Four diterpenoids, including a new ent-kaurane diterpene (1), were isolated from the rhizome of Aralia fargesii Franch. On the basis of chemical and spectral evidence (IR, EI-MS, HREI-MS, H-1-NMR, C-13-NMR and HMQC), ...Four diterpenoids, including a new ent-kaurane diterpene (1), were isolated from the rhizome of Aralia fargesii Franch. On the basis of chemical and spectral evidence (IR, EI-MS, HREI-MS, H-1-NMR, C-13-NMR and HMQC), the structure of compound 1 was established to be 17-acetoxy-16alpha-ent-kauran-19-oic acid The other three known compounds were identified as ent-pimera-8(14) 15-dien-19-oic acid (2), 16alpha-hydroxy-( -)-kauran-19-oic acid (3) and 16alpha-17-dihydroxy-ent-kauran-19-oic acid (4). The three known diterpenoids were obtained from this plant for the first time.展开更多
Objective To observe the changes on multifocal electroretinography （MfERG） in the fellow eyes of patients with high myopia without fundus lesions and rhegmatogenous retinal detachment （RRD）. Methods MfERG was perf...Objective To observe the changes on multifocal electroretinography （MfERG） in the fellow eyes of patients with high myopia without fundus lesions and rhegmatogenous retinal detachment （RRD）. Methods MfERG was performed in 66 patients （ 66 eyes） which were grouped into ： emmetropes （ n = 22 ） as the control eye ; high myopes without fundus lesions （ corrected visual acuity ≥ 1. 0, n = 15 ） ; and fellow eyes of high myopics with RRD （n = 29 ）. The first-order kernels N1, P1, N2 response density and latency were analyzed. Results When compared with the emmetropes group, the high myopes group had significantly reduced N1 , PI , and N2 wave response densities in rings 1 to 6 （ P 〈 0. 05 ）, delayed N1 wave latency in rings 3 to 6, and P1 wave latency in rings 3 to 5 （ P 〈 0. 05 ）. The fellow eyes group had significantly reduced N1, P1, and N2 wave response densities in rings 1 to 6 and significantly delayed N1 and P1 wave latencies in rings 3 to 6 （ P 〈0. 05） compared with the emmetropes group. Compared with the high myopes group, P1 wave response densities in rings 1 to 6, N1 wave response densities in rings 1,3, 4, and 6, and N2 wave response density in ring 1 were significantly decreased in the fellow eyes group （ P 〈 0. 05 ） ; whereas there were no significant differences in latencies between the two groups （P 〉0.05）. Conclusion MfERG can sensitively assess the early changes in visual function in fellow eyes in patients with RRD.展开更多
文摘Four diterpenoids, including a new ent-kaurane diterpene (1), were isolated from the rhizome of Aralia fargesii Franch. On the basis of chemical and spectral evidence (IR, EI-MS, HREI-MS, H-1-NMR, C-13-NMR and HMQC), the structure of compound 1 was established to be 17-acetoxy-16alpha-ent-kauran-19-oic acid The other three known compounds were identified as ent-pimera-8(14) 15-dien-19-oic acid (2), 16alpha-hydroxy-( -)-kauran-19-oic acid (3) and 16alpha-17-dihydroxy-ent-kauran-19-oic acid (4). The three known diterpenoids were obtained from this plant for the first time.
文摘Objective To observe the changes on multifocal electroretinography （MfERG） in the fellow eyes of patients with high myopia without fundus lesions and rhegmatogenous retinal detachment （RRD）. Methods MfERG was performed in 66 patients （ 66 eyes） which were grouped into ： emmetropes （ n = 22 ） as the control eye ; high myopes without fundus lesions （ corrected visual acuity ≥ 1. 0, n = 15 ） ; and fellow eyes of high myopics with RRD （n = 29 ）. The first-order kernels N1, P1, N2 response density and latency were analyzed. Results When compared with the emmetropes group, the high myopes group had significantly reduced N1 , PI , and N2 wave response densities in rings 1 to 6 （ P 〈 0. 05 ）, delayed N1 wave latency in rings 3 to 6, and P1 wave latency in rings 3 to 5 （ P 〈 0. 05 ）. The fellow eyes group had significantly reduced N1, P1, and N2 wave response densities in rings 1 to 6 and significantly delayed N1 and P1 wave latencies in rings 3 to 6 （ P 〈0. 05） compared with the emmetropes group. Compared with the high myopes group, P1 wave response densities in rings 1 to 6, N1 wave response densities in rings 1,3, 4, and 6, and N2 wave response density in ring 1 were significantly decreased in the fellow eyes group （ P 〈 0. 05 ） ; whereas there were no significant differences in latencies between the two groups （P 〉0.05）. Conclusion MfERG can sensitively assess the early changes in visual function in fellow eyes in patients with RRD.
