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遗传性发育性癫痫性脑病神经生物学及临床诊治研究进展
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作者 郑小红 周有峰 胡春辉 《癫痫杂志》 2024年第3期254-259,共6页
发育性癫痫性脑病(Developmental epileptic encephalopathies,DEE)是以早发癫痫、脑电图异常及发育落后或倒退为主要特征的一组疾病,具有病因复杂、药物难治的特点,严重影响患儿,尤其是婴幼儿的发育,是儿童神经系统疾病中的难题。近年... 发育性癫痫性脑病(Developmental epileptic encephalopathies,DEE)是以早发癫痫、脑电图异常及发育落后或倒退为主要特征的一组疾病,具有病因复杂、药物难治的特点,严重影响患儿,尤其是婴幼儿的发育,是儿童神经系统疾病中的难题。近年来,随着精准医学的研究逐渐兴起,已发现越来越多的DEE致病基因,但这些基因在体内具体的致病机制及信号通路依然有待研究。本文主要介绍了DEE遗传模式以及基因检测的选择,通过癫痫表型来辅助判断基因检测的时机,尤其是单基因突变相关的DEE和新的治疗药物,以辅助DEE临床诊疗决策。同时介绍利用用于DEE研究的神经生物学模型来有效推进癫痫研究,从而针对性进行基因靶向治疗。 展开更多
关键词 发育性癫痫性脑病 神经生物学模型 基因 治疗
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Study on Artificial Neural Network Model for Crop Evapotranspiration
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作者 冯雪 潘英华 张振华 《Agricultural Science & Technology》 CAS 2007年第3期11-14,41,共5页
Based on potted plant experiment, BP-artifieial neural network was used to simulate crop evapotranspiration and 3 kinds of artificial neural network models were constructed as ET1 (meteorological factors), ET2( met... Based on potted plant experiment, BP-artifieial neural network was used to simulate crop evapotranspiration and 3 kinds of artificial neural network models were constructed as ET1 (meteorological factors), ET2( meteorological factors and sowing days) and ET3 (meteorological factors, sowing days and water content). And the predicted result was compared with actual value ET that was obtained by weighing method. The results showed that the ET3 model had higher calculation precision and an optimum BP-artificial neural network model for calculating crop evapotranspiration. 展开更多
关键词 Crop evapotranspiration BP-artificial neural network Fitting precision
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Peripheral nerve regeneration and intraneural revascularization 被引量:22
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作者 Martial Caillaud Laurence Richard +2 位作者 Jean-Michel Vallat Alexis Desmoulière Fabrice Billet 《Neural Regeneration Research》 SCIE CAS CSCD 2019年第1期24-33,共10页
Peripheral nerves are particularly vulnerable to injuries and are involved in numerous pathologies for which specific treatments are lacking. This review summarizes the pathophysiological features of the most common t... Peripheral nerves are particularly vulnerable to injuries and are involved in numerous pathologies for which specific treatments are lacking. This review summarizes the pathophysiological features of the most common traumatic nerve injury in humans and the different animal models used in nerve regeneration studies. ~Ihe current knowledge concerning Wallerian degeneration and nerve regrowth is then described. Finally, the involvement of intraneural vascularization in these processes is addressed. As intraneural vascularization has been poorly studied, histological experiments were carried out from rat sciatic nerves damaged by a glycerol injection. The results, taken together with the data from literature, suggest that revascularization plays an important role in peripheral nerve regeneration and must therefore be studied more carefully. 展开更多
关键词 compression CRUSH TRANSECTION Sunderland's classification Wallerian degeneration ANGIOGENESIS TRAUMATIC GLYCEROL
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Bridging peripheral nerve defect with chitosan-collagen film 被引量:5
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作者 魏欣 劳杰 顾玉东 《Chinese Journal of Traumatology》 CAS 2003年第3期131-134,共4页
Objective: To seek new method for the treatment of peripheral nerve injury. Methods: In rat model with sciatic nerve defect, chitosan collagen film was sutured into conduit to bridge 5 mm , 10 mm nerve defects. Rats t... Objective: To seek new method for the treatment of peripheral nerve injury. Methods: In rat model with sciatic nerve defect, chitosan collagen film was sutured into conduit to bridge 5 mm , 10 mm nerve defects. Rats that underwent end to end anastomosis were taken as controls. General observation, electrophysiological study, histological study and image analysis were performed at 4, 8, 12 weeks postoperatively. Results: In 5 mm nerve defects, the quality of nerve regeneration was similar to that of the control group. For 10 mm nerve defect, nerve regeneration was inferior to that of the control group. Chitosan collagen film obviously degraded at 12 weeks postoperatively. Conclusions: Chitosan collagen film conduit can be used to bridge peripheral nerve defect. 展开更多
关键词 Peripheral nerves Nerve regeneration Nerve conduit COLLAGEN CHITOSAN
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