Aim To control the noise of two stroke engine Methods On the basis of noise identification,a new muffler and acoustic shield were designed,Results the car's pass-by noise below the national limit Conclusion throug...Aim To control the noise of two stroke engine Methods On the basis of noise identification,a new muffler and acoustic shield were designed,Results the car's pass-by noise below the national limit Conclusion through proper noise controlling measures,the pass-by noise of two stroke engines could be reduced under national permitting limit.展开更多
The phenomenon of debris flow is intermediate between mass movement and solid transport. Flows can be sudden, severe and destructive. Understanding debris flow erosion processes is the key to providing geomorphic expl...The phenomenon of debris flow is intermediate between mass movement and solid transport. Flows can be sudden, severe and destructive. Understanding debris flow erosion processes is the key to providing geomorphic explanations, but progress has been limited because the physical-mechanical properties, movement laws and erosion characteristics are different from those of sediment-laden flow. Using infinite slope theory, this research examines the process and mechanism of downcutting erosion over a moveable bed in a viscous debris flow gully. It focuses specifically on the scour depth and the critical slope for viscous debris flow,and formulas for both calculations are presented.Both scour depth and the critical conditions of downcutting erosion are related to debris flow properties(sand volume concentration and flow depth) and gully properties(longitudinal slope,viscous and internal friction angle of gully materials,and coefficient of kinetic friction). In addition, a series of flume experiments was carried out to characterize the scouring process of debris flows with different properties. The calculated values agreed well with the experimental data. These theoretical formulas are reasonable, and using infinite slope theory to analyze down cutting erosion from viscous debris flow is feasible.展开更多
Borehole leakage not only affects the gas drainage effect but also presents considerable risk to human security. For the research on the leakage mechanism of gas drainage borehole, the rheological and visco-elastic-pl...Borehole leakage not only affects the gas drainage effect but also presents considerable risk to human security. For the research on the leakage mechanism of gas drainage borehole, the rheological and visco-elastic-plastic characteristics were considered to establish the mechanical model of coal mass around borehole, which is used to analyze the leakage mechanism and deduce the dynamic leakage model. On the basis of the real coal seam conditions, the variation rules of the stress, leakage ring, and air leakage amount were analyzed through numerical simulation, and the influence factors of air leakage amount were also investigated to provide the theoretical basis for the sealing technology. Results show that the air leakage amount of borehole is inversely proportional to the increase in supporting stress and sealing length, and directly correlated with the increase in borehole radius and softening modulus. Using theoretical analysis, we design a novel active supporting sealing technology that can use grouting material to seal the fractures to reduce the leakage channels and also provide supporting stress to prevent borehole deformation. The engineering test results indicate that the average gas concentration with the novel active supporting sealing technology is increased by 162.12% than that of traditional polyurethane sealing method. Therefore, this technology not only effectively resolves borehole leakage but also significantly improves the gas drainage effect.展开更多
Hyperexcitability of neural network is a key neurophysiological mechanism in several neurological disorders including epilepsy, neuropathic pain, and tinnitus. Although standard paradigm of pharmacological management ...Hyperexcitability of neural network is a key neurophysiological mechanism in several neurological disorders including epilepsy, neuropathic pain, and tinnitus. Although standard paradigm of pharmacological management of them is to suppress this hyperexcitability, such as having been exemplified by the use of certain antiepileptic drugs, their frequent refractoriness to drug treatment suggests likely different pathophysiological mechanism. Because the pathogenesis in these disorders exhibits a transition from an initial activity loss after injury or sensory deprivation to subsequent hyperexcitability and paroxysmal discharges, this process can be regarded as a process of functional compensation similar to homeostatic plasticity regulation, in which a set level of activity in neural network is maintained after injury-induced activity loss through enhanced network excitability. Enhancing brain activity, such as cortical stimulation that is found to be effective in relieving symptoms of these disorders, may reduce such hyperexcitability through homeostatic plasticity mechanism. Here we review current evidence of homeostatic plasticity in the mechanism of acquired epilepsy, neuropathic pain, and tinnitus and the effects and mechanism of cortical stimulation. Establishing a role of homeostatic plasticity in these disorders may provide a theoretical basis on their pathogenesis as well as guide the development and application of therapeutic approaches through electrically or pharmacologically stimulating brain activity for treating these disorders.展开更多
MapReduce is a popular program- ming model for processing large-scale datasets in a distributed environment and is a funda- mental component of current cloud comput- ing and big data applications. In this paper, a hea...MapReduce is a popular program- ming model for processing large-scale datasets in a distributed environment and is a funda- mental component of current cloud comput- ing and big data applications. In this paper, a heartbeat mechanism for MapReduce Task Scheduler using Dynamic Calibration (HMTS- DC) is proposed to address the unbalanced node computation capacity problem in a het- erogeneous MapReduce environment. HMTS- DC uses two mechanisms to dynamically adapt and balance tasks assigned to each com- pute node: 1) using heartbeat to dynamically estimate the capacity of the compute nodes, and 2) using data locality of replicated data blocks to reduce data transfer between nodes. With the first mechanism, based on the heart- beats received during the early state of the job, the task scheduler can dynamically estimate the computational capacity of each node. Us- ing the second mechanism, unprocessed Tasks local to each compute node are reassigned and reserved to allow nodes with greater capacities to reserve more local tasks than their weaker counterparts. Experimental results show that HMTS-DC performs better than Hadoop and Dynamic Data Placement Strategy (DDP) in a dynamic environment. Furthermore, an en- hanced HMTS-DC (EHMTS-DC) is proposed bv incorporatin historical data. In contrastto the "slow start" property of HMTS-DC, EHMTS-DC relies on the historical computation capacity of the slave machines. The experimental results show that EHMTS-DC outperforms HMTS-DC in a dynamic environment.展开更多
Beacuse the practical mathematic model of rolling process can't be built accurately,this paper established an expert system to control the rolling steels' gauge by adjusting the setup roll open, which combined...Beacuse the practical mathematic model of rolling process can't be built accurately,this paper established an expert system to control the rolling steels' gauge by adjusting the setup roll open, which combined the experience of theoreticians and operators. The system applied the expression method of rule-skeleton+rule-body', and selected an appropriate non-exact reference model and self-study algorithm. The whole system, including auxiliary routes, is designed in Borland C++. Some experiments on this system have been done, and a good result has been achieved.展开更多
In a hybrid system, the subsystems with discrete dynamics play a central role in a hybrid system. In the course of engineering machinery of cluster construction, the discrete control law is hard to obtain because the ...In a hybrid system, the subsystems with discrete dynamics play a central role in a hybrid system. In the course of engineering machinery of cluster construction, the discrete control law is hard to obtain because the construction environment is complex and there exist many affecting factors. In this paper, hierarchically intelligent control, expert control and fuzzy control are introduced into the discrete subsystems of engineering machinery of cluster hybrid system, so as to rebuild the hybrid system and make the discrete control law easily and effectively obtained. The structures, reasoning mechanism and arithmetic of intelligent control are replanted to discrete dynamic, conti- nuous process and the interface of the hybrid system. The structures of three types of intelligent hybrid system are presented and the human experiences summarized from engineering machinery of cluster are taken into account.展开更多
The dynamic model of cold rolling mill based on strip flatness and thickness integrated control was proposed,containing the following sub-models:the rolling process model,the dynamic model of rolls along axial directi...The dynamic model of cold rolling mill based on strip flatness and thickness integrated control was proposed,containing the following sub-models:the rolling process model,the dynamic model of rolls along axial direction,and the compensation model.Based on the rule of volume flow rate,the dynamic rolling process model was built.The work roll and backup roll were taken as elastic continuous bodies,the effect of shear and moment of inertia were taken into consideration,and then the dynamic model of rolls was built.The two models were coupled together,and the dynamic model of rolling mill was built.In the dynamic model,the thermal expansion of the rolls,the wear of the rolls and other related parameters can not be considered.In order to compensate the dynamic model,the coupled static model of rolls and strip was applied.Then,according to the inner relationship of these models,the dynamic model and the compensation model were coupled,and the dynamic model of rolling mill based on the strip flatness and thickness integrated control was built.The dynamic simulation of the rolling process was made,and the dynamic thickness and the dynamic flatness information were obtained.This model not only provides a theory basis for the virtual rolling,but also provides a platform for the application of advanced control theory.展开更多
Somatic nuclei can be reprogrammed into a pluripotent state by nuclear transfer, cell fusion and expression of transcription factors. However, these reprogramming processes are very inefficient, which has greatly hind...Somatic nuclei can be reprogrammed into a pluripotent state by nuclear transfer, cell fusion and expression of transcription factors. However, these reprogramming processes are very inefficient, which has greatly hindered efforts to elucidate the underlying molecular mechanisms. Here, we report a new reprogramming strategy that combines the advantages of all three reprogramming methodologies into one process. We injected nuclei from cumulus cells into intact MII oocytes. Following activation, 80% of the reconstructed embryos developed to the blastocyst stage, and tetraploid (4N) embryonic stem (ES) cell lines were generated at a rate of 30% per reconstructed oocyte. We also generated triploid (3N) ES cells after injection of somatic nuclei into activated oocytes. 4N and 3N ES cells expressed pluripotent markers and differentiated into cell types of three embryonic germ layers in vivo. Moreover, all ES cells generated histocompatible, differentiated cells after being engrafted in immunocompetent B6D2F1 mice, showing that ES cells derived from this reprogramming strategy might serve as a source of genetically tailored tissues for transplantation. Thus, we have established a simple and highly efficient reprogramming procedure that provides a system for investigating the molecular mechanisms involved in somatic reprogramming.展开更多
A novel fault diagnosis method for sensors in air handling unit(AHU) using wavelet energy entropy was presented. Instead of directly comparing the numerous data under noise conditiom, the wavelet energy entropy resi...A novel fault diagnosis method for sensors in air handling unit(AHU) using wavelet energy entropy was presented. Instead of directly comparing the numerous data under noise conditiom, the wavelet energy entropy residual was compared in the proposed method. Three.level wavelet analysis was used to decompose the measurement data under both fault-free and faulty operation conditions. The concept of Shannon entropy was referred to define wavelet energy entropy of the wavelet coefficients. The sensor faults were diagnosed by comparing the deviation of the wavelet energy entropy of the measured signal and the estimated one with the preset threshold. Testing results showed that the wavelet energy entropy was sensitive to diagnose the biased faults. The wavelet energy entropy residuals exceed the threshold significantly when faults occur. In addition, the severer the faults were, the larger the residuals would be. The results prove that the proposed method is feasible and effective for the fault detection and diagnosis of the sensors.展开更多
The utilization of liquid–liquid extraction for the separation of 2-phenylbutyric acid(2-PBA) enantiomers was proposed. Factors affecting the extract process were investigated, including organic solvents, β-cyclod...The utilization of liquid–liquid extraction for the separation of 2-phenylbutyric acid(2-PBA) enantiomers was proposed. Factors affecting the extract process were investigated, including organic solvents, β-cyclodextrin derivatives, cyclodextrin concentration, p H and temperature. A model was proposed to describe the separation process based on the homogeneous phase reaction mechanism. Important parameters of this model were determined experimentally. The physical distribution coefficients for molecular and ionic 2-PBA were0.129 and 7.455, respectively. The equilibrium constants of the complexation reactions were 89.36 and36.78 L·mol^-1 for(+)-and(-)-2-PBA, respectively. The model was verified by experiments and proved to be an excellent means to optimize the separation system. Through modeling prediction and experiment, the best conditions(e.g., pH value of 3.00, extractant concentration of 0.1 mol·L^-1, temperature of 5.0 ℃) were acquired. Under this condition, the maximum enantioselectivity(2.096) was obtained.展开更多
The effect of composite agglomeration process(CAP) on fluoric iron concentrates sintering was investigated.The yield and quality of the sinter are greatly improved when using CAP assisted with heat airflow and enhanci...The effect of composite agglomeration process(CAP) on fluoric iron concentrates sintering was investigated.The yield and quality of the sinter are greatly improved when using CAP assisted with heat airflow and enhancing magnesium oxide(MgO) contents.For conventional sintering of fluoric iron concentrate,due to lower viscosity of binding phase and higher fluidity of liquid phase,the sinter is formed with large thin-walled holes and the strength of the sinter is deteriorated consequently.The novel process forms composite agglomerate in which acid pellets are embedded in basic sinter.The pellets are solid with interconnecting crystals of hematite(Fe2O3) and magnetic(Fe3O4).For basic sintering,after adding MgO,the viscosity of the melting phase increases and the fluidity decreases;and calcium and aluminum silico-ferrites and magnesium ferrite are formed with perfect crystals and good sintering microstructure.展开更多
Adhesions are the most frequent complication of abdominopelvic surgery,yet the extent of the problem,and its serious consequences,has not been adequately recognized.Adhesions evolved as a life-saving mecha-nism to lim...Adhesions are the most frequent complication of abdominopelvic surgery,yet the extent of the problem,and its serious consequences,has not been adequately recognized.Adhesions evolved as a life-saving mecha-nism to limit the spread of intraperitoneal inflammatory conditions.Three different pathophysiological mechanisms can independently trigger adhesion formation.Mesothelial cell injury and loss during operations,tissue hypoxia and inflammation each promotes adhesion formation separately,and potentiate the effect of each other.Studies have repeatedly demonstrated that interruption of a single pathway does not completely prevent adhesion formation.This review summarizes the pathogenesis of adhesion formation and the results of single gene therapy interventions.It explores the prom-ising role of combinatorial gene therapy and vector modif ications for the prevention of adhesion formation in order to stimulate new ideas and encourage rapid advancements in this field.展开更多
Protease treatments on wool have its inherent defect in shrink-proofing because protease will decompose wool through cell membrane complex (CMC). In order to solve this problem, mechanism of enzyme treatments on woo...Protease treatments on wool have its inherent defect in shrink-proofing because protease will decompose wool through cell membrane complex (CMC). In order to solve this problem, mechanism of enzyme treatments on wool was adequately analyzed and possible enzyme applications were discussed. The mechanism of enzyme treatment on wool was analyzed through weight loss, strength, scanning electron microscopy (SEM), electrophoresis, sodium dodecyl sulfate polyacrylamide gel electrophoresis ( SDS- PAGE), and amino acids composition. Based on the results, a possible novel multifunetional enzyme treatment on wool to achieve shrink-resistance was proposed. In order to shorten enzyme treatment time, the rate of proteolysis of wool was investigated. Considering the specificity of proteases, wool composition, and structure of dyes, a better enzyme pretreatment before dyeing to get better dyeabflity and lower dyeing temperature was discussed.展开更多
The most conventional vehicle pretensioner system consists of an internal gear pair with involute teeth. However, it has been well known that the corresponding gear pairs are relatively weak under the situation of imp...The most conventional vehicle pretensioner system consists of an internal gear pair with involute teeth. However, it has been well known that the corresponding gear pairs are relatively weak under the situation of impact loadings. To improve this phenomenon, a new pretensioning gear system with cycloid teeth rather than the involute ones was proposed, and dual cycloidal gear mechanisms were designed for satisfying geometric constraints and dynamic loading conditions. The simulations of the prototypes were conducted by LS-DYNA program and the experiments for a prototype were performed for a dynamic model with impact loading devices. The results show that the better operation and the smoother motion are confirmed in the proposed cycloidal gear system rather than the conventional one without interferences between gear teeth under the impact of a crash.展开更多
This paper describes the replacement of a controller for a programmable universal machine for assembly (PUMA) 512 robot with a newly designed PC based (open architecture) controller employing a real-time direct contro...This paper describes the replacement of a controller for a programmable universal machine for assembly (PUMA) 512 robot with a newly designed PC based (open architecture) controller employing a real-time direct control of six joints. The original structure of the PUMA robot is retained. The hardware of the new controller includes such in-house designed parts as pulse width modulation (PWM) amplifiers, digital and analog controllers, I/O cards, signal conditioner cards, and 16-bit A/D and D/A boards. An Intel Pentium IV industrial computer is used as the central controller. The control software is implemented using VC++ programming language. The trajectory tracking performance of all six joints is tested at varying velocities. Experimental results show that it is feasible to implement the suggested open architecture platform for PUMA 500 series robots through the software routines running on a PC. By assembling controller from off-the-shell hardware and software components, the benefits of reduced and improved robustness have been realized.展开更多
A rigid rods model for real-time simulation of cloth is presented, which can be used in e-commerce applications, games or Wirtual Reality environment. The proposed algorithm simplifies the basic mass-spring model by r...A rigid rods model for real-time simulation of cloth is presented, which can be used in e-commerce applications, games or Wirtual Reality environment. The proposed algorithm simplifies the basic mass-spring model by replacing the springs of masses with the rigid rods, and using the Verlet Integration method to calculate the position and velocity of the masses. Compared the efficiency and the effect of sinmulation with other similar systems, this algorithm is faster and realistic for some real-time applications.展开更多
Geologists can offer key insights in regard to several high profile environmental issues that are faced today. At the same time, like scientists in most other disciplines, many geologists are not naturally adept at co...Geologists can offer key insights in regard to several high profile environmental issues that are faced today. At the same time, like scientists in most other disciplines, many geologists are not naturally adept at communicating in an effective manner with non-geologists. This paper firstly identifies the more subtle facets of topical major issues (the drivers) where geologists can contribute important perspectives. Next, the detractions to effective communication are identified, along with the recommended means to overcome them (the mechanisms). Many topical issues are in fact geologically-underpinned (e.g. obviously, geohazards), so geologists ought to have something meaningful to say. By the same token, if geologists have difficulty communicating with other scientists, how can they possibly hope to communicate with journalists and with the public at large? Proper scientific contextualization is an ideal starting point, but this fundamental framing step does not always suit protagonists who have non-scientific agendas. Thus, geologists not only have to convey their science (geology) in an understandable way, but to do so in a truly effective manner must recognize and take into account possible predispositions that their audience may have.展开更多
文摘Aim To control the noise of two stroke engine Methods On the basis of noise identification,a new muffler and acoustic shield were designed,Results the car's pass-by noise below the national limit Conclusion through proper noise controlling measures,the pass-by noise of two stroke engines could be reduced under national permitting limit.
基金supported by the National Natural Science Foundation of China (Grant Nos.50979103 and 40901007)
文摘The phenomenon of debris flow is intermediate between mass movement and solid transport. Flows can be sudden, severe and destructive. Understanding debris flow erosion processes is the key to providing geomorphic explanations, but progress has been limited because the physical-mechanical properties, movement laws and erosion characteristics are different from those of sediment-laden flow. Using infinite slope theory, this research examines the process and mechanism of downcutting erosion over a moveable bed in a viscous debris flow gully. It focuses specifically on the scour depth and the critical slope for viscous debris flow,and formulas for both calculations are presented.Both scour depth and the critical conditions of downcutting erosion are related to debris flow properties(sand volume concentration and flow depth) and gully properties(longitudinal slope,viscous and internal friction angle of gully materials,and coefficient of kinetic friction). In addition, a series of flume experiments was carried out to characterize the scouring process of debris flows with different properties. The calculated values agreed well with the experimental data. These theoretical formulas are reasonable, and using infinite slope theory to analyze down cutting erosion from viscous debris flow is feasible.
基金supported by the National Natural Science Foundation of Youth Science Fund Project of China (No. 51604096)Funded by Hebei State Key Laboratory of Mine Disaster Prevention of China (No. KJZH2017K08)+1 种基金Funded by the Research Fund of State and Local Joint Engineering Laboratory for Gas Drainage & Ground Control of Deep Mines (Henan Polytechnic University) of China (No. G201609)He Nan Research Program of Application Foundation and Advanced Technology of China (No. 162300410031)
文摘Borehole leakage not only affects the gas drainage effect but also presents considerable risk to human security. For the research on the leakage mechanism of gas drainage borehole, the rheological and visco-elastic-plastic characteristics were considered to establish the mechanical model of coal mass around borehole, which is used to analyze the leakage mechanism and deduce the dynamic leakage model. On the basis of the real coal seam conditions, the variation rules of the stress, leakage ring, and air leakage amount were analyzed through numerical simulation, and the influence factors of air leakage amount were also investigated to provide the theoretical basis for the sealing technology. Results show that the air leakage amount of borehole is inversely proportional to the increase in supporting stress and sealing length, and directly correlated with the increase in borehole radius and softening modulus. Using theoretical analysis, we design a novel active supporting sealing technology that can use grouting material to seal the fractures to reduce the leakage channels and also provide supporting stress to prevent borehole deformation. The engineering test results indicate that the average gas concentration with the novel active supporting sealing technology is increased by 162.12% than that of traditional polyurethane sealing method. Therefore, this technology not only effectively resolves borehole leakage but also significantly improves the gas drainage effect.
基金supported in part by the NIH DA039530(to XJ)a grant from the CURE Epilepsy Foundation(to XJ)
文摘Hyperexcitability of neural network is a key neurophysiological mechanism in several neurological disorders including epilepsy, neuropathic pain, and tinnitus. Although standard paradigm of pharmacological management of them is to suppress this hyperexcitability, such as having been exemplified by the use of certain antiepileptic drugs, their frequent refractoriness to drug treatment suggests likely different pathophysiological mechanism. Because the pathogenesis in these disorders exhibits a transition from an initial activity loss after injury or sensory deprivation to subsequent hyperexcitability and paroxysmal discharges, this process can be regarded as a process of functional compensation similar to homeostatic plasticity regulation, in which a set level of activity in neural network is maintained after injury-induced activity loss through enhanced network excitability. Enhancing brain activity, such as cortical stimulation that is found to be effective in relieving symptoms of these disorders, may reduce such hyperexcitability through homeostatic plasticity mechanism. Here we review current evidence of homeostatic plasticity in the mechanism of acquired epilepsy, neuropathic pain, and tinnitus and the effects and mechanism of cortical stimulation. Establishing a role of homeostatic plasticity in these disorders may provide a theoretical basis on their pathogenesis as well as guide the development and application of therapeutic approaches through electrically or pharmacologically stimulating brain activity for treating these disorders.
文摘MapReduce is a popular program- ming model for processing large-scale datasets in a distributed environment and is a funda- mental component of current cloud comput- ing and big data applications. In this paper, a heartbeat mechanism for MapReduce Task Scheduler using Dynamic Calibration (HMTS- DC) is proposed to address the unbalanced node computation capacity problem in a het- erogeneous MapReduce environment. HMTS- DC uses two mechanisms to dynamically adapt and balance tasks assigned to each com- pute node: 1) using heartbeat to dynamically estimate the capacity of the compute nodes, and 2) using data locality of replicated data blocks to reduce data transfer between nodes. With the first mechanism, based on the heart- beats received during the early state of the job, the task scheduler can dynamically estimate the computational capacity of each node. Us- ing the second mechanism, unprocessed Tasks local to each compute node are reassigned and reserved to allow nodes with greater capacities to reserve more local tasks than their weaker counterparts. Experimental results show that HMTS-DC performs better than Hadoop and Dynamic Data Placement Strategy (DDP) in a dynamic environment. Furthermore, an en- hanced HMTS-DC (EHMTS-DC) is proposed bv incorporatin historical data. In contrastto the "slow start" property of HMTS-DC, EHMTS-DC relies on the historical computation capacity of the slave machines. The experimental results show that EHMTS-DC outperforms HMTS-DC in a dynamic environment.
文摘Beacuse the practical mathematic model of rolling process can't be built accurately,this paper established an expert system to control the rolling steels' gauge by adjusting the setup roll open, which combined the experience of theoreticians and operators. The system applied the expression method of rule-skeleton+rule-body', and selected an appropriate non-exact reference model and self-study algorithm. The whole system, including auxiliary routes, is designed in Borland C++. Some experiments on this system have been done, and a good result has been achieved.
文摘In a hybrid system, the subsystems with discrete dynamics play a central role in a hybrid system. In the course of engineering machinery of cluster construction, the discrete control law is hard to obtain because the construction environment is complex and there exist many affecting factors. In this paper, hierarchically intelligent control, expert control and fuzzy control are introduced into the discrete subsystems of engineering machinery of cluster hybrid system, so as to rebuild the hybrid system and make the discrete control law easily and effectively obtained. The structures, reasoning mechanism and arithmetic of intelligent control are replanted to discrete dynamic, conti- nuous process and the interface of the hybrid system. The structures of three types of intelligent hybrid system are presented and the human experiences summarized from engineering machinery of cluster are taken into account.
基金Project(E2012203177)supported by the Natural Science Foundation of Hebei Province,ChinaProject(2011BAF15B01)supported by the National Science and Technology Support Plan of China+1 种基金Project(E2006001038)supported by Great Natural Science Foundation of Hebei Province,ChinaProject(NECSR-201202)supported by Open Project Program of National Engineering Research Center for Equipment and Technology of Cold Strip Rolling,China
文摘The dynamic model of cold rolling mill based on strip flatness and thickness integrated control was proposed,containing the following sub-models:the rolling process model,the dynamic model of rolls along axial direction,and the compensation model.Based on the rule of volume flow rate,the dynamic rolling process model was built.The work roll and backup roll were taken as elastic continuous bodies,the effect of shear and moment of inertia were taken into consideration,and then the dynamic model of rolls was built.The two models were coupled together,and the dynamic model of rolling mill was built.In the dynamic model,the thermal expansion of the rolls,the wear of the rolls and other related parameters can not be considered.In order to compensate the dynamic model,the coupled static model of rolls and strip was applied.Then,according to the inner relationship of these models,the dynamic model and the compensation model were coupled,and the dynamic model of rolling mill based on the strip flatness and thickness integrated control was built.The dynamic simulation of the rolling process was made,and the dynamic thickness and the dynamic flatness information were obtained.This model not only provides a theory basis for the virtual rolling,but also provides a platform for the application of advanced control theory.
文摘Somatic nuclei can be reprogrammed into a pluripotent state by nuclear transfer, cell fusion and expression of transcription factors. However, these reprogramming processes are very inefficient, which has greatly hindered efforts to elucidate the underlying molecular mechanisms. Here, we report a new reprogramming strategy that combines the advantages of all three reprogramming methodologies into one process. We injected nuclei from cumulus cells into intact MII oocytes. Following activation, 80% of the reconstructed embryos developed to the blastocyst stage, and tetraploid (4N) embryonic stem (ES) cell lines were generated at a rate of 30% per reconstructed oocyte. We also generated triploid (3N) ES cells after injection of somatic nuclei into activated oocytes. 4N and 3N ES cells expressed pluripotent markers and differentiated into cell types of three embryonic germ layers in vivo. Moreover, all ES cells generated histocompatible, differentiated cells after being engrafted in immunocompetent B6D2F1 mice, showing that ES cells derived from this reprogramming strategy might serve as a source of genetically tailored tissues for transplantation. Thus, we have established a simple and highly efficient reprogramming procedure that provides a system for investigating the molecular mechanisms involved in somatic reprogramming.
基金National Natural Science Foundation of China(No.31101085)
文摘A novel fault diagnosis method for sensors in air handling unit(AHU) using wavelet energy entropy was presented. Instead of directly comparing the numerous data under noise conditiom, the wavelet energy entropy residual was compared in the proposed method. Three.level wavelet analysis was used to decompose the measurement data under both fault-free and faulty operation conditions. The concept of Shannon entropy was referred to define wavelet energy entropy of the wavelet coefficients. The sensor faults were diagnosed by comparing the deviation of the wavelet energy entropy of the measured signal and the estimated one with the preset threshold. Testing results showed that the wavelet energy entropy was sensitive to diagnose the biased faults. The wavelet energy entropy residuals exceed the threshold significantly when faults occur. In addition, the severer the faults were, the larger the residuals would be. The results prove that the proposed method is feasible and effective for the fault detection and diagnosis of the sensors.
基金Supported by the National Basic Research Program of China(2014CB260407)
文摘The utilization of liquid–liquid extraction for the separation of 2-phenylbutyric acid(2-PBA) enantiomers was proposed. Factors affecting the extract process were investigated, including organic solvents, β-cyclodextrin derivatives, cyclodextrin concentration, p H and temperature. A model was proposed to describe the separation process based on the homogeneous phase reaction mechanism. Important parameters of this model were determined experimentally. The physical distribution coefficients for molecular and ionic 2-PBA were0.129 and 7.455, respectively. The equilibrium constants of the complexation reactions were 89.36 and36.78 L·mol^-1 for(+)-and(-)-2-PBA, respectively. The model was verified by experiments and proved to be an excellent means to optimize the separation system. Through modeling prediction and experiment, the best conditions(e.g., pH value of 3.00, extractant concentration of 0.1 mol·L^-1, temperature of 5.0 ℃) were acquired. Under this condition, the maximum enantioselectivity(2.096) was obtained.
基金Project(50725416) supported by the National Science Fund for Distinguished Young Scholars
文摘The effect of composite agglomeration process(CAP) on fluoric iron concentrates sintering was investigated.The yield and quality of the sinter are greatly improved when using CAP assisted with heat airflow and enhancing magnesium oxide(MgO) contents.For conventional sintering of fluoric iron concentrate,due to lower viscosity of binding phase and higher fluidity of liquid phase,the sinter is formed with large thin-walled holes and the strength of the sinter is deteriorated consequently.The novel process forms composite agglomerate in which acid pellets are embedded in basic sinter.The pellets are solid with interconnecting crystals of hematite(Fe2O3) and magnetic(Fe3O4).For basic sintering,after adding MgO,the viscosity of the melting phase increases and the fluidity decreases;and calcium and aluminum silico-ferrites and magnesium ferrite are formed with perfect crystals and good sintering microstructure.
基金Supported by The United States-Egypt Science and Technology Joint Fund in cooperation with United States Department of Agriculturethe Egyptian Science and Technology Development Fund under Project 739
文摘Adhesions are the most frequent complication of abdominopelvic surgery,yet the extent of the problem,and its serious consequences,has not been adequately recognized.Adhesions evolved as a life-saving mecha-nism to limit the spread of intraperitoneal inflammatory conditions.Three different pathophysiological mechanisms can independently trigger adhesion formation.Mesothelial cell injury and loss during operations,tissue hypoxia and inflammation each promotes adhesion formation separately,and potentiate the effect of each other.Studies have repeatedly demonstrated that interruption of a single pathway does not completely prevent adhesion formation.This review summarizes the pathogenesis of adhesion formation and the results of single gene therapy interventions.It explores the prom-ising role of combinatorial gene therapy and vector modif ications for the prevention of adhesion formation in order to stimulate new ideas and encourage rapid advancements in this field.
基金National High-Tech R& D Program of China (No. 2002AA327010)
文摘Protease treatments on wool have its inherent defect in shrink-proofing because protease will decompose wool through cell membrane complex (CMC). In order to solve this problem, mechanism of enzyme treatments on wool was adequately analyzed and possible enzyme applications were discussed. The mechanism of enzyme treatment on wool was analyzed through weight loss, strength, scanning electron microscopy (SEM), electrophoresis, sodium dodecyl sulfate polyacrylamide gel electrophoresis ( SDS- PAGE), and amino acids composition. Based on the results, a possible novel multifunetional enzyme treatment on wool to achieve shrink-resistance was proposed. In order to shorten enzyme treatment time, the rate of proteolysis of wool was investigated. Considering the specificity of proteases, wool composition, and structure of dyes, a better enzyme pretreatment before dyeing to get better dyeabflity and lower dyeing temperature was discussed.
基金supported by the Changwon National University in 2011-2012,Korea
文摘The most conventional vehicle pretensioner system consists of an internal gear pair with involute teeth. However, it has been well known that the corresponding gear pairs are relatively weak under the situation of impact loadings. To improve this phenomenon, a new pretensioning gear system with cycloid teeth rather than the involute ones was proposed, and dual cycloidal gear mechanisms were designed for satisfying geometric constraints and dynamic loading conditions. The simulations of the prototypes were conducted by LS-DYNA program and the experiments for a prototype were performed for a dynamic model with impact loading devices. The results show that the better operation and the smoother motion are confirmed in the proposed cycloidal gear system rather than the conventional one without interferences between gear teeth under the impact of a crash.
文摘This paper describes the replacement of a controller for a programmable universal machine for assembly (PUMA) 512 robot with a newly designed PC based (open architecture) controller employing a real-time direct control of six joints. The original structure of the PUMA robot is retained. The hardware of the new controller includes such in-house designed parts as pulse width modulation (PWM) amplifiers, digital and analog controllers, I/O cards, signal conditioner cards, and 16-bit A/D and D/A boards. An Intel Pentium IV industrial computer is used as the central controller. The control software is implemented using VC++ programming language. The trajectory tracking performance of all six joints is tested at varying velocities. Experimental results show that it is feasible to implement the suggested open architecture platform for PUMA 500 series robots through the software routines running on a PC. By assembling controller from off-the-shell hardware and software components, the benefits of reduced and improved robustness have been realized.
基金Science Research Foundation of Beijing Municipal Education Commission(No.KM200310012049)
文摘A rigid rods model for real-time simulation of cloth is presented, which can be used in e-commerce applications, games or Wirtual Reality environment. The proposed algorithm simplifies the basic mass-spring model by replacing the springs of masses with the rigid rods, and using the Verlet Integration method to calculate the position and velocity of the masses. Compared the efficiency and the effect of sinmulation with other similar systems, this algorithm is faster and realistic for some real-time applications.
文摘Geologists can offer key insights in regard to several high profile environmental issues that are faced today. At the same time, like scientists in most other disciplines, many geologists are not naturally adept at communicating in an effective manner with non-geologists. This paper firstly identifies the more subtle facets of topical major issues (the drivers) where geologists can contribute important perspectives. Next, the detractions to effective communication are identified, along with the recommended means to overcome them (the mechanisms). Many topical issues are in fact geologically-underpinned (e.g. obviously, geohazards), so geologists ought to have something meaningful to say. By the same token, if geologists have difficulty communicating with other scientists, how can they possibly hope to communicate with journalists and with the public at large? Proper scientific contextualization is an ideal starting point, but this fundamental framing step does not always suit protagonists who have non-scientific agendas. Thus, geologists not only have to convey their science (geology) in an understandable way, but to do so in a truly effective manner must recognize and take into account possible predispositions that their audience may have.