Objective To assess whether quick cognitive screening test （QCST） could quickly identify mild cognitive impairment （MCI）. Methods QCST and a full set of standardized neuropsychological tests, including mini-mental...Objective To assess whether quick cognitive screening test （QCST） could quickly identify mild cognitive impairment （MCI）. Methods QCST and a full set of standardized neuropsychological tests, including mini-mental state examination （MMSE） and montreal cognitive assessment （MoCA） were performed. A total number of 121 cases of MCI [41 cases of amnestic MCI-single domain （aMCI-s）; 44 of amnestic MCI-multiple domain （aMCI-m）; 36 of nonamnestic MCI （naMCI）], 79 cases of mild Alzheimer’s disease （AD） and 186 healthy elderly volunteers were employed in the present study. All the participants （55-85 years old） had an educational level no less than 5 years. QCST subtests included word list recall, naming test, animal fluency test, similarity test, color trail-1min, clock drawing test, finger construction test, and digit span test. The total score of QCST was 90 points, 10 points for each index of subtests. Results The total scores of QCST in MCI, AD and the control groups were （58.13±8.18）, （44.53±10.54） and （72.92±6.85） points, respectively. According to the educational level, the cut off scores of participants with an educational level of 5-8 years, 9-12 years and more than 13 years were 63, 65 and 68 points, respectively. The sensitivity and specificity of QCST in detection of MCI were 87.6% （85.7% for aMCI-s, 90.1% for aMCI-m and 89.5% for naMCI） and 84.3%, respectively. The area under the curve was 0.923 （95% CI： 0.892-0.953）. Delayed memory, color trail-1min and similarity test could help distinguish between aMCI and naMCI. Conclusion QCST may have a good sensitivity and specificity for MCI detection, which warrants its further clinical application.展开更多
Objective： To observe the influence of acupuncture-moxibustion treatment on patients with mild cognition disorder. Methods： Sixty patients with mild cognition disorder were randomly divided into a treatment group an...Objective： To observe the influence of acupuncture-moxibustion treatment on patients with mild cognition disorder. Methods： Sixty patients with mild cognition disorder were randomly divided into a treatment group and a control group, with 30 cases in each group. Acupuncture-moxibustion treatment was used in the treatment group, while Western medicine was taken by the patients in the control group. The differences of intra-group and inter-group comparisons were assessed by 3 measurement scales including Mini-mental State Examination （MMSE）, Activity of Daily Living （ADL） and Montreal Cognitive Assessment （MoCA）. Results： After treatment, the MMSE, MoCA and ADL scores of both groups were higher than those before treatment （P〈0.05）. The MMSE, MoCA and ADL scores of the treatment group have more noticeable improvement than those of the control group （P〈0.05）. Conclusion： Acupuncture-moxibustion treatment can effectively improve cognitive function of the patients with mild cognitive impairment.展开更多
基金supported by the National Natural Science Foundation of China (No. 30570601)
文摘Objective To assess whether quick cognitive screening test （QCST） could quickly identify mild cognitive impairment （MCI）. Methods QCST and a full set of standardized neuropsychological tests, including mini-mental state examination （MMSE） and montreal cognitive assessment （MoCA） were performed. A total number of 121 cases of MCI [41 cases of amnestic MCI-single domain （aMCI-s）; 44 of amnestic MCI-multiple domain （aMCI-m）; 36 of nonamnestic MCI （naMCI）], 79 cases of mild Alzheimer’s disease （AD） and 186 healthy elderly volunteers were employed in the present study. All the participants （55-85 years old） had an educational level no less than 5 years. QCST subtests included word list recall, naming test, animal fluency test, similarity test, color trail-1min, clock drawing test, finger construction test, and digit span test. The total score of QCST was 90 points, 10 points for each index of subtests. Results The total scores of QCST in MCI, AD and the control groups were （58.13±8.18）, （44.53±10.54） and （72.92±6.85） points, respectively. According to the educational level, the cut off scores of participants with an educational level of 5-8 years, 9-12 years and more than 13 years were 63, 65 and 68 points, respectively. The sensitivity and specificity of QCST in detection of MCI were 87.6% （85.7% for aMCI-s, 90.1% for aMCI-m and 89.5% for naMCI） and 84.3%, respectively. The area under the curve was 0.923 （95% CI： 0.892-0.953）. Delayed memory, color trail-1min and similarity test could help distinguish between aMCI and naMCI. Conclusion QCST may have a good sensitivity and specificity for MCI detection, which warrants its further clinical application.
基金supported by National Natural Science Foundation of China(30973801)
文摘Objective： To observe the influence of acupuncture-moxibustion treatment on patients with mild cognition disorder. Methods： Sixty patients with mild cognition disorder were randomly divided into a treatment group and a control group, with 30 cases in each group. Acupuncture-moxibustion treatment was used in the treatment group, while Western medicine was taken by the patients in the control group. The differences of intra-group and inter-group comparisons were assessed by 3 measurement scales including Mini-mental State Examination （MMSE）, Activity of Daily Living （ADL） and Montreal Cognitive Assessment （MoCA）. Results： After treatment, the MMSE, MoCA and ADL scores of both groups were higher than those before treatment （P〈0.05）. The MMSE, MoCA and ADL scores of the treatment group have more noticeable improvement than those of the control group （P〈0.05）. Conclusion： Acupuncture-moxibustion treatment can effectively improve cognitive function of the patients with mild cognitive impairment.
