Aim To assess the safety and tolerance of adefovir dipivoxil （ADV） in Chinese healthy volunteers. Methods A total of 52 healthy volunteers, 26 males and 26 females, aged from 19 to 26 were enrolled in the study. For...Aim To assess the safety and tolerance of adefovir dipivoxil （ADV） in Chinese healthy volunteers. Methods A total of 52 healthy volunteers, 26 males and 26 females, aged from 19 to 26 were enrolled in the study. Forty-two subjects were randomized into 5, 10, 20, 40, and 60 mg dose groups （6 - 10 subjects in each） matched by sex and weight for single-dose trial. Ten subjects were orally given 10 mg of ADV tablets once daily for 7 d for multiple-dose trial. Physical examination, vital signs examination, electrocardiography, type-B ultrasonography, chest fluoroscopy, routine blood test, routine urine test, coagulation tests, and blood biochemical test were conducted on schedule and statistically evaluated. Results Asthenia frequently occurred in multiple-dose trial, nausea, abdominal pain, and diarrhea occurred in both single- and multiple-dose trials. ALT, bilirubin, CK, and LDH were slightly elevated. All adverse reactions and laboratory abnormalities were mild, and the frequency and severity were not related to doses. Conclusion ADV is safe and well tolerated in Chinese healthy volunteers at dose of 5 - 60 mg oncedaily or 10 nag once daily for 7 d. The recommended oral dosage regimen is 10 mg once daily. Attention should be paid to renal and liver functions, CK, AMY and LDH, if we take ADV for a long period of time.展开更多
It has been proven by a number of earthquake case studies that an active fault-induced earthquake beneath a city can be devastating. It is an urgent issue for seismic hazard reduction to explore the distribution of ac...It has been proven by a number of earthquake case studies that an active fault-induced earthquake beneath a city can be devastating. It is an urgent issue for seismic hazard reduction to explore the distribution of active faults beneath the urban area and identify the seismic source and the risks underneath. As a pilot project of active fault exploration in China, the project, entitled “Active fault exploration and seismic hazard assessment in Fuzhou City”, started in early 2001 and passed the check before acceptance of China Earthquake Administration in August 2004. The project was aimed to solve a series of scientific issues such as fault location, dating, movement nature, deep settings, seismic risk and hazard, preparedness of earthquake prevention and disaster reduction, and etc. by means of exploration and assessment of active faults by stages, i.e., the preliminary survey and identification of active faults in target area, the exploration of deep seismotectonic settings, the risk evaluation of active seismogenic faults, the construction of geographic information system of active faults, and so on. A lot of exploration methods were employed in the project such as the detection of absorbed mercury, free mercury and radon in soil, the geological radar, multi-channel DC electrical method, tsansient electromagnetic method, shallow seismic refraction and reflection, effect contrast of explored sources, and various sounding experiments, to establish the buried Quaternary standard section of the Fuzhou basin. By summing up, the above explorations and experiments have achieved the following results and conclusions ：展开更多
At present, the social security problems of the disabled in most rural areas are more prominent. There is a big gap between their social security needs and the system and policies. It is an important task for the rura...At present, the social security problems of the disabled in most rural areas are more prominent. There is a big gap between their social security needs and the system and policies. It is an important task for the rural disabled to help the disabled to get rid of poverty and to solve their food and clothing. It is an important task to build a new socialist countryside and build a well-offsociety in an all-round way. It needs to be more effectively solved in the system construction of social security and social services. This paper, taking the rural of Shuyang County of Jiangsu Province as the research object, analyzes the situation and demand of the social security of the disabled in China, points out its existing problems and outs forward some countermeasures and suggestions.展开更多
This paper focuses on Malaysian Muslims perspective towards food safety, environment and animal welfare aspects of Halal principles in manufactured foods. Cross-sectional consumer data were collected through a survey....This paper focuses on Malaysian Muslims perspective towards food safety, environment and animal welfare aspects of Halal principles in manufactured foods. Cross-sectional consumer data were collected through a survey. One thousand seven hundreds and sixteen （1,716） Muslim respondents all over Peninsular Malaysia were interviewed randomly via structured questionnaire in 2009 to address the issues on Muslim consumers＇ understanding and perspective of Halal principles and its relation to food safety, environmentally friendly and animal welfare. Descriptive and Chi-square analysis were used to analyze the data collected. The findings revealed that majority of respondent relate Halal principles to food safety because Halal principle not only about slaughtering of animals but must also be Tyoibah or clean. The consumers from East of Peninsular Malaysia, with higher level religiosity and education level are more likely to understand the true meaning of Halal principles, Measuring the extent of consumers＇ understanding of Halal principles is vital, since Halal does not only focus on the Islamic processing but also sustainable concept of hygiene, sanitation and safety.展开更多
文摘Aim To assess the safety and tolerance of adefovir dipivoxil （ADV） in Chinese healthy volunteers. Methods A total of 52 healthy volunteers, 26 males and 26 females, aged from 19 to 26 were enrolled in the study. Forty-two subjects were randomized into 5, 10, 20, 40, and 60 mg dose groups （6 - 10 subjects in each） matched by sex and weight for single-dose trial. Ten subjects were orally given 10 mg of ADV tablets once daily for 7 d for multiple-dose trial. Physical examination, vital signs examination, electrocardiography, type-B ultrasonography, chest fluoroscopy, routine blood test, routine urine test, coagulation tests, and blood biochemical test were conducted on schedule and statistically evaluated. Results Asthenia frequently occurred in multiple-dose trial, nausea, abdominal pain, and diarrhea occurred in both single- and multiple-dose trials. ALT, bilirubin, CK, and LDH were slightly elevated. All adverse reactions and laboratory abnormalities were mild, and the frequency and severity were not related to doses. Conclusion ADV is safe and well tolerated in Chinese healthy volunteers at dose of 5 - 60 mg oncedaily or 10 nag once daily for 7 d. The recommended oral dosage regimen is 10 mg once daily. Attention should be paid to renal and liver functions, CK, AMY and LDH, if we take ADV for a long period of time.
文摘It has been proven by a number of earthquake case studies that an active fault-induced earthquake beneath a city can be devastating. It is an urgent issue for seismic hazard reduction to explore the distribution of active faults beneath the urban area and identify the seismic source and the risks underneath. As a pilot project of active fault exploration in China, the project, entitled “Active fault exploration and seismic hazard assessment in Fuzhou City”, started in early 2001 and passed the check before acceptance of China Earthquake Administration in August 2004. The project was aimed to solve a series of scientific issues such as fault location, dating, movement nature, deep settings, seismic risk and hazard, preparedness of earthquake prevention and disaster reduction, and etc. by means of exploration and assessment of active faults by stages, i.e., the preliminary survey and identification of active faults in target area, the exploration of deep seismotectonic settings, the risk evaluation of active seismogenic faults, the construction of geographic information system of active faults, and so on. A lot of exploration methods were employed in the project such as the detection of absorbed mercury, free mercury and radon in soil, the geological radar, multi-channel DC electrical method, tsansient electromagnetic method, shallow seismic refraction and reflection, effect contrast of explored sources, and various sounding experiments, to establish the buried Quaternary standard section of the Fuzhou basin. By summing up, the above explorations and experiments have achieved the following results and conclusions ：
文摘At present, the social security problems of the disabled in most rural areas are more prominent. There is a big gap between their social security needs and the system and policies. It is an important task for the rural disabled to help the disabled to get rid of poverty and to solve their food and clothing. It is an important task to build a new socialist countryside and build a well-offsociety in an all-round way. It needs to be more effectively solved in the system construction of social security and social services. This paper, taking the rural of Shuyang County of Jiangsu Province as the research object, analyzes the situation and demand of the social security of the disabled in China, points out its existing problems and outs forward some countermeasures and suggestions.
文摘This paper focuses on Malaysian Muslims perspective towards food safety, environment and animal welfare aspects of Halal principles in manufactured foods. Cross-sectional consumer data were collected through a survey. One thousand seven hundreds and sixteen （1,716） Muslim respondents all over Peninsular Malaysia were interviewed randomly via structured questionnaire in 2009 to address the issues on Muslim consumers＇ understanding and perspective of Halal principles and its relation to food safety, environmentally friendly and animal welfare. Descriptive and Chi-square analysis were used to analyze the data collected. The findings revealed that majority of respondent relate Halal principles to food safety because Halal principle not only about slaughtering of animals but must also be Tyoibah or clean. The consumers from East of Peninsular Malaysia, with higher level religiosity and education level are more likely to understand the true meaning of Halal principles, Measuring the extent of consumers＇ understanding of Halal principles is vital, since Halal does not only focus on the Islamic processing but also sustainable concept of hygiene, sanitation and safety.
