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在生物教学法课中提高学生生物科学素养 被引量:4
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作者 蒙绍权 李桂芬 《玉林师范学院学报》 2005年第5期94-97,109,共5页
新的基础教育课程改革所倡导的新理念,对中学生物教师的教学工作提出了新的要求.为全面提高未来中学生物教师的科学素养、职业素质和教学能力,以适应新课改的时代要求,从高师生物教学法课程教学着手,结合中学生物新课改的教学理念,探讨... 新的基础教育课程改革所倡导的新理念,对中学生物教师的教学工作提出了新的要求.为全面提高未来中学生物教师的科学素养、职业素质和教学能力,以适应新课改的时代要求,从高师生物教学法课程教学着手,结合中学生物新课改的教学理念,探讨了提高学生生物科学素养的几种途径:注重渗透STS教育、重视生物科学史的学习与教学、开展课外活动、加强生物理论教学与生活、生产实践的联系等,为高师生物教学法课程教学改革提供理论依据. 展开更多
关键词 生物教学法 新课程改革 生物科学素
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多元化测评培养学生科学素养 被引量:5
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作者 何大源 孙刚 《教育与装备研究》 2018年第9期88-92,共5页
以学生为主体,让学生亲身经历以探究为主的学习活动,立足于课堂教学中,培养学生综合实验能力,促进学生科学核心素养的发展。评价主体多元化、评价方法多样化和评价时机全程化,科学的评价有利于学生实验能力的提升。大数据交互式智能校... 以学生为主体,让学生亲身经历以探究为主的学习活动,立足于课堂教学中,培养学生综合实验能力,促进学生科学核心素养的发展。评价主体多元化、评价方法多样化和评价时机全程化,科学的评价有利于学生实验能力的提升。大数据交互式智能校园的广泛应用,要求建立多种样式的学生学业分析体系和教师教学评价体系,有效监测和反馈学生学业状况和教师教学状况。 展开更多
关键词 学生实验能力 科学素核心 多元化测评
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对科学发展及其必要性的认识
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作者 曾铁 《决策咨询通讯》 2009年第3期10-13,59,共5页
经济社会发展的新阶段、新境界就是科学发展,即不是拼资源、拼消耗、拼廉价劳动力的粗放式发展或不合理、非理性的发展,而是节约发展、清洁发展、安全发展和主要依靠科技进步的发展。又好又快发展是环保优先和理性、良性的发展,发展循... 经济社会发展的新阶段、新境界就是科学发展,即不是拼资源、拼消耗、拼廉价劳动力的粗放式发展或不合理、非理性的发展,而是节约发展、清洁发展、安全发展和主要依靠科技进步的发展。又好又快发展是环保优先和理性、良性的发展,发展循环经济、促进低碳经济是科学发展的需求与标志。科学发展的特征是资源节约、环境友好和可持续发展,是开放型而非封闭型的发展。科学发展的立足点、着力点是不断提高公民科学文化素质与健康素质,努力改善民生,提升生活品质与幸福指数,增强综合国力。为民谋福利,让百姓获得更多的实惠和民安国泰是科学发展的取向。科学发展主体是人,客体也包括人,人的全面发展是科学发展的目的。 展开更多
关键词 科学发展 环境保护 科学教育 科学素
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The Chemical Constituents of Elsholtzia blanda 被引量:10
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作者 吕金顺 沈彤 +2 位作者 郭珍 沈序维 郑尚珍 《Acta Botanica Sinica》 CSCD 2001年第5期545-550,共6页
Nine compounds were isolated from Elsholtzia blanda (Benth.) Benth. Their structures were identified with spectral and chemical methods as follows: 5,6-dihydro-6-styry-2-pyrone (1), friedelin (2), 4-hydroxy-3-methoxys... Nine compounds were isolated from Elsholtzia blanda (Benth.) Benth. Their structures were identified with spectral and chemical methods as follows: 5,6-dihydro-6-styry-2-pyrone (1), friedelin (2), 4-hydroxy-3-methoxystyrene (3), 5,2'-dimethoxy-6, 7-methylene dioxyflavanone (4), 5-hydroxy-7-methoxy-6-O-[alpha -L-rhamnopyranosyl(1 -->2) -beta -D-fucopyranosyl] flavone glycoside (5), 5, 5'-dihydroxy-7-acetoxyl-6, 8, 3',3'-tetramethylpyran (3',4') navone (6), 5, 5'-dihydroxy-7-(alpha -methyl) butyroxyl-6, 8, 3 ', 3'-tetramethylpyran (3',4') flavone (7), 5,5'-dihydroxy-6, 7-methylenedioxy-8, 3', 3'-trimethylpyran (3',4') navone (8), glucosyringic acid (9). Among them, 6, 7 and 8 are new compounds, named as sifanghaoine I,II and III, respectively. 展开更多
关键词 Elsholtzia blanda LABIATAE sifanghaoine
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开展人素科学的研究,进一步提高机组的安全保障作用 被引量:1
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作者 刘汉辉 郝瑜哲 《民航经济与技术》 1997年第10期26-28,共3页
According to the basic elements’ methods,the shortages in our country’s human factor are analysed and elaborated.Enhance knowledge training and standard awareness,as well as avoid the trap of overconfidence,understa... According to the basic elements’ methods,the shortages in our country’s human factor are analysed and elaborated.Enhance knowledge training and standard awareness,as well as avoid the trap of overconfidence,understanding the traps in language,so as to improve capability of distinguish in language. In this paper,the subject of individual character of pilot is made an inquiry. 展开更多
关键词 科学 飞行安全 机组 安全保障
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把科协、老科协组织建设成为学习型、服务型、创新型的坚强阵地——浅谈科协、老科协组织在建设创新型城市中的作用
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作者 王延飞 《今日科苑》 2011年第11期54-59,共6页
坚持走中国特色自主创新道路、建设创新型国家,是党中央、国务院审时度势、面向世界、把握未来的重大战略举措。聊城市委、市政府也提出,要全面落实全国科学技术大会精神,把加快科技进步、提高自主创新能力作为增强经济核心竞争力的中... 坚持走中国特色自主创新道路、建设创新型国家,是党中央、国务院审时度势、面向世界、把握未来的重大战略举措。聊城市委、市政府也提出,要全面落实全国科学技术大会精神,把加快科技进步、提高自主创新能力作为增强经济核心竞争力的中心环节和关键所在,加快推进创新型城市建设,促进全市经济社会又快又好发展。在这一伟大实践中,聊城市各级科协、老科协组织任重道远,担负着艰巨任务,这就要求我们一定要认清形势,不辱使命,为建设创新型城市而不懈奋斗。要完成这样的任务,各级科协、老科协组织至少应发挥五个作用: 展开更多
关键词 老科协 科技工作者 集成创新能力 科技竞争力 科技进步 组织建设 科技体制改革 科技发展 农民科学素
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法拉第电磁感应定律在高中物理教学中的应用分析
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作者 刘 佳 《学生·家长·社会》 2022年第17期0073-0075,共3页
法拉第电磁感应定律是高中物理教学中的重要内容之一。论文探讨分析法拉第电磁感应定律在高中物理教学中的应用。首先,介绍法拉第电磁感应定律的基本原理和公式,然后探讨该定律在课堂教学中的实际应用,包括感应电流、电磁感应现象的解... 法拉第电磁感应定律是高中物理教学中的重要内容之一。论文探讨分析法拉第电磁感应定律在高中物理教学中的应用。首先,介绍法拉第电磁感应定律的基本原理和公式,然后探讨该定律在课堂教学中的实际应用,包括感应电流、电磁感应现象的解释和应用、电磁感应产生的电动势等方面。论文还讨论如何通过实验和示例来帮助学生更好地理解和应用这一定律。最后,强调法拉第电磁感应定律在高中物理教学中的重要性,不仅有助于学生理解电磁学的基本原理,还为学生今后的学习和科研提供了坚实的基础。 展开更多
关键词 法拉第电磁感应定律 感应电流 电磁感应现象及应用 实验教学 高中物理教育 实际应用探讨 科学素
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Depression and chronic heart failure in the elderly: an intriguing relationship 被引量:17
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作者 Ilaria Liguori Gennaro Russo +8 位作者 Francesco Curcio Giuseppe Sasso David Della-Morte Gaetano Gargiulo Flora Pirozzi Francesco Cacciatore Domenico Bonaduce Pasquale Abete Gianluca Testa 《Journal of Geriatric Cardiology》 SCIE CAS CSCD 2018年第6期451-459,共9页
Chronic heart failure and depressive disorders have a high prevalence and incidence in the elderly. Several studies have shown how depression tends to exacerbate coexisting chronic heart failure and its clinical outco... Chronic heart failure and depressive disorders have a high prevalence and incidence in the elderly. Several studies have shown how depression tends to exacerbate coexisting chronic heart failure and its clinical outcomes and vice versa, especially in the elderly. The negative synergism between chronic heart failure and depression in the elderly may be approached only taking into account the multifaceted pathophysiological characteristics underlying both these conditions, such as behavioural factors, neurohormonal activation, inflammatory mediators, hypercoagulability and vascular damage. Nevertheless, the pathophysiological link between these two conditions is not well established yet. Despite the high prevalence of depression in chronic heart failure elderly patients and its negative prognostic value, it is often unrecognized especially because of shared symptoms. So the screening of mood disorders, using reliable questionnaires, is recommended in elderly patients with chronic heart failure, even if cannot substitute a diagnostic interview by mental health professionals. In this setting, treatment of depression requires a multidisciplinary approach including: psychotherapy, antidepressants, exercise training and electroconvulsive therapy. Pharmacological therapy with selective serotonin reuptake inhibitors, despite conflicting results, improves quality of life but does not guarantee better outcomes. Exercise training is effective in improving quality of life and prognosis but at the same time cardiac rehabilitation services are vastly underutilized. 展开更多
关键词 Chronic heart failure DEPRESSION The elderly
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Case Report:Adenoma of nonpigmented epithelium in ciliary body:literature review and case report 被引量:3
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作者 CHEN Zhi-qing FANG Xiao-yun 《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》 SCIE CAS CSCD 2007年第9期612-615,共4页
Adenomas of the nonpigmented ciliary epithelium (NPCE) are often clinically indistinguishable from amelanotic malignant melanomas of the ciliary body or metastatic carcinomas. This paper reports a case study of a dist... Adenomas of the nonpigmented ciliary epithelium (NPCE) are often clinically indistinguishable from amelanotic malignant melanomas of the ciliary body or metastatic carcinomas. This paper reports a case study of a distinctive variant of adenoma of the NPCE, which clinically appears as epiretinal membrane in the macular region. Histopathologic studies have revealed this is an adenoma of the NPCE. Identification of this clinic feature is important because it will miss the diagnosis of the adenoma of the NPCE. In this case study, B-scan ultrasonography as well as computerized tomography (CT) has been used to provide help in diagnosing the ciliary body tumor. Because of their anterior location in the ciliary body, partial lamellar sclerou-vectomy is an effective method of treatment. 展开更多
关键词 Epiretinal membrane Ciliary body Uveal tumor ADENOMA
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Application of Stable Isotope Tracing Technologies in Identification of Transformation among Waters in Sanjiang Plain,Northeast China 被引量:6
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作者 XU Yingying YAN Baixing +2 位作者 LUAN Zhaoqing ZHU Hui WANG Lixia 《Chinese Geographical Science》 SCIE CSCD 2013年第4期435-444,共10页
In order to investigate the transformation among the precipitation,groundwater,and surface water in the Sanjiang Plain,Northeast China,precipitation and groundwater samples which were collected at the meteorological s... In order to investigate the transformation among the precipitation,groundwater,and surface water in the Sanjiang Plain,Northeast China,precipitation and groundwater samples which were collected at the meteorological station of the Sanjiang Mire Wetland Experimental Station,Chinese Academy of Sciences and the surface water which collected from the Wolulan River were used to identify the transformation of three types of water.The isotope composition of different kinds of water sources were analyzed via stable isotope(deuterium and oxygen-18) investigation of natural water.The results show a clear seasonal difference in the stable isotopes in precipitation.During the cold half-year,the mean stable isotope in precipitation in the Sanjiang Plain reaches its minimum with the minimum temperature.The δ18O and δD values are high in the rainy season.In the Wolulan River,the evaporation is the highest in August and September.The volume of evaporation and the replenishment to the river is mostly same.The groundwater is recharged more by the direct infiltration of precipitation than by the river flow.The results of this study indicate that the water bodies in the Sanjiang Plain have close hydrologic relationships,and that the transformation among each water system frequently occurs. 展开更多
关键词 hydrogen and oxygen stable isotopes GROUNDWATER PRECIPITATION water cycle RECHARGE
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A Strategy to Strengthen the US Economy
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作者 Khalid Mehtabdin Greg Hayes 《Chinese Business Review》 2011年第3期168-172,共5页
For decades, the United States' competitive position in global manufacturing has steadily declined. Analysts point to increasingly automated manufacturing processes, changing domestic demand factors, outsourcing, and... For decades, the United States' competitive position in global manufacturing has steadily declined. Analysts point to increasingly automated manufacturing processes, changing domestic demand factors, outsourcing, and over confidence in service export surplnses. However, Asian and European competitors, undergoing the same pressures, have been able to maintain a healthy percentage of their GDP in manufacturing by growing high techjobs while the United States continues to fall behind, Perhaps the most flmdamental and overlooked contribution to this decline is the lackluster performance of the United States education system. After comparing the performance of US students to that of the other G-8 nations in the critical disciplines of math and science literacy, US students rank last. Furthermore, the most recent PISA test results show US students rank in the bottom half of 30 participating nations in the ability to apply math and science concepts to real world problems. This is particularly troubling when one considers that among the compared nations, the US spends the most on math and science teacher compensation. If the US intends to successfully compete in the global manufacturing arena, significant changes to the education system must be enacted. A new strategy aligning the system with real world demands should begin with a national initiative to increase Pre-K enrollments, a paradigm shift from liberal arts to math, science, problem solving and critical thinking, standardized policies aligning high school graduation requirements with college and work place expectations, and standardized college and career readiness assessment programs. These steps combined with more rigorous secondary education teacher certifications, continued education and involvement with universities and manufacturing f'mns within the community, should more adeq^tely prepare high school students for further study or to enter the skilled workforce. At the post secondary level, federal and state funding should be targeted to R&D programs specificly to industrial design, engineering, and alternative energy. Industry investment in such programs should be federally incentivized to foster cooperative relationships between business and academia. Such relationships will ensure faculty spend time focusing on how their discipline relates to manufacturing and instilling the necessary skill sets, knowledge and abilities which graduates will need to compete in the global market. Such a revised system will position the US to create and keep high paying manufacturing positions on its way to sustainable economic growth. 展开更多
关键词 JOBS TECHNOLOGY research/development
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Integration of SEM/WDX elemental mapping and micromorphology to determine mineralogical traits of peat soils(case study:Northern Iran) 被引量:1
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作者 Milad Kurdi Taymor Eslamkish 《Acta Geochimica》 EI CAS CSCD 2017年第2期298-315,共18页
We explored the potential use of combining wavelength-dispersive X-ray spectroscopy(WDX) and micromorphology of thin sections to identify minerals in peat soils. Peat soil minerals from three peats and swamps across G... We explored the potential use of combining wavelength-dispersive X-ray spectroscopy(WDX) and micromorphology of thin sections to identify minerals in peat soils. Peat soil minerals from three peats and swamps across Golestan Province in northern Iran were first characterized by micromorphological studies. Soils were composed mainly of quartz, muscovite, biotite, pyroxene,sericitized Fe-nodules, and iron-rich garnet. In addition,micromorphological results indicated that Galougah Coastal Swamp sections contained some inorganic residue with biological origin including oyster and limpet, which may be related to the swamp's location near Gorgan Gulf.In order to determine mineralogical properties of samples,twelve unknown grains were chosen for elemental concentration map studies. Quartz, garnet, ilmenite, calcite,and pyroxene in Suteh samples; epidote and Fe-nodule in Ghaleh-Ghafeh Peat Swamp; and barite, phyllosilicates,and calcite in Galougah were identified by WDX mapping of Si, Al, Fe, Ca, Mg, C, Ba, S, and Ti. Composition of the oysters' body was also analyzed by WDX for Si, Ca, Fe,and C. The results indicated that most of the minerals in all sections likely formed through weathering, inheriting their composition from the parent rock. This research suggests that merging micromorphology and SEM/WDX image techniques can be useful in confirming the presence of mineral particles in soil science. 展开更多
关键词 Elemental mapping MICROMORPHOLOGY Mineralogical characterization Peat and swamp soil SEM/WDX
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Controlled Entropy and Gauge Theory in Recycling Condensed Matter by Solar Energy
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作者 Nilo Sylvio Costa Serpa 《Journal of Physical Science and Application》 2017年第6期6-14,共9页
This article discusses the physical principles to be considered in a thermodynamic engineering solar system running under operational control algorithms designed to minimize entropy rates. The proposed plant is based ... This article discusses the physical principles to be considered in a thermodynamic engineering solar system running under operational control algorithms designed to minimize entropy rates. The proposed plant is based on scientific foundations established by thermodynamics and classical field theory, and empirical disciplines that deal with properties of chemical elements and with technologies of calorific capture from remote sources. The gauge principle was applied in theoretical formalization as an essential tool in the control background of the entropy rates involved. The industrial system presented was planned to recycle condensed matter within the scope of a solid waste management policy. 展开更多
关键词 Waste THERMODYNAMICS gauge principle PYROLYSIS solar energy cleaner production
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Psychological evaluation of patients after breast cancer surgery and care strategies improvement 被引量:1
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作者 Yanjun Zhang Caigang Liu Feng Jin 《The Chinese-German Journal of Clinical Oncology》 CAS 2011年第10期584-587,共4页
Objective: The aim of the study was to investigate the level of self-image of patients after breast cancer surgery, and explore factors influencing self-image among patients who have experienced different types of sur... Objective: The aim of the study was to investigate the level of self-image of patients after breast cancer surgery, and explore factors influencing self-image among patients who have experienced different types of surgeries, and set out a foundation for the improvement of care strategies. Methods: The 538 patients with primary breast cancer who underwent surgery in the Department of Breast Surgery, First Hospital of China Medical University, Shenyang, China, from January 2004 to January 2009 were included in the study. The psychological status of the patients was evaluated by body image after breast cancer questionnaire (BIBCQ), social support rating scale (SSRS), self-rating anxiety scale (SRAS), depression rating scale (DRS), and general information questionnaire. The factors influencing the self-image were selected by a stepwise regression analysis. Results: The patients who underwent breast-conserving surgery were the most satisfied with their body image, followed by those underwent surgery of modified radical mastectomy with reconstruction. However, cases treated by modified radical mastectomy without reconstruction had negative outcomes. Regardless of operation type, the self-image was influenced by anxiety, level of abuse by husband, and sexual satisfaction after operation. Conclusion: The self-image of patients who underwent different breast cancer surgeries was influenced by different factors, and individualized nursing should be offered in accordance with the specific situation. 展开更多
关键词 breast cancer operation NURSING SELF-IMAGE ANXIETY influencing factors
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Offering English and American Literature Optional Courses to Enhance Humanistic Qualities of Students in Universities of Science and Technology
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作者 WANG Huan 《Sino-US English Teaching》 2012年第9期1486-1492,共7页
Recently, the universities of science and technology pay more attention to their own specialized subjects and tak, little notice of humanities. This phenomenon results in the weakness of college students' humanistic ... Recently, the universities of science and technology pay more attention to their own specialized subjects and tak, little notice of humanities. This phenomenon results in the weakness of college students' humanistic qualities, Therefore, cultivating and enhancing students' humanistic qualities in universities of science and technolog become the main issues that are viewed intensively by the current educational circles. This paper analyzes th, current situation of English and American literature optional courses in universities of science and technolog3, gives the importance of offering the optional courses of English and American literature, and analyzes the activ roles and important significance of optional courses of English and American literature in the course of humanisti qualities of students in universities of science and technology. This paper also gives the necessities and ne~ methods of giving the optional courses of English and American literature under the circumstances of colleg, English teaching reform 展开更多
关键词 English and American literature optional courses students in universities of science and technology humanistic quality college English teaching
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Patterns and prognosis of locally recurrent rectal cancer following multidisciplinary treatment 被引量:5
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作者 Jun Zhao Chang-Zheng Du +1 位作者 Ying-Shi Sun Jin Gu 《World Journal of Gastroenterology》 SCIE CAS CSCD 2012年第47期7015-7020,共6页
AIM:To investigate the patterns and decisive prognostic factors for local recurrence of rectal cancer treated with a multidisciplinary team(MDT) modality.METHODS:Ninety patients with local recurrence were studied,out ... AIM:To investigate the patterns and decisive prognostic factors for local recurrence of rectal cancer treated with a multidisciplinary team(MDT) modality.METHODS:Ninety patients with local recurrence were studied,out of 1079 consecutive rectal cancer patients who underwent curative surgery from 1999 to 2007.For each patient,the recurrence pattern was assessed by specialist radiologists from the MDT using imaging,and the treatment strategy was decided after discussion by the MDT.The associations between clinicopathological factors and long-term outcomes were evaluated using both univariate and multivariate analysis.RESULTS:The recurrence pattern was classified as follows:Twenty-seven(30%) recurrent tumors were evaluated as axial type,21(23.3%) were anterior type,8(8.9%) were posterior type,and 13(25.6%) were lateral type.Forty-one patients had tumors that were evaluated as resectable by the MDT and ultimately received surgery,and R0 resection was achieved in 36(87.8%) of these patients.The recurrence pattern was closely associated with resectability and R0 resection rate(P < 0.001).The recurrence pattern,interval to recurrence,and R0 resection were significantly associated with 5-year survival rate in univariate analysis.Multivariate analysis showed that the R0 resection was the unique independent factor affecting long-term survival.CONCLUSION:The MDT modality improves patient selection for surgery by enabling accurate classification of the recurrence pattern;R0 resection is the most significant factor affecting long-term survival. 展开更多
关键词 Rectal cancer Local recurrence PROGNOSIS SURVIVAL SURGERY
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Recommendations on Strengthening the Development of Nuclear Medicine in China
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作者 Shih-chen Wang 《Chinese Medical Sciences Journal》 CAS CSCD 2009年第1期3-11,共9页
This paper outlines briefly the role of nuclear medicine in life sciences and health care. Molecular imaging by using isotopic tracers can noninvasively visualize the chemistry or hidden process in the cells and tissu... This paper outlines briefly the role of nuclear medicine in life sciences and health care. Molecular imaging by using isotopic tracers can noninvasively visualize the chemistry or hidden process in the cells and tissues inside the body, obtaining "functional" images to provide early information of any disease and revealing the secrets of life. The vitality of nuclear medicine is its ability to translate bench into new clinical application that can benefits the patients. Although nuclear medicine community in China has made significant achievement with a great effort since 1950s, there are many obstacles to future development. Recommended measures are proposed here in an attempt to solve our existing problems. 展开更多
关键词 nuclear medicine China
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Advances in the Study on Nutrient Requirements of Grouper (Epinephelus sp.): a Review 被引量:1
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作者 LUOZhi LIUYongjian +1 位作者 MAIKangsen TIANLixia 《Journal of Ocean University of China》 SCIE CAS 2005年第2期93-98,共6页
The paper reviews the recent advances in studying grouper nutrition requirement for the development of cost-effective and environmentally friendly artificial diets. It consists of seven parts: protein and amino acid, ... The paper reviews the recent advances in studying grouper nutrition requirement for the development of cost-effective and environmentally friendly artificial diets. It consists of seven parts: protein and amino acid, lipid and essential fatty acid, carbohydrate, vitamin, mineral, alternative protein source, broodstock and larval nutrition. The review provides some basic information for further investigation of nutrient requirements of groupers. 展开更多
关键词 EPINEPHELUS GROUPER nutrient requirement fish nutrition
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Biodegradation of Microcystin-RR by a New Isolated Sphingopyxis sp. USTB-05 被引量:17
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作者 王俊峰 吴鹏飞 +1 位作者 陈建 闫海 《Chinese Journal of Chemical Engineering》 SCIE EI CAS CSCD 2010年第1期108-112,共5页
A promising bacterial strain for the biodegradation of Microcystins(MCs)was isolated from Dianchi lake in China and identified as Sphingopyxis sp.USTB-05 by the analysis of 16s rDNA.Initial MC-RR of 42.3 mg·L -1 ... A promising bacterial strain for the biodegradation of Microcystins(MCs)was isolated from Dianchi lake in China and identified as Sphingopyxis sp.USTB-05 by the analysis of 16s rDNA.Initial MC-RR of 42.3 mg·L -1 was completely degraded by USTB-05 within 36 h,which was a relatively high biodegradation rate of MC-RR.With the cell-free extract(CE)of Sphingopyxis sp.USTB-05,MC-RR was biodegraded at a more rapid biodegradation rate compared with its strain,so that initial MC-RR of 42.3 mg·L -1 was completely biodegraded within 10 h.During the bio-reaction of MC-RR catalyzed by CE,two intermediate metabolites and a dead-end product of MC-RR were observed on HPLC profiles and all of them had similar scanning profiles in the wavelength from 200 to 300 nm,indicating that the group of Adda in all products of MC-RR remained intact. 展开更多
关键词 MICROCYSTIN-RR Sphingopyxis sp.USTB-05 cell-free extract BIODEGRADATION
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Impact of lymphatic and/or blood vessel invasion in stage Ⅱ gastric cancer 被引量:19
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作者 Chun-Yan Du Jing-Gui Chen +4 位作者 Ye Zhou Guang-Fa Zhao Hong Fu Xue-Ke Zhou Ying-Qiang Shi 《World Journal of Gastroenterology》 SCIE CAS CSCD 2012年第27期3610-3616,共7页
AIM: To determine the prognostic value of lymphatic and/or blood vessel invasion (LBVI) in patients with stage 11 gastric cancer. METHODS: From January 2001 to December 2006, 487 patients with histologically confi... AIM: To determine the prognostic value of lymphatic and/or blood vessel invasion (LBVI) in patients with stage 11 gastric cancer. METHODS: From January 2001 to December 2006, 487 patients with histologically confirmed primary gas- tric adenocarcinoma were diagnosed with stage 11 gas- tric cancer according to the new 7th edition American Joint Committee on Cancer stage classification at the Department of Gastric Cancer and Soft Tissue Surgery, Fudan University Shanghai Cancer Center. All patients underwent curative gastrectomy with standard lymph node (LN) dissection. Fifty-one patients who died in the postoperative period, due to various complications or other conditions, were excluded. Clinicopathologicalfindings and clinical outcomes were analyzed. Patients were subdivided into four groups according to the status of LBVI and LN metastases. These four patient groups were characterized with regard to age, sex, tumor site, pT category, tumor grading and surgical procedure (subtotal resection vs total resection), and compared for 5-year overall survival by univariate and multivariate analysis. RESULTS: The study was composed of 320 men and 116 women aged 58.9 ± 11.5 years (range: 23-88 years). The 5-year overall survival rates were 50.7% and the median survival time was 62 too. Stage Ⅱ a cancer was observed in 334 patients, including 268 T3N0, 63 T2N1, and three TIN2, and stage Ⅱb was observed in 102 patients, including 49 patients T3N1, 51 T2N2, one TIN3, and one T4aN0. The incidence of LBVI was 28.0% in stage II gastric cancer with 19.0% (51/269) and 42.5% (71/167) in LN-negative and LN- positive patients, respectively. In 218 patients (50.0%), there was neither a histopathologically detectable LBVI nor LN metastases (LBVI-/LN-, group I); in 51 patients (11.7%), LBVI with no evidence of LN me- tastases was detected (LBVILN-, group 11). In 167 patients (38.3%), LN metastases were found. Among those patients, LBVI was not determined in 96 patients (22.0%) (LBVI-γLN, group Ⅲ), and was determined in 71 patients (16.3%) (LBVI+LN+, group Ⅳ). Correla- tion analysis showed that N category and the number of positive LNs were significantly associated with the presence of LBVI (P 〈 0.001). The overall 5-year sur- vival was significantly longer in LN-negative patients compared with LN-positive patients (56.1% vs 42.3%, P = 0.015). There was a significant difference in the overall 5-year survival between LBVI-positive and LBVI- negative tumors (39.6% vs 54.8%, P = 0.006). Overall 5-year survival rates in each group were 58.8% ( Ⅰ), 45.8% (Ⅱ), 45.7% (Ⅲ) and 36.9% (Ⅳ), and there was a significant difference in overall survival between the four groups (P=-0.009). Multivariate analysis in stage 11 gastric cancer patients revealed that LBVI in- dependently affected patient prognosis in LN-negativepatients (P = 0.018) but not in LN-positive patients (P = 0.508). CONCLUSION: In LN-negative stage 11 gastric cancer patients, LBVI is an additional independent prognostic markeF, and may provide useful information to identify patients with poorer prognosis. 展开更多
关键词 Stage cancer Gastric cancer Lymphaticinvasion Blood vessel invasion PROGNOSIS
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