京万红凝胶剂对大鼠神经变性型糖尿病足的影响

[目的]观察京万红凝胶剂对大鼠神经变性型糖尿病足的影响。[方法]采用神经变性型糖尿病足溃疡模型,观察京万红凝胶剂对模型大鼠的影响。[结果]1)采用京万红凝胶剂、油膏剂,重组人表皮生长因子分别给药,各给药组给药14d后,给药各组与模型组相比,均有明显的好转。2)各给药组均有改善大鼠神经变性型糖尿足症状的趋势,病灶逐渐减小,炎症逐渐减轻,基本趋于正常。[结论]在该实验条件下,京万红凝胶剂与京万红油膏剂、重组人表皮生长因子具有相同的促进大鼠神经变性型糖尿足病灶愈合的作用。

针灸配合中药治疗糖尿病末梢神经变性麻痹型足病疗效观察

目的:观察针灸配合中药治疗糖尿病末梢神经变性麻痹型足病的临床疗效。方法:60例随机分为两组各30例,两组均皮下注射胰岛素控制血糖、血脂、血压,对照组加用甲钴胺口服,治疗组加用针灸和中药口服。结果:总有效率治疗组90%、对照组60%,两组比较有极显著性差异(P<0.01)。结论:针灸配合中药治疗糖尿病末稍神经变性麻痹型足病疗效较好。

泛酸激酶依赖型神经退行性疾病1例报告及文献复习

患者,男,12岁。主因双眼视力下降7年伴言语不清,行走不稳2年余于2015年3月24日收住院。患者于7年前出现夜视差,随后双眼视力逐渐下降,行走时易摔倒,未予特殊诊治。2年前无明显诱因出现言语不清,伴行走不稳,口角及双上肢不自主运动,症状持续不缓解。6个月前出现流涎,偶有饮水呛咳,伴吞咽费力。查体：神志清楚,构音障碍,计算力下降,理解力差,双侧瞳孔直径3 mm,对光反射灵敏,双眼球运动自如。

C-型多系统萎缩患者的护理

对收治的31例C-型多系统萎缩患者以对症或支持治疗为主,使用金刚烷胺改善临床症状。结果除1例因肺部感染死亡外,余30例住院3~111 d,平均48.0 d,未发生严重并发症及护理意外事件,症状缓解出院。提出自理协助、对症护理与健康教育,注意安抚患者和家属的心理情绪,提高家庭照顾者连续长期照护此类患者的能力是护理重点。

Diabetic retinopathy: recent advances towards understanding neurodegeneration and vision loss

Diabetic retinopathy （DR） is one of the most common retinal diseases world-wide. It has a complex pathology that involves the vasculature of the inner retina and breakdown of the blood-retinal barrier. Extensive research has determined that DR is not only a vascular disease but also has a neurodegenerative component and that essentially all types of ceils in the retina are affected, leading to chronic loss of visual function. A great deal of work using animal models of DR has established the loss of neurons and pathology of other cell types, including supporting glial cells. There has also been an increased emphasis on measuring retinal function in the models, as well as further validation and extension of the animal studies by clinical and translational research. This article will attempt to summarize the more recent developments in research towards understanding the complexities of retinal neurodegeneration and functional vision loss in DR.