目的基于氢质子磁共振波谱(Hydrogen Proton Magnetic Resonance Spectroscopy,^(1)H-MRS)探究成年男性精神分裂症患者杏仁核神经代谢物水平与阳性及阴性症状精神症状评定量表(Positive and Negative Syndrome Scale,PANSS)评分的相关...目的基于氢质子磁共振波谱(Hydrogen Proton Magnetic Resonance Spectroscopy,^(1)H-MRS)探究成年男性精神分裂症患者杏仁核神经代谢物水平与阳性及阴性症状精神症状评定量表(Positive and Negative Syndrome Scale,PANSS)评分的相关性。方法纳入2021年4月~2023年6月湖南省第二人民医院精神科收治的59例成年男性精神分裂症患者作为患者观察组,另纳入18例健康体检者作为健康对照组。所有对象均行PANSS量表评分、MRI以及杏仁核区^(1)H-MRS检测。收集纳入者左右侧杏仁核N-乙酰基天门冬氨酸(N-acetylaspartate,NAA)、肌酸(Creatine,Cr)和胆碱(Choline,Cho)水平,比较两组基线资料,比较两组Cho/Cr、NAA/Cho、NAA/(Cho+Cr)比值的差异,分析患者组杏仁核神经代谢物指标与PANSS评分的相关性。结果男性精神分裂症患者左侧杏仁核的NAA/(Cho+Cr)、NAA/Cr、NAA/Cho、Cho/Cr比值均高于健康对照组,差异具有统计学意义(P<0.05)。Pearson相关性结果显示,患者组左侧杏仁核NAA/(Cho+Cr)、NAA/Cr、NAA/Cho与阴性症状评分呈负相关,相关性有统计学意义(P<0.05)。结论基于~1H-MRS发现男性精神分裂症患者左侧杏仁核区神经代谢物水平异常增高,可能与患者PANSS评估中阴性症状相关。展开更多
Alzheimer＇s disease （AD） is a most common neurodegenerative disorder, which associates with impaired cognition. Gut microbiota can modulate host brain function and behavior via microbiota-gut-brain axis, including ...Alzheimer＇s disease （AD） is a most common neurodegenerative disorder, which associates with impaired cognition. Gut microbiota can modulate host brain function and behavior via microbiota-gut-brain axis, including cognitive behavior. Germ-free animals, antibiotics, probiotics intervention and diet can induce alterations of gut microbiota and gut physiology and also host cognitive behavior, increasing or decreasing risks of AD. The increased permeability of intestine and blood-brain barrier induced by gut rnicrobiota disturbance will increase the incidence of neurodegeneration disorders. Gut microbial metabolites and their effects on host neurochemical changes may increase or decrease the risk of AD. Pathogenic microbes infection will also increase the risk of AD, and meanwhile, the onset of AD support the ＂hygiene hypothesis＂. All the results suggest that AD may begin in the gut, and is closely related to the imbalance of gut microbiota. Modulation of gut microbiota through personalized diet or beneficial microbiota intervention will probably become a new treatment for AD.展开更多
文摘目的基于氢质子磁共振波谱(Hydrogen Proton Magnetic Resonance Spectroscopy,^(1)H-MRS)探究成年男性精神分裂症患者杏仁核神经代谢物水平与阳性及阴性症状精神症状评定量表(Positive and Negative Syndrome Scale,PANSS)评分的相关性。方法纳入2021年4月~2023年6月湖南省第二人民医院精神科收治的59例成年男性精神分裂症患者作为患者观察组,另纳入18例健康体检者作为健康对照组。所有对象均行PANSS量表评分、MRI以及杏仁核区^(1)H-MRS检测。收集纳入者左右侧杏仁核N-乙酰基天门冬氨酸(N-acetylaspartate,NAA)、肌酸(Creatine,Cr)和胆碱(Choline,Cho)水平,比较两组基线资料,比较两组Cho/Cr、NAA/Cho、NAA/(Cho+Cr)比值的差异,分析患者组杏仁核神经代谢物指标与PANSS评分的相关性。结果男性精神分裂症患者左侧杏仁核的NAA/(Cho+Cr)、NAA/Cr、NAA/Cho、Cho/Cr比值均高于健康对照组,差异具有统计学意义(P<0.05)。Pearson相关性结果显示,患者组左侧杏仁核NAA/(Cho+Cr)、NAA/Cr、NAA/Cho与阴性症状评分呈负相关,相关性有统计学意义(P<0.05)。结论基于~1H-MRS发现男性精神分裂症患者左侧杏仁核区神经代谢物水平异常增高,可能与患者PANSS评估中阴性症状相关。
文摘Alzheimer＇s disease （AD） is a most common neurodegenerative disorder, which associates with impaired cognition. Gut microbiota can modulate host brain function and behavior via microbiota-gut-brain axis, including cognitive behavior. Germ-free animals, antibiotics, probiotics intervention and diet can induce alterations of gut microbiota and gut physiology and also host cognitive behavior, increasing or decreasing risks of AD. The increased permeability of intestine and blood-brain barrier induced by gut rnicrobiota disturbance will increase the incidence of neurodegeneration disorders. Gut microbial metabolites and their effects on host neurochemical changes may increase or decrease the risk of AD. Pathogenic microbes infection will also increase the risk of AD, and meanwhile, the onset of AD support the ＂hygiene hypothesis＂. All the results suggest that AD may begin in the gut, and is closely related to the imbalance of gut microbiota. Modulation of gut microbiota through personalized diet or beneficial microbiota intervention will probably become a new treatment for AD.
