从《医法心传》中浅析程鉴治疫特色

《医法心传》是清代嘉道年间新安医家程鉴的代表作之一,程鉴集唐宋各家之所长,融会贯通于一身,对疫病多有见解。现从气血、时行、虚实寒热三方面进行梳理,总结程氏治疫特色为:以气血为基,辨疫之异;以时行为常,重视时病;以虚实寒热为纲,详议虚损及痢疾、痘症证治,以备后学参考并发挥其对疫病治疗指导意义。

新安医家程鉴生平考及其学术成就探析

程鉴为清嘉庆至同治年间徽州府歙县(今安徽省黄山市歙县)人,生卒年月不详,嘉庆年间秀才,为名医程正通后人,幼承家传医术,后于浙江衢州行医,传道雷逸仙,逸仙之子少逸得父传,为程氏再传弟子,少逸之子雷大震与歙县程曦、三衢江诚等人,皆受业于少逸。程鉴精悉历代医籍融会贯通,学术造诣颇深,撰有《医法心传》1卷、《医约》4卷流传于世。学术上,程鉴不仅推崇张仲景之学,对伤寒、温病见解颇深且尊古不泥,创新五行之说。临证中,一方面程鉴辨治诸疾、审察病机,药稽本草、验之有得,用药独到每获良效,并以临床实际力证其对伤寒、温疫、痢疾、痘科及损伤等病证的独到见解;另一方面程鉴集前人之所学,探本溯源,揭示张仲景伤寒杂病合论之旨,即张仲景伤寒方论本可统治杂病。

向审稿人致谢

在广大读者特别是审稿人的支持下,本刊2015年的出版工作顺利完成,并取得了较好成绩。在此公布2015年本刊审稿人的名单,向审稿人表达诚挚的尊敬和衷心的感谢!(1)本统计结果为审稿完成时间2014年12月16日—2015年12月15日;(2)本排名不分先后,但相同姓氏审者分列不同行列时,则前者群体审稿频次多于后者。

Quality prediction of batch process using the global-local discriminant analysis based Gaussian process regression model

The conventional single model strategy may be ill- suited due to the multiplicity of operation phases and system uncertainty. A novel global-local discriminant analysis （GLDA） based Gaussian process regression （GPR） approach is developed for the quality prediction of nonlinear and multiphase batch processes. After the collected data is preprocessed through batchwise unfolding, the hidden Markov model （HMM） is applied to identify different operation phases. A GLDA algorithm is also presented to extract the appropriate process variables highly correlated with the quality variables, decreasing the complexity of modeling. Besides, the multiple local GPR models are built in the reduced- dimensional space for all the identified operation phases. Furthermore, the HMM-based state estimation is used to classify each measurement sample of a test batch into a corresponding phase with the maximal likelihood estimation. Therefore, the local GPR model with respect to specific phase is selected for online prediction. The effectiveness of the proposed prediction approach is demonstrated through the multiphase penicillin fermentation process. The comparison results show that the proposed GLDA-GPR approach is superior to the regular GPR model and the GPR based on HMM （HMM-GPR） model.

Species-specific SCAR markers for authentication of Sinocalycanthus chinensis

Sinocalycanthus chmensis, an endangered species endemic to China, is cultivated as an omamental landscape tree in China. However, S. chinensis, Chimonanthus species and Calycanthusfloridus are difficult to be distinguished in seedling market because of their similar morphological characters. In this study, ISSR （inter-simple sequence repeats） were applied to detect S. chinensis from its closely related species. A unique 748-bp band was found in all accessions of S. chinensis. SCAR （sequence characterized amplified regions） markers were created by cloning and sequencing the specific band, and designing a pair of primers to amplify the band of 748 bp. Diagnostic PCRs were performed using the primer pair with the total DNAs ofS. chinensis, Chimonanthus species and C. floridus as templates, with only S. chinensis being able to be amplified. This amplification is not only rapid （results can be obtained in less than 3 h）, but is also easy to perform. Hence it is a feasible method for identifying S. chmensis in seedling market.

Consequence Identification for Maloperation in Batch Process

Batch processes are important in chemical industry,in which operators usually play a major role and hazards may arise by their inadvertent acts.In this paper,based on hazard and operability study and concept of qualitative simulation,an automatic method for adverse consequence identification for potential maloperation is proposed.The qualitative model for production process is expressed by a novel directed graph.Possible operation deviations from normal operating procedure are identified systematically by using a group of guidewords.The proposed algorithm is used for qualitative simulation of batch processes to identify the effects of maloperations.The method is illustrated with a simple batch process and a batch reaction process.The results show that batch processes can be simulated qualitatively and hazards can be identified for operating procedures including maloperations.After analysis for possible plant maloperations,some measures can be taken to avoid maloperations or reduce losses resulted from maloperations.

New Exact Traveling Wave Solutions for Compound KdV-Type Equation with Nonlinear Terms of Any Order

The compound KdV-type equation with nonlinear terms of any order is reduced to the integral form. Using the complete discrimination system for polynomial, its all possible exact traveling wave solutions are obtained. Among those, a lot of solutions are new.

Rapid Identification for Drought Resistance of Wheat Using Near-infrared Diffuse Reflectance Spectroscopy

[Objective] This study aimed to establish an identification system for drought-resistance in wheat by using near-infrared diffuse reflectance spectroscopy. [Method] In 2006-2007, 36 wheat varieties with different drought resistance were selected and were classified according to their drought resistance grades determined by the Technical Specification of Identification and Evaluation for Drought Resistance in Wheat （GB/T 21127-2007）. In addition, the harvested wheat seed samples were spectrally analyzed with FOSS NIRSystems5000 near-infrared spectrum analyzer for grain quality （full spectrum analyzer） and then the forecasted regression equations were established. [Result] After the establishment of a database and validation, dis- criminated functions were obtained. The determination coefficient （RSQ） and coeffi- cients of determination for cross validation （1-VR） in the discriminant function built with seed samples from water stress area were 0.846 0 and 0.781 8, respectively, which indicated that the consistency between drought resistance and spectral charac- teristics in wheat varieties was good, and there was high correlation between the near-infrared diffuse reflectance spectra of seeds and the drought resistance in wheat. [Conclusiou] Under water stress condition, it is feasible to establish a conve- nient, rapid and no-damage identification system for the drought resistance in wheat by using the near-infrared diffuse reflectance spectrum technique to scan wheat seeds.

Two Modifications on IKE Protocol with Pre-shared Key Authentication

This paper proposed two modifications on IKE protocol with pre-shared key authentication. The first modification can improve its immunity against DDoS attack by authenticating the initiator before the responder generates the computation-intensive Diffie-Hellman public value. The second modification can improve its efficiency when the attack on messages occurs because it can detect the attack quickly by replacing the centralized authentication in origical IKE protocol with immediate authentication. In addition, the two modifications can be integrated into one protocol compactly.

Identification of Differentially Expressed Genes in Grape Skin at Veraison and Maturity and Construction of Co-expression Network

The ripening process of grape is an important stage during grape growth and development. During this process, color of grape skin is the most obvious change. The molecular mechanism for the ripening of grape(a non-climacteric fruit, which ripens without ethylene and respiration bursts) is still unclear. Although numerous studies have been done on the changes in the contents of metabolites during grape ripening, the differentially expressed genes at veraison and maturity stages have not been systematically analyzed. In this study, 1 524 genes that are significantly differentially expressed in grape(Pinot Noir) skin at veraison and maturity stages were identified, and a co-expression network of these genes was built. Some of the eight co-expression modules we identified may be closely related to the synthesis or metabolism of anthocyanins, sugar acids, and other flavor substances. The transcription factor families WRKY, b ZIP, HSF and WOX may play an important role in the regulation of anthocyanin synthesis or metabolism. The results provide a foundation for further study of the molecular mechanism of grape ripening.

An Integrated Approach to Oscillation Propagation Identification and Source Locating in Process Multi-loop Systems

An integrated method for identifying the propagation of multi-loop process oscillations and their source location is proposed in this paper. Oscillatory process loop variables are automatically selected based on the component-related ratio index and a mixing matrix, both of which are obtained in data preprocessing by spectral independent component analysis. The complex causality among oscillatory process variables is then revealed by Granger causality test and is visualized in the form of causality diagram. The simplification of causal connectivity in the diagram is performed according to the understanding of process knowledge and the final simplest causality diagram, which represents the main oscillation propagation paths, is achieved by the automated cutting-off thresh-old search, with which less significant causality pathways are filtered out. The source of the oscillation disturbance can be identified intuitively through the final causality diagram. Both simulated and real plant data tests are presented to demonstrate the effectiveness and feasibility of the proposed method.

Hazard degree identification of goafs based on scale effect of structure by RS-TOPSIS method

In order to precisely predict the hazard degree of goaf(HDG), the RS-TOPSIS model was built based on the results of expert investigation. To evaluate the HDG in the underground mine, five structure size factors, i.e. goaf span, exposed area, goaf height, goaf depth, and pillar width, were selected as the evaluation indexes. And based on rough dependability in rough set(RS)theory, the weights of evaluation indexes were identified by calculating rough dependability between evaluation indexes and evaluation results. Fourty goafs in some mines of western China, whose indexes parameters were measured by cavity monitoring system(CMS), were taken as evaluation objects. In addition, the characteristic parameters of five grades' typical goafs were built according to the interval limits value of single index evaluation. Then, using the technique for order preference by similarity to ideal solution(TOPSIS), five-category classification of HDG was realized based on closeness degree, and the HDG was also identified.Results show that the five-category identification of mine goafs could be realized by RS-TOPSIS method, based on the structure-scale-effect. The classification results are consistent with those of numerical simulation based on stress and displacement,while the coincidence rate is up to 92.5%. Furthermore, the results are more conservative to safety evaluation than numerical simulation, thus demonstrating that the proposed method is more easier, reasonable and more definite for HDG identification.

Biosynthesis of Polyhydroxyalkanoate （PHA） by Hydrogenophaga sp. Isolated from Soil Environment during Batch Fermentation

In this work, sucrose utilizing microbes from soil were screened to evaluate their ability for accumulation of biopolymer of polyhydroxyalkanoate （PHA）. Among 72 isolates were transferred to mineral salt medium （MSM）, 33 strains can be grown on sucrose agar medium. However, only one strain showed a strong black color for Sudan Black and gave positive result for Nile blue A. Identification by 16S rDNA nucleotide sequence homology of the isolate showed very closely to Hydrogenophaga sp. （99% identify）. To consider PHA production, the isolate was grown in the medium containing sucrose as a sole carbon under controlled conditions of 35 ℃ and at pH 7. Maximum dry cell weight （DCW） and PHA production were obtained at 3.61 g/L and 2.41 g/L after 36 and 42 h batch fermentation. Sucrose uptake measured in term of total organic carbon （TOC） showed at 14.73 g within 48 h. The highest PHA was 68.15% （gPHA/gDCW） giving maximum PHA yield （YP/s） of 0.17 （gPHA/gs ） and a productivity of 0.057 gPHA/L.h. This highlights the potential of microbial resources in soil environment and may be an exploitable application for the industrial production of PHA.

The Development of Forensic Process Model for Criminal Investigation in Three Southern Border Provinces of Thailand

The purpose of this research is to study the process of forensic science execution in order to use crime investigation in three southern border provinces of Thailand, such as the study of problems and obstacles including the factors that affect forensic examination to use criminal investigation in three southern border provinces, offer the guidance in pattern development of forensic sciences examination in three southern border provinces with standard, and are able to use in criminal investigation effectively. Data were collected from all related agencies. The results of this research have showed that executive process of forensic science is used to investigate the crime in three southern border provinces that can be divided the operations into three main issues as following： crime scene examination, evidence testing, autopsy in case of crime scene, and factors which affect forensic work for using in criminal investigation in three southern border provinces of police practitioners. They should have the knowledge about forensic science, commitment, bravery, and cunning work.

Human bone morphogenetic protein-2 gene transfer induces human mesenchymal stem cell proliferation and differentiation in vitro

Objective: To identify eukaryotic expression vector of human bone morphogenetic protein 2 pcDNA3/BMP2, verify its expression in transfected human mesenchymal stem cells (hMSCs) and the effect on hMSCs differentiation. Methods: The BMP2 gene was cloned into a eukaryotic expression vector pcDNA3. Transfected the recombinant into hMSCs by liposome. Immunnohistochemistry and in situ hybridization methods were used to identify the expression of BMP2 mRNA and protein; ALP and Von Kossa stains were performed to identify the BMP2 gene differentiated effect on the hMSCs. Results: The pcDNA3/BMP2 fragments were as large as theory. BMP2 mRNA and protein were expressed and synthesized both in 48 h and 4 weeks after transfection, the ALP and Ca deposit exhibition, which marked the osteogenic lineage of hMSCs, were enhanced and sped. Conclusion: Transfection of pcDNA3/BMP2 is able to provide transient and persistent expression in hMSCs, and promote the MSCs differentiation to osteogenic lineage.

Identification of Sustainability Indicators and Evaluation of Transportation Corridors during Construction Using Fuzzy VIKOR Method

Sustainability is popularly defined as meeting the needs of the present generation without compromising the ability of future generations to meet their own needs. Social, economic and environmental parameters are most commonly accepted as the three pillars of sustainability. In this paper, various sustainability indicators have been identified during the construction stage for elevated transportation corridors and thereafter classified under various categories. Using fuzzy VIKOR technique, sustainability evaluation of transportation corridors is made on two selected project sites of two different government organizations using various identified sustainability indicators, i.e., a 3.2-km long elevated road project under construction from Vikaspuri to Meerabagh in West Delhi by PWD （Public Works Department） and the metro rail elevated corridor （part） from Punjabi Bagh to Mayapuri as a part of Phase 3, Line 7 by DMRC （Delhi Metro Rail Corporation）. The study is made at both sites in the midst of the construction period and it is identified that during the construction stage, the sustainability of these transportation corridors is just not limited to three pillars, but in actuality, it is much beyond that. From the study, it is inferred that the metro rail elevated corridor is a more sustainable corridor, in the context of the identified sustainability indicators.

進一步做好東北區一九五四年的勞動工作

一 東北地區一九五三年的勞動工作,在黨的總路線、總任務的照耀下,在各級黨委、政府直接领导下,經過各企業行政領導和各級勞動幹部與全體職工的積極努力,基本上完成國家在第一個五年計劃第一个年度計劃中生產和基本建设上有關勞動方面的任務。如: 在勞動力調配方面:一年來,全區共約調配了四十五萬人次,其中百分之八十五以上是調給了國防和重工業部門,正確地貫徹了黨和政府以國防建設和重工業建设为重點的方針;基本上保证了國家基本建設和生產廠矿所需要的勞動力,並在此基礎上,開始實行了有計劃的供應。在調配工作上,由於實行了勞動力平衡計划與統一調配制度,加强了勞動資源的統計工作,部分省市對大工地派遣了勞動力調配駐在員,採用了‘集體辦公’制度等措施,因而逐漸地提高了調配工作的計劃性與準確性,減少了窩工、私自招工、挖工和勞動力盲目流動現象。

古代书法的题跋与我的手卷创作

手卷是一种出现较早的书画作品形式。传统的手卷宽度在一尺左右,长度六尺左右。过宽过长则称之为高头长卷。手卷一般包括主题、题跋、诗塘、隔水等。一幅手卷经过流传,通过不同人的鉴赏题跋逐渐会加长丰富起来,成为研究历史、风俗、书画的主要资料。近三十年来,书法活动如火如茶,书法展赛接踵而来。

上海女知青朱美华失踪案

我像从梦中醒来一般。揉揉眼已近不惑之年,青少年时代那些许多生活的画面,差不多都让岁月的流水从心底洗去,惟有三十年前二团七营三连那桩上海女知青失踪案,却象铆钉一样牢牢地钉在我的心扉上。 1974年4月2日晚是原云南生产建设兵团一师二团七营三连上海女知青朱美华失踪的日子。朱美华失踪案在当时成了二团的头号新闻,因为她的失踪惊动了国务院知识青年上山下乡办公室。云南省革委。

Optimal programmable unambiguous discriminator between two unknown latitudinal states

Two unknown states can be unambiguously distinguished by a universal programmable discriminator, which has been widely discussed in previous works and the optimal solution has also been obtained. In this paper, we investigate the programmable unambiguous discriminator between two unknown "latitudinal" states, which lie in a subspace of the total state space. By equivalence of unknown pure states to known average mixed states, the optimal solution for this problem is systematically derived, and the analytical success probabilities for the optimal unambiguous discrimination are obtained. It is beyond one's expectation that the optimal setting for the programmable unambiguous discrimination between two unknown "latitudinal" states is the same as that for the universal ones. The results in this work can be used for the realization of the programmable discriminator in laboratory.