《道藏》洞神部医方研究

通过研究《道藏》洞神部的医方文献,介绍洞神部医方之概况,并总结出该部医方文献的4个特点——医方文献分布集中,存在同名异方现象,剂型以丸剂为主,功效以疗疾、养生为主。认为应当挖掘道教文献中与中医学相关内容,重视道医与中医的关系。

三部益智调神推拿法治疗脑卒中后睡眠倒错疗效观察

目的观察三部益智调神推拿法治疗脑卒中后睡眠倒错的临床疗效。方法将50例脑卒中后睡眠倒错患者随机分为治疗组和对照组,各25例,治疗组采用三部益智调神推拿法治疗,对照组采用右佐匹克隆口服治疗,治疗3个疗程前后采用阿森斯失眠量表(AIS)评价睡眠状态。结果治疗后2组患者AIS评分较治疗前显著改善(P<0.05),且治疗组改善程度显著大于对照组(P<0.05);治疗组临床总有效率优于对照组(P<0.05)。结论三部益智调神推拿法能显著改善脑卒中后睡眠倒错患者的睡眠质量,并且疗效优于右佐匹克隆。

三部六病调神汤治疗肝胃不和型胃痞(功能性胃肠病)的临床观察

探究三部六病调神汤治疗肝胃不和型胃痞(功能性胃肠病)的临床效果。方法:以简单随机抽样法纳入2019年3月-2020年7月的74例肝胃不和型胃痞(功能性胃肠病)患者作为研究对象,以抽签方式将其分为对照组和治疗组(各37例),前者给予常规西药治疗,后者给予三部六病调神汤治疗。以统计学对患者治疗前后症状积分、治疗有效率等数据进行处理分析。结果:治疗前,两组患者胃脘痞胀、嗳气、口干苦、眠差等症状积分相似(P>0.05)。治疗一个月后,治疗组各症状积分明显低于对照组(P<0.05)。治疗组治疗有效率91.89%明显高于参照组72.97%(P<0.05)。结论:三部六病调神汤治疗肝胃不和型胃痞(功能性胃肠病)的临床效果显著,可优先选择。

Therapeutic Effects of Stereotactic Radiotherapy on 389 Cases of Brain Glioma

Objective： To investigate the treatment effectiveness and side effects of stereotactic radiotherapy for brain glioma. Methods： From Jun. 1995 to Dec. 1998, 389 cases of brain gliomas were treated by stereotactic radiotherapy, among which 151 cases were treated by stereotactic radiosurgery （SRS） and the other 238 cases, by fractionated stereotactic radiotherapy （FSRT）. In the SRS group, the marginal tumor dose was 20 to 30 Gy （median, 2.6 Gy）. One to 6 isocenters （median, 2.48） and 5 to 21 irradiation arcs （median, 8.45） were applied. In the FSRT group, the per-fraction marginal tumor dose was 8 to 12 Gy with 1 to 6 isocenters （median, 2.53）, 6 to 20 irradiation arcs （median, 8.25） and 2-5 fractions delivered everyday or every other day. Results： Three months after treatment, the complete and partial response rates were 13.9% and 45.7% in SRS group respectively. The stable disease rate was 17.2%. The total effective rate was 76.8%. In FSRT group, the complete and partial remission rates were 19.7% and 47.9% respectively. The stable disease rate was 20.6%. The total effective rate was 88.2%. The total effective rate of FSRT group was higher than that in SRS group （X^2=9.874, P=0.020）. The 1-year, 3-year and 5-year survival rate of all patients was 54.3%, 29.3%, 16.5% respectively. The 1-year, 3-year and 5-year survival rate in SRS group and FSRT group was 52.3% vs 26.5%, 11.9% vs 55.5%, and 31.1 vs 19.3% respectively. There was no significant difference between the two groups （X^2=2.16, P=0.1417）. The brain edema caused by the main radiation was more severe in the SRS group than in FSRT group （X^2=4.916, P=0.027）. Conclusion： It is effective for brain glioma to be treated by stereotactic radiotherapy. Compared with SRS, the FSRT has the advantage of good effect and less side response.

A prediction comparison between univariate and multivariate chaotic time series

The methods to determine time delays and embedding dimensions in the phase space delay reconstruction of multivariate chaotic time series are proposed. Three nonlinear prediction methods of multivariate chaotic time series including local mean prediction, local linear prediction and BP neural networks prediction are considered. The simulation results obtained by the Lorenz system show that no matter what nonlinear prediction method is used, the prediction error of multivariate chaotic time series is much smaller than the prediction error of univariate time series, even if half of the data of univariate time series are used in multivariate time series. The results also verify that methods to determine the time delays and the embedding dimensions are correct from the view of minimizing the prediction error.

Effects of nuclei ambiguus and dorsal motor nuclei of vagus on gastric H^+ and HCO_3^- secretion in rats

AIM: To determine the effects of electrical stimulation of nucleus ambiguus (NA) and dorsal motor nuclei of vagus (DMV) on gastric acid and bicarbonate secretion in rats. METHODS: NA and DMV in rats were electrically stimulated. Pylorus ligation or esophagus perfusion was used to collect the gastric secretion. The titratable H+ quantum, H+ concentration, HCO3- secretion quantum were measured. RESULTS: Electrical stimulation of NA had no effects on the volume of gastric juice, titratable acidity and acid concentration, but elicited a pronounced increase in the total bicarbonate. However, electrical stimulation of DMV significantly increased the titratable acidity, the volume of gastric juice and the acid concentration. Similarly, electrical stimulation of either NA or DMV decreased the respiratory frequency and sinus bradycardia. CONCLUSION: NA in rats can not control the secretion of gastric acid but the secretion of bicarbonate in gastric juice, while DMV controls the secretion of gastric acid.

Facial pain induces the alteration of transient receptor potential vanilloid receptor 1 expression in rat trigeminal ganglion

Objective To investigate the involvement of transient receptor potential vanilloid receptor 1 （TRPV1） in the facial inflammatory pain in relation to thermal hyperalgesia and cold pain sensation. Methods Facial inflammatory pain model was developed by subcutaneous injection of turpentine oil （TO） into rat facial area. Head withdrawal thermal latency （HWTL） and head withdrawal cold latency （HWCL） were measured once a day for 21 d after TO treatment using thermal and cold measurement apparatus. The immunohistochemical staining, cell-size frequency analysis and the survey of average optical density （OD） value were used to observe the changes of TRPV1 expression in the neurons of the trigeminal ganglion （TG）, peripheral nerve fibers in the vibrissal pad, and central projection processes in the trigeminal sensory nuclei caudalis （Vc） on day 3, 5, 7, 14, and 21 after TO injection. Results HWTL and HWCL decreased significantly from day 1 to day 14 after TO injection with the lowest value on day 5 and day 3, respectively, and both recovered on day 21. The number of TRPV1-labeled neurons increased remarkably from day 1 to day 14 with a peak on day 7, and returned back to the normal level on day 21. In control rats, only small and medium-sized TG neurons were immunoreactive （IR） to TRPV1, and the TRPV1-IR terminals were abundant in both the vibrissal pad and the Vc. Within 2 weeks of inflammation, the expression of TRPV1 in small and medium-sized TG neurons increased obviously. Also the TRPV1 stained terminals and fibers appeared more frequent and denser in both the vibrissal pad skin and throughout laminae Ⅰ and the outer zone of laminae Ⅱ （Ⅱo） of Vc. Conclusion Facial inflammatory pain could induce hyperalgesia to noxious heat and cold stimuli, and result in increase of the numbers of TRPV1 positive TG neurons and the peripheral and central terminals of TG. These results suggest that the phenotypic changes of TRPV1 expression in small and medium-sized TG neurons and terminals might play an important role in the development and maintenance of TO-induced inflammatory thermal hyperalgesia and cold pain sensation.

Type-dependent differential expression of neuropeptide Y in chicken hypothalamus (Gallus domesticus)

Neuropeptide Y （NPY） is one of the most important orexigenic agents in central regulation of feeding behavior, body weight and energy homeostasis in domestic chickens. To examine differences in the hypothalamic NPY between layer-type and meat-type of chickens, which are two divergent kinds of the domestic chickens in feeding behavior and body weight, we detected mRNA levels of NPY in hypothalamic infundibular nucleus （IN）, paraventricular nucleus （PVN） and lateral hypothalamic area （LHA） of these two types of chickens using one-step real time RT-PCR. The meat-type chicken had more food daily （about 1.7 folds） and greater body weights （about 1.5 folds） and brain weights than the layer-type chicken at the age of 14 d. In the meat-type of chicken, NPY mRNA levels of the IN and PVN were significantly greater than those of the LHA, and were not significantly different between the lN and PVN. However, in the layer-type of chicken, NPY mRNA levels were significantly greater in the IN than those in the LHA and PVN, and were not significantly different between the PVN and LHA. In all these hypothalamic regions the layer-type of chicken had significantly higher NPY mRNA levels than the meat-type chicken did. These results suggest the expression of NPY in the hypothalamus has a type-dependent pattern in domestic chickens.

Basic fibroblast growth factor alleviates brain injury following global ischemia reperfusion in rabbits

The study was to explore the protective effect of basic fibroblast growth factor (bFGF) on brain injury following global ischemia reperfusion and its mechanisms. Brain injury following global ischemia was induced by four vessels occlusion and systemic hypotension. Twenty-four rabbits were randomized into three groups: group A, only dissection of vessels; group B, intravenous infusion of normal saline after reperfusion for 6 h; group C, 30 μg/kg bFGF injected intravenously at the onset of reperfusion, then infused with 10 μg/(kg&middoth) for 6 h. Serum neuron specific enolase (NSE), S-100B, tumor necrosis factor-α (TNF-α), interleukin-1 (IL-1), interleukin-8 (IL-8) were measured before ischemia, 30 min after ischemia, 0.5, 1, 3, 6 h after reperfusion. Brain water content was determined and cerebral histopathological damages were compared. NSE and S-100B were increased 1 h after reperfusion and reached their peaks 6 h after reperfusion, but were much higher in group B than those in group C 3, 6 h after reperfusion. In groups B and C, TNF-a was increased after ischemia and IL-1 and IL-8 were increased significantly 0.5 h after reperfusion, then reached their peaks 6 h, 3 h, 6 h after reperfusion respectively. TNF-a and IL-8 at the time points of 1 h and 3 h and IL-1 at 3 h and 6 h in group C were correspondingly lower than those in group B. These indices in group A were nearly unchanged. There were less severe cerebral histopathological damages in group C compared with group B, but no difference in brain water content. It could be concluded that bFGF alleviates brain injury following global ischemia and reperfusion by down-regulating expression of inflammatory factors and inhibiting their activities.

OBSERVATION ON CLINICAL THERAPEUTIC EFFECTS OF SCALP ACUPUNCTURE FOR FACIAL SPASM

Objective; To observe clinical therapeutic effect of scalp acupuncture in the treatment of facial spasm. Methods： Sixty-five cases of facial spasm were randomly divided into control group （n = 31 ） and treatment group（n = 34）. Patients of the treatment group were treated with penetrative acupuncture from Qienshencong（前神聪 Extra） to Xuanli（悬厘 GB 6）, Baihui（百会 GV 20） to Qubin（曲鬓 GB 7）, etc., and those of control group treated with acupuncture of Taiyang（太阳 EX-HN 5）, Yengbai（阳白 GB 14）, Quanliao（颧髎 SI 18） and Xiaguan（下关 ST 7）, etc. once daily, 20 sessions altogether. Results. After treatment, of the 31 cases and 34 cases in control and treatment groups, 5 and 12 were cured, 8 and 13 had remarkable improvement, 11 and 8 had improvement, 7 and 1 failed, with the total effective rates being 77.42% and 97.06% respectively; and the therapeutic elfact of treatment group was significantly superior to that of control group（P〈0.01）. Conclusion; Scalp acupurcture has an obvious therapeutic effect for facial spasm.

Hybrid internal model control and proportional control of chaotic dynamical systems

A new chaos control method is proposed to take advantage of chaos or avoid it. The hybrid Internal Model Control and Proportional Control learning scheme are introduced. In order to gain the desired robust performance and ensure the system's stability, Adaptive Momentum Algorithms are also developed. Through properly designing the neural network plant model and neural network controller, the chaotic dynamical systems are controlled while the parameters of the BP neural network are modified. Taking the Lorenz chaotic system as example, the results show that chaotic dynamical systems can be stabilized at the desired orbits by this control strategy.

Investigation of fundo-antral reflex in human beings

AIM： To examine the sensory and motor response（s） of the stomach following fundic distention and to assess whether cholinergic mechanisms influence these responses. METHODS： Fundic tone, gastric sensory responses and antral motility were evaluated in eight healthy volunteers after a probe with two sensors was placed in the antrum and a highly compliant balloon in the fundus. Isobaric balloon distentions were performed with a barostat. Study was repeated in six volunteers after intravenous atropine was given. RESULTS： Fundic antral contractions curve was higher First sensation distention induced large amplitude in all subjects. The area under the （P〈0.05） during fundic distention. was reported at 12±4 mmHg, moderate sensation at 18±4 mmHg and discomfort at 21±4 mmHg. Discomfort was associated with a decrease in antral motility. After atropine was given, the area under the curve of pressure waves and fundic tone decreased （P〈0.05）. Sensory thresholds were not affected. CONCLUSIONS： Fundic balloon distention induces an antral motor response, the fundo-antral reflex, which in part may be mediated by cholinergic mechanisms.

Transferring superior gluteal nerve to pudendal nerve in reconstructing functional impairment in simple conus medullaris or pudendal nerve injury

Objective: 1Department of Anatomy, College of Basic Medical Sciences, Second Military Medical University, Shanghai 200433, China 2Department of Orthopedic Surgery, Changhai Hospital, Second Military Medical University, Shanghai 200433, China Abstract Objective: To study the anatomical basis of transferring the superior gluteal nerve to the pudendal nerve in reconstructing the functional impairment in simple conus medullaris or pudendal nerve injury. Methods: Superior gluteal nerve and pudendal nerve were observed and measured by the gross and microsurgical anatomical methods in 62 sides of 31 adult cadavers. Results: Superior gluteal nerve came out of the superior foreman of piriformis as 1 to 4 branches(29.03%,56.45%,12.90% and 1.61% respectively) and the pelvic-leaving points were mainly in the middle 1/3(85.48%) of the line from the posterior superior iliac spine to the ischial tuberosity. The length of the inferior branch of the superior gluteal nerve was more than 5 cm, and the distance between the pelvic-leaving points of the superior gluteal nerve and pudandal nerve was about 4 cm only. The pudendal nerve left the pelvis mainly in the middle 1/3(48.39%) of the line from the posterior superior iliac spine to the ischial tuberosity,or at the junction of its inferior-middle 1/3(46.77%). In clinic, we have successfully made the operation transferring the superior gluteal nerve to the pudendal nerve in 3 patients suffered from the injury of conus medullaris. Conclusion: Distance between the pelvic-leaving points of the superior gluteal nerve and the pudendal nerve is close, so the inferior branch of the gluteal nerve can be anastomosed with the pudendal nerve directly. Transferring the superior gluteal nerve with higher spinal segemental origin to the pudendal nerve of a lower spinal segemental origin is practical and easy.

Olfactory ensheathing cells promote nerve regeneration and functional recovery after facial nerve defects

Olfactory ensheathing cells from the olfactory bulb and olfactory mucosa have been tbund to increase axonal sprouting and pathfinding and promote the recovery of vibrissae motor performance in facial nerve transection injured rats. However, it is not yet clear whether olfactory ensheathing cells promote the reparation of facial nerve defects in rats. In this study, a collagen sponge and silicone tube neural conduit was implanted into the 6-mm defect of the buccal branch of the facial nerve in adult rats. Olfactory ensheathing cells isolated from the olfactory bulb of newborn Sprague-Dawley rats were injected into the neural conduits connecting the ends of tile broken nerves, the morphology and function of the regenerated nerves were compared between the rats implanted with olfactory ensheathing cells with the rats injected with saline. Facial paralysis was assessed. Nerve electrography was used to measure facial nerve-induced action potentials. Visual inspection, anatomical microscopy and hematoxylin-eosin staining were used to assess the histomorphology around the trans planted neural conduit and the morphology of the regenerated nerve. Using fluorogold retrograde tracing, toluidine blue staining and lead uranyl acetate staining, we also measured the number of neurons in the anterior exterior lateral f：acial nerve motor nucleus, the number of myelinated nerve fibers, and nerve fiber diameter and myelin sheath thickness, respectively. After surgery, olfactory ensheathing cells de- creased facial paralysis and the latency of the facial nerve-induced action potentials. There were no differences in the general morphology of the regenerating nerves between the rats implanted with olfactory ensheathing cells and the rats injected with saline. Between-group results showed that olfactory ensheathing cell treatment increased the number of regenerated neurons, improved nerve fiber morphology, and increased the number of myelinated nerve fibers, nerve fiber diameter, and myelin sheath thickness. In conclusion, implantation of olfactory ensheathing cells can promote regeneration and functional recovery after facial nerve damage in rats.

试论《斯巴年绕》及其内容特点

《斯巴年绕》是一部关于西藏阿里地区婚俗的文本,该文本研究包括两大方面的意义,一是对尘封已久相关文献进行的整理性研究;二是对濒临失传的相关现实活态进行抢救性研究。文章通过对尘封与活态之间进行互识、互证、互补的方法研究发现:一方面,古藏人认为传统知识分佛教、雍仲苯教、世俗奏拉三大体系,这里的《斯巴年绕》属于第三大体系世俗奏拉类。另一方面,古藏人在器情世界形成的终极追问中认为“有生于无”,其形成顺序为空=>光=>爱+共同业力=>器情世界,进一步形容青藏高原是南赡部洲的肩胛骨,且认为神树是南赡部洲的标志。人类史源于时空观斯巴与嘎巴,粮食源于鸟类。再一个方面,在《斯巴年绕》相关资料中,不仅主张“有生于无”,同时还提出了“有中存空”。同理,在《斯巴年绕》相关资料中,神树不仅是南赡部洲的标志,同时,神树象征三界九地,神鸟象征菩提心的座驾。

ACUPUNCTURE TREATMENT OF OCCIPITAL NEURALGIA WITH DAZHUI AND FENGCHI ACUPOINTS

Objective: To explore therapeutic method for occipital neuralgia. Methods: A total of 90 occipital neuralgia patients were randomly divided into treatment group (n=60 cases) and control group (n=30). In treatment group, Dazhui (GV 14) was punctured and stimulated with reinforcing method, and Fengchi (GB 20) punctured and stimulated with reducing needling method. In control group, the tender point was punctured and stimulated with reducing needling method. The acupuncture needles were retained for 30 min and the treatment was conducted once daily, with 10 times being a therapeutic course. Results: After one session of treatment, the markedly effective rates of treatment and control groups were 98% and 57% respectively. Comparison between two groups showed a considerable difference in the therapeutic effect (P<0.05). Conclusion: Acupuncture of Dazhui (GV 14) and Fengchi (GB 20) are effective in the treatment of occipital neuralgia.

A data-derived soft-sensor method for monitoring effluent total phosphorus

The effluent total phosphorus(ETP) is an important parameter to evaluate the performance of wastewater treatment process(WWTP). In this study, a novel method, using a data-derived soft-sensor method, is proposed to obtain the reliable values of ETP online. First, a partial least square(PLS) method is introduced to select the related secondary variables of ETP based on the experimental data. Second, a radial basis function neural network(RBFNN) is developed to identify the relationship between the related secondary variables and ETP. This RBFNN easily optimizes the model parameters to improve the generalization ability of the soft-sensor. Finally, a monitoring system, based on the above PLS and RBFNN, named PLS-RBFNN-based soft-sensor system, is developed and tested in a real WWTP. Experimental results show that the proposed monitoring system can obtain the values of ETP online and own better predicting performance than some existing methods.

Synchronization of a Class of Delayed Neural Networks with Sector Nonlinearity

In this paper, global synchronization is discussed for a general class of delayed neural networks with time-varying and distributed delays. Furthermore, the activation func- tions in the neural networks can be different type. Based on the drive-response concept and the Lyapunov stability theorem, some sufficient criteria are obtained to guarantee the global synchronization of the considered models even when input sector nonlinearity caused by physical limitations is presented in response systems. Finally, a typical example is also given to illustrate the effectiveness of the proposed synchronization scheme.

A quantitative BP neural network analysis of the relationships between ΣREE content and impact factors in the Beibu Gulf

The distribution characteristics of rare earth elements （REE） in bottomsediments are influenced by many factors. Hence, conducting a quantitative analysis isdifficult. A qualitative analysis of the relationships between ΣREE content andprovenance, hydrodynamics, grain size and mineral distribution in the Beibu Gulf showsthat terrestrial rocks control the ΣREE composition. Both weaker hydrodynamics andfiner grain size lead to a higher ΣREE content. Relative curves revealing therelationships between individual impact factors and ΣREE content were obtained fromthe combination of qualitative and quantitative analyses of the BP neural network,which trained the position of samples, gravel content, sand content, silt content, claycontent and clay mineral content. The results are consistent with those of thequantitative analysis. The self-learning algorithm is automatically determined andcalculated quantitatively. The impact of each factor on REEs and how each factorcontrols the ΣREE distribution is identified. Thus, environmental changes and thegeological evolution of the region can be inferred based on curve variation and the geological evolution of the region can be inferred based on curve variation and theactual situation. This method also provides useful theoretical guidance for the analysisof REE enrichment and dispersion.

Stuck with the Sur-face： An Ethical Approach to Facial Disfigurement in Willa Cather＇s ＂The Profile＂

The human face consists of three dimensions： （1） the visible, static sur-face, （2） the mobile dimension, which communicates thoughts, emotions, and states of mind, and （3） the invisible dimension, the face aspars-pro-toto for the whole person who owns the face. In this latter sense, the human face is at the center of Emmanuel Levinas＇ theory of ethics： We encounter each other face-to-face, he argues, and it is the other＇s face that calls for my ethical response to the holiness of his/her wholeness and essence. The primary ethical imperative is： ＂Thou shalt not kill.＂ When we encounter a facially disfigured person, we usually fail to respond ethically because we concentrate on the disfigurement. The second dimension, as a result of the disfigurement, is often impaired and thus incapable of communicating in such a way that we can ＂read＂ the face. With our gaze fixed on the disfigured part of the face, we lose sight of the person as a whole. Metaphorically speaking, we could even say that we ＂kill＂ the person. Levinas conceives of the other＇s face not in its plastic manifestation. But the encounter with the other does at first take place as embodiment. According to Merleau-Ponty, this encounter is by definition interactive and dialogical. In Willa Cather＇s short story ＂The Profile,＂ young beautiful Virginia marries a portrait painter after he has finished her portrait in profile. The left side of her face is severely disfigured because of a burn. Her husband is waiting impatiently for her to talk about ＂it＂ and the suffering it must cause her in order to ＂heal＂ her with his love, but she behaves as if it did not exist and even likes to dress extravagantly. In the following analysis of the short story, it will be illustrated how the husband fails to respond to his wife＇s face＇s invitation to interact with it and get in touch with the wholeness of her person that it stands for. Instead, he reduces her to the disfigurement. When he finally names the scar, he metaphorically ＂kills＂ her, as well as their marriage.