目的探究安神补脑胶囊结合针刺对原发性失眠(心神不宁型)的临床研究。方法选取2021年6月—2022年6月收治的124例原发性失眠患者为研究对象。根据治疗方法分为观察组(n=64)与对照组(n=60),对照组采用针刺治疗,观察组在此基础上结合安神...目的探究安神补脑胶囊结合针刺对原发性失眠(心神不宁型)的临床研究。方法选取2021年6月—2022年6月收治的124例原发性失眠患者为研究对象。根据治疗方法分为观察组(n=64)与对照组(n=60),对照组采用针刺治疗,观察组在此基础上结合安神补脑胶囊治疗。采用阿森斯量表(Athens Insomnia Scale,AIS)、生活质量评分(the MOS item short from health survey,SF-36)量表、失眠严重指数量表(The insomnia severity index,ISI)记录两组患者治疗前后水平。观察组两组患者治疗前后血清指标肿瘤坏死因子(Tumor necrosis factor,TNF-α)、γ-氨基丁酸(γaminobutyric acid,GABA)、5-羟色胺(5-hydroxy tryptamine,5-HT)、核因子κB(nuclear factor kappa-B,NF-κB)含量水平变化。观察两组患者临床疗效和中医症候积分。结果两组患者治疗前入睡时间、白天情绪、白天身体功能、夜间苏醒、总睡眠时间、总睡眠质量、白天思睡评分、比期望的时间早醒评分无显著差异(P>0.05)。治疗后观察组入睡时间、白天情绪、白天身体功能、夜间苏醒、总睡眠时间、总睡眠质量、白天思睡评分、比期望的时间早醒评分显著低于对照组(P<0.05)。两组患者治疗前生理功能、身体疼痛、角色限制、总体健康、社会功能、活力、精神健康、情感职能无显著差异(P>0.05)。治疗后观察组生理功能、身体疼痛、角色限制、总体健康、社会功能、活力、精神健康、情感职能评分显著高于对照组(P<0.05)。两组患者治疗前ISI、中医症候积分无显著差异(P>0.05)。治疗后观察组ISI、中医症候积分较对照组显著降低(P<0.05)。两组患者治疗前TNF-α、NF-κB、GABA和5-HT水平无显著差异(P>0.05)。治疗后观察组TNF-α、NF-κB水平较对照组显著降低,且GABA和5-HT水平较对照组显著升高(P>0.05)。观察组总有效率为93.75%显著高于对照组81.67%(χ^(2)=4.252,P=0.039)。结论安神补脑胶囊结合针刺能有效改善血清因子水平,提升睡眠质量、提高临床疗效和生活质量。展开更多
The holistic characterization and quality control of all the medicinal herbs of proprietary Chinese medicines(PCMs)are of great significance to ensure their safety,efficacy,and consistency.Thin-layer chromatography(TL...The holistic characterization and quality control of all the medicinal herbs of proprietary Chinese medicines(PCMs)are of great significance to ensure their safety,efficacy,and consistency.Thin-layer chromatography(TLC),a simple and classic approach for qualitatively characterizing and examining quality markers of natural products,has been widely used in the characterization and quality control of traditional Chinese medicines.Zaoren Anshen(ZRAS)capsule,prepared from three medicinal herbs of fried Ziziphi Spinosae Semen,Salvia Miltiorrhiza Radix et Rhizoma,and vinegar-processed Schisandrae Chinensis Fructus,is a famous PCM in China for the treatment of insomnia,amnesia,and dizziness in clinical practice.However,no effective method is available so far for simultaneous identification and examination of all the three medicinal herbs of ZRAS capsule.In the present study,we developed a TLC method via twice-development and visualization by UV light or chromogenic agent,which could be used for simultaneous qualitative identification of all the three medicinal herbs of ZRAS capsule in one plate.Moreover,the sample preparation method was optimized.The developed TLC method was rapid,simple,low-cost,and effective,and thus it could be used for quality control of ZRAS capsule.展开更多
文摘目的探究安神补脑胶囊结合针刺对原发性失眠(心神不宁型)的临床研究。方法选取2021年6月—2022年6月收治的124例原发性失眠患者为研究对象。根据治疗方法分为观察组(n=64)与对照组(n=60),对照组采用针刺治疗,观察组在此基础上结合安神补脑胶囊治疗。采用阿森斯量表(Athens Insomnia Scale,AIS)、生活质量评分(the MOS item short from health survey,SF-36)量表、失眠严重指数量表(The insomnia severity index,ISI)记录两组患者治疗前后水平。观察组两组患者治疗前后血清指标肿瘤坏死因子(Tumor necrosis factor,TNF-α)、γ-氨基丁酸(γaminobutyric acid,GABA)、5-羟色胺(5-hydroxy tryptamine,5-HT)、核因子κB(nuclear factor kappa-B,NF-κB)含量水平变化。观察两组患者临床疗效和中医症候积分。结果两组患者治疗前入睡时间、白天情绪、白天身体功能、夜间苏醒、总睡眠时间、总睡眠质量、白天思睡评分、比期望的时间早醒评分无显著差异(P>0.05)。治疗后观察组入睡时间、白天情绪、白天身体功能、夜间苏醒、总睡眠时间、总睡眠质量、白天思睡评分、比期望的时间早醒评分显著低于对照组(P<0.05)。两组患者治疗前生理功能、身体疼痛、角色限制、总体健康、社会功能、活力、精神健康、情感职能无显著差异(P>0.05)。治疗后观察组生理功能、身体疼痛、角色限制、总体健康、社会功能、活力、精神健康、情感职能评分显著高于对照组(P<0.05)。两组患者治疗前ISI、中医症候积分无显著差异(P>0.05)。治疗后观察组ISI、中医症候积分较对照组显著降低(P<0.05)。两组患者治疗前TNF-α、NF-κB、GABA和5-HT水平无显著差异(P>0.05)。治疗后观察组TNF-α、NF-κB水平较对照组显著降低,且GABA和5-HT水平较对照组显著升高(P>0.05)。观察组总有效率为93.75%显著高于对照组81.67%(χ^(2)=4.252,P=0.039)。结论安神补脑胶囊结合针刺能有效改善血清因子水平,提升睡眠质量、提高临床疗效和生活质量。
基金National Key Research and Development Program of China(Grant No.2018YFC1707300)。
文摘The holistic characterization and quality control of all the medicinal herbs of proprietary Chinese medicines(PCMs)are of great significance to ensure their safety,efficacy,and consistency.Thin-layer chromatography(TLC),a simple and classic approach for qualitatively characterizing and examining quality markers of natural products,has been widely used in the characterization and quality control of traditional Chinese medicines.Zaoren Anshen(ZRAS)capsule,prepared from three medicinal herbs of fried Ziziphi Spinosae Semen,Salvia Miltiorrhiza Radix et Rhizoma,and vinegar-processed Schisandrae Chinensis Fructus,is a famous PCM in China for the treatment of insomnia,amnesia,and dizziness in clinical practice.However,no effective method is available so far for simultaneous identification and examination of all the three medicinal herbs of ZRAS capsule.In the present study,we developed a TLC method via twice-development and visualization by UV light or chromogenic agent,which could be used for simultaneous qualitative identification of all the three medicinal herbs of ZRAS capsule in one plate.Moreover,the sample preparation method was optimized.The developed TLC method was rapid,simple,low-cost,and effective,and thus it could be used for quality control of ZRAS capsule.
