Ⅲ期非小细胞肺癌同期NP方案化疗与后程大分割三维适形放射治疗

目的探讨同期NP方案化疗与后程大分割三维适形放射(3DCRT)治疗Ⅲ期非小细胞肺癌的疗效及不良反应。方法60例Ⅲ期非小细胞肺癌(NSCLC)随机分成后程大分割3DCRT组(A组)和常规分割放疗组(B组)。A组先接受常规分割放疗(2Gy/次,5次/周)40Gy后2周行大分割适形放疗24～30Gy(4～5Gy/次,3次/周);B组均接受常规分割放疗至66Gy。两组均于放疗第1天起接受1周期NP方案化疗,放疗结束后接受3周期NP方案化疗。结果A、B组完全缓解(CR)率分别为26.7%、16.7%(P>0.05),部分缓解(PR)率分别为50%、30%(P<0.05),有效率(CR+PR)分别为76.7%、46.7%(P<0.05);1、2、3年生存率A组分别为83.3%、46.7%、36.7%,B组分别为46.7%、20%、16.7%,两组1～3年生存率比较差异有统计学意义。急性造血系统反应、放射性食管炎和放射性肺炎发生率相当。结论后程大分割三维适形放射治疗加化疗治疗Ⅲ期NSCLC的效果优于常规分割放疗,且不良反应相当。

Ⅲ期非小细胞肺癌后程大分割三维适形放疗疗效分析

目的评价后程大分割三维适形放疗(3DCRT)Ⅲ期非小细胞肺癌(NSCLC)的疗效与并发症。方法60例Ⅲ期NSCLC随机均分成后程大分割3DCRT组(A组)和常规分割3DCRT组(B组)。A组先接受常规分割放疗(2 Gy/次,5次/周)40 Gy,然后接受后程大分割放疗(4 Gy/次,3次/周)至56 Gy或60 Gy;B组均接受常规分割放疗至60～66 Gy。两组均在放疗第1天接受1个疗程NP方案化疗,放疗结束后接受3个疗程NP方案化疗,NP方案为长春瑞滨25 mg/m^2第1、8天,顺铂30 mg/m^2连用3 d。结果后程大分割放疗组、常规分割组完全缓解率分别为47%、20%(P<0.01),部分缓解率无差异;1～3年生存率曲线比较差异有统计学意义(X^2=4.20,P<0.05),中位生存时间分别为26、12个月;放射性食管炎、放射性肺炎的发生率无差异。结论后程大分割三维适形放疗Ⅲ期NSCL的效果优于常规分割放疗,且毒副反应相当。

非小细胞肺癌周围型病变后程大分割放疗Ⅱ期临床研究

目的探讨非小细胞肺癌周围型病变在图像引导放射治疗后期予以大分割放疗的疗效和安全性。方法研究纳入具有周围型病灶的19例非小细胞肺癌患者,所有患者均接受配合呼吸门控的图像引导放射治疗,完成常规分割照射30Gy/15次后,接受单次剂量6～12Gy,2～5次的大分割放疗,治疗在4周内完成。结果肿瘤客观缓解率为74%,中位生存时间21个月,1、2级急性放射性肺炎发生率为68%,3级为21%。结论利用图像引导放射治疗,对非小细胞肺癌周围型病变在疗程后期予以大分割放疗是安全有效的。

College English autonomous teaching and learning research and practice

This paper intends to promote a college English autonomous teaching and learning approach by introducing the whole process of its implementation and feedback from the learners. The theoretical and practical framework of this approach is： with multiple autonomous learning research and practice models as its core, with process syllabus as its guidance, with task-based teaching as its essential principle, with group cooperation and reciprocal learning as its means, with extracurricular activities, online learning and self-access center as its learning environment, with formative assessment system as its guarantee and with cultivation of learners＇ comprehensive English practical skills and autonomy as its goal. Through this approach, we provide the learners with a favorable learning environment where they can learn by themselves and learn by reflection and practice so that they can learn how to learn and how to behave and how to survive.

Heterogeneous Uptake of Hydrogen Peroxide on Mineral Oxides

The interaction of mineral oxides （α-A12O3, MgO, Fe2O3, and SiO2） with hydrogen peroxide was investigated using the Knudsen cell reactor. The initial reactive uptake coefficients for tile commercially available powders are measured as （1.00±0.11）×10-4 for α-A1203, （1.66±0.23）×10-4 for MgO, （9.70±1.95）×10-5 for Fe203, and （5.22±0.9）×10-5 for SiO2. These metal oxide powders exhibit some catalytic behavior toward the decomposition of hydrogen peroxide excluding SiO2. H2O2 can be destroyed on Fe2O3 surface and O2 is formed. The experimental results suggest that the heterogeneous loss on mineral surface can represent an important sink of hydrogen peroxide.

Variations in tidal currents and suspended sediment concentration of the upper part of the North Channel of Changjiang Estuary over the past 10 years

The tidal current duration （TCD） and velocity （TCV） and suspended sediment concentration （SSC） were measured in the dry season in December, 2011 and in the flood season in June, 2012 at the upper part of the North Channel of Changjiang Estuary. They were assimilated with the measured data in 2003, 2004, 2006 and 2007, using the tidal range＇s proportion conversion. Variations in TCD and TCV, preferential flow and SSC have been calculated. Influences of typical engineering projects such as Qingcaosha fresh water reservoir, Yangtze River Bridge, and land reclamation on the ebb and flood TCD, TCV and SSC in the North Channel for the last 10 years are discussed. The results show that： （1） currently, in the upper part of North Channel, the ebb tide dominates; after the construction of the typical projects, ebb TCD and TCV tends to be larger and the vertical average ebb and flood SSC decrease during the flood season while SSC increases during the dry season; （2） changes in the vertical average TCV are mainly contributed by seasonal runoff variation during the flood season, which is larger in the flood season than that in the dry season; the controlling parameters of increasing ebb TCD and TCV are those large-scale engineering projects in the North Channel; variation in SSC may result mainly from the reduction of basin annual sediment loads, large-scale nearshore projects and so on.

Construction analysis on integral lifting of steel structure by the vector form intrinsic finite element

A newnumerical method based on vector form intrinsic finite element（VFIFE） is proposed to simulate the integral lifting process of steel structures. First, in order to verify the validity of the VFIFE method, taking the steel gallery between the integrated building and the attached building of Nanjing M obile Communication Buildings for example, the static analysis was carried out and the corresponding results were compared with the results achieved by the traditional finite element method. Then, according to the characteristics of dynamic construction of steel structure integral lifting, the tension cable element was employed to simulate the behavior of dynamic construction. The VFIFE method avoids the iterative solution of the stiffness matrix and the singularity problems. Therefore, it is simple to simulate the complete process of steel structure lifting construction.Finally, by using the VFIFE, the displacement and internal force time history curves of the steel structures under different lifting speeds are obtained. The results show that the lifting speed has influence on the lifting force, the internal force, and the displacement of the structure. In the case of normal lifting speed, the dynamic magnification factor of 1. 5 is safe and reasonable for practical application.

Test of Resource Competition Theory Between Microalga and Macroalga Under Phosphate Limitation

Short_term batch cultures were used to measure the phosphate_dependent growth kinetics for a marine microalga, Tetraselmis subcordiformis (Wille) Hazen, and a marine macroalga, Ulva pertusa Kjellm. Results were fitted to the Monod model. U. pertusa had a lower half_saturation constant and maximum growth rate, which were 0.016 μmol/L and 0.16 d -1 respectively, while the growth kinetics of T. subcordiformis were 0.021 μmol/L and 0.83 d -1 . Long_term semicontinuous nutrient competition experiments were performed between T. subcordiformis and U. pertusa under phosphate limitation in laboratory. Loss rates were manipulated to get the same or different resource requirement values ( R * ) of the two species. Comparison between the theoretical predictions derived from Monod kinetics and the outcome of competition experiments indicated that the Monod model could predict the results only when the R * values of the two species were significantly different, and T. subcordiformis displaced U. pertusa when they had the same resource requirements. The Monod model can only partly predict the competition results between microalga and macroalga.

考虑滑面材质的碎屑流试验堆积特征分析

为分析高速远程滑坡运动与堆积特征,在室内设置物理试验模型,设计级配、坡角、碎屑流质量、滑面材质4种因素,分析各因素对碎屑流堆积特征的影响。研究结果表明:坡角减小、滑面更粗糙使部分颗粒堆积或滞留于坡面,颗粒堆积特征与颗粒完全堆积于坡底时相比存在差异;滑面材质与冲程等堆积特征基本呈负相关,坡角与堆积特征基本呈正相关,二者对堆积特征影响最大;碎屑流质量与堆积特征基本呈负相关,对颗粒堆积特征分布影响较小;级配与颗粒堆积特征无明显相关性。

Parallel rapid relaxation inversion of 3D magnetotelluric data

We implement a parallel algorithm with the advantage of MPI （Message Passing Interface） to speed up the rapid relaxation inversion for 3D magnetotelluric data. We test the parallel rapid relaxation algorithm with synthetic and real data. The execution efficiency of the algorithm for several different situations is also compared. The results indicate that the parallel rapid relaxation algorithm for 3D magnetotelluric inversion is effective. This parallel algorithm implemented on a common PC promotes the practical application of 3D magnetotelluric inversion and can be suitable for the other geophysical 3D modeling and inversion.

Exact Solutions for a Higher-Order Nonlinear Schrodinger Equation in Atmospheric Dynamics

By giving prior assumptions on the form of the solutions, we succeed to find several exact solutions for a higher-order nonlinear Schroetinger equation derived from one important model in the study of atmospheric and ocean dynamical systems. Our analytical solutions include bright and dark solitary waves, and periodical solutions, which can be used to explain atmospheric phenomena.

The Estimation for Lower Bounds of the Solutions of Fermat's Equation

Let p be a prime with p≡3(mod 4). In this paper,by using some results relate the representation of integers by primitive binary quadratic forms,we prove that if x,y,z are positive integers satisfying x^p+y^p=z^p, p|xyz, x<y<z, then y>p^(6p-2)/2.

Marine Structures: Future Trends and the Role of Universities

This paper emphasizes some of the challenges and trends associated with the future development of marine structures. Its main focus is on ways to improve the efficiency of energy-consuming ships, and on design challenges related to energy-producing offshore structures. This paper also discusses the analysis tools that are most needed to enable sustainable designs for future ships and offshore structures. The last section of the paper contains thoughts on the role of universities in education, research, and innovation regarding marine structures. It discusses curriculum requirements for maritime-technology education, basic research activities, and international cooperation.

Characteristics of karst groundwater system in the northern basin of Laiyuan Spring area

Guided by the theory of groundwater system, based on the groundwater level data from the northern basin of Laiyuan Spring area, the authors took into account factors such as the lithology, geological structure and topography to study the relationship between groundwater recharge, runoff and drainage in this area. It was concluded that the infiltration of atmospheric precipitation is the main source of groundwater supply in this area; the upper layer of the Spring area is distributed with the Cambrian-Lower Ordovician karst water, and the lower layer is filled with the Jixian system karst water. The upper layer of karst water supplies to the lower layer of karst water or the pore water in loose strata through the fault while the lower layer of karst water runs to the three strong runoff belts from the east and west sides of the watershed, southwards into the basin, partially replenishing the pore water in loose strata, or forming fault Springs(e.g. Nanguan Spring, Beihai Spring) when dolomite movement encounters faults. Replenished by atmospheric precipitation and the upper and lower layers of karst waters, the pore water in loose strata joins the groundwater in the southern basin and then flows eastwards, in the end it flows out of the system in Shangfanpu. Through the analyses of groundwater level data and hydrogeological drilling data, based on groundwater D and ^(18) O isotope test results, the karst groundwater circulation system in the northern basin of Laiyuan Spring area is further verified, which provides hydrogeological basis for water resources development and utilization as well as protection in this area.

Motivating in the Production-Oriented Approach:From Theory to Practice

Motivating is the most creative phase of the Production-Oriented Approach(POA),making it different from other teaching approaches from the outset.This study aims to introduce the theory of motivating and its application to College English teaching practice by adopting dialectal research(DR).First,it gives an overall introduction to motivating,including its function,steps,and categories.Then it demonstrates two rounds of motivating practice in teaching College English by using the POA-based textbook iEnglish.The first round of motivating practice mainly focuses on how to follow the three steps of motivating in a specific case,namely,the teacher providing scenarios,the students trying out the productive activity,and the teacher explaining the productive objectives.The second round attempts to apply the criteria of motivating effectiveness to practice,namely,authentic communication,cognitive challenges and appropriate productive objectives.Furthermore,the teaching effectiveness of the motivating practice is appraised by both the teacher’s and students’retrospective evaluations.Finally,some suggestions for motivating design and future research are proposed.

Three-Dimensional Numerical Investigation of the Separation Process in a Vortex Tube at Different Operating Conditions

Air separators provide safe, clean, and appropriate air flow to engines and are widely used in vehicles with large engines such as ships and submarines. In this operational study, the separation process in a Ranque-Hilsch vortex tube cleaning （cooling） system is investigated to analyze the impact of the operating gas type on the vortex tube performance; the operating gases used are air, nitrogen, oxygen, carbon dioxide and nitrogen dioxide. The computational fluid dynamic model used is equipped with a three-dimensional structure, and the steady-state condition is applied during computations. The standard k-c turbulence model is employed to resolve nonlinear flow equations, and various key parameters, such as hot and cold exhaust thermal drops, and power separation rates, are described numerically. The results show that nitrogen dioxide creates the greatest separation power out of all gases tested, and the numerical results are validated by good agreement with available experimental data. In addition, a comparison is made between the use of two different boundary conditions, the pressure-far-field and the pressure-outlet, when analyzing complex turbulent flows in the air separators. Results present a comprehensive and practical solution for use in future numerical studies.

Key Issues on Cryospheric Changes,Trends and Their Impacts

On the basis of analyzing the importance of cryospheric researches in China and current status of cryospheric sciences in the world, this paper addresses key issues and main contents of present cryospheric sciences in China. The key issues currently addressed are： i） mechanisms of different types of glaciers in response to climate change and the scale-conversion in water resources assessments; ii） modeling of water and heat exchanges between frozen soil and vegetation; iii） parameterization of physical processes in cryosphere as well as coupling with climate models. To gain full clarification of these key issues, works of the following three aspects should be highlighted, i.e., cryospheric processes and responses to climate change, influences of cryospheric changes, and adaptation strategies for cryospheric changes.

High level of ezrin expression in colorectal cancer tissues is closely related to tumor malignancy

AIM:To investigate the ezrin expression in normal colorectal mucosa and colorectal cancer tissues, and study the correlation between ezrin expression in colorectal cancer tissues and tumor invasion and metastasis.METHODS: Eighty paraffin-embedded cancer tissue samples were selected from primary colorectal adenocarcinoma. Twenty-eight patients had well-differentiated, 22 had moderately differentiated and 30 had poorly differentiated adenocarcinoma. Forty-five patients and 35 patients had lymph node metastasis. Forty-five patients were of Dukes A to B stage, and 35 were of C to D stage. Another 22 paraffi n-embedded tissue blocks of normal colorectal epithelium (>5 cm away from the edge of the tumor) were selected as the control group. All patients with colorectal cancer were treated surgically and diagnosed histologically, without preoperative chemotherapy or radiotherapy. The immunohistochemistry was used to detect the ezrin expression in paraffin-embedded normal colorectal mucosa tissues and colorectal cancer tissue samples.RESULTS: Ezrin expression in colorectal cancer was significantly higher than in normal colorectal mucosa (75.00% vs 9.09%, P<0.01), and there was a close relationship between ezrin expression and the degree of tumor differentiation, lymph node metastasis and Dukes stage (88.46% vs 50.00%, P<0.01; 94.28% vs 51.11%, P<0.01; 94.28% vs 51.11%, P<0.01).CONCLUSION: Ezrin expression is obviously higher in colorectal cancer tissues than in normal colorectal mucosa tissues, and the high level of ezrin expression is closely related to the colorectal cancer invasion and metastasis process.

Coupled Nonlinear Schrodinger Equation: Symmetries and Exact Solutions

The symmetries, symmetry reductions, and exact solutions of a coupled nonlinear Schrodinger （CNLS） equation derived from the governing system for atmospheric gravity waves are researched by means of classical Lie group approach in this paper. Calculation shows the CNLS equation is invariant under some Galilean transformations, scaling transformations, phase shifts, and space-time translations. Some ordinary differential equations are derived from the CNLS equation. Several exact solutions including envelope cnoidal waves, solitary waves and trigonometric function solutions for the CNLS equation are also obtained by making use of symmetries.