子宫内膜异位症术后卵巢储备功能减退的中医药治疗策略

卵巢储备指人类女性卵巢皮质内含有的原始卵泡。卵巢储备功能是指卵巢产生卵子数量和质量的能力。子宫内膜异位症手术治疗可能会影响卵巢储备功能,导致卵巢功能下降或早衰。中医治疗卵巢储备功能减退可有效改善卵巢功能且不良反应少。本文就子宫内膜异位症术后伴卵巢储备功能减退的中医药治疗作一综述。

Treatment of Hyperlipemia by Acupoint Catgut-embedding in 34 Cases

With the therapeutic method of acupoint catgut embedding, the authors have in recent years treated hyperlipemia and achieved satisfactory therapeutic results. A report follows.

CLINICAL STUDY ON TREATMENT OF INFANTILE PRIMARY EPILEPSY WITH ACUPOINT CATGUT-IMPLANTATION THERAPY

Aim: To observe the therapeutic effect of acupoint catgut implantation therapy in the treatment of infantile primary epilepsy. Methods: A total of 63 cases of primary epilepsy children were randomly divided into medication group (n=32) and acupoint catgut implantation group (n=31) and treated respectively with Sodium Valproate 5-10 mg/kg/d and catgut implantation at Changqiang (GV 1), Jiuwei (CV 15), bilateral Xinshu (BL 15) and bilateral Zusanli (ST 36). Results: Following 60 days of treatment, the abnormal changes of electroencephlogram (EEG), the seizure frequency and duration and clinical symptoms were improved apparently in comparison with those of pre treatment, but no significant differences were found between the two groups (P>0.05). There was a significant difference between two groups in the cure rate of the short term effect (P<0.05), with the therapeutic effect of the treatment group being superior to that of medication group. Conclusion: Acupoint catgut implantation therapy has a good therapeutic effect in the treatment of primary infantile epilepsy.

Clinical Observation in 46 Cases of Angina Pectoris Treated by the Catgut-embedding Therapy

With the catgut-embedding therapy, the author treated 46 cases of angina pectoris from October 1997 to February 2002, and achieved good therapeutic results. This is reported as follows.

CLINICAL OBSERVATION ON 67 CASES OF VASCULAR HEADACHE TREATED BY NEEDLING FOR BLOODLETTING PLUS POINT EMBEDDING

Objective: To observe the therapeutic effect of bloodletting plus point implantation of catgut in the treatment of 67 cases of vascular headache. Methods: A total of 107 cases of vascular headache patients were divided into treatment group (n=67) and control group (n=40). Bilateral Taiyang (EX-HN 5) and Jiaosun (TE 20) were pricked with a needle to let a little blood out, once every 4 days. Bilateral Fengmen (BL 12) and Ganshu (BL 18) were used for embedding catgut, once every 16 days. Patients of control group were ordered to take Rotunding, Oryzanol and Nimodipine, 3 times daily. Results: After 16 days’ treatment, of the 67 cases in treatment group, 26 were cured, 37 responded with improvement in their symptoms and 4 failed; while of the 40 cases in control group, 10 were cured, 19 responded with improvement in their symptoms and 11 failed. The total effective rate of treatment group was significantly superior to that of control group (P<0.01). In addition, the time of headache disappearance of treatment group was strikingly shorter than that of control group; while the duration of sleep of treatment group was strikingly longer than that of control group (P<0.01). Conclusion: The therapeutic effect of acupoint bloodletting plus acupoint embedding of catgut is superior to that of Western medicine in the treatment of vascular headache.

Systematic review on the effectiveness of embedding catgut therapy for simple obesity

Objective To systematically evaluate the effect of acupoint catgut embedding therapy （ACET） for simple obesity. Methods Computer retrieval was used for randomized controlled trials on the treatment effect of simple obesity with ACET in databases of the China National Knowledge Infrastructure （CNKI）, Wanfang Data system, and the China Biology Medicine disc （CBMDisc）. The Jadad Quality Scale was used in the evaluation of included studies. The outcome indicators were analyzed with the Review Manage 5.1 software. Results A total of 16 randomized controlled trials were included finally. The meta-analysis result showed that compared with the control group, there was statistically significance on the total efficiency of using ACET for simple obesity [OR=2.51, 95% confidence interval （1.74, 3.63）, Z=4.91, P〈0.000 01]. The analysis on the literature quality showed that there was only 2 article marked as 3 points. The other 25 articles marked ≤2 points. The quality of published articles was generally low. There were publication biases and the blinding method was seldom used, the losses of follow-up / drop oup / withdraw were reported with less. There were 27 acupoints used in the treatment, which mainly included Tianshu （天枢ST 25）, Zhongwan （中脘 CV 12）, Fenglong （丰隆 ST 40）, Shufen （水分 CV 9）, Qihai （气海 CV 6）, Sanyinjiao （三阴交 SP 6）, Zusnli （足三里 ST 36）, Ashi point, Daheng （大横 SP 25）. The five kinds of catgut embedding needle were injection needles ＋ acupuncture needle, specialized catgut embedding needle, spinal needle, triangular needle, and skin suture needle. Conclusion There is definite efficiency of using ACET in the treatment of simple obesity. However, the clinical efficiency still lacks of sufficient evidences. Therefore, further clinical research should be conducted in the providing of reliable evidences in the clinical decision-making in the future.

Clinical efficacy observation of primary dysmenorrhea treated with the embedding catgut therapy

Objective To explore the therapeutic effect on primary dysmenorrhea treated with the embedding catgut therapy so as to discover a better therapeutic method for the treatment of this disease. Methods One hundred and fifty cases were randomized into 3 groups, 50 cases in each one. In the embedding catgut group, the embedding catgut therapy was applied to Sānyīnjiāo （三阴交 SP 6）, Cìliáo （次髎 BL 32） and Guānyuán （关元 CV 4）. In the acupuncture group, the conventional acupuncture therapy was applied to Guānyuán （关元 CV 4）, Sānyīnjiāo （三阴交 SP 6）, Dìjī （地机 SP 8） and Shíqīzhuī （十七椎 EX-B 8）. In the western medicine group, indometacin was prescribed for oral administration, 25 mg, three times a day and fenbid was supplemented for the aggravated pain, 300 mg, twice a day. One session of treatment was one month in each group and 3 sessions were required totally. Before and after treatment, the symptom scores of dysmenorrhea were observed. Results The symptom scores of dysmenorrhea were all reduced obviously in three groups after treatment （all P0.05）. The result in the embedding catgut group was much more apparent as compared with that in the western medicine group （P0.01） and the acupuncture group （P0.05） separately. Of 49 cases in the embedding catgut group, 32 cases （65.3%） were cured clinically, 10 cases （20.4%） effective remarkably, 6 cases （12.2%） effective and 1 case （2.0%） failed. The total effective rate was 98.0%. Conclusion The embedding catgut therapy achieves the significant efficacy for primary dysmenorrhea. This therapy is simple in practice and deserves to be promoted in clinic.

Twenty-seven cases of adverse reaction in postoperative chemotherapy of breast cancer treated with acupoint catgut-embedding therapy

Objective To observe the effect of acupoint catgut-embedding therapy on adverse reaction in chemotherapy of breast cancer. Methods Fifty-four cases were randomly divided into a comprehensive acupuncture and moxibustion group and a western medicine group, 27 cases in each group. All the postoperative cases with breast cancer used the CAF chemotherapy regimen. In the comprehensive acupuncture and moxibustion group, acupoint catgut-embedding therapy was applied to Tiānshū （天枢 ST 25）, Wèishū （胃俞 BL 21） and Zúsānlǐ （足三里 ST 36）, etc., and moxibustion was used at Zúsānlǐ （足三里 ST 36）. In the western medicine group, Ondansetron Hydrochloride, Metoclopramide, Metoclopramide and Qianglishengbai Tablets for oral administration were prescribed. A course was 28 days, and the whole treatment included 6 courses. The status of intake, nausea and vomiting were observed, and the leukocyte was detected before and after chemotherapy. Results After treatment, The status of intake in the comprehensive acupuncture and moxibustion group was superior to that in the western medicine group （P〈0.05）. The total effective rate on controlling nausea and vomiting in the comprehensive acupuncture and moxibustion group was 88.9% （24/27）, which was higher than that of 51.8% （14/27） in the western medicine group （P〈0.05）, the improving leukocyte effective rate was 92.6% （25/27） in comprehensive acupuncture and moxibustion group, which was higher than that of 77.8% （21/27） in western medicine group （P〈0.05）. Conclusion Acupoint catgut-embedding therapy can relieve the gastrointestinal reaction and improve patients’ immunity and quality of life during chemotherapy.

Effects of acupoint thread-embedding therapy on serum apelin and GLP-1 in type 2 diabetes mellitus patients with obesity due to dampness-heat encumbering spleen

Objective:To observe the effects of acupoint thread-embedding therapy on serum apelin and glucagon-like peptide-1(GLP-1)in type 2 diabetes mellitus patients with obesity due to dampness-heat encumbering spleen.Methods:Sixty-six patients were randomly divided into a control group and an observation group according to the random number table method,with 33 cases in each group.Patients in the control group were treated with exenatide and metformin,while patients in the observation group were treated with additional acupoint thread-embedding.After 12-week treatment,the obesity-related indicators,including body mass index(BMI),waist circumference and body fat rate,the glycometabolism indicators,including fasting blood glucose,2 h postprandial blood glucose and glycosylated hemoglobin,and the lipid metabolism indicators,including total cholesterol(TC),triglyceride(TG)and low-density lipoprotein cholesterol(LDL-C),as well as serum apelin and GLP-1 levels were observed in patients of the two groups.Results:After treatment,the BMI,waist circumference and body fat rate of patients in the two groups were all reduced(all P<0.05),and were lower in the observation group than in the control group(all P<0.05);the fasting blood glucose,2 h postprandial blood glucose and glycosylated hemoglobin levels of patients in both groups were all decreased(all P<0.05),and were significantly lower in the observation group than in the control group(all P<0.05);the TC level was decreased(P<0.05),while the TG and LDL-C levels did not change significantly in the control group(both P>0.05);the TC,TG and LDL-C levels were all significantly reduced in the observation group(all P<0.05),lower than those in the control group(all P<0.05);the serum apelin level was decreased(P<0.05)and the serum GLP-1 level was increased(P<0.05)in the observation group,statistically different from those in the control group(both P<0.05).Conclusion:Combined with the conventional medication,acupoint thread-embedding therapy can significantly improve the obesity-related indicators,glycometabolism and lipid metabolism in type 2 diabetes mellitus patients with obesity due to dampness-heat encumbering spleen.This may be achieved by regulating the serum apelin and GLP-1 levels.

Acupoint catgut-embedding therapy as promising treatment for non-alcoholic fatty liver disease

Objective:To investigate the effect of acupoint catgut-embedding therapy on non-alcoholic fatty liver disease(NAFLD).Methods:Twenty-three participants were subjected to acupoint catgut-embedding therapy for 3 sessions.The second session was performed one month after the first session and the third session two months after the second session.Three months after the third session of catgut-embedding therapy,the patients were subjected to fibroscan analysis.A total of 20 acupoints were selected in three sessions.Same acupoints were selected for all the patients at the same session but different points were selected at different sessions.Results:Of the 23 participants,5 cases showed significant improvement and 8 cases showed moderate improvement as the steatosis stage was reduced by 1 or 2 degrees.The whole group showed significant improvements in terms of patient score,fat percentage,NAFLD steatosis stage,weight loss and abdominal circumference reduction after acupoint catgut-embedding therapy(all P<0.05).Conclusion:The acupoint catgut-embedding therapy can significantly improve the important factors in patients with NAFLD.

Clinical efficacy observation of acupoint thread-embedding in treating obese patients with food addiction

Objective To observe the effects of acupoint thread-embedding therapy and low-carbohydrate diet therapy on obese patients with food addiction.Methods Sixty-five eligible patients were randomized into a thread-embedding group of 33 cases and a diet group of 32 cases to respectively receive 12-week treatment.Before treatment,after treatment and at 6-month follow-up,the two groups were observed and compared in terms of body mass(BM),waist circumference(WC),hip circumference(HC),waist-to-hip ratio(WHR),body mass index(BMI),body fat rate(BFR),basal metabolic rate(BMR)and Yale food addiction scale version 2.0(YFAS 2.0).Results At the end of treatment,there were no significant differences in the general efficacy,and the improvements in BM,BMI,WC,HC,WHR and BFR between the thread-embedding group and diet group(all P>0.05).At follow-up,the thread-embedding group showed more significant improvements in all the aforementioned indicators compared with the diet group except HC(all P<0.05).At the end of treatment and follow-up,BMR and YFSA 2.0 had more significant improvements in the thread-embedding group than in the diet group(all P<0.05).Conclusion Acupoint thread-embedding therapy can produce significant efficacy in treating obese patients with food addiction;it can improve the food addiction state and work better in maintaining the efficacy compared with low-carbohydrate diet therapy.