目的:观察理肺消积丸对Lewis肺癌小鼠肿瘤生长的影响作用。方法:将50只小鼠随机分为空白对照组、模型对照组、理肺消积丸组[240μg/(g·d)]、顺铂组[0.5μg/(g·d)]、联合组[理肺消积丸240μg/(g·d)+顺铂0.5μg/(g·d)...目的:观察理肺消积丸对Lewis肺癌小鼠肿瘤生长的影响作用。方法:将50只小鼠随机分为空白对照组、模型对照组、理肺消积丸组[240μg/(g·d)]、顺铂组[0.5μg/(g·d)]、联合组[理肺消积丸240μg/(g·d)+顺铂0.5μg/(g·d)]。采用皮下接种法建立Lewis肺癌小鼠模型,制备模型次日进行药物干预。2周后分别采用活体成像技术检测小鼠体内肿瘤生长情况,HE染色评价肿瘤组织病理学形态,免疫组化技术观察肿瘤细胞增殖细胞核抗原(Proliferating cell nuclear antigen,PCNA)及人第10号染色体缺失的磷酸酶及张力蛋白同源物(gene of phosphate and tension homology deleted on chromosome ten,PTEN)的表达情况,TUNEL技术评价肿瘤细胞凋亡情况。结果:模型对照组小鼠体内肿瘤增殖明显,肿瘤细胞异型性明显、核分裂象多见,PCNA蛋白表达程度极高,而细胞凋亡率及PTEN蛋白表达量极低。与模型对照组对比,理肺消积丸组的肿瘤生长受到抵制,肿瘤细胞异型性及核分裂象减少,PCNA蛋白表达下降,肿瘤细胞凋亡率升高,PTEN蛋白表达升高,差异均有统计学意义(P<0.05)。而顺铂组和联合组除PTEN蛋白表达较模型对照组差异无统计学意义外,其余指标均有统计学意义。结论:理肺消积丸可显著抑制Lewis肺癌小鼠肿瘤生长,其机制可能与其抑制肺癌细胞增殖、上调细胞凋亡和PTEN蛋白表达有关。展开更多
Nano-CeO2 （RE） particles were co-deposited into Ni-P binary composite coatings by applying pulse current （PC） under ultrasonic （U） field. Morphology, chemical content and crystal microstructure were characterize...Nano-CeO2 （RE） particles were co-deposited into Ni-P binary composite coatings by applying pulse current （PC） under ultrasonic （U） field. Morphology, chemical content and crystal microstructure were characterized by environmental scanning electron microscopy （E-SEM） with energy dispersive X-ray analysis （EDXA）, XRD diffractometry and transmission electron microscopy （TEM）. Experimental results show that Ni-P coating reinforced with 15g/L nano-CeO2, in amorphous state and with compact structure, can be improved in the microhardness from HV0.2580 to HV0.2780 by annealing at 600 °C for 2 h. The highest content of codeposited Ce and deposition rate can reach 2.3% and 68 μm/h, respectively. Furthermore, the effect of RE adsorption and pulse overpotential on depositional mechanism was investigated. n-CeO2 particles or Ce4＋ ions with strong adsorption capacity acted as the catalytic nucleus to improve densification effectively. During annealing at 600 °C for 2 h, n-CeO2 particles will uniformly adsorb on crystal grain to preferentially pad and heal up gaps of cracking Ni boundaries, promoting dispersion strengthening with refiner-grained structure.展开更多
The cadmium （Cd） contents in rice plants and Cd accumulation in different parts of rice under Cd stress were studied to screen out Cd-highly tolerant and high-yield rice varieties. With different vadeties of japonic...The cadmium （Cd） contents in rice plants and Cd accumulation in different parts of rice under Cd stress were studied to screen out Cd-highly tolerant and high-yield rice varieties. With different vadeties of japonica and indica rice as the research objects, Cd contents and Cd accumulation of different rice varieties in harvest time were discussed by pot experiment, under two treatments of no adding Cd and Cd stress. Under both the two treatments, the Cd contents in different parts of rice all ranked as root〉stem〉leaf〉husk〉grain, and Cd was manly concentrated in dce roots. Cd accumulation and distribution differed among different rice varieties, especially among grains of different rice varieties. Among the 8 rice varieties, the increase of grain Cd content of Chunyou 84 was the smallest, indicating a weaker Cd accumulation ability. At the same time, the Cd accumulation in japonica rice was higher than that in indica rice under Cd stress. Under Cd stress, the yield of indica rice decreased significantly, while that of japonica rice increased. The lowest grain Cd content of Chunyou 84 indicated significant Cd tolerance. Although its yield was affected, it can still be recommended to be promoted in the Cd-polluted region of Hunan Province, considering the Cd security.展开更多
Aim To extend several fundamental theorems of conventional elasticity theory to quasicrystalelasticity theory. Methods The basic governing equations of quasicrystal elasticity theory and Gauss's theorem were appli...Aim To extend several fundamental theorems of conventional elasticity theory to quasicrystalelasticity theory. Methods The basic governing equations of quasicrystal elasticity theory and Gauss's theorem were applied in the derivation. Results and Conclusion The principle of virtual work, Betti's reciprocal theorem and the uniqueness theorem of quasicrystal elasticity theory are proud, and some conservative integrals in quasicrystal elasticty theory are obtained.展开更多
The ultra high strength SiC particles （SiCp） reinforced Al-10%Zn-3.6%Mg-1.8%Cu-0.36%Zr-0.15% Ni composite was prepared by spray co-deposition. Microstructures of the extruded and different heat-treated bars were ana...The ultra high strength SiC particles （SiCp） reinforced Al-10%Zn-3.6%Mg-1.8%Cu-0.36%Zr-0.15% Ni composite was prepared by spray co-deposition. Microstructures of the extruded and different heat-treated bars were analyzed by transmission electron microscopy （TEM） and energy dispersive spectrometry （EDS）. Grain size of the composites prepared by two-stage solution is smaller than that by single-stage solution. After single-stage solution aging treatment, fine precipitates of both η and AlZnMgCu-rich phase can be found both intragranularly and intergranularly. While after the two-stage solution, an amorphous Si-Cu-Al-O （5 nm） layer appears at the interface. The addition of Ni and Zr modified the influence of the two-stage solution and inhibited the growth of the 7090/SiCp composite grain size. Heat treatments can significantly improve the fracture toughness of the composite. The fracture toughness first decreases then increases with the elongation of the aging time.展开更多
To improve the corrosion resistance, electrodeposition of Cu coating on Mg-3.0Nd-0.2Zn-0.4Zr （mass fraction, %NZ30K） magnesium alloy via an appropriate pretreatment was investigated. The surface morphologies, compos...To improve the corrosion resistance, electrodeposition of Cu coating on Mg-3.0Nd-0.2Zn-0.4Zr （mass fraction, %NZ30K） magnesium alloy via an appropriate pretreatment was investigated. The surface morphologies, compositions and microstructures of the pretreated films and Cu coating were characterized in detail. The results show that the activation film consists of fluoride and phosphates and Zn immersion film forms preferentially on the eutectic compound Mg12Nd phase region. A smooth, uniform and dense Cu coating is successfully obtained. Potentiodynamic polarization tests reveal that Cu coating can greatly improve the corrosion resistance of NZ30K magnesium alloy. Open circuit potential （OCP） and electrochemical impedance spectroscopy （EIS） tests during long-term immersion further demonstrate that Cu coating can provide an effective protection for NZ30K magnesium alloy from corrosion up to ~60 h, due to its dense structure and a stable passive film formed. In addition, Cu coating exhibits good adhesion to substrate as confirmed by thermal shock test.展开更多
文摘目的:观察理肺消积丸对Lewis肺癌小鼠肿瘤生长的影响作用。方法:将50只小鼠随机分为空白对照组、模型对照组、理肺消积丸组[240μg/(g·d)]、顺铂组[0.5μg/(g·d)]、联合组[理肺消积丸240μg/(g·d)+顺铂0.5μg/(g·d)]。采用皮下接种法建立Lewis肺癌小鼠模型,制备模型次日进行药物干预。2周后分别采用活体成像技术检测小鼠体内肿瘤生长情况,HE染色评价肿瘤组织病理学形态,免疫组化技术观察肿瘤细胞增殖细胞核抗原(Proliferating cell nuclear antigen,PCNA)及人第10号染色体缺失的磷酸酶及张力蛋白同源物(gene of phosphate and tension homology deleted on chromosome ten,PTEN)的表达情况,TUNEL技术评价肿瘤细胞凋亡情况。结果:模型对照组小鼠体内肿瘤增殖明显,肿瘤细胞异型性明显、核分裂象多见,PCNA蛋白表达程度极高,而细胞凋亡率及PTEN蛋白表达量极低。与模型对照组对比,理肺消积丸组的肿瘤生长受到抵制,肿瘤细胞异型性及核分裂象减少,PCNA蛋白表达下降,肿瘤细胞凋亡率升高,PTEN蛋白表达升高,差异均有统计学意义(P<0.05)。而顺铂组和联合组除PTEN蛋白表达较模型对照组差异无统计学意义外,其余指标均有统计学意义。结论:理肺消积丸可显著抑制Lewis肺癌小鼠肿瘤生长,其机制可能与其抑制肺癌细胞增殖、上调细胞凋亡和PTEN蛋白表达有关。
基金Project (CXLX12_0151) supported by Jiangsu Innovation program for Graduate Education and Fundamental Research Funds for Central Unibersities, China
文摘Nano-CeO2 （RE） particles were co-deposited into Ni-P binary composite coatings by applying pulse current （PC） under ultrasonic （U） field. Morphology, chemical content and crystal microstructure were characterized by environmental scanning electron microscopy （E-SEM） with energy dispersive X-ray analysis （EDXA）, XRD diffractometry and transmission electron microscopy （TEM）. Experimental results show that Ni-P coating reinforced with 15g/L nano-CeO2, in amorphous state and with compact structure, can be improved in the microhardness from HV0.2580 to HV0.2780 by annealing at 600 °C for 2 h. The highest content of codeposited Ce and deposition rate can reach 2.3% and 68 μm/h, respectively. Furthermore, the effect of RE adsorption and pulse overpotential on depositional mechanism was investigated. n-CeO2 particles or Ce4＋ ions with strong adsorption capacity acted as the catalytic nucleus to improve densification effectively. During annealing at 600 °C for 2 h, n-CeO2 particles will uniformly adsorb on crystal grain to preferentially pad and heal up gaps of cracking Ni boundaries, promoting dispersion strengthening with refiner-grained structure.
文摘The cadmium （Cd） contents in rice plants and Cd accumulation in different parts of rice under Cd stress were studied to screen out Cd-highly tolerant and high-yield rice varieties. With different vadeties of japonica and indica rice as the research objects, Cd contents and Cd accumulation of different rice varieties in harvest time were discussed by pot experiment, under two treatments of no adding Cd and Cd stress. Under both the two treatments, the Cd contents in different parts of rice all ranked as root〉stem〉leaf〉husk〉grain, and Cd was manly concentrated in dce roots. Cd accumulation and distribution differed among different rice varieties, especially among grains of different rice varieties. Among the 8 rice varieties, the increase of grain Cd content of Chunyou 84 was the smallest, indicating a weaker Cd accumulation ability. At the same time, the Cd accumulation in japonica rice was higher than that in indica rice under Cd stress. Under Cd stress, the yield of indica rice decreased significantly, while that of japonica rice increased. The lowest grain Cd content of Chunyou 84 indicated significant Cd tolerance. Although its yield was affected, it can still be recommended to be promoted in the Cd-polluted region of Hunan Province, considering the Cd security.
文摘Aim To extend several fundamental theorems of conventional elasticity theory to quasicrystalelasticity theory. Methods The basic governing equations of quasicrystal elasticity theory and Gauss's theorem were applied in the derivation. Results and Conclusion The principle of virtual work, Betti's reciprocal theorem and the uniqueness theorem of quasicrystal elasticity theory are proud, and some conservative integrals in quasicrystal elasticty theory are obtained.
基金Project (02Gky2004) supported by Hunan Provincial Science and Technology Department, China
文摘The ultra high strength SiC particles （SiCp） reinforced Al-10%Zn-3.6%Mg-1.8%Cu-0.36%Zr-0.15% Ni composite was prepared by spray co-deposition. Microstructures of the extruded and different heat-treated bars were analyzed by transmission electron microscopy （TEM） and energy dispersive spectrometry （EDS）. Grain size of the composites prepared by two-stage solution is smaller than that by single-stage solution. After single-stage solution aging treatment, fine precipitates of both η and AlZnMgCu-rich phase can be found both intragranularly and intergranularly. While after the two-stage solution, an amorphous Si-Cu-Al-O （5 nm） layer appears at the interface. The addition of Ni and Zr modified the influence of the two-stage solution and inhibited the growth of the 7090/SiCp composite grain size. Heat treatments can significantly improve the fracture toughness of the composite. The fracture toughness first decreases then increases with the elongation of the aging time.
基金Project(51371116)supported by the National Natural Science Foundation of ChinaProject supported by the Foundation of Open Research Topic in State Key Laboratory of Metal Matrix Composite,China
文摘To improve the corrosion resistance, electrodeposition of Cu coating on Mg-3.0Nd-0.2Zn-0.4Zr （mass fraction, %NZ30K） magnesium alloy via an appropriate pretreatment was investigated. The surface morphologies, compositions and microstructures of the pretreated films and Cu coating were characterized in detail. The results show that the activation film consists of fluoride and phosphates and Zn immersion film forms preferentially on the eutectic compound Mg12Nd phase region. A smooth, uniform and dense Cu coating is successfully obtained. Potentiodynamic polarization tests reveal that Cu coating can greatly improve the corrosion resistance of NZ30K magnesium alloy. Open circuit potential （OCP） and electrochemical impedance spectroscopy （EIS） tests during long-term immersion further demonstrate that Cu coating can provide an effective protection for NZ30K magnesium alloy from corrosion up to ~60 h, due to its dense structure and a stable passive film formed. In addition, Cu coating exhibits good adhesion to substrate as confirmed by thermal shock test.
