The relationship between ship stability and sail area is firstly investigated based on the sail-assisted ship＇s stability in this paper. Then a height-adjustable sail structure is proposed that could be automatically...The relationship between ship stability and sail area is firstly investigated based on the sail-assisted ship＇s stability in this paper. Then a height-adjustable sail structure is proposed that could be automatically adjusted according to the wind conditions, ship loading and other requirements. The influences on the sail height in different ship load conditions, different wind apparent velocity and wind direction are analyzed of a sail-assisted bulk carrier. Finally a control procedure of sail height adjustment in real time is proposed according to the actual load conditions, wind conditions, ship velocity and other parameters to make the best use of wind energy, which is significant for the practical application of sail-assisting technology in the future.展开更多
Polycomblike2(PCL2) is a well-known component of polycomb repressive complex 2(PRC2) and plays important roles in H3 K27 methylation and homeotic gene silencing.However,the involvement of PCL2 in breast cancer develop...Polycomblike2(PCL2) is a well-known component of polycomb repressive complex 2(PRC2) and plays important roles in H3 K27 methylation and homeotic gene silencing.However,the involvement of PCL2 in breast cancer development remains unclear.Here,we established PCL2 as a tumor suppressor gene in breast cancer.Expression level of PCL2 was significantly downregulated in breast cancer tissue samples observed at different TNM stages.Ectopic expression of PCL2 could significantly inhibit cell proliferation and promoted apoptosis.PCL2 also remarkably elevated levels of p53 and its targets by increasing p53 stability.Mechanistically,PCL2 protected p53 proteins from MDM2-mediated ubiquitination and degradation by sequestering MDM2 into the nucleolus.Overexpression of PCL2 also suppressed migration and invasion by inhibiting epithelial-mesenchymal transition.PCL2 expression was correlated with Ecadherin expression and was inversely correlated with vimentin expression.Furthermore,PCL2 knockdown could attenuate anti-tumor effect of MLN4924.Taken together,our findings indicated that PCL2 played a tumor suppressor role in development and progression of breast cancer and may be a prognostic and predictive marker for breast cancer.展开更多
文摘The relationship between ship stability and sail area is firstly investigated based on the sail-assisted ship＇s stability in this paper. Then a height-adjustable sail structure is proposed that could be automatically adjusted according to the wind conditions, ship loading and other requirements. The influences on the sail height in different ship load conditions, different wind apparent velocity and wind direction are analyzed of a sail-assisted bulk carrier. Finally a control procedure of sail height adjustment in real time is proposed according to the actual load conditions, wind conditions, ship velocity and other parameters to make the best use of wind energy, which is significant for the practical application of sail-assisting technology in the future.
基金supported by the National Key R&D Program of China(2016YFE0129200)the National Natural Science Foundation of China(31571321,31171428)the Institute of the Fundamental Research Funds of Shandong University(2015JC036)
文摘Polycomblike2(PCL2) is a well-known component of polycomb repressive complex 2(PRC2) and plays important roles in H3 K27 methylation and homeotic gene silencing.However,the involvement of PCL2 in breast cancer development remains unclear.Here,we established PCL2 as a tumor suppressor gene in breast cancer.Expression level of PCL2 was significantly downregulated in breast cancer tissue samples observed at different TNM stages.Ectopic expression of PCL2 could significantly inhibit cell proliferation and promoted apoptosis.PCL2 also remarkably elevated levels of p53 and its targets by increasing p53 stability.Mechanistically,PCL2 protected p53 proteins from MDM2-mediated ubiquitination and degradation by sequestering MDM2 into the nucleolus.Overexpression of PCL2 also suppressed migration and invasion by inhibiting epithelial-mesenchymal transition.PCL2 expression was correlated with Ecadherin expression and was inversely correlated with vimentin expression.Furthermore,PCL2 knockdown could attenuate anti-tumor effect of MLN4924.Taken together,our findings indicated that PCL2 played a tumor suppressor role in development and progression of breast cancer and may be a prognostic and predictive marker for breast cancer.
