By numerically solving the Sch6dinger equation of a three-nuclear-spin system, the effects of the non-uniform nearest-neighbor （NN） interaction on the fidelity of a quantum controlled-controlled-no （CCN） gate are...By numerically solving the Sch6dinger equation of a three-nuclear-spin system, the effects of the non-uniform nearest-neighbor （NN） interaction on the fidelity of a quantum controlled-controlled-no （CCN） gate are investigated for a digital initial state and a superposition initial state respectively. It is found from our simulation that the ratio of the deviation of the NN coupling δJ to the NN coupling J should be smaller than 0.0005 to ensure a high fidelity of the quantum CCN gate.展开更多
To predict the temperature of a motorized spindle more accurately,a novel temperature prediction model based on the back-propagation neural network optimized by adaptive particle swarm optimization(APSO-BPNN)is propos...To predict the temperature of a motorized spindle more accurately,a novel temperature prediction model based on the back-propagation neural network optimized by adaptive particle swarm optimization(APSO-BPNN)is proposed.First,on the basis of the PSO-BPNN algorithm,the adaptive inertia weight is introduced to make the weight change with the fitness of the particle,the adaptive learning factor is used to obtain different search abilities in the early and later stages of the algorithm,the mutation operator is incorporated to increase the diversity of the population and avoid premature convergence,and the APSO-BPNN model is constructed.Then,the temperature of different measurement points of the motorized spindle is forecasted by the BPNN,PSO-BPNN,and APSO-BPNN models.The experimental results demonstrate that the APSO-BPNN model has a significant advantage over the other two methods regarding prediction precision and robustness.The presented algorithm can provide a theoretical basis for intelligently controlling temperature and developing an early warning system for high-speed motorized spindles and machine tools.展开更多
Axon regeneration is crucial for recovery from neurological diseases. Numerous studies have identified several genes, microRNAs （miRNAs）, and transcription factors （TFs） that influence axon regeneration. However, ...Axon regeneration is crucial for recovery from neurological diseases. Numerous studies have identified several genes, microRNAs （miRNAs）, and transcription factors （TFs） that influence axon regeneration. However, the regulatory networks involved have not been fully elucidated. In the present study, we analyzed a regulatory network of 51 miRNAs, 27 TFs, and 59 target genes, which is involved in axon regeneration. We identified 359 pairs of feed- forward loops （FFLs）, seven important genes （Naplll, Arhgef12, Sema6d, Akt3, Trim2, Rabllfip2, and Rps6ka3）, six important miRNAs （hsa-miR-204-5p, hsa-miR-124-3p, hsa-miR-26a-5p, hsa-miR-16-5p, hsa-miR-17-5p, and hsa- miR-15b-5p）, and eight important TFs （Smada2, Flil, Wtl, Sp6, Sp3, Smad4, Smad5, and Crebl）, which appear to play an important role in axon regeneration. Functional enrichment analysis revealed that axon-associated genes are involved mainly in the regulation of cellular component organization, axonogenesis, and cell morphogenesis during neuronal differentiation. However, these findings need to be validated by further studies.展开更多
Objective:To study the effect of nerve growth f actor (NGF) and Schwann cells on axon regeneration of the inferior alveolar nerv e following mandibular lengthening with distraction osteogenesis. Methods:Unilateral man...Objective:To study the effect of nerve growth f actor (NGF) and Schwann cells on axon regeneration of the inferior alveolar nerv e following mandibular lengthening with distraction osteogenesis. Methods:Unilateral mandibular osteodistraction was performed i n 9 healthy adult male goats with a distraction rate of 1 mm/d. Every 3 goats we re killed on days 7, 14 and 28 after mandibular lengthening, respectively. The i nferior alveolar nerves in the distraction callus were harvested and processed f or ultrastructural and NGF immunohistochemical study. The inferior alveolar nerv es from the contralateral side were used as controls. Results:On day 7 after distraction, axon degeneration and Schw ann cell proliferation were observed, and very strong staining of NGF in the dis tracted nerve was detected. On day 14 after distraction, axon regeneration and r emyelination were easily observed, and NGF expression started to decline. On day 28 after distraction, the gray scale of NGF immunoreactivity recovered to the n ormal value and the Schwann cells almost recovered to their normal state. Conclusions:Gradual mandibular osteodistraction can result in mild or moderate axon degeneration of the inferior alveolar nerve. Nerve trauma may stimulate the proliferation of Schwann cells and promote the synthesis and s ecretion of NGF in the Schwann cells. Schwann cells and NGF might play important roles in axon regeneration of the injured inferior alveolar nerve following man dibular lengthening.展开更多
基金Supported by National Science Foundation of China under Grant Nos. 10874021 and 10774107Science Foundation of Education Committee of Jiangsu Province under Grant No. 07KJB140002
文摘By numerically solving the Sch6dinger equation of a three-nuclear-spin system, the effects of the non-uniform nearest-neighbor （NN） interaction on the fidelity of a quantum controlled-controlled-no （CCN） gate are investigated for a digital initial state and a superposition initial state respectively. It is found from our simulation that the ratio of the deviation of the NN coupling δJ to the NN coupling J should be smaller than 0.0005 to ensure a high fidelity of the quantum CCN gate.
基金The National Natural Science Foundation of China(No.51465035)the Natural Science Foundation of Gansu,China(No.20JR5R-A466)。
文摘To predict the temperature of a motorized spindle more accurately,a novel temperature prediction model based on the back-propagation neural network optimized by adaptive particle swarm optimization(APSO-BPNN)is proposed.First,on the basis of the PSO-BPNN algorithm,the adaptive inertia weight is introduced to make the weight change with the fitness of the particle,the adaptive learning factor is used to obtain different search abilities in the early and later stages of the algorithm,the mutation operator is incorporated to increase the diversity of the population and avoid premature convergence,and the APSO-BPNN model is constructed.Then,the temperature of different measurement points of the motorized spindle is forecasted by the BPNN,PSO-BPNN,and APSO-BPNN models.The experimental results demonstrate that the APSO-BPNN model has a significant advantage over the other two methods regarding prediction precision and robustness.The presented algorithm can provide a theoretical basis for intelligently controlling temperature and developing an early warning system for high-speed motorized spindles and machine tools.
基金Project supported by the Key Project of Hebei North University(No.120177)the Science and Technology Bureau Research Development Plan of Zhangjiakou City in Hebei(No.0911021D-4)China
文摘Axon regeneration is crucial for recovery from neurological diseases. Numerous studies have identified several genes, microRNAs （miRNAs）, and transcription factors （TFs） that influence axon regeneration. However, the regulatory networks involved have not been fully elucidated. In the present study, we analyzed a regulatory network of 51 miRNAs, 27 TFs, and 59 target genes, which is involved in axon regeneration. We identified 359 pairs of feed- forward loops （FFLs）, seven important genes （Naplll, Arhgef12, Sema6d, Akt3, Trim2, Rabllfip2, and Rps6ka3）, six important miRNAs （hsa-miR-204-5p, hsa-miR-124-3p, hsa-miR-26a-5p, hsa-miR-16-5p, hsa-miR-17-5p, and hsa- miR-15b-5p）, and eight important TFs （Smada2, Flil, Wtl, Sp6, Sp3, Smad4, Smad5, and Crebl）, which appear to play an important role in axon regeneration. Functional enrichment analysis revealed that axon-associated genes are involved mainly in the regulation of cellular component organization, axonogenesis, and cell morphogenesis during neuronal differentiation. However, these findings need to be validated by further studies.
基金ThisstudywassupportedbytheNationalNaturalScienceFoundationofChina (No .3 9970 797)
文摘Objective:To study the effect of nerve growth f actor (NGF) and Schwann cells on axon regeneration of the inferior alveolar nerv e following mandibular lengthening with distraction osteogenesis. Methods:Unilateral mandibular osteodistraction was performed i n 9 healthy adult male goats with a distraction rate of 1 mm/d. Every 3 goats we re killed on days 7, 14 and 28 after mandibular lengthening, respectively. The i nferior alveolar nerves in the distraction callus were harvested and processed f or ultrastructural and NGF immunohistochemical study. The inferior alveolar nerv es from the contralateral side were used as controls. Results:On day 7 after distraction, axon degeneration and Schw ann cell proliferation were observed, and very strong staining of NGF in the dis tracted nerve was detected. On day 14 after distraction, axon regeneration and r emyelination were easily observed, and NGF expression started to decline. On day 28 after distraction, the gray scale of NGF immunoreactivity recovered to the n ormal value and the Schwann cells almost recovered to their normal state. Conclusions:Gradual mandibular osteodistraction can result in mild or moderate axon degeneration of the inferior alveolar nerve. Nerve trauma may stimulate the proliferation of Schwann cells and promote the synthesis and s ecretion of NGF in the Schwann cells. Schwann cells and NGF might play important roles in axon regeneration of the injured inferior alveolar nerve following man dibular lengthening.
