目的分析达格列净治疗2型糖尿病(T2DM)对患者糖脂水平和胰岛素指标及血清网膜素-1的影响及血清网膜素-1与稳态模型评估-胰岛素抵抗指数(HOMA-IR)的相关性。方法选取2018年11月至2019年10月于长江大学附属仙桃市第一人民医院内分泌科收治...目的分析达格列净治疗2型糖尿病(T2DM)对患者糖脂水平和胰岛素指标及血清网膜素-1的影响及血清网膜素-1与稳态模型评估-胰岛素抵抗指数(HOMA-IR)的相关性。方法选取2018年11月至2019年10月于长江大学附属仙桃市第一人民医院内分泌科收治的46例T2DM患者作为观察组,另选取同期32名健康志愿者作为对照组。采用酶联免疫吸附试验(ELISA)测定两组血清omentin-1水平,比较观察组治疗前与对照组及观察组治疗前后体重指数(BMI)、腰臀比(WHR)、血压、糖脂水平、胰岛素指标及血清omentin-1水平,分析T2DM患者治疗前后omentin-1水平与HOMA-IR的相关性。结果观察组治疗前与对照组BMI、WHR、收缩压(SBP)、舒张压(DBP)、总胆固醇(TC)、三酰甘油(TG)水平比较差异均无统计学意义;观察组治疗前空腹血糖(FBG)、餐后2 h血糖(2 h PG)、糖化血红蛋白(HbA1c)、空腹胰岛素(FINS)水平及HOMA-IR均高于对照组,稳态模型评估-胰岛β细胞功能指数(HOMA-β)、血清omentin-1水平均低于对照组,差异有统计学意义(P<0.05)。治疗后,观察组WHR、BMI、FBG、2 h PG、HbA1c、HOMA-IR水平均低于治疗前,HOMA-β、血清omentin-1水平均高于治疗前,差异有统计学意义(P<0.05)。Pearson直线相关分析结果显示,T2DM患者血清omentin-1水平与HOMA-IR呈负相关(r<0,P<0.05)。结论T2DM患者糖脂、血清omentin-1水平和胰岛β细胞功能异常,血清omentin-1与HOMA-IR呈负相关,达格列净能有效降低T2DM患者糖脂水平,提高血清omentin-1水平,进而可改善胰岛β细胞功能。展开更多
Objective: To determine the prevalence of insulin resistance (IR) in a large p opulation of patients with the polycystic ovary syndrome (PCOS). Design: Prospec tive, case-control. Setting: University medical center. P...Objective: To determine the prevalence of insulin resistance (IR) in a large p opulation of patients with the polycystic ovary syndrome (PCOS). Design: Prospec tive, case-control. Setting: University medical center. Patient(s): Two hundred seventy-one PCOS patients and 260 eumenorrheic, non-hirsute, control women. I ntervention(s): History and physical examination and blood sampling. Main Outcom e Measure(s): Total T, free T, DHEAS, sex hormone-binding globulin, and fasting glucose and insulin levels; homeostatic model assessment values for IR (HOMA-I R) and percent β-cell function (HOMA-%β-cell). Result(s): Patients with PC OS and controls differed significantly in all parameters studied, except fasting glucose. Because the HOMA-IR and HOMA-%β-cell values were variably associa ted with race, age, and body mass index, the HOMA-IR and HOMA-%β-cell value s were then adjusted for these cofounders. After adjustment, 64.4%of PCOS patie nts were noted to be insulin resistant, and 2.6%had β-cell dysfunction. Compa red with PCOS patients without IR (n = 96), patients with IR (n = 174) were more obese and had higher β-cell function. Conclusion(s): In patients with PCOS, t he prevalence of IR was 64%according to the HOMA-IR measurement, after adjustm ent. Patients with IR were more clinically affected. Although IR is a common abn ormality in PCOS, it does not seem to be a universal feature.展开更多
文摘目的分析达格列净治疗2型糖尿病(T2DM)对患者糖脂水平和胰岛素指标及血清网膜素-1的影响及血清网膜素-1与稳态模型评估-胰岛素抵抗指数(HOMA-IR)的相关性。方法选取2018年11月至2019年10月于长江大学附属仙桃市第一人民医院内分泌科收治的46例T2DM患者作为观察组,另选取同期32名健康志愿者作为对照组。采用酶联免疫吸附试验(ELISA)测定两组血清omentin-1水平,比较观察组治疗前与对照组及观察组治疗前后体重指数(BMI)、腰臀比(WHR)、血压、糖脂水平、胰岛素指标及血清omentin-1水平,分析T2DM患者治疗前后omentin-1水平与HOMA-IR的相关性。结果观察组治疗前与对照组BMI、WHR、收缩压(SBP)、舒张压(DBP)、总胆固醇(TC)、三酰甘油(TG)水平比较差异均无统计学意义;观察组治疗前空腹血糖(FBG)、餐后2 h血糖(2 h PG)、糖化血红蛋白(HbA1c)、空腹胰岛素(FINS)水平及HOMA-IR均高于对照组,稳态模型评估-胰岛β细胞功能指数(HOMA-β)、血清omentin-1水平均低于对照组,差异有统计学意义(P<0.05)。治疗后,观察组WHR、BMI、FBG、2 h PG、HbA1c、HOMA-IR水平均低于治疗前,HOMA-β、血清omentin-1水平均高于治疗前,差异有统计学意义(P<0.05)。Pearson直线相关分析结果显示,T2DM患者血清omentin-1水平与HOMA-IR呈负相关(r<0,P<0.05)。结论T2DM患者糖脂、血清omentin-1水平和胰岛β细胞功能异常,血清omentin-1与HOMA-IR呈负相关,达格列净能有效降低T2DM患者糖脂水平,提高血清omentin-1水平,进而可改善胰岛β细胞功能。
文摘Objective: To determine the prevalence of insulin resistance (IR) in a large p opulation of patients with the polycystic ovary syndrome (PCOS). Design: Prospec tive, case-control. Setting: University medical center. Patient(s): Two hundred seventy-one PCOS patients and 260 eumenorrheic, non-hirsute, control women. I ntervention(s): History and physical examination and blood sampling. Main Outcom e Measure(s): Total T, free T, DHEAS, sex hormone-binding globulin, and fasting glucose and insulin levels; homeostatic model assessment values for IR (HOMA-I R) and percent β-cell function (HOMA-%β-cell). Result(s): Patients with PC OS and controls differed significantly in all parameters studied, except fasting glucose. Because the HOMA-IR and HOMA-%β-cell values were variably associa ted with race, age, and body mass index, the HOMA-IR and HOMA-%β-cell value s were then adjusted for these cofounders. After adjustment, 64.4%of PCOS patie nts were noted to be insulin resistant, and 2.6%had β-cell dysfunction. Compa red with PCOS patients without IR (n = 96), patients with IR (n = 174) were more obese and had higher β-cell function. Conclusion(s): In patients with PCOS, t he prevalence of IR was 64%according to the HOMA-IR measurement, after adjustm ent. Patients with IR were more clinically affected. Although IR is a common abn ormality in PCOS, it does not seem to be a universal feature.
