Spinal cord injury(SCI),which is much in the public eye,is still a refractory disease compromising the well-being of both patients and society.In spite of there being many methods dealing with the lesion,there is stil...Spinal cord injury(SCI),which is much in the public eye,is still a refractory disease compromising the well-being of both patients and society.In spite of there being many methods dealing with the lesion,there is still a deficiency in comprehensive strategies covering all facets of this damage.Further,we should also mention the structure called the corticospinal tract(CST)which plays a crucial role in the motor responses of organisms,and it will be the focal point of our attention.In this review,we discuss a variety of strategies targeting different dimensions following SCI and some treatments that are especially efficacious to the CST are emphasized.Over recent decades,researchers have developed many effective tactics involving five approaches:(1)tackle more extensive regions;(2)provide a regenerative microenvironment;(3)provide a glial microenvironment;(4)transplantation;and(5)other auxiliary methods,for instance,rehabilitation training and electrical stimulation.We review the basic knowledge on this disease and correlative treatments.In addition,some well-formulated perspectives and hypotheses have been delineated.We emphasize that such a multifaceted problem needs combinatorial approaches,and we analyze some discrepancies in past studies.Finally,for the future,we present numerous brand-new latent tactics which have great promise for curbing SCI.展开更多
基金Project supported by the National Natural Science Foundation of China(Nos.81472504,81401822,and 81572177)the Science and Technology Foundation of Zhejiang Province(No.2016C33151)+1 种基金the Medical Science and Technology Project of Zhejiang Province of China(Nos.2016146428,2016KYA096,and 2017KY071)the Zhejiang Provincial Natural Science Foundation of China(Nos.Y17H160033,LQ14H060002,and LY14H060004)
文摘Spinal cord injury(SCI),which is much in the public eye,is still a refractory disease compromising the well-being of both patients and society.In spite of there being many methods dealing with the lesion,there is still a deficiency in comprehensive strategies covering all facets of this damage.Further,we should also mention the structure called the corticospinal tract(CST)which plays a crucial role in the motor responses of organisms,and it will be the focal point of our attention.In this review,we discuss a variety of strategies targeting different dimensions following SCI and some treatments that are especially efficacious to the CST are emphasized.Over recent decades,researchers have developed many effective tactics involving five approaches:(1)tackle more extensive regions;(2)provide a regenerative microenvironment;(3)provide a glial microenvironment;(4)transplantation;and(5)other auxiliary methods,for instance,rehabilitation training and electrical stimulation.We review the basic knowledge on this disease and correlative treatments.In addition,some well-formulated perspectives and hypotheses have been delineated.We emphasize that such a multifaceted problem needs combinatorial approaches,and we analyze some discrepancies in past studies.Finally,for the future,we present numerous brand-new latent tactics which have great promise for curbing SCI.
