The ideological and political education in vocational colleges has ＂employment oriented＂, ＂practicability＂ and ＂practicalness＂ and other features, while facing the practical difficulties that the cultural spirit...The ideological and political education in vocational colleges has ＂employment oriented＂, ＂practicability＂ and ＂practicalness＂ and other features, while facing the practical difficulties that the cultural spirit is insufficient, the specialization of the teachers is not strong, and the students lack their own active participation and so on. The higher vocational colleges must deepen the concepts of running higher vocational education, strengthen the construction of the team of the ideological and political theory education, pay more attention to the combination of the ideological and political education with the practice, cultivate the people-oriented model of the ideological and political education, and improve the effectiveness of the ideological and political education.展开更多
The bed nucleus of the stria terminalis(BNST) plays a critical role in regulating anxiety, yet the involved specific cell types and their connections functioning in anxiety-related behaviors remains elusive. Here we i...The bed nucleus of the stria terminalis(BNST) plays a critical role in regulating anxiety, yet the involved specific cell types and their connections functioning in anxiety-related behaviors remains elusive. Here we identified two cell subpopulations—corticotropin-releasing hormone-positive(CRH+) and protein kinase C-δ-positive(PKC-δ+) neurons—each displayed discrete emotionally valenced behaviors in the anterior-dorsal BNST(ad BNST). Using whole-cell patch-clamp recordings and virus-assisted circuit tracing techniques, we delineated the local and long-range connectivity networks in a cell-type-specific manner. The results show that the CRH+ and PKC-δ+ neurons received inputs from similar brain regions and exhibited significant differences in the downstream projection density. In addition, in vivo calcium imaging as well as gain-and loss-of-function studies characterized the physiological response properties and the functional heterogeneities in modulating anxiety, further suggesting the similarity and individuality between the two ad BNST cell types. These results provide novel insights into the circuit architecture of ad BNST neurons underlying the functionally specific neural pathways that relate to anxiety disorders.展开更多
文摘The ideological and political education in vocational colleges has ＂employment oriented＂, ＂practicability＂ and ＂practicalness＂ and other features, while facing the practical difficulties that the cultural spirit is insufficient, the specialization of the teachers is not strong, and the students lack their own active participation and so on. The higher vocational colleges must deepen the concepts of running higher vocational education, strengthen the construction of the team of the ideological and political theory education, pay more attention to the combination of the ideological and political education with the practice, cultivate the people-oriented model of the ideological and political education, and improve the effectiveness of the ideological and political education.
基金This work was supported by the National Natural Science Foundation of China(31671105)Science Fund for Creative Research Group of China(61721092),“National Basic Research Program of China”(973 program 2015CB755603)Director Fund of the Wuhan National Laboratory for Optoelectronics and partly supported by the open funds of the State Key Laboratory of Medical Neurobiology,Fudan University.
文摘The bed nucleus of the stria terminalis(BNST) plays a critical role in regulating anxiety, yet the involved specific cell types and their connections functioning in anxiety-related behaviors remains elusive. Here we identified two cell subpopulations—corticotropin-releasing hormone-positive(CRH+) and protein kinase C-δ-positive(PKC-δ+) neurons—each displayed discrete emotionally valenced behaviors in the anterior-dorsal BNST(ad BNST). Using whole-cell patch-clamp recordings and virus-assisted circuit tracing techniques, we delineated the local and long-range connectivity networks in a cell-type-specific manner. The results show that the CRH+ and PKC-δ+ neurons received inputs from similar brain regions and exhibited significant differences in the downstream projection density. In addition, in vivo calcium imaging as well as gain-and loss-of-function studies characterized the physiological response properties and the functional heterogeneities in modulating anxiety, further suggesting the similarity and individuality between the two ad BNST cell types. These results provide novel insights into the circuit architecture of ad BNST neurons underlying the functionally specific neural pathways that relate to anxiety disorders.
