In order to study the variation o f the asphalt pavement water film thickness influenced by multi-factors,anew method for predicting water film thickness was developed by the combination o f the artificial neural netw...In order to study the variation o f the asphalt pavement water film thickness influenced by multi-factors,anew method for predicting water film thickness was developed by the combination o f the artificial neural network(ANN)a d two-dimensional shallow water equations based on hydrodynamic theory.Multi-factors included the rainfall intensity,pavement width,cross slope,longitudinal slope a d pavement roughness coefficient.The two-dimensional hydrodynamic method was validated by a natural rainfall event.Based on the design scheme o f Shen-Sha expressway engineering project,the limited training data obtained by the two-dimensional hydrodynamic simulation model was used to predict water film thickness.Furthermore,the distribution of the water film thickness influenced by multi-factors on the pavement was analyzed.The accuracy o f the ANN model was verified by the18sets o f data with a precision o f0.991.The simulation results indicate that the water film thickness increases from the median strip to the edge o f the pavement.The water film thickness variation is obviously influenced by rainfall intensity.Under the condition that the pavement width is20m and t e rainfall intensity is3m m/h,t e water film thickness is below10mm in the fast lane and20mm in t e lateral lane.Athough there is fluctuation due to the amount oftraining data,compared with the calculation on the basis o f the existing criterion and theory,t e ANN model exhibits a better performance for depicting the macroscopic distribution of the asphalt pavement water film.展开更多
The adaptive learning and prediction of a highly nonlinear and time-varying bioreactor benchmark process is studied using Neur-On-Line, a graphical tool kit for developing and deploying neural networks in the G2 real ...The adaptive learning and prediction of a highly nonlinear and time-varying bioreactor benchmark process is studied using Neur-On-Line, a graphical tool kit for developing and deploying neural networks in the G2 real time intelligent environment,and a new modified Broyden, Fletcher, Goldfarb, and Shanno (BFGS) quasi-Newton algorithm. The modified BFGS algorithm for the adaptive learning of back propagation (BP) neural networks is developed and embedded into NeurOn-Line by introducing a new search method of learning rate to the full memory BFGS algorithm. Simulation results show that the adaptive learning and prediction neural network system can quicklv track the time-varving and nonlinear behavior of the bioreactor.展开更多
One of biggest recent achievements of neurobiology is the study on neurotrophic factors. The neurotrophins are exciting examples of these factors. They belong to a family of proteins consisting of nerve growth fac-tor...One of biggest recent achievements of neurobiology is the study on neurotrophic factors. The neurotrophins are exciting examples of these factors. They belong to a family of proteins consisting of nerve growth fac-tor (NGF), brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3), NT-4/5, NT-6, and NT-7. Today, NGF and BDNF are well recognized to mediate a diz-zying number of trophobiological effects, ranging from neurotrophic through immunotrophic and epitheliotro-phic to metabotrophic effects. These are implicated in the pathogenesis of various diseases. In the same vein, recent studies in adipobiology reveal that this tissue is the body’s largest endocrine and paracrine organ producing multiple signaling proteins collectively termed adipokines, with NGF and BDNF being also produced from adipose tissue. Altogether, neurobio-logy and adipobiology contribute to the improvement of our knowledge on diseases beyond obesity such as cardiometabolic (atherosclerosis, type 2 diabetes, and metabolic syndrome) and neuropsychiatric (e.g. , Alzheimer’s disease and depression) diseases. The present review updates evidence for (1) neurotrophic and metabotrophic potentials of NGF and BDNF linking the pathogenesis of these diseases, and (2) NGF- and BDNF-mediated effects in ampakines, NMDA receptor antagonists, antidepressants, selective deacetylase inhibitors, statins, peroxisome proliferator-activated receptor gamma agonists, and purinergic P2X3 recep-tor up-regulation. This may help to construct a novel paradigm in the feld of translational pharmacology of neuro-metabotrophins, particularly NGF and BDNF.展开更多
This paper attempts to survey a minor character--the governess in Rebecca with the psychoanalytical theory, especially emphasizing her abnormal maternity towards Rebecca and trying to dig out its profound causes and i...This paper attempts to survey a minor character--the governess in Rebecca with the psychoanalytical theory, especially emphasizing her abnormal maternity towards Rebecca and trying to dig out its profound causes and its several abnormal characteristics. At last, the following conclusion is drawn: It is just this abnormal maternity that leads to the governess' self-destruction.展开更多
Apply the visual management in the teaching of the nursing education, and strengthen the cultivation of the spirit of Nightingale of the nursing students. According to the characteristics of the method of the visual m...Apply the visual management in the teaching of the nursing education, and strengthen the cultivation of the spirit of Nightingale of the nursing students. According to the characteristics of the method of the visual management, using the visual and iconic teaching methods, construct the scene and the atmosphere of the rich cultural atmosphere, to stimulate the students' human emotional experience. Through several approaches, carry forward the spirit of Nightingale education of the nursing students, and make the students establish the lofty values of the nursing occupation, to provide the nursing care of high quality for the patients.展开更多
A direct feedback control system based on fuzzy recurrent neural network is proposed, and a method of training weights of fuzzy recurrent neural network was designed by applying modified contract mapping genetic algor...A direct feedback control system based on fuzzy recurrent neural network is proposed, and a method of training weights of fuzzy recurrent neural network was designed by applying modified contract mapping genetic algorithm. Computer simulation results indicate that fuzzy recurrent neural network controller has perfect dynamic and static performances .展开更多
Artifi cial neural network is a kind of artificial intelligence method to simulate the function of human brain, and deep learning technology can establish a depth network model with hierarchical structure on the basis...Artifi cial neural network is a kind of artificial intelligence method to simulate the function of human brain, and deep learning technology can establish a depth network model with hierarchical structure on the basis of artificial neural network. Deep learning brings new development direction to artificial neural network. Convolution neural network is a new artificial neural network method, which combines artificial neural network and deep learning technology, and this new neural network is widely used in many fields of computer vision. Modern image recognition algorithm requires classifi cation system to adapt to different types of tasks, and deep network and convolution neural network is a hot research topic in neural networks. According to the characteristics of satellite digital image, we use the convolution neural network to classify the image, which combines texture features with spectral features. The experimental results show that the convolution neural network algorithm can effectively classify the image.展开更多
A new algorithm to exploit the learning rates of gradient descent method is presented, based on the second-order Taylor expansion of the error energy function with respect to learning rate, at some values decided by &...A new algorithm to exploit the learning rates of gradient descent method is presented, based on the second-order Taylor expansion of the error energy function with respect to learning rate, at some values decided by "award-punish" strategy. Detailed deduction of the algorithm applied to RBF networks is given. Simulation studies show that this algorithm can increase the rate of convergence and improve the performance of the gradient descent method.展开更多
In the context of new risks and threats associated to nuclear, biological and chemical (NBC) attacks, and given the shortcomings of certain analytical methods such as principal component analysis (PCA), a neural n...In the context of new risks and threats associated to nuclear, biological and chemical (NBC) attacks, and given the shortcomings of certain analytical methods such as principal component analysis (PCA), a neural network approach seems to be more accurate. PCA consists in projecting the spectrum of a gas collected from a remote sensing system in, firstly, a three-dimensional space, then in a two-dimensional one using a model of Multi-Layer Perceptron based neural network. It adopts during the learning process, the back propagation algorithm of the gradient, in which the mean square error output is continuously calculated and compared to the input until it reaches a minimal threshold value. This aims to correct the synaptic weights of the network. So, the Artificial Neural Network (ANN) tends to be more efficient in the classification process. This paper emphasizes the contribution of the ANN method in the spectral data processing, classification and identification and in addition, its fast convergence during the back propagation of the gradient.展开更多
Objective To observe the influence of hypotherrnic circulatory arrest (HCA) on the apoptotic processes of neurons in the hippocampus and the expression of the related genes Bcl-2 and Bax, and compare to the intermit...Objective To observe the influence of hypotherrnic circulatory arrest (HCA) on the apoptotic processes of neurons in the hippocampus and the expression of the related genes Bcl-2 and Bax, and compare to the intermittent antegrade cerebral perfusion. Methods Eighteen dogs were randomly divided into three groups: control group (6 animals, underwent normal temperature cardiopulmonary bypass, NCPB), HCA group (6 animals, underwent HCA for 1 h), and HCA + IACP group (6 animals, underwent HCA for 1 h, combined with intermittent antegrade cerebral perfusion (IACP) every 15 min). The hippocampus tissue was retrieved 2h after the CPB discontinued The expression of Bcl-2 and Bax were examined with immunohistochemistry method. The cytomorphologic changes of the hippocampus tissue were investigated with transmission electron microscopy (TEM). Results The immunohistochemical staining showed that Bax protein levels were significantly higher in HCA group than in the other two groups (P〈0.01), while Bcl-2 protein levels were significantly higher in HCA + IACP group than that of the other two groups (P〈0.01). Meanwhile, the TEM results showed that there was no apoptosis of neurons in control group, but neuronal apoptotic changes could be clearly observed in HCA group, and only a small amount of apoptotic neurons were seen in HCA + IACP group. Conclusions HCA alone can induce neuronal apoptosis in the hippocampus. IACP during the HCA period has a protective effect on the cerebral tissue through suppressing apoptosis by decreasing Bax expression and increasing Bcl-2 expression.展开更多
Neural network and genetic algorithms are complementary technologies in the design of adaptive intelligent system. Neural network learns from scratch by adjusting the interconnections betweens layers. Genetic algorith...Neural network and genetic algorithms are complementary technologies in the design of adaptive intelligent system. Neural network learns from scratch by adjusting the interconnections betweens layers. Genetic algorithms are a popular computing framework that uses principals from natural population genetics to evolve solutions to problems. Various forecasting methods have been developed on the basis of neural network, but accuracy has been matter of concern in these forecasts. In neural network methods forecasted values depend to the choose of neural predictor structure, the number of the input, the lag. To remedy to these problem, in this paper, the authors are investing the applicability of an automatic design of a neural predictor realized by real Genetic Algorithms to predict the future value of a time series. The prediction method is tested by using meteorology time series that are daily and weekly mean temperatures in Melbourne, Australia, 1980-1990.展开更多
In this paper, we conduct research on the causes and coping strategies of the land subsidence caused by the tunnel construction projects. We analyze the issues from the following of the perspectives. (1) Analysis me...In this paper, we conduct research on the causes and coping strategies of the land subsidence caused by the tunnel construction projects. We analyze the issues from the following of the perspectives. (1) Analysis method. To solve large scale system of the development of computer hardware and the numerical calculation method, we use the basic analysis to deal with it. (2) The empirical of methods. Ground motion is usually leads to the basic development of the inclined tunnel surface vertical displacement, the result of the movement process can turn to a settling tank. (3) Machine learning based approaches. In one of biggest difficulties when using neural network method is to obtain all possible parameters related to ground subsidence, we use the machine learning model to handle the challenge. In the final part, we show prospect for the future research, we will combine more numerical analysis tools to optimize the current methodology.展开更多
Synchronization of neurons plays an important role in vision, movement and memory. However, many neurological disorders such as epilepsies, Parkinson disease and essen- tial tremor are related to excessive synchroniza...Synchronization of neurons plays an important role in vision, movement and memory. However, many neurological disorders such as epilepsies, Parkinson disease and essen- tial tremor are related to excessive synchronization of neurons. In the line of therapy, stimulations to these pathologically synchronized neurons should be capable of breaking synchrony. As the first step of designing an effective stimulation, we consider desynchro- nization problem of coupled limit-cycle oscillators ensemble. First, the desynchronization problem is redefined in a nonlinear output regulation framework. Then, we design an output regulator (stimulation) which forces limit-cycle oscillators to track exogenous sinusoidal references with different phases. The proposed stimulation is robust against variations of oscillators' frequencies. Mathematical analysis and simulation results reveal the efficiency of the proposed technique.展开更多
A novel linear microprobe array(LMPA)has been developed by a conventional microfabrication method from silicon.The LMPA leverages the properties of conventional microwire with additional features of naturally formed r...A novel linear microprobe array(LMPA)has been developed by a conventional microfabrication method from silicon.The LMPA leverages the properties of conventional microwire with additional features of naturally formed regular spacing.With the help of periodic microprobe arrays and double-side V-grooves fabricated in advance between each pair of the two microprobes’rear ends,the number of microprobe units for assembly in one array can be flexibly chosen by cleavage fracture from the LMPA.The fabrication method was demonstrated and the prototype device was assessed by electrochemical impedance spectroscopy(EIS)and in vivo test.The SNR of the spikes recorded was 6.展开更多
Autism is a complex neuropsychiatric disorder of developmental origin, where multiple genetic and environmental factors likely interact resulting in a clinical continuum between "affected" and "unaffect...Autism is a complex neuropsychiatric disorder of developmental origin, where multiple genetic and environmental factors likely interact resulting in a clinical continuum between "affected" and "unaffected" individuals in the general population. During the last two decades, relevant progress has been made in identifying chromosomal regions and genes in linkage or association with autism, but no single gene has emerged as a major cause of disease in a large number of patients. The purpose of this paper is to discuss specific methodological issues and experimental strategies in autism genetic research, based on fourteen years of experience in patient recruitment and association studies of autism spectrum disorder in Italy.展开更多
Clinical medicine and experiments have shown that electrophysiological activities on neuronal disease systems such as the epilepsy and Parkinson can exhibit the evolutions of complex dynamical behaviors and their tran...Clinical medicine and experiments have shown that electrophysiological activities on neuronal disease systems such as the epilepsy and Parkinson can exhibit the evolutions of complex dynamical behaviors and their transitions, which are closely related to the generation mechanism of neuronal diseases. Traditionally, electrophysiological activities have been analyzed from the statistical methods. Although some ideal results have been obtained, mechanisms of complex electrophysiological activities in neuronal systems cannot yet be disclosed. Dynamics modelling can help researchers to explore the mechanisms of electro- physiological activities of neuronal disease systems. By constructing reasonable physiological dynamical model, inner relation between the dynamics model and representation behaviors of the neuronal disease systems can be further studied. In addition, based on the constructed network model, we can also explore mechanisms of the evolutions of dynamical behaviors and their transitions of the initiation, propagation and termination of different kinds of the seizures. Finally, we can design the feasible control method to regulate dynamics behaviors of the seizures so as to realize the healthy neuronal firings.展开更多
基金The National Natural Science Foundation of China(No.51478114,51778136)the Transportation Science and Technology Program of Liaoning Province(No.201532)
文摘In order to study the variation o f the asphalt pavement water film thickness influenced by multi-factors,anew method for predicting water film thickness was developed by the combination o f the artificial neural network(ANN)a d two-dimensional shallow water equations based on hydrodynamic theory.Multi-factors included the rainfall intensity,pavement width,cross slope,longitudinal slope a d pavement roughness coefficient.The two-dimensional hydrodynamic method was validated by a natural rainfall event.Based on the design scheme o f Shen-Sha expressway engineering project,the limited training data obtained by the two-dimensional hydrodynamic simulation model was used to predict water film thickness.Furthermore,the distribution of the water film thickness influenced by multi-factors on the pavement was analyzed.The accuracy o f the ANN model was verified by the18sets o f data with a precision o f0.991.The simulation results indicate that the water film thickness increases from the median strip to the edge o f the pavement.The water film thickness variation is obviously influenced by rainfall intensity.Under the condition that the pavement width is20m and t e rainfall intensity is3m m/h,t e water film thickness is below10mm in the fast lane and20mm in t e lateral lane.Athough there is fluctuation due to the amount oftraining data,compared with the calculation on the basis o f the existing criterion and theory,t e ANN model exhibits a better performance for depicting the macroscopic distribution of the asphalt pavement water film.
文摘The adaptive learning and prediction of a highly nonlinear and time-varying bioreactor benchmark process is studied using Neur-On-Line, a graphical tool kit for developing and deploying neural networks in the G2 real time intelligent environment,and a new modified Broyden, Fletcher, Goldfarb, and Shanno (BFGS) quasi-Newton algorithm. The modified BFGS algorithm for the adaptive learning of back propagation (BP) neural networks is developed and embedded into NeurOn-Line by introducing a new search method of learning rate to the full memory BFGS algorithm. Simulation results show that the adaptive learning and prediction neural network system can quicklv track the time-varving and nonlinear behavior of the bioreactor.
文摘One of biggest recent achievements of neurobiology is the study on neurotrophic factors. The neurotrophins are exciting examples of these factors. They belong to a family of proteins consisting of nerve growth fac-tor (NGF), brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3), NT-4/5, NT-6, and NT-7. Today, NGF and BDNF are well recognized to mediate a diz-zying number of trophobiological effects, ranging from neurotrophic through immunotrophic and epitheliotro-phic to metabotrophic effects. These are implicated in the pathogenesis of various diseases. In the same vein, recent studies in adipobiology reveal that this tissue is the body’s largest endocrine and paracrine organ producing multiple signaling proteins collectively termed adipokines, with NGF and BDNF being also produced from adipose tissue. Altogether, neurobio-logy and adipobiology contribute to the improvement of our knowledge on diseases beyond obesity such as cardiometabolic (atherosclerosis, type 2 diabetes, and metabolic syndrome) and neuropsychiatric (e.g. , Alzheimer’s disease and depression) diseases. The present review updates evidence for (1) neurotrophic and metabotrophic potentials of NGF and BDNF linking the pathogenesis of these diseases, and (2) NGF- and BDNF-mediated effects in ampakines, NMDA receptor antagonists, antidepressants, selective deacetylase inhibitors, statins, peroxisome proliferator-activated receptor gamma agonists, and purinergic P2X3 recep-tor up-regulation. This may help to construct a novel paradigm in the feld of translational pharmacology of neuro-metabotrophins, particularly NGF and BDNF.
文摘This paper attempts to survey a minor character--the governess in Rebecca with the psychoanalytical theory, especially emphasizing her abnormal maternity towards Rebecca and trying to dig out its profound causes and its several abnormal characteristics. At last, the following conclusion is drawn: It is just this abnormal maternity that leads to the governess' self-destruction.
文摘Apply the visual management in the teaching of the nursing education, and strengthen the cultivation of the spirit of Nightingale of the nursing students. According to the characteristics of the method of the visual management, using the visual and iconic teaching methods, construct the scene and the atmosphere of the rich cultural atmosphere, to stimulate the students' human emotional experience. Through several approaches, carry forward the spirit of Nightingale education of the nursing students, and make the students establish the lofty values of the nursing occupation, to provide the nursing care of high quality for the patients.
文摘A direct feedback control system based on fuzzy recurrent neural network is proposed, and a method of training weights of fuzzy recurrent neural network was designed by applying modified contract mapping genetic algorithm. Computer simulation results indicate that fuzzy recurrent neural network controller has perfect dynamic and static performances .
文摘Artifi cial neural network is a kind of artificial intelligence method to simulate the function of human brain, and deep learning technology can establish a depth network model with hierarchical structure on the basis of artificial neural network. Deep learning brings new development direction to artificial neural network. Convolution neural network is a new artificial neural network method, which combines artificial neural network and deep learning technology, and this new neural network is widely used in many fields of computer vision. Modern image recognition algorithm requires classifi cation system to adapt to different types of tasks, and deep network and convolution neural network is a hot research topic in neural networks. According to the characteristics of satellite digital image, we use the convolution neural network to classify the image, which combines texture features with spectral features. The experimental results show that the convolution neural network algorithm can effectively classify the image.
基金Open Foundation of State Key Lab of Transmission of Wide-Band FiberTechnologies of Communication Systems
文摘A new algorithm to exploit the learning rates of gradient descent method is presented, based on the second-order Taylor expansion of the error energy function with respect to learning rate, at some values decided by "award-punish" strategy. Detailed deduction of the algorithm applied to RBF networks is given. Simulation studies show that this algorithm can increase the rate of convergence and improve the performance of the gradient descent method.
文摘In the context of new risks and threats associated to nuclear, biological and chemical (NBC) attacks, and given the shortcomings of certain analytical methods such as principal component analysis (PCA), a neural network approach seems to be more accurate. PCA consists in projecting the spectrum of a gas collected from a remote sensing system in, firstly, a three-dimensional space, then in a two-dimensional one using a model of Multi-Layer Perceptron based neural network. It adopts during the learning process, the back propagation algorithm of the gradient, in which the mean square error output is continuously calculated and compared to the input until it reaches a minimal threshold value. This aims to correct the synaptic weights of the network. So, the Artificial Neural Network (ANN) tends to be more efficient in the classification process. This paper emphasizes the contribution of the ANN method in the spectral data processing, classification and identification and in addition, its fast convergence during the back propagation of the gradient.
文摘Objective To observe the influence of hypotherrnic circulatory arrest (HCA) on the apoptotic processes of neurons in the hippocampus and the expression of the related genes Bcl-2 and Bax, and compare to the intermittent antegrade cerebral perfusion. Methods Eighteen dogs were randomly divided into three groups: control group (6 animals, underwent normal temperature cardiopulmonary bypass, NCPB), HCA group (6 animals, underwent HCA for 1 h), and HCA + IACP group (6 animals, underwent HCA for 1 h, combined with intermittent antegrade cerebral perfusion (IACP) every 15 min). The hippocampus tissue was retrieved 2h after the CPB discontinued The expression of Bcl-2 and Bax were examined with immunohistochemistry method. The cytomorphologic changes of the hippocampus tissue were investigated with transmission electron microscopy (TEM). Results The immunohistochemical staining showed that Bax protein levels were significantly higher in HCA group than in the other two groups (P〈0.01), while Bcl-2 protein levels were significantly higher in HCA + IACP group than that of the other two groups (P〈0.01). Meanwhile, the TEM results showed that there was no apoptosis of neurons in control group, but neuronal apoptotic changes could be clearly observed in HCA group, and only a small amount of apoptotic neurons were seen in HCA + IACP group. Conclusions HCA alone can induce neuronal apoptosis in the hippocampus. IACP during the HCA period has a protective effect on the cerebral tissue through suppressing apoptosis by decreasing Bax expression and increasing Bcl-2 expression.
文摘Neural network and genetic algorithms are complementary technologies in the design of adaptive intelligent system. Neural network learns from scratch by adjusting the interconnections betweens layers. Genetic algorithms are a popular computing framework that uses principals from natural population genetics to evolve solutions to problems. Various forecasting methods have been developed on the basis of neural network, but accuracy has been matter of concern in these forecasts. In neural network methods forecasted values depend to the choose of neural predictor structure, the number of the input, the lag. To remedy to these problem, in this paper, the authors are investing the applicability of an automatic design of a neural predictor realized by real Genetic Algorithms to predict the future value of a time series. The prediction method is tested by using meteorology time series that are daily and weekly mean temperatures in Melbourne, Australia, 1980-1990.
文摘In this paper, we conduct research on the causes and coping strategies of the land subsidence caused by the tunnel construction projects. We analyze the issues from the following of the perspectives. (1) Analysis method. To solve large scale system of the development of computer hardware and the numerical calculation method, we use the basic analysis to deal with it. (2) The empirical of methods. Ground motion is usually leads to the basic development of the inclined tunnel surface vertical displacement, the result of the movement process can turn to a settling tank. (3) Machine learning based approaches. In one of biggest difficulties when using neural network method is to obtain all possible parameters related to ground subsidence, we use the machine learning model to handle the challenge. In the final part, we show prospect for the future research, we will combine more numerical analysis tools to optimize the current methodology.
文摘Synchronization of neurons plays an important role in vision, movement and memory. However, many neurological disorders such as epilepsies, Parkinson disease and essen- tial tremor are related to excessive synchronization of neurons. In the line of therapy, stimulations to these pathologically synchronized neurons should be capable of breaking synchrony. As the first step of designing an effective stimulation, we consider desynchro- nization problem of coupled limit-cycle oscillators ensemble. First, the desynchronization problem is redefined in a nonlinear output regulation framework. Then, we design an output regulator (stimulation) which forces limit-cycle oscillators to track exogenous sinusoidal references with different phases. The proposed stimulation is robust against variations of oscillators' frequencies. Mathematical analysis and simulation results reveal the efficiency of the proposed technique.
基金supported the National Basic Research Program of China("973"Project)(Grant Nos.2011CB933203 and 2011CB933102)the National Hi-Tech Research and Development Program of China("863"Project)(Grant Nos.2012AA030308 and 2013AA032204)+1 种基金the National Natural Science Foundation of China(Grant Nos.61275200,61335010,61178051 and 61178082)the National Important Scientific Apparatus Developing Project(Grant No.2011YQ04008204)
文摘A novel linear microprobe array(LMPA)has been developed by a conventional microfabrication method from silicon.The LMPA leverages the properties of conventional microwire with additional features of naturally formed regular spacing.With the help of periodic microprobe arrays and double-side V-grooves fabricated in advance between each pair of the two microprobes’rear ends,the number of microprobe units for assembly in one array can be flexibly chosen by cleavage fracture from the LMPA.The fabrication method was demonstrated and the prototype device was assessed by electrochemical impedance spectroscopy(EIS)and in vivo test.The SNR of the spikes recorded was 6.
基金supported by the Italian Ministry for University,Scientific Research and Technologythe Italian Ministry of Health,the Fondazione Giuseppe e Mafalda Luce(Milan,Italy)+3 种基金Autism Aid ONLUS(Naples,Italy)the Autism Speaks Foundation(Princeton,NJ)the Autism Research Institute(San Diego,CA)the European Union(IMI project EU-AIMS)
文摘Autism is a complex neuropsychiatric disorder of developmental origin, where multiple genetic and environmental factors likely interact resulting in a clinical continuum between "affected" and "unaffected" individuals in the general population. During the last two decades, relevant progress has been made in identifying chromosomal regions and genes in linkage or association with autism, but no single gene has emerged as a major cause of disease in a large number of patients. The purpose of this paper is to discuss specific methodological issues and experimental strategies in autism genetic research, based on fourteen years of experience in patient recruitment and association studies of autism spectrum disorder in Italy.
文摘Clinical medicine and experiments have shown that electrophysiological activities on neuronal disease systems such as the epilepsy and Parkinson can exhibit the evolutions of complex dynamical behaviors and their transitions, which are closely related to the generation mechanism of neuronal diseases. Traditionally, electrophysiological activities have been analyzed from the statistical methods. Although some ideal results have been obtained, mechanisms of complex electrophysiological activities in neuronal systems cannot yet be disclosed. Dynamics modelling can help researchers to explore the mechanisms of electro- physiological activities of neuronal disease systems. By constructing reasonable physiological dynamical model, inner relation between the dynamics model and representation behaviors of the neuronal disease systems can be further studied. In addition, based on the constructed network model, we can also explore mechanisms of the evolutions of dynamical behaviors and their transitions of the initiation, propagation and termination of different kinds of the seizures. Finally, we can design the feasible control method to regulate dynamics behaviors of the seizures so as to realize the healthy neuronal firings.