OBJECTIVE Various studies examining the relationship be-tween HER-2 over-expression and the response to chemotherapy and clinical outcome in patients with osteosarcoma have yielded inconclusive results.The purpose of ...OBJECTIVE Various studies examining the relationship be-tween HER-2 over-expression and the response to chemotherapy and clinical outcome in patients with osteosarcoma have yielded inconclusive results.The purpose of the current study was to evaluate the relation of HER-2 status with the response to chemo-therapy and clinical outcome in osteosarcoma.METHODS We conducted a meta-analysis of 6 studies that evaluated the correlation between HER-2 status and histologic response to chemotherapy and 2-year survival.Data were syn-thesized in summary receiver operating characteristic curves and with summary likelihood ratios(LRs) and relative risk.RESULTS The quantitative synthesis showed that HER-2 status is not a prognostic factor for the response to chemotherapy.The positive LR was 1.27(95% conf idence interval,0.91～1.77),and the negative LR was 0.68(95% confidence interval,0.38～1.22).There was no significant between-study heterogeneity.HER2-positive status tended to be associated with a worse 2-year survival,but the overall results were not formally statistically signif icant.CONCLUSION HER-2 status is not associated with the histo-logic response to chemotherapy in patients with osteosarcoma,whereas HER-2 positive patients may be associated with decreased survival.展开更多
Objective：To introduce an acupuncture method called flash acupuncture which combines Ashi points acupuncture with the time-related acupuncture based on traditional Chinese Medicine theories.Methods：Flash acupuncture...Objective：To introduce an acupuncture method called flash acupuncture which combines Ashi points acupuncture with the time-related acupuncture based on traditional Chinese Medicine theories.Methods：Flash acupuncture is carried out with magnetic platelets （6 000 Gauss） mainly at Ashi points,preferably with double magnetic platelets （DMP）,which means that 2 magnetic platelets are put together one above the other.Results：In the case of sciatica,satisfactory curative result was achieved within seconds andminutes with this integrated acupuncture method.Conclusion：For the efficient action and convenience of flash acupuncture,it is worth popularization and application in clinic for treating various diseases.展开更多
文摘OBJECTIVE Various studies examining the relationship be-tween HER-2 over-expression and the response to chemotherapy and clinical outcome in patients with osteosarcoma have yielded inconclusive results.The purpose of the current study was to evaluate the relation of HER-2 status with the response to chemo-therapy and clinical outcome in osteosarcoma.METHODS We conducted a meta-analysis of 6 studies that evaluated the correlation between HER-2 status and histologic response to chemotherapy and 2-year survival.Data were syn-thesized in summary receiver operating characteristic curves and with summary likelihood ratios(LRs) and relative risk.RESULTS The quantitative synthesis showed that HER-2 status is not a prognostic factor for the response to chemotherapy.The positive LR was 1.27(95% conf idence interval,0.91～1.77),and the negative LR was 0.68(95% confidence interval,0.38～1.22).There was no significant between-study heterogeneity.HER2-positive status tended to be associated with a worse 2-year survival,but the overall results were not formally statistically signif icant.CONCLUSION HER-2 status is not associated with the histo-logic response to chemotherapy in patients with osteosarcoma,whereas HER-2 positive patients may be associated with decreased survival.
基金supported by National Natural Science Foundation of China （81072761） Project of Science and Technology Commission of Shanghai Municipality （10695842000） Shanghai Leading Academic Discipline Project （S30304）
文摘Objective：To introduce an acupuncture method called flash acupuncture which combines Ashi points acupuncture with the time-related acupuncture based on traditional Chinese Medicine theories.Methods：Flash acupuncture is carried out with magnetic platelets （6 000 Gauss） mainly at Ashi points,preferably with double magnetic platelets （DMP）,which means that 2 magnetic platelets are put together one above the other.Results：In the case of sciatica,satisfactory curative result was achieved within seconds andminutes with this integrated acupuncture method.Conclusion：For the efficient action and convenience of flash acupuncture,it is worth popularization and application in clinic for treating various diseases.
