随着心脏手术例数的增加和社会老龄化的加剧,手术风险相应增高。故心脏手术前评估病情程度,对于正确选择治疗方式和时机,提高疗效,合理配置医疗资源和改善医患沟通具有重要意义。中国冠状动脉旁路移植手术风险评估系统(Sino System for ...随着心脏手术例数的增加和社会老龄化的加剧,手术风险相应增高。故心脏手术前评估病情程度,对于正确选择治疗方式和时机,提高疗效,合理配置医疗资源和改善医患沟通具有重要意义。中国冠状动脉旁路移植手术风险评估系统(Sino System for Coronary Operation Risk Evalution,Sino SCORE)是我国首个心脏手术风险评估系统,已广泛应用于临床。文中就Sino SCORE的来源、构成、临床应用等作一简介。展开更多
Purpose: To evaluate the clinical efficacy of FK-506 on suppressing high-risk cornea transplantation rejection.Methods: In a randomized controlled clinical trial, 56 eyes of 56 patients with high-risk keratoplasty (in...Purpose: To evaluate the clinical efficacy of FK-506 on suppressing high-risk cornea transplantation rejection.Methods: In a randomized controlled clinical trial, 56 eyes of 56 patients with high-risk keratoplasty (including total corneal transplantation TCT, total corneal transplantation with circular lamellar sclera CST, vascularization corneal transplantation and corneal retransplantation) were divided into the experimental group and the control group(each with 28 eyes).The experimental group was treated by FK-506 eyedrops (0.5 mg/ml) and TobraDex eyedrops, compared with the control group that was treated by 1% CsA eyedrops and TobraDex eyedrops. In the average 8.1-month follow-up period, the visual acuity, graft transparent duration and Rejection Index (RI) of grafts were observed. Results: In the follow-up period, the graft rejection rate of the experimental and the control group was 63.6% and 95.2% respectively (χ2＝4. 72, P ＜ 0. 05) with significant difference.Conclusions: The local application of FK-506 suppressed effectively the graft rejection of corneal transplantation of the patients at high risk.展开更多
目的评价中国冠状动脉旁路移植手术风险评估系统(Sino System for Coronary Operative Risk Evalua-tion,SinoSCORE)对华西医院(本中心)成人心脏手术后院内死亡风险的预测价值。方法连续纳入2010年1月至2012年5月进入中国成人心脏外科...目的评价中国冠状动脉旁路移植手术风险评估系统(Sino System for Coronary Operative Risk Evalua-tion,SinoSCORE)对华西医院(本中心)成人心脏手术后院内死亡风险的预测价值。方法连续纳入2010年1月至2012年5月进入中国成人心脏外科数据库、本中心2 088例行心脏手术患者的临床资料,比较本中心与中国成人心脏外科数据库中所有患者术前危险因素的差异。计算每例患者的SinoSCORE累计积分,评价SinoSCORE预测本中心患者院内死亡风险的鉴别度和校准度。结果本中心2 088例患者中行冠状动脉旁路移植术(CABG)168例(8.05%),心瓣膜手术1 884例(90.23%),其它手术36例(1.72%)。本中心患者的高脂血症、脑卒中、心血管手术史、肾脏疾病等与中国成人心脏外科数据库中全部患者的差异有统计学意义。本中心患者实际术后院内病死率为2.25%(47/2 088),SinoSCORE预测院内病死率为2.35%(49/2 088)[95%CI(2.18,2.47)]。SinoSCORE预测本中心患者术后院内病死率的校准度(χ2=3.164,P=0.582)和鉴别度[受试者工作特征曲线下面积0.751,95%CI(0.719,0.924)]均较好。结论 SinoSCORE对中国西南地区成人心脏手术后院内死亡风险的预测虽高估风险,但仍适用。展开更多
文摘随着心脏手术例数的增加和社会老龄化的加剧,手术风险相应增高。故心脏手术前评估病情程度,对于正确选择治疗方式和时机,提高疗效,合理配置医疗资源和改善医患沟通具有重要意义。中国冠状动脉旁路移植手术风险评估系统(Sino System for Coronary Operation Risk Evalution,Sino SCORE)是我国首个心脏手术风险评估系统,已广泛应用于临床。文中就Sino SCORE的来源、构成、临床应用等作一简介。
文摘Purpose: To evaluate the clinical efficacy of FK-506 on suppressing high-risk cornea transplantation rejection.Methods: In a randomized controlled clinical trial, 56 eyes of 56 patients with high-risk keratoplasty (including total corneal transplantation TCT, total corneal transplantation with circular lamellar sclera CST, vascularization corneal transplantation and corneal retransplantation) were divided into the experimental group and the control group(each with 28 eyes).The experimental group was treated by FK-506 eyedrops (0.5 mg/ml) and TobraDex eyedrops, compared with the control group that was treated by 1% CsA eyedrops and TobraDex eyedrops. In the average 8.1-month follow-up period, the visual acuity, graft transparent duration and Rejection Index (RI) of grafts were observed. Results: In the follow-up period, the graft rejection rate of the experimental and the control group was 63.6% and 95.2% respectively (χ2＝4. 72, P ＜ 0. 05) with significant difference.Conclusions: The local application of FK-506 suppressed effectively the graft rejection of corneal transplantation of the patients at high risk.
