铜诱导大鼠大脑皮层和海马组织bax、bcl-2和热休克蛋白70基因的表达

目的 通过观察铜诱导大鼠大脑皮层和海马组织凋亡基因bcl 2、bax和热休克蛋白 70 (HSP70 )的mRNA表达 ,了解神经组织对铜诱导的反应性变化。方法 建立铜诱导鼠模型 ,提取实验组和对照组大脑皮层和海马组织RNA并反转录cDNA ,用bax、bcl 2、HSP70和 β actincDNA特异性引物在适宜条件下PCR扩增 ,半定量分析cDNA比值 ,并经t检验。结果 实验鼠皮层、海马组织中bax基因表达较对照组鼠明显增强 (P <0 .0 5 ) ,bcl 2基因表达无差异 ,HSP70表达明显减弱 (P <0 .0 5 )。结论 铜诱导大鼠bax基因表达增强 ,推测可能细胞凋亡增强 ;HSP70基因表达减弱 。

绿茶有益睡眠健康

美国肯塔基州立大学科研人员一项研究结果表明，绿茶所含的一种化合物，能帮助人们预防因睡眠呼吸障碍而造成的大脑神经组织损害。 研究人员在对小鼠的实验中发现，给小鼠饮用水中加入绿茶中的抗氧化物，可明显改善小鼠因睡眠呼吸暂停而导致的脑神经组织损害。研究人员称，绿茶中一种称为儿茶多酚的物质，有预防和治疗睡眠呼吸暂停症（OSA）的作用。

Peripheral nerve regeneration and intraneural revascularization

Peripheral nerves are particularly vulnerable to injuries and are involved in numerous pathologies for which specific treatments are lacking. This review summarizes the pathophysiological features of the most common traumatic nerve injury in humans and the different animal models used in nerve regeneration studies. ~Ihe current knowledge concerning Wallerian degeneration and nerve regrowth is then described. Finally, the involvement of intraneural vascularization in these processes is addressed. As intraneural vascularization has been poorly studied, histological experiments were carried out from rat sciatic nerves damaged by a glycerol injection. The results, taken together with the data from literature, suggest that revascularization plays an important role in peripheral nerve regeneration and must therefore be studied more carefully.

高压氧疗法对颅脑损伤大鼠神经元凋亡的影响及其机制研究

颅脑损伤严重危害人类健康，如何减轻原发性损伤所造成的神经组织损害，延缓颅脑损伤后各种继发性损伤的发生和发展，进一步改善预后，一直是临床和基础研究的课题。