Objective: To observe the therapeutic e ffect of injection of "Chuan-Shen-Tong" Injectio (川参通注射液) at Huiyin (会阴 CV 1) on benign hyperplasia of prostate . Methods: 60 cases of benign hyperplasia of pr...Objective: To observe the therapeutic e ffect of injection of "Chuan-Shen-Tong" Injectio (川参通注射液) at Huiyin (会阴 CV 1) on benign hyperplasia of prostate . Methods: 60 cases of benign hyperplasia of prostate patients were evenly randomized into treatment group and control group. Those of treatment group were treated with injection o f "Chuan-Shen-Tong" Injectio (composed of Rhizoma Ligustici Chuanxiong, Rad ix Salviae Miltiorrhizae, etc. for relieving hyperplasis of prostate, 4 mL/acupoin t) into Huiyin (CV 1) and the other 60 cases of control group were treated by oral administration of Hytrin (1 mg/d in the 1 st week and increasing 1 mg/3 d, 4 mg at m ost). After 28 days’ treatment, their therapeutic effects were compared. Result s: After treatment, of each 60 cases in treatment and control groups, 11 (18.3%) and 11 (11.7%) were controlled in their symptoms, 25 (41.7%) and 16 (26.7%) had marked improvement, 18 (30.0%) and 17 (28.3%) had improvement, and 6 (10.0%) an d 20 (33.3%) failed, with the effective rate and the markedly effective rate bei ng 90.0% and 66.7% in the treatment group and 66.7% and 38.3% in the control gro up respectively. The therapeutic effect of treatment group was significantly sup erior to that of control group (P<0.01 and P< 0.05). Conclusion: The therapeutic effect of point-injection of "Chuan-Shen-Tong" for benign hyperplasia of p rostate is better than that of oral administration of Hytrin.展开更多
OBJECTIVE:To compare the effects of carbamylβ-methylcholine chloride(CMCC) administered by intra-acupuncture point injection(IAI),intramuscular injection(IMI),and intravenous injection(IVI),and to analyze the mechani...OBJECTIVE:To compare the effects of carbamylβ-methylcholine chloride(CMCC) administered by intra-acupuncture point injection(IAI),intramuscular injection(IMI),and intravenous injection(IVI),and to analyze the mechanisms.METHODS:In the IAI group,CMCC was injected into the Zusanli acupoint(ST 36) immediately after 30-min stimulation by electro-acupuncture(EA) at the acupoints,and into the femoral vein and skeletal muscle in IVI and IMI groups,respectively.Intra-gastric pressure was detected.The plasma concentration of CMCC was measured at various times.RESULTS:The gastric effect of CMCC in the IVI group was enhanced and attenuated more rapidly than in the other groups.In the IAI group,this effect was significantly stronger than that in the IMI group at 2 min and 15 min,but not significantly different between the two groups at 5 min and 30 min.Plasma concentration of CMCC in the IAI group was similar to that in the IVI group at 2 min,but higher than that in the IMI group.The concentration in the IAI group was higher than that in the IV group and similar to that in the IMI group at 5,15 and 30 min,indicating rapid increase and slower reduction of the plasma concentration of the drug in the IAI group.There was a positive correlation between the plasma concentration of CMCC and intragastric pressure in all groups.CONCLUSION:The effect of IAI with CMCC was stronger than that of IMI and longer-lasting than that of IVI,which correlated with the blood concentration of CMCC.展开更多
文摘Objective: To observe the therapeutic e ffect of injection of "Chuan-Shen-Tong" Injectio (川参通注射液) at Huiyin (会阴 CV 1) on benign hyperplasia of prostate . Methods: 60 cases of benign hyperplasia of prostate patients were evenly randomized into treatment group and control group. Those of treatment group were treated with injection o f "Chuan-Shen-Tong" Injectio (composed of Rhizoma Ligustici Chuanxiong, Rad ix Salviae Miltiorrhizae, etc. for relieving hyperplasis of prostate, 4 mL/acupoin t) into Huiyin (CV 1) and the other 60 cases of control group were treated by oral administration of Hytrin (1 mg/d in the 1 st week and increasing 1 mg/3 d, 4 mg at m ost). After 28 days’ treatment, their therapeutic effects were compared. Result s: After treatment, of each 60 cases in treatment and control groups, 11 (18.3%) and 11 (11.7%) were controlled in their symptoms, 25 (41.7%) and 16 (26.7%) had marked improvement, 18 (30.0%) and 17 (28.3%) had improvement, and 6 (10.0%) an d 20 (33.3%) failed, with the effective rate and the markedly effective rate bei ng 90.0% and 66.7% in the treatment group and 66.7% and 38.3% in the control gro up respectively. The therapeutic effect of treatment group was significantly sup erior to that of control group (P<0.01 and P< 0.05). Conclusion: The therapeutic effect of point-injection of "Chuan-Shen-Tong" for benign hyperplasia of p rostate is better than that of oral administration of Hytrin.
基金Supported by Beijing Natural Science Foundation Grant(grant number 7072053)the National Basic Research Pro-gram of China (973 Program) of China Grant(2006CB504506)+1 种基金the National Natural Science Foundationof China (NSFC) Grants (30873295 and 30801485)the Business fees of China academy of Chinese Medical Sciences for independent Topics of Basic Researchers (ZZ2007001)
文摘OBJECTIVE:To compare the effects of carbamylβ-methylcholine chloride(CMCC) administered by intra-acupuncture point injection(IAI),intramuscular injection(IMI),and intravenous injection(IVI),and to analyze the mechanisms.METHODS:In the IAI group,CMCC was injected into the Zusanli acupoint(ST 36) immediately after 30-min stimulation by electro-acupuncture(EA) at the acupoints,and into the femoral vein and skeletal muscle in IVI and IMI groups,respectively.Intra-gastric pressure was detected.The plasma concentration of CMCC was measured at various times.RESULTS:The gastric effect of CMCC in the IVI group was enhanced and attenuated more rapidly than in the other groups.In the IAI group,this effect was significantly stronger than that in the IMI group at 2 min and 15 min,but not significantly different between the two groups at 5 min and 30 min.Plasma concentration of CMCC in the IAI group was similar to that in the IVI group at 2 min,but higher than that in the IMI group.The concentration in the IAI group was higher than that in the IV group and similar to that in the IMI group at 5,15 and 30 min,indicating rapid increase and slower reduction of the plasma concentration of the drug in the IAI group.There was a positive correlation between the plasma concentration of CMCC and intragastric pressure in all groups.CONCLUSION:The effect of IAI with CMCC was stronger than that of IMI and longer-lasting than that of IVI,which correlated with the blood concentration of CMCC.
