Objective： To report a case ser/es of six neglected cervical spine dislocations without neurological deficit, which were managed operatively. Methods： The study was conducted fromAugust 2010 to December 2011 and ca...Objective： To report a case ser/es of six neglected cervical spine dislocations without neurological deficit, which were managed operatively. Methods： The study was conducted fromAugust 2010 to December 2011 and cases were selected from the out- patient department of Postgraduate Institute of Medical Education and Research, India. The patients were in the age group of 30 to 50 years. All patients were operated via both anterior and posterior approaches. Results： During the immediate postoperative period, five （83.33%） patients had normal neurological status. One （16.67%） patient who had C5-C6 subluxation developed neu- rological deficit with sensory loss below C6 level and motor power of 2/5 in the lower limb and 3/5 in the upper limb below C6 level. Conclusion： There is no role of skull traction in ne- glected distractive flexion injuries to cervical spine delayed for more than 3 weeks. Posterior followed by anterior ap- proach saves much time. If both approaches are to be done in the same sitting, there is no need for instrumentation posteriorly. But if staged procedure is planed, posterior sta- bilization is recommended, as there is a risk of deterioration in neurological status.展开更多
The primary reason for the failure of traditional medicine in treating the disorders of the central nervous system(CNS) is the obstruction to traverse the blood-brain barrier(BBB). Due to the unique physiochemical pro...The primary reason for the failure of traditional medicine in treating the disorders of the central nervous system(CNS) is the obstruction to traverse the blood-brain barrier(BBB). Due to the unique physiochemical properties of nanoparticles, they can preferably help deliver drugs passing through the BBB. Researchers have been investigating the capacity of multifunctional nanomaterials as theranostical agents. However, some of the studies have reported controversial results, which might be due to different schematic designs, including size, surface charge, and shape. This review summarizes the applications of nanoparticles to overcome the BBB or contribute to improving the diagnostic and therapeutic effects in CNS diseases.展开更多
文摘Objective： To report a case ser/es of six neglected cervical spine dislocations without neurological deficit, which were managed operatively. Methods： The study was conducted fromAugust 2010 to December 2011 and cases were selected from the out- patient department of Postgraduate Institute of Medical Education and Research, India. The patients were in the age group of 30 to 50 years. All patients were operated via both anterior and posterior approaches. Results： During the immediate postoperative period, five （83.33%） patients had normal neurological status. One （16.67%） patient who had C5-C6 subluxation developed neu- rological deficit with sensory loss below C6 level and motor power of 2/5 in the lower limb and 3/5 in the upper limb below C6 level. Conclusion： There is no role of skull traction in ne- glected distractive flexion injuries to cervical spine delayed for more than 3 weeks. Posterior followed by anterior ap- proach saves much time. If both approaches are to be done in the same sitting, there is no need for instrumentation posteriorly. But if staged procedure is planed, posterior sta- bilization is recommended, as there is a risk of deterioration in neurological status.
基金supported by the National Natural Science Foundation of China (31771031 and 81701829)
文摘The primary reason for the failure of traditional medicine in treating the disorders of the central nervous system(CNS) is the obstruction to traverse the blood-brain barrier(BBB). Due to the unique physiochemical properties of nanoparticles, they can preferably help deliver drugs passing through the BBB. Researchers have been investigating the capacity of multifunctional nanomaterials as theranostical agents. However, some of the studies have reported controversial results, which might be due to different schematic designs, including size, surface charge, and shape. This review summarizes the applications of nanoparticles to overcome the BBB or contribute to improving the diagnostic and therapeutic effects in CNS diseases.
