Because of the difficulty in deciding on the structure of BP neural network in operational meteorological application and the tendency for the network to transform to an issue of local solution, a hybrid Particle Swar...Because of the difficulty in deciding on the structure of BP neural network in operational meteorological application and the tendency for the network to transform to an issue of local solution, a hybrid Particle Swarm Optimization Algorithm based on Artificial Neural Network (PSO-BP) model is proposed for monthly mean rainfall of the whole area of Guangxi. It combines Particle Swarm Optimization (PSO) with BP, that is, the number of hidden nodes and connection weights are optimized by the implementation of PSO operation. The method produces a better network architecture and initial connection weights, trains the traditional backward propagation again by training samples. The ensemble strategy is carried out for the linear programming to calculate the best weights based on the "east sum of the error absolute value" as the optimal rule. The weighted coefficient of each ensemble individual is obtained. The results show that the method can effectively improve learning and generalization ability of the neural network.展开更多
Objective: To evaluate correlation between chemosensitivity of tumor cells in vitro and their clinical responsiveness in vivo by comparing the difference of curative effect between chemotherapy of cerebral gliomas di...Objective: To evaluate correlation between chemosensitivity of tumor cells in vitro and their clinical responsiveness in vivo by comparing the difference of curative effect between chemotherapy of cerebral gliomas directed by chemosensitivity test in vitro and its routine chemotherapy. Methods: Sixty-two patients with cerebral gliomas were recruited as the experiment group, who had received total resection or subtotal resection of the tumor. The resected tumor cells were cultured in vitro, followed by chemosensitivity test using colorimetric MTT assay. Finally, chemotherapeutic protocol was made based on the results of the chemosensitivity test. Fifty patients with cerebral gliomas subjected to the routine chemotherapeutic protocol were simultaneously recruited as the control group, whose age, gender, survival functional status and operational fashion were matched with the experiment group. The two groups were equally followed up for the survival functional status, recurrence and death. All data were analyzed using SPSS 10.0 software. Results: At the time of evaluation, KPS values of 64.52 ± 35.84 were seen in the experiment group, and 33.60 ± 36.24 in the control group, showing statistical difference between the two groups (t = 4.5163, P = 0.000). During 2-4 years of follow up, a recurrence rate of 32.26% was seen in the experimental group, and 60.00% in the control group, showing a statistical difference between the two groups (X^2 = 8.620, P = 0.003). The fatality was 22.58% in the experiment group, and 48.00% in the control group, showing a statistical difference between the two groups (X^2 = 7.978, P = 0.005). The survival rate of the experimental group was higher than that of the control group, showing a statistical differences between the two groups (X^2= 7.29, P = 0.0069). Conclusion: Chemotherapy of glio- mas under the guidance of chemosensitivity test in vitro contributes to obvious improvement on the current survival functional status, a clear decline of the recurrence rates and fatality rate, and raised survival rates of the patients. A close correlation between the chemosensitivity in vitro and clinical responsiveness in vivo is observed.展开更多
A DRNN (diagonal recurrent neural network) and its RPE (recurrent prediction error) learning algorithm are proposed in this paper .Using of the simple structure of DRNN can reduce the capacity of calculation. The prin...A DRNN (diagonal recurrent neural network) and its RPE (recurrent prediction error) learning algorithm are proposed in this paper .Using of the simple structure of DRNN can reduce the capacity of calculation. The principle of RPE learning algorithm is to adjust weights along the direction of Gauss-Newton. Meanwhile, it is unnecessary to calculate the second local derivative and the inverse matrixes, whose unbiasedness is proved. With application to the extremely short time prediction of large ship pitch, satisfactory results are obtained. Prediction effect of this algorithm is compared with that of auto-regression and periodical diagram method, and comparison results show that the proposed algorithm is feasible.展开更多
In order to study the variation o f the asphalt pavement water film thickness influenced by multi-factors,anew method for predicting water film thickness was developed by the combination o f the artificial neural netw...In order to study the variation o f the asphalt pavement water film thickness influenced by multi-factors,anew method for predicting water film thickness was developed by the combination o f the artificial neural network(ANN)a d two-dimensional shallow water equations based on hydrodynamic theory.Multi-factors included the rainfall intensity,pavement width,cross slope,longitudinal slope a d pavement roughness coefficient.The two-dimensional hydrodynamic method was validated by a natural rainfall event.Based on the design scheme o f Shen-Sha expressway engineering project,the limited training data obtained by the two-dimensional hydrodynamic simulation model was used to predict water film thickness.Furthermore,the distribution of the water film thickness influenced by multi-factors on the pavement was analyzed.The accuracy o f the ANN model was verified by the18sets o f data with a precision o f0.991.The simulation results indicate that the water film thickness increases from the median strip to the edge o f the pavement.The water film thickness variation is obviously influenced by rainfall intensity.Under the condition that the pavement width is20m and t e rainfall intensity is3m m/h,t e water film thickness is below10mm in the fast lane and20mm in t e lateral lane.Athough there is fluctuation due to the amount oftraining data,compared with the calculation on the basis o f the existing criterion and theory,t e ANN model exhibits a better performance for depicting the macroscopic distribution of the asphalt pavement water film.展开更多
Artifi cial neural network is a kind of artificial intelligence method to simulate the function of human brain, and deep learning technology can establish a depth network model with hierarchical structure on the basis...Artifi cial neural network is a kind of artificial intelligence method to simulate the function of human brain, and deep learning technology can establish a depth network model with hierarchical structure on the basis of artificial neural network. Deep learning brings new development direction to artificial neural network. Convolution neural network is a new artificial neural network method, which combines artificial neural network and deep learning technology, and this new neural network is widely used in many fields of computer vision. Modern image recognition algorithm requires classifi cation system to adapt to different types of tasks, and deep network and convolution neural network is a hot research topic in neural networks. According to the characteristics of satellite digital image, we use the convolution neural network to classify the image, which combines texture features with spectral features. The experimental results show that the convolution neural network algorithm can effectively classify the image.展开更多
This letter analyzes the reasons why the known Neural Back Promulgation (NBP)network learning algorithm has slower speed and greater sample error. Based on the analysis and experiment, the training group descending En...This letter analyzes the reasons why the known Neural Back Promulgation (NBP)network learning algorithm has slower speed and greater sample error. Based on the analysis and experiment, the training group descending Enhanced Combination Algorithm (ECA) is proposed.The analysis of the generalized property and sample error shows that the ECA can heighten the study speed and reduce individual error.展开更多
The adaptive learning and prediction of a highly nonlinear and time-varying bioreactor benchmark process is studied using Neur-On-Line, a graphical tool kit for developing and deploying neural networks in the G2 real ...The adaptive learning and prediction of a highly nonlinear and time-varying bioreactor benchmark process is studied using Neur-On-Line, a graphical tool kit for developing and deploying neural networks in the G2 real time intelligent environment,and a new modified Broyden, Fletcher, Goldfarb, and Shanno (BFGS) quasi-Newton algorithm. The modified BFGS algorithm for the adaptive learning of back propagation (BP) neural networks is developed and embedded into NeurOn-Line by introducing a new search method of learning rate to the full memory BFGS algorithm. Simulation results show that the adaptive learning and prediction neural network system can quicklv track the time-varving and nonlinear behavior of the bioreactor.展开更多
One of biggest recent achievements of neurobiology is the study on neurotrophic factors. The neurotrophins are exciting examples of these factors. They belong to a family of proteins consisting of nerve growth fac-tor...One of biggest recent achievements of neurobiology is the study on neurotrophic factors. The neurotrophins are exciting examples of these factors. They belong to a family of proteins consisting of nerve growth fac-tor (NGF), brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3), NT-4/5, NT-6, and NT-7. Today, NGF and BDNF are well recognized to mediate a diz-zying number of trophobiological effects, ranging from neurotrophic through immunotrophic and epitheliotro-phic to metabotrophic effects. These are implicated in the pathogenesis of various diseases. In the same vein, recent studies in adipobiology reveal that this tissue is the body’s largest endocrine and paracrine organ producing multiple signaling proteins collectively termed adipokines, with NGF and BDNF being also produced from adipose tissue. Altogether, neurobio-logy and adipobiology contribute to the improvement of our knowledge on diseases beyond obesity such as cardiometabolic (atherosclerosis, type 2 diabetes, and metabolic syndrome) and neuropsychiatric (e.g. , Alzheimer’s disease and depression) diseases. The present review updates evidence for (1) neurotrophic and metabotrophic potentials of NGF and BDNF linking the pathogenesis of these diseases, and (2) NGF- and BDNF-mediated effects in ampakines, NMDA receptor antagonists, antidepressants, selective deacetylase inhibitors, statins, peroxisome proliferator-activated receptor gamma agonists, and purinergic P2X3 recep-tor up-regulation. This may help to construct a novel paradigm in the feld of translational pharmacology of neuro-metabotrophins, particularly NGF and BDNF.展开更多
The proposed controller incorporates FL (fuzzy logic) algorithm with ANN (artificial neural network). ANFIS replaces the conventional PI controller, tuning the fuzzy inference system with a hybrid learning algorit...The proposed controller incorporates FL (fuzzy logic) algorithm with ANN (artificial neural network). ANFIS replaces the conventional PI controller, tuning the fuzzy inference system with a hybrid learning algorithm. A tuning method is proposed for training of the neuro-fuzzy controller. The best rule base and the best training algorithm chosen produced high performance in the ANFIS controller. Simulation was done on Matlab Ver. 2010a. A case study was chopper-fed DC motor drive, in continuous and discrete modes. Satisfactory results show the ANFIS controller is able to control dynamic highly-nonlinear systems. Tuning it further improved the results.展开更多
The hot deformation behavior of 2A70 aluminum alloy was investigated by means of isothermal compression tests performed on a Gleeble-1500 thermal simulator over 360~480 ℃ with strain rates in the range of 0.01~1 s-...The hot deformation behavior of 2A70 aluminum alloy was investigated by means of isothermal compression tests performed on a Gleeble-1500 thermal simulator over 360~480 ℃ with strain rates in the range of 0.01~1 s-1 and the largest deformation up to 60%. On the basis of experiments, a BP artificial neural network (ANN) model was constructed to predict 2A70 aluminum alloy flow stress. True strain, strain rates and temperatures were input to the network, and flow stress was the only output. The comparison between predicted values and experimental data showed that the relative error for the trained model was less than ±3% for the sampled data while it was less than ±6% for the non-sampled data. Furthermore, the neural network model gives better results than nonlinear regression method. It is evident that the model constructed by BP ANN can be used to accurately predict the 2A70 alloy flow stress.展开更多
OBJECTIVE Various studies examining the relationship be-tween HER-2 over-expression and the response to chemotherapy and clinical outcome in patients with osteosarcoma have yielded inconclusive results.The purpose of ...OBJECTIVE Various studies examining the relationship be-tween HER-2 over-expression and the response to chemotherapy and clinical outcome in patients with osteosarcoma have yielded inconclusive results.The purpose of the current study was to evaluate the relation of HER-2 status with the response to chemo-therapy and clinical outcome in osteosarcoma.METHODS We conducted a meta-analysis of 6 studies that evaluated the correlation between HER-2 status and histologic response to chemotherapy and 2-year survival.Data were syn-thesized in summary receiver operating characteristic curves and with summary likelihood ratios(LRs) and relative risk.RESULTS The quantitative synthesis showed that HER-2 status is not a prognostic factor for the response to chemotherapy.The positive LR was 1.27(95% conf idence interval,0.91~1.77),and the negative LR was 0.68(95% confidence interval,0.38~1.22).There was no significant between-study heterogeneity.HER2-positive status tended to be associated with a worse 2-year survival,but the overall results were not formally statistically signif icant.CONCLUSION HER-2 status is not associated with the histo-logic response to chemotherapy in patients with osteosarcoma,whereas HER-2 positive patients may be associated with decreased survival.展开更多
The operating temperature of a proton exchange membrane fuel cell stack is a very important control parameter. It should be controlled within a specific range, however, most of existing PEMFC mathematical models are t...The operating temperature of a proton exchange membrane fuel cell stack is a very important control parameter. It should be controlled within a specific range, however, most of existing PEMFC mathematical models are too complicated to be effectively applied to on-line control. In this paper, input-output data and operating experiences will be used to establish PEMFC stack model and operating temperature control system. An adaptive learning algorithm and a nearest-neighbor clustering algorithm are applied to regulate the parameters and fuzzy rules so that the model and the control system are able to obtain higher accuracy. In the end, the simulation and the experimental results are presented and compared with traditional PID and fuzzy control algorithms.展开更多
基金Natural Science Foundation of Guangxi (0832019Z)Natural Science Foundation of China (40675023)
文摘Because of the difficulty in deciding on the structure of BP neural network in operational meteorological application and the tendency for the network to transform to an issue of local solution, a hybrid Particle Swarm Optimization Algorithm based on Artificial Neural Network (PSO-BP) model is proposed for monthly mean rainfall of the whole area of Guangxi. It combines Particle Swarm Optimization (PSO) with BP, that is, the number of hidden nodes and connection weights are optimized by the implementation of PSO operation. The method produces a better network architecture and initial connection weights, trains the traditional backward propagation again by training samples. The ensemble strategy is carried out for the linear programming to calculate the best weights based on the "east sum of the error absolute value" as the optimal rule. The weighted coefficient of each ensemble individual is obtained. The results show that the method can effectively improve learning and generalization ability of the neural network.
文摘Objective: To evaluate correlation between chemosensitivity of tumor cells in vitro and their clinical responsiveness in vivo by comparing the difference of curative effect between chemotherapy of cerebral gliomas directed by chemosensitivity test in vitro and its routine chemotherapy. Methods: Sixty-two patients with cerebral gliomas were recruited as the experiment group, who had received total resection or subtotal resection of the tumor. The resected tumor cells were cultured in vitro, followed by chemosensitivity test using colorimetric MTT assay. Finally, chemotherapeutic protocol was made based on the results of the chemosensitivity test. Fifty patients with cerebral gliomas subjected to the routine chemotherapeutic protocol were simultaneously recruited as the control group, whose age, gender, survival functional status and operational fashion were matched with the experiment group. The two groups were equally followed up for the survival functional status, recurrence and death. All data were analyzed using SPSS 10.0 software. Results: At the time of evaluation, KPS values of 64.52 ± 35.84 were seen in the experiment group, and 33.60 ± 36.24 in the control group, showing statistical difference between the two groups (t = 4.5163, P = 0.000). During 2-4 years of follow up, a recurrence rate of 32.26% was seen in the experimental group, and 60.00% in the control group, showing a statistical difference between the two groups (X^2 = 8.620, P = 0.003). The fatality was 22.58% in the experiment group, and 48.00% in the control group, showing a statistical difference between the two groups (X^2 = 7.978, P = 0.005). The survival rate of the experimental group was higher than that of the control group, showing a statistical differences between the two groups (X^2= 7.29, P = 0.0069). Conclusion: Chemotherapy of glio- mas under the guidance of chemosensitivity test in vitro contributes to obvious improvement on the current survival functional status, a clear decline of the recurrence rates and fatality rate, and raised survival rates of the patients. A close correlation between the chemosensitivity in vitro and clinical responsiveness in vivo is observed.
文摘A DRNN (diagonal recurrent neural network) and its RPE (recurrent prediction error) learning algorithm are proposed in this paper .Using of the simple structure of DRNN can reduce the capacity of calculation. The principle of RPE learning algorithm is to adjust weights along the direction of Gauss-Newton. Meanwhile, it is unnecessary to calculate the second local derivative and the inverse matrixes, whose unbiasedness is proved. With application to the extremely short time prediction of large ship pitch, satisfactory results are obtained. Prediction effect of this algorithm is compared with that of auto-regression and periodical diagram method, and comparison results show that the proposed algorithm is feasible.
基金The National Natural Science Foundation of China(No.51478114,51778136)the Transportation Science and Technology Program of Liaoning Province(No.201532)
文摘In order to study the variation o f the asphalt pavement water film thickness influenced by multi-factors,anew method for predicting water film thickness was developed by the combination o f the artificial neural network(ANN)a d two-dimensional shallow water equations based on hydrodynamic theory.Multi-factors included the rainfall intensity,pavement width,cross slope,longitudinal slope a d pavement roughness coefficient.The two-dimensional hydrodynamic method was validated by a natural rainfall event.Based on the design scheme o f Shen-Sha expressway engineering project,the limited training data obtained by the two-dimensional hydrodynamic simulation model was used to predict water film thickness.Furthermore,the distribution of the water film thickness influenced by multi-factors on the pavement was analyzed.The accuracy o f the ANN model was verified by the18sets o f data with a precision o f0.991.The simulation results indicate that the water film thickness increases from the median strip to the edge o f the pavement.The water film thickness variation is obviously influenced by rainfall intensity.Under the condition that the pavement width is20m and t e rainfall intensity is3m m/h,t e water film thickness is below10mm in the fast lane and20mm in t e lateral lane.Athough there is fluctuation due to the amount oftraining data,compared with the calculation on the basis o f the existing criterion and theory,t e ANN model exhibits a better performance for depicting the macroscopic distribution of the asphalt pavement water film.
文摘Artifi cial neural network is a kind of artificial intelligence method to simulate the function of human brain, and deep learning technology can establish a depth network model with hierarchical structure on the basis of artificial neural network. Deep learning brings new development direction to artificial neural network. Convolution neural network is a new artificial neural network method, which combines artificial neural network and deep learning technology, and this new neural network is widely used in many fields of computer vision. Modern image recognition algorithm requires classifi cation system to adapt to different types of tasks, and deep network and convolution neural network is a hot research topic in neural networks. According to the characteristics of satellite digital image, we use the convolution neural network to classify the image, which combines texture features with spectral features. The experimental results show that the convolution neural network algorithm can effectively classify the image.
基金the National Defense Research item "Data fusion" of Tenth Five-Year Plan 102010203
文摘This letter analyzes the reasons why the known Neural Back Promulgation (NBP)network learning algorithm has slower speed and greater sample error. Based on the analysis and experiment, the training group descending Enhanced Combination Algorithm (ECA) is proposed.The analysis of the generalized property and sample error shows that the ECA can heighten the study speed and reduce individual error.
文摘The adaptive learning and prediction of a highly nonlinear and time-varying bioreactor benchmark process is studied using Neur-On-Line, a graphical tool kit for developing and deploying neural networks in the G2 real time intelligent environment,and a new modified Broyden, Fletcher, Goldfarb, and Shanno (BFGS) quasi-Newton algorithm. The modified BFGS algorithm for the adaptive learning of back propagation (BP) neural networks is developed and embedded into NeurOn-Line by introducing a new search method of learning rate to the full memory BFGS algorithm. Simulation results show that the adaptive learning and prediction neural network system can quicklv track the time-varving and nonlinear behavior of the bioreactor.
文摘One of biggest recent achievements of neurobiology is the study on neurotrophic factors. The neurotrophins are exciting examples of these factors. They belong to a family of proteins consisting of nerve growth fac-tor (NGF), brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3), NT-4/5, NT-6, and NT-7. Today, NGF and BDNF are well recognized to mediate a diz-zying number of trophobiological effects, ranging from neurotrophic through immunotrophic and epitheliotro-phic to metabotrophic effects. These are implicated in the pathogenesis of various diseases. In the same vein, recent studies in adipobiology reveal that this tissue is the body’s largest endocrine and paracrine organ producing multiple signaling proteins collectively termed adipokines, with NGF and BDNF being also produced from adipose tissue. Altogether, neurobio-logy and adipobiology contribute to the improvement of our knowledge on diseases beyond obesity such as cardiometabolic (atherosclerosis, type 2 diabetes, and metabolic syndrome) and neuropsychiatric (e.g. , Alzheimer’s disease and depression) diseases. The present review updates evidence for (1) neurotrophic and metabotrophic potentials of NGF and BDNF linking the pathogenesis of these diseases, and (2) NGF- and BDNF-mediated effects in ampakines, NMDA receptor antagonists, antidepressants, selective deacetylase inhibitors, statins, peroxisome proliferator-activated receptor gamma agonists, and purinergic P2X3 recep-tor up-regulation. This may help to construct a novel paradigm in the feld of translational pharmacology of neuro-metabotrophins, particularly NGF and BDNF.
文摘The proposed controller incorporates FL (fuzzy logic) algorithm with ANN (artificial neural network). ANFIS replaces the conventional PI controller, tuning the fuzzy inference system with a hybrid learning algorithm. A tuning method is proposed for training of the neuro-fuzzy controller. The best rule base and the best training algorithm chosen produced high performance in the ANFIS controller. Simulation was done on Matlab Ver. 2010a. A case study was chopper-fed DC motor drive, in continuous and discrete modes. Satisfactory results show the ANFIS controller is able to control dynamic highly-nonlinear systems. Tuning it further improved the results.
文摘The hot deformation behavior of 2A70 aluminum alloy was investigated by means of isothermal compression tests performed on a Gleeble-1500 thermal simulator over 360~480 ℃ with strain rates in the range of 0.01~1 s-1 and the largest deformation up to 60%. On the basis of experiments, a BP artificial neural network (ANN) model was constructed to predict 2A70 aluminum alloy flow stress. True strain, strain rates and temperatures were input to the network, and flow stress was the only output. The comparison between predicted values and experimental data showed that the relative error for the trained model was less than ±3% for the sampled data while it was less than ±6% for the non-sampled data. Furthermore, the neural network model gives better results than nonlinear regression method. It is evident that the model constructed by BP ANN can be used to accurately predict the 2A70 alloy flow stress.
文摘OBJECTIVE Various studies examining the relationship be-tween HER-2 over-expression and the response to chemotherapy and clinical outcome in patients with osteosarcoma have yielded inconclusive results.The purpose of the current study was to evaluate the relation of HER-2 status with the response to chemo-therapy and clinical outcome in osteosarcoma.METHODS We conducted a meta-analysis of 6 studies that evaluated the correlation between HER-2 status and histologic response to chemotherapy and 2-year survival.Data were syn-thesized in summary receiver operating characteristic curves and with summary likelihood ratios(LRs) and relative risk.RESULTS The quantitative synthesis showed that HER-2 status is not a prognostic factor for the response to chemotherapy.The positive LR was 1.27(95% conf idence interval,0.91~1.77),and the negative LR was 0.68(95% confidence interval,0.38~1.22).There was no significant between-study heterogeneity.HER2-positive status tended to be associated with a worse 2-year survival,but the overall results were not formally statistically signif icant.CONCLUSION HER-2 status is not associated with the histo-logic response to chemotherapy in patients with osteosarcoma,whereas HER-2 positive patients may be associated with decreased survival.
文摘The operating temperature of a proton exchange membrane fuel cell stack is a very important control parameter. It should be controlled within a specific range, however, most of existing PEMFC mathematical models are too complicated to be effectively applied to on-line control. In this paper, input-output data and operating experiences will be used to establish PEMFC stack model and operating temperature control system. An adaptive learning algorithm and a nearest-neighbor clustering algorithm are applied to regulate the parameters and fuzzy rules so that the model and the control system are able to obtain higher accuracy. In the end, the simulation and the experimental results are presented and compared with traditional PID and fuzzy control algorithms.