Objective:To evaluate whether early neurofunctional assessment may be useful in predicting neurodevelopmental outcome in children of very low birth weight(V LBW).Design:Observational longitudinal study.Settings:Northe...Objective:To evaluate whether early neurofunctional assessment may be useful in predicting neurodevelopmental outcome in children of very low birth weight(V LBW).Design:Observational longitudinal study.Settings:Northern Italy.Patien ts:A total of 250 VLBW children(129 boys,121 girls)born consecutively 1996-1999.Main outcome measures:Neurodevelopment at 36 months of chronological age,classified in accordance with the classification of Tardieu and the Internation al classification of functioning.Results:Of the infants exhibiting normal neur odevelopment(n = 183)or major dysfunction(n = 17)at 3 months of corrected ag e,72%and 94%respectively did not change their score during the study.Minor d ysfunctions at 3 months of corrected age were transient in 17(34%)children.A fter adjustment for neonatal variables,neurodevelopment at 3 months of correcte d age remained predictive of dysfunction at 36 months(odds ratio = 4.33,95%co nfidence interval 2.05 to 9.12).If the results for the normal and minor dysfunc tion groups were pooled,the predictive qualities of the 3 month neurofunctional assessment were:sensitivity 0.5,specificity 0.99,positive predictive value 0.94,negative predictive value 0.93.Conclusion:Early neurofunctional evaluatio n may be useful in predicting later neurodevelopmental outcome in VLBW children.展开更多
文摘Objective:To evaluate whether early neurofunctional assessment may be useful in predicting neurodevelopmental outcome in children of very low birth weight(V LBW).Design:Observational longitudinal study.Settings:Northern Italy.Patien ts:A total of 250 VLBW children(129 boys,121 girls)born consecutively 1996-1999.Main outcome measures:Neurodevelopment at 36 months of chronological age,classified in accordance with the classification of Tardieu and the Internation al classification of functioning.Results:Of the infants exhibiting normal neur odevelopment(n = 183)or major dysfunction(n = 17)at 3 months of corrected ag e,72%and 94%respectively did not change their score during the study.Minor d ysfunctions at 3 months of corrected age were transient in 17(34%)children.A fter adjustment for neonatal variables,neurodevelopment at 3 months of correcte d age remained predictive of dysfunction at 36 months(odds ratio = 4.33,95%co nfidence interval 2.05 to 9.12).If the results for the normal and minor dysfunc tion groups were pooled,the predictive qualities of the 3 month neurofunctional assessment were:sensitivity 0.5,specificity 0.99,positive predictive value 0.94,negative predictive value 0.93.Conclusion:Early neurofunctional evaluatio n may be useful in predicting later neurodevelopmental outcome in VLBW children.
