Aim To study the most stable pH value of endomorphin-1 solution and toestimate the shelf-life of EM-1 solution. Methods The content of EM-1 in its solution was determinedby HPLC, and stability was studied by accelerat...Aim To study the most stable pH value of endomorphin-1 solution and toestimate the shelf-life of EM-1 solution. Methods The content of EM-1 in its solution was determinedby HPLC, and stability was studied by accelerated tests. Results The most stable pH value of EM-1solution was observed. By the accelerated tests we obtained the Arrhe-nius relationship and thepharmacokinetic parameters. Conclusion The most stable pH value of EM-1 solution is 4.5 -4.8. Thet_(1/2)(25℃) is 45 d.展开更多
In acoustic logging-while-drilling (ALWD) finite difference in time domain (FDTD) simulations, large drill collar occupies, most of the fluid-filled borehole and divides the borehole fluid into two thin fluid colu...In acoustic logging-while-drilling (ALWD) finite difference in time domain (FDTD) simulations, large drill collar occupies, most of the fluid-filled borehole and divides the borehole fluid into two thin fluid columns (radius -27 mm). Fine grids and large computational models are required to model the thin fluid region between the tool and the formation. As a result, small time step and more iterations are needed, which increases the cumulative numerical error. Furthermore, due to high impedance contrast between the drill collar and fluid in the borehole (the difference is 〉30 times), the stability and efficiency of the perfectly matched layer (PML) scheme is critical to simulate complicated wave modes accurately. In this paper, we compared four different PML implementations in a staggered grid finite difference in time domain (FDTD) in the ALWD simulation, including field-splitting PML (SPML), multiaxial PML(M- PML), non-splitting PML (NPML), and complex frequency-shifted PML (CFS-PML). The comparison indicated that NPML and CFS-PML can absorb the guided wave reflection from the computational boundaries more efficiently than SPML and M-PML. For large simulation time, SPML, M-PML, and NPML are numerically unstable. However, the stability of M-PML can be improved further to some extent. Based on the analysis, we proposed that the CFS-PML method is used in FDTD to eliminate the numerical instability and to improve the efficiency of absorption in the PML layers for LWD modeling. The optimal values of CFS-PML parameters in the LWD simulation were investigated based on thousands of 3D simulations. For typical LWD cases, the best maximum value of the quadratic damping profile was obtained using one do. The optimal parameter space for the maximum value of the linear frequency-shifted factor (a0) and the scaling factor (β0) depended on the thickness of the PML layer. For typical formations, if the PML thickness is 10 grid points, the global error can be reduced to 〈1% using the optimal PML parameters, and the error will decrease as the PML thickness increases.展开更多
This paper discusses the stability of theoretical solutions for nonlinear multi-variable delay perturbation problems (MVDPP) of the form x′(t)=f(x(t),x(t-τ 1(t)),...,x(t-τ m(t)),y(t),y(t-τ 1(t)),...,y(t-τ m(t...This paper discusses the stability of theoretical solutions for nonlinear multi-variable delay perturbation problems (MVDPP) of the form x′(t)=f(x(t),x(t-τ 1(t)),...,x(t-τ m(t)),y(t),y(t-τ 1(t)),...,y(t-τ m(t))), and εy′(t)=g(x(t),x(t-τ 1(t)),...,x(t-τ m(t)),y(t),y(t-τ 1(t)),...,y(t-τ m(t))), where 0<ε1. A sufficient condition of stability for the systems is obtained. Additionally we prove the numerical solutions of the implicit Euler method are stable under this condition.展开更多
Dynamic analysis steps and general flow of fast lagrangian analysis of continua in 3 dimensions(FLAC3D) were discussed. Numerical simulation for influence of excavation and blasting vibration on stability of mined-out...Dynamic analysis steps and general flow of fast lagrangian analysis of continua in 3 dimensions(FLAC3D) were discussed. Numerical simulation for influence of excavation and blasting vibration on stability of mined-out area was carried out with FLAC3D. The whole analytical process was divided into two steps, including the static analysis and the dynamic analysis which were used to simulate the influence of excavation process and blasting vibration respectively. The results show that the shape of right upper boundary is extremely irregular after excavation, and stress concentration occurs at many places and higher tensile stress appears. The maximum tensile stress is higher than the tensile strength of rock mass, and surrounding rock of right roof will be damaged with tension fracture. The maximum displacement of surrounding rock is 4.75 mm after excavation. However, the maximum displacement increases to 5.47 mm after the blasting dynamic load is applied. And the covering area of plastic zones expands obviously, especially at the foot of right upper slope. The analytical results are in basic accordance with the observed results on the whole. Damage and disturbance on surrounding rock to some degree are caused by excavation, while blasting dynamic load increases the possibility of occurrence of dynamic instability and destruction further. So the effective supporting and vibration reducing measures should be taken during mining.展开更多
In actual production,deep coal mine roadways are often under typical static-dynamic coupling stress(SDCS)conditions with high ground stress and strong dynamic disturbances.With the increasing number of disasters and a...In actual production,deep coal mine roadways are often under typical static-dynamic coupling stress(SDCS)conditions with high ground stress and strong dynamic disturbances.With the increasing number of disasters and accidents induced by SDCS conditions,the safe and efficient production of coal mines is seriously threatened.Therefore,it is of great practical significance to study the deformation and failure characteristics of the roadway surrounding rock under SDCS.In this paper,the effects of different in-situ stress fields and dynamic load conditions on the surrounding rock are studied by numerical simulations,and the deformation and failure characteristics are obtained.According to the simulation results,the horizontal stress,vertical stress and dynamic disturbance have a positive correlation with the plastic failure of the surrounding rock.Among these factors,the influence of the dynamic disturbance is the most substantial.Under the same stress conditions,the extents of deformation and plastic failure of the roof and ribs are always greater than those of the floor.The effect of horizontal stresses on the roadway deformation is more notable than that of vertical stresses.The results indicate that for the roadway under high-stress conditions,the in-situ stress test must be strengthened first.After determining the magnitude of the in-situ stress,the location of the roadway should be reasonably arranged in the design to optimize the mining sequence.For roadways that are strongly disturbed by dynamic loads,rock supports(rebar/cable bolts,steel set etc.)that are capable of maintaining their effectiveness without failure after certain dynamic loads are required.The results of this study contribute to understanding the characteristics of the roadway deformation and failure under SDCS,and can be used to provide a basis for the support design and optimization under similar geological and geotechnical circumstances.展开更多
文摘Aim To study the most stable pH value of endomorphin-1 solution and toestimate the shelf-life of EM-1 solution. Methods The content of EM-1 in its solution was determinedby HPLC, and stability was studied by accelerated tests. Results The most stable pH value of EM-1solution was observed. By the accelerated tests we obtained the Arrhe-nius relationship and thepharmacokinetic parameters. Conclusion The most stable pH value of EM-1 solution is 4.5 -4.8. Thet_(1/2)(25℃) is 45 d.
基金supported by NSFC(No.41174118)one of the major state S&T special projects(No.2008ZX05020-004)+1 种基金a Postdoctoral Fellowship of China(No.2013M530106)China Scholarship Council(No.2010644006)
文摘In acoustic logging-while-drilling (ALWD) finite difference in time domain (FDTD) simulations, large drill collar occupies, most of the fluid-filled borehole and divides the borehole fluid into two thin fluid columns (radius -27 mm). Fine grids and large computational models are required to model the thin fluid region between the tool and the formation. As a result, small time step and more iterations are needed, which increases the cumulative numerical error. Furthermore, due to high impedance contrast between the drill collar and fluid in the borehole (the difference is 〉30 times), the stability and efficiency of the perfectly matched layer (PML) scheme is critical to simulate complicated wave modes accurately. In this paper, we compared four different PML implementations in a staggered grid finite difference in time domain (FDTD) in the ALWD simulation, including field-splitting PML (SPML), multiaxial PML(M- PML), non-splitting PML (NPML), and complex frequency-shifted PML (CFS-PML). The comparison indicated that NPML and CFS-PML can absorb the guided wave reflection from the computational boundaries more efficiently than SPML and M-PML. For large simulation time, SPML, M-PML, and NPML are numerically unstable. However, the stability of M-PML can be improved further to some extent. Based on the analysis, we proposed that the CFS-PML method is used in FDTD to eliminate the numerical instability and to improve the efficiency of absorption in the PML layers for LWD modeling. The optimal values of CFS-PML parameters in the LWD simulation were investigated based on thousands of 3D simulations. For typical LWD cases, the best maximum value of the quadratic damping profile was obtained using one do. The optimal parameter space for the maximum value of the linear frequency-shifted factor (a0) and the scaling factor (β0) depended on the thickness of the PML layer. For typical formations, if the PML thickness is 10 grid points, the global error can be reduced to 〈1% using the optimal PML parameters, and the error will decrease as the PML thickness increases.
文摘This paper discusses the stability of theoretical solutions for nonlinear multi-variable delay perturbation problems (MVDPP) of the form x′(t)=f(x(t),x(t-τ 1(t)),...,x(t-τ m(t)),y(t),y(t-τ 1(t)),...,y(t-τ m(t))), and εy′(t)=g(x(t),x(t-τ 1(t)),...,x(t-τ m(t)),y(t),y(t-τ 1(t)),...,y(t-τ m(t))), where 0<ε1. A sufficient condition of stability for the systems is obtained. Additionally we prove the numerical solutions of the implicit Euler method are stable under this condition.
基金Project (50490272) supported by the National Natural Science Foundation of China project(NCET-05-0687) supportedby Programfor New Century Excellent Talents project (040109) supported bythe Doctor Degree Paper Innovation Engineering of CentralSouth University
文摘Dynamic analysis steps and general flow of fast lagrangian analysis of continua in 3 dimensions(FLAC3D) were discussed. Numerical simulation for influence of excavation and blasting vibration on stability of mined-out area was carried out with FLAC3D. The whole analytical process was divided into two steps, including the static analysis and the dynamic analysis which were used to simulate the influence of excavation process and blasting vibration respectively. The results show that the shape of right upper boundary is extremely irregular after excavation, and stress concentration occurs at many places and higher tensile stress appears. The maximum tensile stress is higher than the tensile strength of rock mass, and surrounding rock of right roof will be damaged with tension fracture. The maximum displacement of surrounding rock is 4.75 mm after excavation. However, the maximum displacement increases to 5.47 mm after the blasting dynamic load is applied. And the covering area of plastic zones expands obviously, especially at the foot of right upper slope. The analytical results are in basic accordance with the observed results on the whole. Damage and disturbance on surrounding rock to some degree are caused by excavation, while blasting dynamic load increases the possibility of occurrence of dynamic instability and destruction further. So the effective supporting and vibration reducing measures should be taken during mining.
基金Projects(52074166,51774195,51704185)supported by the National Natural Science Foundation of ChinaProject(2019M652436)supported by the China Postdoctoral Science Foundation。
文摘In actual production,deep coal mine roadways are often under typical static-dynamic coupling stress(SDCS)conditions with high ground stress and strong dynamic disturbances.With the increasing number of disasters and accidents induced by SDCS conditions,the safe and efficient production of coal mines is seriously threatened.Therefore,it is of great practical significance to study the deformation and failure characteristics of the roadway surrounding rock under SDCS.In this paper,the effects of different in-situ stress fields and dynamic load conditions on the surrounding rock are studied by numerical simulations,and the deformation and failure characteristics are obtained.According to the simulation results,the horizontal stress,vertical stress and dynamic disturbance have a positive correlation with the plastic failure of the surrounding rock.Among these factors,the influence of the dynamic disturbance is the most substantial.Under the same stress conditions,the extents of deformation and plastic failure of the roof and ribs are always greater than those of the floor.The effect of horizontal stresses on the roadway deformation is more notable than that of vertical stresses.The results indicate that for the roadway under high-stress conditions,the in-situ stress test must be strengthened first.After determining the magnitude of the in-situ stress,the location of the roadway should be reasonably arranged in the design to optimize the mining sequence.For roadways that are strongly disturbed by dynamic loads,rock supports(rebar/cable bolts,steel set etc.)that are capable of maintaining their effectiveness without failure after certain dynamic loads are required.The results of this study contribute to understanding the characteristics of the roadway deformation and failure under SDCS,and can be used to provide a basis for the support design and optimization under similar geological and geotechnical circumstances.