Phytochemical investigation of the leaves of Premna microphylla Turcz led to the isolation of 13 known compounds. Based on spectroscopic and chemical evidences, their structures were identified as diosmetin （1）, blu...Phytochemical investigation of the leaves of Premna microphylla Turcz led to the isolation of 13 known compounds. Based on spectroscopic and chemical evidences, their structures were identified as diosmetin （1）, blumenol A （2）, （3S,5R,6S,7E,9R）-5,6-epoxy-3,9-dihydroxy-7-megastigmene （3）, 3β-hydroxy-5a,6a-epoxy-γ-megastigmen-9-one （4）, ixerol B （5）, （-）-dehydrovomifoliol （6）, 3S,5R-dihydroxy-6S,7-megastigmadien-9-one （7）, loliotide （8）, （＋）-dehydrololiolide （9）, （＋）-medioresinol （10）, 4-oxopinoresinol （11）, tormentic acid （12）, and indole-3-carboxylic acid （13）. Compounds 2-13 described above were isolated from this genus for the first time.展开更多
Metallic implants are commonly used in various orthopaedic surgeries, like fracture fixation, spinal instrumentation, joint replacement and bone tumour surgery.Patients may need to adapt to the fixed dimensions of the...Metallic implants are commonly used in various orthopaedic surgeries, like fracture fixation, spinal instrumentation, joint replacement and bone tumour surgery.Patients may need to adapt to the fixed dimensions of the standard implants. It may result in suboptimal fit to the host bones and possible adverse clinical results. The standard traditional implants may not address the reconstructive challenges such as severe bone deformity or bone loss after implant loosening and bone tumour resection. With the advent of digital technologies in medical imaging, computer programming in three-dimensional（3 D） modelling and computer-assisted tools in precise placement of implants, patient-specific implants（PSI） have gained more attention in complex orthopaedic reconstruction. Additive manufacturing technology, in contrast to the conventional subtractive manufacturing, is a flexible process that can fabricate anatomically conforming implants that match the patients’ anatomy and surgical requirements. Complex internal structures with porous scaffold can also be built to enhance osseointegration for better implant longevity. Although basic studies have suggested that additive manufactured（AM） metal structures are good engineered biomaterials for bone replacement, not much peer-reviewed literature is available on the clinical results of the new types of implants. The article gives an overview of the metallic materials commonly used for fabricating orthopaedic implants, describes the metal-based additive manufacturing technology and the processing chain in metallic implants; discusses the features of AM implants;reports the current status in orthopaedic surgical applications and comments on the challenges of AM implants in orthopaedic practice.展开更多
基金National Natural Science Foundation of China(Grant No.31270390)Program for New Century Excellent Talents in University(Grant No.NCET-08-0224)
文摘Phytochemical investigation of the leaves of Premna microphylla Turcz led to the isolation of 13 known compounds. Based on spectroscopic and chemical evidences, their structures were identified as diosmetin （1）, blumenol A （2）, （3S,5R,6S,7E,9R）-5,6-epoxy-3,9-dihydroxy-7-megastigmene （3）, 3β-hydroxy-5a,6a-epoxy-γ-megastigmen-9-one （4）, ixerol B （5）, （-）-dehydrovomifoliol （6）, 3S,5R-dihydroxy-6S,7-megastigmadien-9-one （7）, loliotide （8）, （＋）-dehydrololiolide （9）, （＋）-medioresinol （10）, 4-oxopinoresinol （11）, tormentic acid （12）, and indole-3-carboxylic acid （13）. Compounds 2-13 described above were isolated from this genus for the first time.
文摘Metallic implants are commonly used in various orthopaedic surgeries, like fracture fixation, spinal instrumentation, joint replacement and bone tumour surgery.Patients may need to adapt to the fixed dimensions of the standard implants. It may result in suboptimal fit to the host bones and possible adverse clinical results. The standard traditional implants may not address the reconstructive challenges such as severe bone deformity or bone loss after implant loosening and bone tumour resection. With the advent of digital technologies in medical imaging, computer programming in three-dimensional（3 D） modelling and computer-assisted tools in precise placement of implants, patient-specific implants（PSI） have gained more attention in complex orthopaedic reconstruction. Additive manufacturing technology, in contrast to the conventional subtractive manufacturing, is a flexible process that can fabricate anatomically conforming implants that match the patients’ anatomy and surgical requirements. Complex internal structures with porous scaffold can also be built to enhance osseointegration for better implant longevity. Although basic studies have suggested that additive manufactured（AM） metal structures are good engineered biomaterials for bone replacement, not much peer-reviewed literature is available on the clinical results of the new types of implants. The article gives an overview of the metallic materials commonly used for fabricating orthopaedic implants, describes the metal-based additive manufacturing technology and the processing chain in metallic implants; discusses the features of AM implants;reports the current status in orthopaedic surgical applications and comments on the challenges of AM implants in orthopaedic practice.
