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卵巢组织冻存移植安全性的研究进展 被引量:4
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作者 程姣姣 阮祥燕 +3 位作者 杜娟 金凤羽 李扬璐 谷牧青 《首都医科大学学报》 CAS 北大核心 2021年第4期505-510,共6页
卵巢组织冻存与移植技术是一项成熟的生育力保护技术,然而,有些癌症类型中,冻存的卵巢组织中可能存在恶性细胞,因此在患者疾病痊愈后不建议进行卵巢组织移植。为了恢复这些患者的生育力,目前主要采用两种策略:1)人工卵巢移植,其主要目... 卵巢组织冻存与移植技术是一项成熟的生育力保护技术,然而,有些癌症类型中,冻存的卵巢组织中可能存在恶性细胞,因此在患者疾病痊愈后不建议进行卵巢组织移植。为了恢复这些患者的生育力,目前主要采用两种策略:1)人工卵巢移植,其主要目的是模拟卵巢天然器官;2)体外培养卵巢组织:将分离的卵泡体外培养成熟至可受精的卵母细胞。本文主要综述冻存卵巢组织移植安全性及避免携癌风险高的卵巢组织移植导致疾病复发的新方法的研究进展。 展开更多
关键词 卵巢组织冻存 卵巢组织移植 生育力保护 移植安全性 人工卵巢 窦前卵泡 体外培养
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卵巢组织冻存移植的安全性研究进展 被引量:1
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作者 李妍秋 谷牧青 阮祥燕 《中国医刊》 CAS 2022年第11期1179-1183,共5页
卵巢组织冻存移植技术是一项很有前景的新的生育力保护方法。但对于某些实体瘤及血液系统恶性肿瘤患者,存在卵巢冻存组织移植后肿瘤细胞移回体内的安全性问题。本文就如何尽可能提高卵巢冻存组织移植的安全性进行综述。
关键词 卵巢组织冻存 冻存卵巢组织移植 生育力保护 恶性疾病 移植安全性
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自体骨髓单个核细胞移植对急性肝损伤小鼠组织成瘤性的实验研究 被引量:1
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作者 韩明子 金世柱 +5 位作者 许军 曲波 宋艳燕 赵晶 薛洪璐 胡菱 《胃肠病学和肝病学杂志》 CAS 2013年第8期729-733,共5页
目的观察急性肝损伤小鼠接受自体骨髓单个核细胞(BMMNC)移植后能否导致肿瘤的发生,从而对自体骨髓干细胞(BMSC)移植的安全性进行初步探讨。方法采用CCl4/2-AAF制备小鼠急性肝损伤模型,随机分为6组,A组:BMMNC移植对照组;B组:腹部皮下注射... 目的观察急性肝损伤小鼠接受自体骨髓单个核细胞(BMMNC)移植后能否导致肿瘤的发生,从而对自体骨髓干细胞(BMSC)移植的安全性进行初步探讨。方法采用CCl4/2-AAF制备小鼠急性肝损伤模型,随机分为6组,A组:BMMNC移植对照组;B组:腹部皮下注射BMMNC0.3ml;C组:经尾静脉注射BMMNC0.3ml;D组:经尾静脉注射BMMNC0.9ml;E组:模型检测组;F组:供体组。BMMNC采用PKH26标记。病理观察小鼠接受BMMNC移植后皮下及肝脏内有无肿瘤形成。结果 C组及D组肝脏内未见肿瘤形成;B组皮下形成一肿物,病理证实为脂肪及淋巴细胞的炎性坏死所形成的包裹。结论理论上自体BMSC移植虽有形成肿瘤的可能性,但在本实验中未见肿瘤形成,自体BMSC移植能否诱发肿瘤还有待进一步探讨。 展开更多
关键词 干细胞移植 骨髓单个核细胞 干细胞移植成瘤性 干细胞移植安全性 急性肝损伤
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Clinical study on safety of adult-to-adult living donor liver transplantation in both donors and recipients 被引量:18
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作者 Bin Liu Lu-Nan Yan Wen-Tao Wang Bo Li Yong Zeng Tian-Fu Wen Ming-Qing Xu Jia-Yin Yang Zhe-Yu Chen Ji-Chun Zhao Yu-Kui Ma Jiang-Wen Liu Hong Wu 《World Journal of Gastroenterology》 SCIE CAS CSCD 2007年第6期955-959,共5页
AIM: TO investigate the safety of adult-to-adult living donor liver transplantation (A-A LDLT) in both donors and recipients. METHODS: From January 2002 to July 2006, 50 cases of A-A LDLT were performed at West Ch... AIM: TO investigate the safety of adult-to-adult living donor liver transplantation (A-A LDLT) in both donors and recipients. METHODS: From January 2002 to July 2006, 50 cases of A-A LDLT were performed at West China Hospital, Sichuan University, consisting of 47 cases using right lobe graft without middle hepatic vein (HHV), and 3 cases using dual grafts (one case using two left lobe, 2 using one right lobe and one left lobe). The most common diagnoses were hepatitis B liver cirrosis, 30 (60%) cases; and hepatocellular carcinoma, 15 (30%) cases in adult recipients. Among them, 10 cases had the model of end-stage liver disease (HELD) with a score of more than 25. Donor screening consisted of reconstruction of the hepatic blood vessels and biliary system with 3-dimension computed tomography and volumetry of whole liver and right liver volume. Various improved surgical techniques were adopted in the procedures for both donors and recipients. RESULTS: Forty-nine right lobes and 3 left lobes (2 left lobe grafts for 1 recipient, 1 left lobe graft for 1 recipient who had received right lobe graft donated by relative living donor) were obtained from 52 living donors. The 49 right lobe grafts, without HHV, weighed 400 g-850 g (media 550 g), and the ratio of graft volume to recipient standard liver volume (GV/SLV) ranged from 31.74% to 71.68% (mean 45.35%). All donors' remnant liver volume was over 35% of the whole liver volume. There was no donor mortality. With a follow- up of 2-52 mo (media 9 too), among 50 adult recipients, complications occurred in 13 (26%) cases and 4 (8%) died postoperatively within 3 mo. Their 1-year actual survival rate was 92%.CONCLUSION: When preoperative CT volumetry shows volume of remnant liver is more than 350, the ratio of right lobe graft to recipients standard liver volume exceeding 40%, A-A LDLT using right lobe graft without MHV should be a very safe procedure for both donors and recipients, otherwise dual grafts liver transplantation should be considered. 展开更多
关键词 Adult-to-adult living donor liver transplantation Middle hepatic vein Dual grafts Right lobe graft Standard liver volume GRAFTS Weight COMPLICATION
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Safety evaluation of donors for living-donor liver transplantation in Chinese mainland:A single-center report 被引量:3
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作者 Guo-Qiang Li Feng Zhang Xiang-Cheng Li Bei-Cheng Sun Feng Cheng Wen-Gang Ge Xue-Hao Wang 《World Journal of Gastroenterology》 SCIE CAS CSCD 2007年第32期4379-4384,共6页
AIM: To discuss the safety of donors during living donor liver transplantation (LDLT) and the authors' experience with 50 cases. METHODS: Between January 1995 and March 2006, 50 patients with end-stage liver dise... AIM: To discuss the safety of donors during living donor liver transplantation (LDLT) and the authors' experience with 50 cases. METHODS: Between January 1995 and March 2006, 50 patients with end-stage liver disease received LDLT in our department. Donors (at the age of 27-58 years) were healthy and antibody (ABO)-compatible. The protocol of evaluation and selection of donors, choice of surgical methods and strategy applied in the safety evaluation of donors were analyzed. RESULTS: A total of 115 candidate donors were evaluated for LDLT at our center. Of these, 50 underwent successful hepatectomy for living donation. The elimination rate for donors was 43.5%. Positive hepatitis serology and ABO incompatibility were the main factors for excluding candidates. All donors recovered uneventfully. The follow-up time ranged from 3 to 135 too. The incidence of major and minor medical complications was 12.0% and 28.0%, respectively. CONCLUSION: LDLT provides an excellent approach to the problem of donor shortage in China. With a thorough and complete preoperative workup and meticulous intra-and postoperative management, LDLT can be performed with minimal donor morbidity. 展开更多
关键词 Liver transplantation Living donor SAFETY EVALUATION
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Donor safety and remnant liver volume in living donor liver transplantation 被引量:2
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作者 Zheng-Rong Sh Lu-Nan Yan Cheng-You Du 《World Journal of Gastroenterology》 SCIE CAS CSCD 2012年第48期7327-7332,共6页
AIM:To evaluate the relationship between donor safety and remnant liver volume in right lobe living donor liver transplantation(LDLT).METHODS:From July 2001 to January 2009,our liver transplant centers carried out 197... AIM:To evaluate the relationship between donor safety and remnant liver volume in right lobe living donor liver transplantation(LDLT).METHODS:From July 2001 to January 2009,our liver transplant centers carried out 197 LDLTs.The clinical data from 151 cases of adult right lobe living donors(not including the middle hepatic vein) were analyzed.The conditions of the three groups of donors were well matched in terms of the studied parameters.The donors' preoperative data,intraoperative and postoperative data were calculated for the three groups:Group 1 remnant liver volume(RLV) < 35%,group 2 RLV 36%-40%,and group 3 RLV > 40%.Comparisons included the different remnant liver volumes on postoperative liver function recovery and the impact of systemic conditions.Correlations between remnant liver volume and post-operative complications were also analyzed.RESULTS:The donors' anthroposomatology data,op-eration time,and preoperative donor blood test indicators were calculated for the three groups.No significant differences were observed between the donors' gender,age,height,weight,and operation time.According to the Chengdu standard liver volume formula,the total liver volume of group 1 was 1072.88 ± 131.06 mL,group 2 was 1043.84 ± 97.11 mL,and group 3 was 1065.33 ± 136.02 mL.The three groups showed no statistically significant differences.When the volume of the remnant liver was less than 35% of the total liver volume,the volume of the remnant had a significant effect on the recovery of liver function and intensive care unit time.In addition,the occurrence of complications was closely related to the remnant liver volume.When the volume of the remnant liver was more than 35% of the total liver volume,the remnant volume change had no significant effect on donor recovery.CONCLUSION:To ensure donor safety,the remnant liver volume should be greater than the standard liver volume(35%) in right lobe living donor liver transplantation. 展开更多
关键词 Donor safety Remnant liver volume Living donor Liver transplantation Complications grade
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Donor safety in adult living donor liver transplantation using the right lobe: Single center experience in China 被引量:4
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作者 Fu-Gui Li Lu-Nan Yan Yong Zeng Jia-Yin Yang Qi-Yuan Lin Xiao-Zhong Jiang Bin Liu 《World Journal of Gastroenterology》 SCIE CAS CSCD 2007年第27期3752-3755,共4页
AIM: To evaluate the safety of donors in adult living donor liver transplantation (LDLT) using the right lobe in a single liver transplantation center in China. METHODS: We investigated retrospectively 52 living donor... AIM: To evaluate the safety of donors in adult living donor liver transplantation (LDLT) using the right lobe in a single liver transplantation center in China. METHODS: We investigated retrospectively 52 living donor liver resections performed from October 2003 to July 2006. All patients were evaluated by blood tests and abdominal CT. The mean donor age was 28.2 ± 7.4 years. Residual liver volume was 42.1% ± 4.7%. Mean operative time was 420 ± 76.2 min; mean ICU stay, less than 36 h; mean hospital stay, 16.4 ± 8.6 d; and mean follow-up period, 6 mo. RESULTS: There was no mortality. The overall complication rate was 40% (21 donors). Major complications included biliary leak in two, and pneumonia in 2 donors. Minor complications included mild pleural effusion in 12 donors, transient ascites in 6, mild depression in 4, intra-abdominal collections in 2, and wound infections in 1 donor. Residual liver volume did not affect the complication rate. None required re- operation. Return to pre-donation activity occurred within 5-8 wk. CONCLUSION: Right hemi-hepatectomy can be performed safely with minimal risk in cases of careful donor selection. Major complications occurred in only 7.7% of our series. 展开更多
关键词 Safety DONOR Liver transplantation COMPLICATION
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血浆预肿胀技术在自体脂肪面部填充中的应用效果
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作者 陈伟 王恒 +1 位作者 金磊 高雪辉 《中文科技期刊数据库(全文版)医药卫生》 2022年第9期143-146,共4页
探讨使用以血浆(PPP)及富血小板血浆(PRP)为主要成分的肿胀麻醉液,在面部自体脂肪移植前,进行预肿胀填充技术对提高面部自体脂肪填充安全性及成活率的应用效果。方法:回顾性分析自2020年5月-2022年3月,西安高一生医疗美容医院美容外科... 探讨使用以血浆(PPP)及富血小板血浆(PRP)为主要成分的肿胀麻醉液,在面部自体脂肪移植前,进行预肿胀填充技术对提高面部自体脂肪填充安全性及成活率的应用效果。方法:回顾性分析自2020年5月-2022年3月,西安高一生医疗美容医院美容外科接诊的247例面部自体脂肪移植患者,以自愿选择移植方案的方式将其分为2组。对照组123例患者在脂肪填充前,先采用含有利多卡因及肾上腺素的普通肿胀液对填充层次进行预肿胀技术,再进行脂肪移植手术;观察组124例患者采用自体PPP+PRP为主要成分的预肿胀液麻醉液预先给予填充层次进行预肿胀技术。对2组患者的临床治疗效果、满意度进行观察比较。结果:术后6个月,临床总有效率(96.77%)高于对照组(72.35%)(P<0.05);就观察组和对照组的医生和患者满意度考察得出,前者124例的满意度均在后者123例之上,P<0.05。结论:以富血小板血浆(PRP+PPP)为主要成分的预肿胀填充技术,对提高脂肪移植存活率;提高手术安全性及术后患者满意度均有明显优势,临床应用效果好。 展开更多
关键词 血浆预肿胀填充技术 自体脂肪移植安全性 脂肪成活率
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