Sirtuins(SIRTs) are nicotinamide adenine dinucleotide(NAD^+)-dependent protein deacetylases,which regulate important biological processes ranging from apoptosis,age-associated pathophysiologies,adipocyte and muscle di...Sirtuins(SIRTs) are nicotinamide adenine dinucleotide(NAD^+)-dependent protein deacetylases,which regulate important biological processes ranging from apoptosis,age-associated pathophysiologies,adipocyte and muscle differentiation,and energy expenditure to gluconeogenesis.Very recently,sirtuin 5(SIRT5) has received considerable attention due to that it was found to have weak deacetylase activity but strong desuccinylase,demalonylase and deglutarylase activities,and it was also found to be associated with several human diseases such as cancer,Alzheimer's disease,and Parkinson's disease.In this review,we for the first time summarized the structure characteristics,known peptide and small-molecule inhibitors of SIRT5,extracted some clues from current available information and introduced some feasible,practical in silico methods,which might be useful in further efforts to develop new SIRT5 inhibitors.展开更多
In this paper, the famous Amann three-solution theorem is generalized. Multiplicity question of fixed points for nonlinear operators via two coupled parallel sub-super solutions is studied. Under suitable conditions, ...In this paper, the famous Amann three-solution theorem is generalized. Multiplicity question of fixed points for nonlinear operators via two coupled parallel sub-super solutions is studied. Under suitable conditions, the existence of at least six distinct fixed points of nonlinear operators is proved. The theoretical results are then applied to nonlinear system of Hammerstein integral equations.展开更多
We consider the estimation of three-dimensional ROC surfaces for continuous tests given covariates.Three way ROC analysis is important in our motivating example where patients with Alzheimer's disease are usually ...We consider the estimation of three-dimensional ROC surfaces for continuous tests given covariates.Three way ROC analysis is important in our motivating example where patients with Alzheimer's disease are usually classified into three categories and should receive different category-specific medical treatment.There has been no discussion on how covariates affect the three way ROC analysis.We propose a regression framework induced from the relationship between test results and covariates.We consider several practical cases and the corresponding inference procedures.Simulations are conducted to validate our methodology.The application on the motivating example illustrates clearly the age and sex effects on the accuracy for Mini-Mental State Examination of Alzheimer's disease.展开更多
基金supported by the Chun hui of Ministry of Education Project(Z2015120)the National Natural Science Foundation of China(81502989)the China Postdoctoral Science Foundation Funded Project(2015M570789)
文摘Sirtuins(SIRTs) are nicotinamide adenine dinucleotide(NAD^+)-dependent protein deacetylases,which regulate important biological processes ranging from apoptosis,age-associated pathophysiologies,adipocyte and muscle differentiation,and energy expenditure to gluconeogenesis.Very recently,sirtuin 5(SIRT5) has received considerable attention due to that it was found to have weak deacetylase activity but strong desuccinylase,demalonylase and deglutarylase activities,and it was also found to be associated with several human diseases such as cancer,Alzheimer's disease,and Parkinson's disease.In this review,we for the first time summarized the structure characteristics,known peptide and small-molecule inhibitors of SIRT5,extracted some clues from current available information and introduced some feasible,practical in silico methods,which might be useful in further efforts to develop new SIRT5 inhibitors.
基金This research is supported by NSFC (10071042)NSFSP (Z2000A02).
文摘In this paper, the famous Amann three-solution theorem is generalized. Multiplicity question of fixed points for nonlinear operators via two coupled parallel sub-super solutions is studied. Under suitable conditions, the existence of at least six distinct fixed points of nonlinear operators is proved. The theoretical results are then applied to nonlinear system of Hammerstein integral equations.
基金support provided by the National Alzheimer's Coordinating Center(NACC)supported by National University of Singapore Academic Research Funding(Grant No.R-155-000-109-112)+2 种基金a CBRG grant from the National Medical Research Council in Singapore,NACC(Grant No.U01AG16976)the National Institute of Health(Grant No.R01EB005829)National Natural Science Foundation of China(Grant No.30728019)
文摘We consider the estimation of three-dimensional ROC surfaces for continuous tests given covariates.Three way ROC analysis is important in our motivating example where patients with Alzheimer's disease are usually classified into three categories and should receive different category-specific medical treatment.There has been no discussion on how covariates affect the three way ROC analysis.We propose a regression framework induced from the relationship between test results and covariates.We consider several practical cases and the corresponding inference procedures.Simulations are conducted to validate our methodology.The application on the motivating example illustrates clearly the age and sex effects on the accuracy for Mini-Mental State Examination of Alzheimer's disease.
