirmed case of systemic Basidiobolus ranarum infection in an immunosuppressed patient A 55 yearold female renal transplant recipient developed chronic hard nonpitting oedema of the right lower extremity and abdominal wall concurrent with the infection from the same organism involving the uterus, urinary bladder and intra abdominal lymph nodes The patient responded successfully, both clinically and radiographically, to medical therapy without surgical resection The treatment regimen consisted of potassium iodide and trimethoprim/sulfamethoxazole for 3 months, and the patient remains clear of symptoms after 10 monthsfollow展开更多
The aim of this study was to determine presence of Salmonella spp. in chicken meat samples collected from Ankara, Turkey and determine the susceptibility of the Salmonella isolates to some antimicrobial agents. For th...The aim of this study was to determine presence of Salmonella spp. in chicken meat samples collected from Ankara, Turkey and determine the susceptibility of the Salmonella isolates to some antimicrobial agents. For this purpose, 127 chicken samples were collected from local markets. Investigation of Salmonella was done according to horizontal method, the guidelines of the method recommended by International Standards Organization （ISO）. Antimicrobial susceptibilities of Salmonella spp. was performed with microdilution method according to the guidelines of CLSI M100-SI8. Ampicillin, gentamicin sulphate, ofloxacin, levofloxacin, ciprofloxacin, enrofloxacin, tetracycline, ceftriaxon, amoxicillin/clavulanic acid and trimethoprim/sulfamethoxazole were used in the study. Salmonella spp. was isolated from 5 （3.94%） of the 127 chicken meat samples. Although our findings are not within Turkish Food Codex （TFC） values, lower number of samples that involve Salmonella spp. indicates an improvement in the hygienic conditions in Turkey. Among 5 isolates, one isolate was sensitive to all antimicrobial agents tested. 2 isolates exhibited multidrug resistance. Successfully, all the isolates were sensitive to quinolones as a good result in spite of the reported reduced susceptibility from different regions of the world. However, this study should be improved with more chicken samples and Salmonella spp. isolate numbers to support these results.展开更多
A total of 57 samples, of which 17 were surface water samples and 40 were dairy food samples （raw milk, pasteurized milk, icecream, sweet, milk based drink like matha and borhani） were tested for the isolation ofLis...A total of 57 samples, of which 17 were surface water samples and 40 were dairy food samples （raw milk, pasteurized milk, icecream, sweet, milk based drink like matha and borhani） were tested for the isolation ofListeria spp. Putative Listeria isolates were identified by conventional microbiological tests and Analytical Profile Index. Overall prevalence ofListeria spp. in both food and water samples were 8.77%, of which one was （1.75%） Listeria monocytogenes, 2 （3.5%） were Listeria innocua and 2 were （3.5%） Listeria welshimeri. When compared between two types of samples, water samples contained two Listeria spp. （11.76%） of which one was pathogenic Listeria monocytogenes and the other was Listeria innocua. In case of food samples, three Listeria spp. （7.5%） were isolated of which one was Listeria innocua （icecream sample） and two were Listeria welshimeri （icecream sample and raw milk）. No Listeria was found in pasteurized milk, sweet, matha and borhani. Antibiotic resistance profile of the Listeria isolates showed that 60% isolates were resistant to Ampicillin and Erythromycin, 20% isolates were Sulphamethoxazole and Ciprofloxacin resistant. No resistance was observed to Chloramphenicol for any Listeria isolates.展开更多
文摘Polysensitivity in fixed drug eruption is a rare finding that occurs because of chemically unrelated drugs.In cases of polysensitivity, the lesions may occur on identical or separate sites, the latter indicating the role of antigen-specific mechanisms in the site-specificity of fixed drug eruption.I herein report a patient with separate site involvement induced by trimethoprim-sulfamethoxazole and tenoxicam, a drug combination that has not been reported before.Reactivation of old trimethoprim-sulfamethoxazole-specific lesions after a long resting period was another striking feature.
文摘Background. High-dose intravenous immunoglobulin (IVIG)is emerging as a promising new therapy for treating the rare but potentially fatal drug reaction toxic epidermal necrolysis (TEN). Experimental in vitro studies support that IVIG can block the Fas-FasL-mediated apoptosis in TEN. Methods. Twelve consecutive patients (7M, 5F) with TEN admitted over a 5-year period from January 1998 to December 2002 were treated with a dose of 0.5-1.0 g/kg/d of IVIG for 45 days along with standard care protocol. Clinical outcome in terms of average duration to arrest the progression, complete healing, hospital stay, side-effects and complications were determined to find the efficacy of IVIG treatment. Results. Average age was 27.16 years (7-50 years). There were four children (2M, 2F) aged 7-12 years. One patient had an underlying malignancy. No patient had HIV infection. The average total body surface area involvement was 57.5%(30-90%). An IVIG infusion was started, on average, 1.58 days (1-3 days) after admission. All patients responded well to the treatment. There was no mortality. The disease progression was arrested in a mean of 2.83 days (1-5 days). Time taken for complete healing (re-epithelialization)was 7.33 days (5-13 days). The average duration of hospital stay was 12.5 days (7-21 days). No side-effects of the IVIG treatment were observed in these patients. The drugs triggering TEN in these patients were phenytoin (four patients), followed by penicillin (three), cotrimoxazole (two), phenobarbital and furosemide (one patient each), respectively. In one patient, the offending drug could not be ascertained. Conclusion. Our experience of treating 12 patients with TEN using IVIG, in Kuwait, confirms that it is a safe and effective treatment for these patients.
文摘Basidiobolomycosis is a chronic inflammatory disease that occurs exclusively in healthy individuals.Clinically, the infection is generally restricted to subcutaneous tissue; however, the disease has been documented to emerge in visceral organs but seldom spreads to cause disseminated infection We describe the first culture confirmed case of systemic Basidiobolus ranarum infection in an immunosuppressed patient A 55 yearold female renal transplant recipient developed chronic hard nonpitting oedema of the right lower extremity and abdominal wall concurrent with the infection from the same organism involving the uterus, urinary bladder and intra abdominal lymph nodes The patient responded successfully, both clinically and radiographically, to medical therapy without surgical resection The treatment regimen consisted of potassium iodide and trimethoprim/sulfamethoxazole for 3 months, and the patient remains clear of symptoms after 10 monthsfollow
文摘The aim of this study was to determine presence of Salmonella spp. in chicken meat samples collected from Ankara, Turkey and determine the susceptibility of the Salmonella isolates to some antimicrobial agents. For this purpose, 127 chicken samples were collected from local markets. Investigation of Salmonella was done according to horizontal method, the guidelines of the method recommended by International Standards Organization （ISO）. Antimicrobial susceptibilities of Salmonella spp. was performed with microdilution method according to the guidelines of CLSI M100-SI8. Ampicillin, gentamicin sulphate, ofloxacin, levofloxacin, ciprofloxacin, enrofloxacin, tetracycline, ceftriaxon, amoxicillin/clavulanic acid and trimethoprim/sulfamethoxazole were used in the study. Salmonella spp. was isolated from 5 （3.94%） of the 127 chicken meat samples. Although our findings are not within Turkish Food Codex （TFC） values, lower number of samples that involve Salmonella spp. indicates an improvement in the hygienic conditions in Turkey. Among 5 isolates, one isolate was sensitive to all antimicrobial agents tested. 2 isolates exhibited multidrug resistance. Successfully, all the isolates were sensitive to quinolones as a good result in spite of the reported reduced susceptibility from different regions of the world. However, this study should be improved with more chicken samples and Salmonella spp. isolate numbers to support these results.
文摘A total of 57 samples, of which 17 were surface water samples and 40 were dairy food samples （raw milk, pasteurized milk, icecream, sweet, milk based drink like matha and borhani） were tested for the isolation ofListeria spp. Putative Listeria isolates were identified by conventional microbiological tests and Analytical Profile Index. Overall prevalence ofListeria spp. in both food and water samples were 8.77%, of which one was （1.75%） Listeria monocytogenes, 2 （3.5%） were Listeria innocua and 2 were （3.5%） Listeria welshimeri. When compared between two types of samples, water samples contained two Listeria spp. （11.76%） of which one was pathogenic Listeria monocytogenes and the other was Listeria innocua. In case of food samples, three Listeria spp. （7.5%） were isolated of which one was Listeria innocua （icecream sample） and two were Listeria welshimeri （icecream sample and raw milk）. No Listeria was found in pasteurized milk, sweet, matha and borhani. Antibiotic resistance profile of the Listeria isolates showed that 60% isolates were resistant to Ampicillin and Erythromycin, 20% isolates were Sulphamethoxazole and Ciprofloxacin resistant. No resistance was observed to Chloramphenicol for any Listeria isolates.
