AIM:To quantitatively assess the relationship between coffee consumption and incidence of pancreatic cancer in a meta-analysis of cohort studies. METHODS:We searched MEDLINE,EMBASE,Science Citation Index Expanded and ...AIM:To quantitatively assess the relationship between coffee consumption and incidence of pancreatic cancer in a meta-analysis of cohort studies. METHODS:We searched MEDLINE,EMBASE,Science Citation Index Expanded and bibliographies of retrieved articles.Studies were included if they reported relative risks(RRs)and corresponding 95%CIs of pancreatic cancer with respect to frequency of coffee intake.We performed random-effects meta-analyses and metaregressions of study-specific incremental estimates to determine the risk of pancreatic cancer associated with a 1 cup/d increment in coffee consumption. RESULTS:Fourteen studies met the inclusion criteria, which included 671 080 individuals(1496 cancer events) with an average follow-up of 14.9 years.Compared with individuals who did not drink or seldom drank coffee per day,the pooled RR of pancreatic cancer was 0.82 (95%CI:0.69-0.95)for regular coffee drinkers,0.86 (0.76-0.96)for low to moderate coffee drinkers,and 0.68(0.51-0.84)for high drinkers.In subgroup analyses,we noted that,coffee drinking was associated witha reduced risk of pancreatic cancer in men,while this association was not seen in women.These associations were also similar in studies from North America,Europe, and the Asia-Pacific region. CONCLUSION:Findings from this meta-analysis suggest that there is an inverse relationship between coffee drinking and risk of pancreatic cancer.展开更多
Growing competition has prompted enterprises to choose construct Technological Innovation Network to promote innovation, however the innovation network is a risky innovation system, how to carry out a comprehensive ri...Growing competition has prompted enterprises to choose construct Technological Innovation Network to promote innovation, however the innovation network is a risky innovation system, how to carry out a comprehensive risk assessment of the innovation network is particularly important. This paper focused on the technological innovation network risk analysis, used extenics to define which risk levels should these various risk factors in technological innovation network belongs to. And used Shanghai Caohejing hi tech park to do the empirical research, comfirmed risk factors which have the larger influence on technological innovation network.Enterprises can face them as the main objects of enterprise risk managemenL in order to improve the success rate of the innovation of the enterprise technological innovation network.展开更多
Chinese scientists make history by editing humangenes with new technologyIs it possible for humans to wall off a branch of knowledge that is deemed too dangerous,risky or formidable to pursue?That is what James Burke...Chinese scientists make history by editing humangenes with new technologyIs it possible for humans to wall off a branch of knowledge that is deemed too dangerous,risky or formidable to pursue?That is what James Burke,the science historian,asked in his 1985 documentary series,展开更多
文摘AIM:To quantitatively assess the relationship between coffee consumption and incidence of pancreatic cancer in a meta-analysis of cohort studies. METHODS:We searched MEDLINE,EMBASE,Science Citation Index Expanded and bibliographies of retrieved articles.Studies were included if they reported relative risks(RRs)and corresponding 95%CIs of pancreatic cancer with respect to frequency of coffee intake.We performed random-effects meta-analyses and metaregressions of study-specific incremental estimates to determine the risk of pancreatic cancer associated with a 1 cup/d increment in coffee consumption. RESULTS:Fourteen studies met the inclusion criteria, which included 671 080 individuals(1496 cancer events) with an average follow-up of 14.9 years.Compared with individuals who did not drink or seldom drank coffee per day,the pooled RR of pancreatic cancer was 0.82 (95%CI:0.69-0.95)for regular coffee drinkers,0.86 (0.76-0.96)for low to moderate coffee drinkers,and 0.68(0.51-0.84)for high drinkers.In subgroup analyses,we noted that,coffee drinking was associated witha reduced risk of pancreatic cancer in men,while this association was not seen in women.These associations were also similar in studies from North America,Europe, and the Asia-Pacific region. CONCLUSION:Findings from this meta-analysis suggest that there is an inverse relationship between coffee drinking and risk of pancreatic cancer.
文摘Growing competition has prompted enterprises to choose construct Technological Innovation Network to promote innovation, however the innovation network is a risky innovation system, how to carry out a comprehensive risk assessment of the innovation network is particularly important. This paper focused on the technological innovation network risk analysis, used extenics to define which risk levels should these various risk factors in technological innovation network belongs to. And used Shanghai Caohejing hi tech park to do the empirical research, comfirmed risk factors which have the larger influence on technological innovation network.Enterprises can face them as the main objects of enterprise risk managemenL in order to improve the success rate of the innovation of the enterprise technological innovation network.
文摘Chinese scientists make history by editing humangenes with new technologyIs it possible for humans to wall off a branch of knowledge that is deemed too dangerous,risky or formidable to pursue?That is what James Burke,the science historian,asked in his 1985 documentary series,