目的研究神经内分泌标志物嗜铬粒蛋白A(chromogranin A, CGA)、促胃泌素释放肽(pro-gastrin-releasing peptide,ProGRP)和神经元特异性烯醇化酶(neuron-specific enolase, NSE)表达水平在肺小细胞癌患者中的临床意义及对预后的影响。方...目的研究神经内分泌标志物嗜铬粒蛋白A(chromogranin A, CGA)、促胃泌素释放肽(pro-gastrin-releasing peptide,ProGRP)和神经元特异性烯醇化酶(neuron-specific enolase, NSE)表达水平在肺小细胞癌患者中的临床意义及对预后的影响。方法用固相"双位点夹心"免疫放射分析实验方法,前瞻性分析肺小细胞癌(small cell lung cancer, SCLC)神经内分泌标志物循环神经内分泌标志物嗜铬粒蛋白A(CGA)、促胃泌素释放肽(ProGRP)和神经元特异性烯醇化酶(NSE)的分泌,分析其临床病理资料、评估其疾病分期;统计分析各因素对与生存率的相关性。结果单变量分析和单变量Cox回归模型发现存活率与一般健康状态(performance status, PS),疾病分期,CGA,ProGRP和NSE水平之间存在显著统计学相关性,PS≥2(中位生存期MS为12 vs 14月,P=0.001),广泛期疾病(extensive disease ED)(MS为10 vs 15月,P<0.001),血清CGA水平>56ng/mL(MS 10 vs 14月,P<0.001),血清ProGRP水平>58 pg/mL(MS 10 vs 15月,P<0.001),血清NSE水平>19ng/mL(MS 10 vs 15月,P<0.001)的患者生存期较短。结论 ProGRP,NSE和CGA在SCLC患者的分期和预后评估价值中具有潜在的作用。展开更多
子宫颈神经内分泌癌（neuro endocrine carcinoma of the uterine cervix）是一种少见而独特的宫颈原发恶性肿瘤，占宫颈浸润癌的0．31％～2％，具有恶性度高、进展快、复发率高等特点。早期发生淋巴结转移及血行播散，预后极差，神经...子宫颈神经内分泌癌（neuro endocrine carcinoma of the uterine cervix）是一种少见而独特的宫颈原发恶性肿瘤，占宫颈浸润癌的0．31％～2％，具有恶性度高、进展快、复发率高等特点。早期发生淋巴结转移及血行播散，预后极差，神经内分泌标志物有助于诊断，手术、放、化疗相结合的综合治疗能明显改善早期肿瘤患者的预后。本文综述现阶段国内外对子宫颈神经内分泌癌的临床分析及最新研究进展。展开更多
AIM: To investigate the incidence of neuroendocrine (NE)cells and their hormone products in adenocarcinomas and evaluate their significance in clinical pathology and prognosis.METHODS: By using tissue sectioning and i...AIM: To investigate the incidence of neuroendocrine (NE)cells and their hormone products in adenocarcinomas and evaluate their significance in clinical pathology and prognosis.METHODS: By using tissue sectioning and immunocytochemistry, 356 cases of adenocarcinomas were studied to examine the presence of chromorgranin and polypeptide hormones in adenocarcinoma samples from our hospital.RESULTS: The positive rate of NE cells and hormone products was 41.5 % (54/130) and 59.3 % (32/54), respectively in large intestinal adenocarcinoma cases; 39.6 % (38/96) and 36.8 % (14/38), respectively in gastric cancer cases; 38.1%(8/21) and 50.0 % (4/8), respectively in prostatic cancer cases; 21.0 % (17/81) and 17.6 % (3/17), respectively in breasr cancer cases; 17.9 % (5/28) and 60.0 % (3/5),respectively in pancreatic cancer cases. Among carcinomas of large intestine, pancreas and breast, the highly differentiated NE cell numbers were higher than the poorly differentiated NE cell numbers; while the gastric carcinoma cases had more poorly differentiated NE cells than highly differentiated NE cells. The higher detection rate of NE cells and their hormone products, the higher 5-year survival rate among the large intestine cancer cases.CONCLUSION: Close correlation was observed between NE cells and their hormone products with the cancer differentiations. For colorectal carcinomas, there is a close correlation of the presence of NE cells and their hormone products with the tumor staging and prognosis.展开更多
文摘目的研究神经内分泌标志物嗜铬粒蛋白A(chromogranin A, CGA)、促胃泌素释放肽(pro-gastrin-releasing peptide,ProGRP)和神经元特异性烯醇化酶(neuron-specific enolase, NSE)表达水平在肺小细胞癌患者中的临床意义及对预后的影响。方法用固相"双位点夹心"免疫放射分析实验方法,前瞻性分析肺小细胞癌(small cell lung cancer, SCLC)神经内分泌标志物循环神经内分泌标志物嗜铬粒蛋白A(CGA)、促胃泌素释放肽(ProGRP)和神经元特异性烯醇化酶(NSE)的分泌,分析其临床病理资料、评估其疾病分期;统计分析各因素对与生存率的相关性。结果单变量分析和单变量Cox回归模型发现存活率与一般健康状态(performance status, PS),疾病分期,CGA,ProGRP和NSE水平之间存在显著统计学相关性,PS≥2(中位生存期MS为12 vs 14月,P=0.001),广泛期疾病(extensive disease ED)(MS为10 vs 15月,P<0.001),血清CGA水平>56ng/mL(MS 10 vs 14月,P<0.001),血清ProGRP水平>58 pg/mL(MS 10 vs 15月,P<0.001),血清NSE水平>19ng/mL(MS 10 vs 15月,P<0.001)的患者生存期较短。结论 ProGRP,NSE和CGA在SCLC患者的分期和预后评估价值中具有潜在的作用。
文摘子宫颈神经内分泌癌（neuro endocrine carcinoma of the uterine cervix）是一种少见而独特的宫颈原发恶性肿瘤，占宫颈浸润癌的0．31％～2％，具有恶性度高、进展快、复发率高等特点。早期发生淋巴结转移及血行播散，预后极差，神经内分泌标志物有助于诊断，手术、放、化疗相结合的综合治疗能明显改善早期肿瘤患者的预后。本文综述现阶段国内外对子宫颈神经内分泌癌的临床分析及最新研究进展。
文摘AIM: To investigate the incidence of neuroendocrine (NE)cells and their hormone products in adenocarcinomas and evaluate their significance in clinical pathology and prognosis.METHODS: By using tissue sectioning and immunocytochemistry, 356 cases of adenocarcinomas were studied to examine the presence of chromorgranin and polypeptide hormones in adenocarcinoma samples from our hospital.RESULTS: The positive rate of NE cells and hormone products was 41.5 % (54/130) and 59.3 % (32/54), respectively in large intestinal adenocarcinoma cases; 39.6 % (38/96) and 36.8 % (14/38), respectively in gastric cancer cases; 38.1%(8/21) and 50.0 % (4/8), respectively in prostatic cancer cases; 21.0 % (17/81) and 17.6 % (3/17), respectively in breasr cancer cases; 17.9 % (5/28) and 60.0 % (3/5),respectively in pancreatic cancer cases. Among carcinomas of large intestine, pancreas and breast, the highly differentiated NE cell numbers were higher than the poorly differentiated NE cell numbers; while the gastric carcinoma cases had more poorly differentiated NE cells than highly differentiated NE cells. The higher detection rate of NE cells and their hormone products, the higher 5-year survival rate among the large intestine cancer cases.CONCLUSION: Close correlation was observed between NE cells and their hormone products with the cancer differentiations. For colorectal carcinomas, there is a close correlation of the presence of NE cells and their hormone products with the tumor staging and prognosis.
