Objective The resting-state functional magnetic resonance imaging(rs-f MRI)method was used to observe brain activity and its functional connection upon electroacupuncture stimulation at bilateral uterine acupoints(EX-...Objective The resting-state functional magnetic resonance imaging(rs-f MRI)method was used to observe brain activity and its functional connection upon electroacupuncture stimulation at bilateral uterine acupoints(EX-CA1),as well as to investigate the mechanism of acupuncture in the treatment of gynecological diseases.Methods Twenty-two healthy female subjects were stimulated by electroacupuncture at bilateral uterine acupoints;rs-f MRI data of the brain were acquired and standardized.Degree centrality(DC),amplitude of low-frequency fluctuation(ALFF),and regional homogeneity(ReHo)were used to analyze local spontaneous brain activity via acupuncture.An independent component analysis was used to evaluate the functional connectivity of the resting brain networks after acupuncture.Results Analytical results showed that the neural activity intensity of the precuneus lobe,orbitofrontal cortex,lingual gyrus,amygdala,and posterior central gyrus decreased after acupuncture(voxel P<0.001,cluster P<0.05).Functional connectivity analysis revealed weakened auditory and right frontal-parietal networks(voxel P<0.001,cluster P<0.05),enhanced visual network(voxel P<0.001,cluster P<0.05),and synergistic auditory network and hypothalamic-pituitary system.Conclusion Significant differences in neural activity and functional connectivity in specific brain regions were observed after acupuncture intervention at uterine acupoints;the hypothalamic-pituitary system also showed various active states in different brain regions.It is speculated that the effective mechanism of acupuncture at uterine acupoints is related to the regulation of reproductive hormones,emotional changes,and somatic sensations.Therefore,the methods used in this study could clarify the neural mechanism of uterine-point acupuncture in the treatment of gynecological diseases and may serve as a reference for other studies pertaining to acupuncture.展开更多
Objective： To investigate the clinical effect of ginger-partitioned moxibustion at Zigong（EX-CA 1） for primary dysmenorrhea. Methods： A total of 112 patients with primary dysmenorrhea were randomized into an obser...Objective： To investigate the clinical effect of ginger-partitioned moxibustion at Zigong（EX-CA 1） for primary dysmenorrhea. Methods： A total of 112 patients with primary dysmenorrhea were randomized into an observation group and a control group according to their visiting sequence, 56 cases in each group. Patients in the observation group received ginger-partitioned moxibustion at Zigong（EX-CA 1）, while patients in the control group received oral intake of analgesic. For both groups, treatment started 1 week before menstruation and lasted for 3 menstrual cycles, continued by a 3-month follow-up visit, then the clinical efficacy was evaluated. Results： By the end of treatment, symptom score in the observation group was lower than that in the control group, showing a statistical significance（P〈0.05）. After 3 months of treatment, the value of prostaglandin F2 a（PGF2α）, systolic-to-diastolic peak velocity ratio（S/D）, resistance index（RI） and pulsatility index（PI） in the observation group were significantly higher than those in the control group, showing statistical significances（all P〈0.01）.The recovery rate in the observation group was higher than that in the control group, showing a statistical significance（P〈0.05）. Conclusion： Ginger-partitioned moxibustion at Zigong（EX-CA 1） for primary dysmenorrhea is a combination of the merits of warming function of moxibustion, dissipating function of ginger and stimulation of acupoint, and is better than oral intake of analgesic.展开更多
Objective:To observe the clinical efficacy of herbal cake-partitioned moxibustion for dysmenorrhea due to deficiency cold.Methods:A total of 70 patients with dysmenorrhea who met the inclusion criteria were randomized...Objective:To observe the clinical efficacy of herbal cake-partitioned moxibustion for dysmenorrhea due to deficiency cold.Methods:A total of 70 patients with dysmenorrhea who met the inclusion criteria were randomized into a mild moxibustion group and a herbal cake-partitioned moxibustion group by the random number table,with 35 cases in each group.Shenque(CV 8),Zhongji(CV 3)and bilateral Zigong(EX-CA 1)were selected for both groups.The treatment continued for 3 menstrual cycles.The visual analog scale(VAS)and COX menstrual symptom scale(CMSS)were scored in both groups before treatment,after treatment and at the end of the 3rd menstrual cycle after treatment.The clinical efficacy was evaluated at the end of the 3rd menstrual cycle after treatment.Results:After treatment,the clinical efficacy of the herbal cake-partitioned moxibustion group had the tendency to be superior to that of the mild moxibustion group,while there was no statistically significant difference in the overall efficacy between the two groups(P>0.05).The VAS and CMSS scores after treatment and at the follow-up were significantly lower than those before treatment in both groups(all P<0.05).At the follow-up,the VAS scores in both groups had no significant intra-group differences from those after treatment(both P>0.05).The CMSS scores in both groups were significantly lower than those after treatment(both P<0.05).The VAS scores at the follow-up of both groups had no statistical differences from those after treatment(both P>0.05).After treatment,the CMSS score in the herbal cake-partitioned moxibustion group was significantly lower than that in the mild moxibustion group(P<0.05).At the follow-up,there were no statistical differences in the CMSS score between the two groups(P>0.05).Conclusion:The herbal cake-partitioned moxibustion has the same therapeutic efficacy for dysmenorrhea as the mild moxibustion;the two moxibustion methods can significantly improve the concomitant symptoms of dysmenorrhea,and the herbal cake-partitioned moxibustion is little better.展开更多
Two hundred and twenty patients in hydrotubation were divided into experiment group and control group, with 110 cases in each group. Injection of vitamin K1 at Zusanli（ST 36） was used in the patients of experiment g...Two hundred and twenty patients in hydrotubation were divided into experiment group and control group, with 110 cases in each group. Injection of vitamin K1 at Zusanli（ST 36） was used in the patients of experiment group before the operation. The control was given nothing. The observation showed that the number of case with adverse effects was less in experiment group than that in control group, and the measures was also milder in comparison with control group. The cases of unobstructed oviducts in experiment group were 89, accounting for 89.9%, while the cases in control group were 63, accounting for 57.3%.展开更多
Objective:To observe the blood perfusion volume variation pattern in the body surface microcirculation at the Yuan-Primary and the Xi-Cleft points during the menstrual cycle in female college students with moderate co...Objective:To observe the blood perfusion volume variation pattern in the body surface microcirculation at the Yuan-Primary and the Xi-Cleft points during the menstrual cycle in female college students with moderate constitution under normal physiological state of the uterus;to explore the specific laws of the body surface microcirculation at the Yuan-Primary and Xi-Cleft points in response to the uterine qi and blood changes under normal physiological conditions,and to provide the experimental basis for the specificity of acupoints reflecting the uterine function.Methods:Forty-three healthy and moderate constitution female college students with regular menstrual cycles,without dysmenorrhea and not yet giving birth were recruited.Bilateral Yuan-Primary points[Taichong(LR 3),Taibai(SP 3)and Taixi(KI 3)]and Xi-Cleft points[Zhongdu(LR 6),Diji(SP 8)and Shuiquan(KI 5)],belonging to the three yin meridians of foot and adjacent to the spinal cord segment of the uterus,were selected as the detection acupoints;the crossing point of the three yin meridians of foot[Sanyinjiao(SP 6)],the uterus-related meridian acupoint[Xuehai(SP 10)],the uterus-non-related meridian acupoint[Xuanzhong(GB 39)],and the non-meridian non-acupoint point were selected as the control points.The laser speckle blood flow imaging technique was used to monitor the blood perfusion volume in skin microcirculation at the above points at the menstrual,follicular,ovulatory,and luteal phases of the subjects.Results:The blood perfusion volume in the body surface microcirculation at the right Zhongdu(LR 6)at the ovulatory phase was higher than that at the menstrual,follicular and luteal phases(all P<0.05);there was no significant difference in the microcirculation blood perfusion volume at the other points among different phases(all P>0.05).Conclusion:The blood perfusion volume in the body surface microcirculation at Zhongdu(LR 6),the Xi-Cleft point of the Liver Meridian,shows a specific response to qi and blood changes in the uterus of women with moderate constitution.展开更多
基金National Nature Science Foundation of China(61872225)Natural Science Foundation of Shandong Province(ZR2020KF013,ZR2020ZD44,ZR2019ZD04,and ZR2020QF043)+1 种基金Introduction and Cultivation Program for Young Creative Talents in Colleges and Universities of Shandong Province(2019-173)Special Fund of Qilu Health and Health Leading Talents Training Project。
文摘Objective The resting-state functional magnetic resonance imaging(rs-f MRI)method was used to observe brain activity and its functional connection upon electroacupuncture stimulation at bilateral uterine acupoints(EX-CA1),as well as to investigate the mechanism of acupuncture in the treatment of gynecological diseases.Methods Twenty-two healthy female subjects were stimulated by electroacupuncture at bilateral uterine acupoints;rs-f MRI data of the brain were acquired and standardized.Degree centrality(DC),amplitude of low-frequency fluctuation(ALFF),and regional homogeneity(ReHo)were used to analyze local spontaneous brain activity via acupuncture.An independent component analysis was used to evaluate the functional connectivity of the resting brain networks after acupuncture.Results Analytical results showed that the neural activity intensity of the precuneus lobe,orbitofrontal cortex,lingual gyrus,amygdala,and posterior central gyrus decreased after acupuncture(voxel P<0.001,cluster P<0.05).Functional connectivity analysis revealed weakened auditory and right frontal-parietal networks(voxel P<0.001,cluster P<0.05),enhanced visual network(voxel P<0.001,cluster P<0.05),and synergistic auditory network and hypothalamic-pituitary system.Conclusion Significant differences in neural activity and functional connectivity in specific brain regions were observed after acupuncture intervention at uterine acupoints;the hypothalamic-pituitary system also showed various active states in different brain regions.It is speculated that the effective mechanism of acupuncture at uterine acupoints is related to the regulation of reproductive hormones,emotional changes,and somatic sensations.Therefore,the methods used in this study could clarify the neural mechanism of uterine-point acupuncture in the treatment of gynecological diseases and may serve as a reference for other studies pertaining to acupuncture.
文摘Objective： To investigate the clinical effect of ginger-partitioned moxibustion at Zigong（EX-CA 1） for primary dysmenorrhea. Methods： A total of 112 patients with primary dysmenorrhea were randomized into an observation group and a control group according to their visiting sequence, 56 cases in each group. Patients in the observation group received ginger-partitioned moxibustion at Zigong（EX-CA 1）, while patients in the control group received oral intake of analgesic. For both groups, treatment started 1 week before menstruation and lasted for 3 menstrual cycles, continued by a 3-month follow-up visit, then the clinical efficacy was evaluated. Results： By the end of treatment, symptom score in the observation group was lower than that in the control group, showing a statistical significance（P〈0.05）. After 3 months of treatment, the value of prostaglandin F2 a（PGF2α）, systolic-to-diastolic peak velocity ratio（S/D）, resistance index（RI） and pulsatility index（PI） in the observation group were significantly higher than those in the control group, showing statistical significances（all P〈0.01）.The recovery rate in the observation group was higher than that in the control group, showing a statistical significance（P〈0.05）. Conclusion： Ginger-partitioned moxibustion at Zigong（EX-CA 1） for primary dysmenorrhea is a combination of the merits of warming function of moxibustion, dissipating function of ginger and stimulation of acupoint, and is better than oral intake of analgesic.
文摘Objective:To observe the clinical efficacy of herbal cake-partitioned moxibustion for dysmenorrhea due to deficiency cold.Methods:A total of 70 patients with dysmenorrhea who met the inclusion criteria were randomized into a mild moxibustion group and a herbal cake-partitioned moxibustion group by the random number table,with 35 cases in each group.Shenque(CV 8),Zhongji(CV 3)and bilateral Zigong(EX-CA 1)were selected for both groups.The treatment continued for 3 menstrual cycles.The visual analog scale(VAS)and COX menstrual symptom scale(CMSS)were scored in both groups before treatment,after treatment and at the end of the 3rd menstrual cycle after treatment.The clinical efficacy was evaluated at the end of the 3rd menstrual cycle after treatment.Results:After treatment,the clinical efficacy of the herbal cake-partitioned moxibustion group had the tendency to be superior to that of the mild moxibustion group,while there was no statistically significant difference in the overall efficacy between the two groups(P>0.05).The VAS and CMSS scores after treatment and at the follow-up were significantly lower than those before treatment in both groups(all P<0.05).At the follow-up,the VAS scores in both groups had no significant intra-group differences from those after treatment(both P>0.05).The CMSS scores in both groups were significantly lower than those after treatment(both P<0.05).The VAS scores at the follow-up of both groups had no statistical differences from those after treatment(both P>0.05).After treatment,the CMSS score in the herbal cake-partitioned moxibustion group was significantly lower than that in the mild moxibustion group(P<0.05).At the follow-up,there were no statistical differences in the CMSS score between the two groups(P>0.05).Conclusion:The herbal cake-partitioned moxibustion has the same therapeutic efficacy for dysmenorrhea as the mild moxibustion;the two moxibustion methods can significantly improve the concomitant symptoms of dysmenorrhea,and the herbal cake-partitioned moxibustion is little better.
文摘Two hundred and twenty patients in hydrotubation were divided into experiment group and control group, with 110 cases in each group. Injection of vitamin K1 at Zusanli（ST 36） was used in the patients of experiment group before the operation. The control was given nothing. The observation showed that the number of case with adverse effects was less in experiment group than that in control group, and the measures was also milder in comparison with control group. The cases of unobstructed oviducts in experiment group were 89, accounting for 89.9%, while the cases in control group were 63, accounting for 57.3%.
文摘Objective:To observe the blood perfusion volume variation pattern in the body surface microcirculation at the Yuan-Primary and the Xi-Cleft points during the menstrual cycle in female college students with moderate constitution under normal physiological state of the uterus;to explore the specific laws of the body surface microcirculation at the Yuan-Primary and Xi-Cleft points in response to the uterine qi and blood changes under normal physiological conditions,and to provide the experimental basis for the specificity of acupoints reflecting the uterine function.Methods:Forty-three healthy and moderate constitution female college students with regular menstrual cycles,without dysmenorrhea and not yet giving birth were recruited.Bilateral Yuan-Primary points[Taichong(LR 3),Taibai(SP 3)and Taixi(KI 3)]and Xi-Cleft points[Zhongdu(LR 6),Diji(SP 8)and Shuiquan(KI 5)],belonging to the three yin meridians of foot and adjacent to the spinal cord segment of the uterus,were selected as the detection acupoints;the crossing point of the three yin meridians of foot[Sanyinjiao(SP 6)],the uterus-related meridian acupoint[Xuehai(SP 10)],the uterus-non-related meridian acupoint[Xuanzhong(GB 39)],and the non-meridian non-acupoint point were selected as the control points.The laser speckle blood flow imaging technique was used to monitor the blood perfusion volume in skin microcirculation at the above points at the menstrual,follicular,ovulatory,and luteal phases of the subjects.Results:The blood perfusion volume in the body surface microcirculation at the right Zhongdu(LR 6)at the ovulatory phase was higher than that at the menstrual,follicular and luteal phases(all P<0.05);there was no significant difference in the microcirculation blood perfusion volume at the other points among different phases(all P>0.05).Conclusion:The blood perfusion volume in the body surface microcirculation at Zhongdu(LR 6),the Xi-Cleft point of the Liver Meridian,shows a specific response to qi and blood changes in the uterus of women with moderate constitution.
