群文阅读之路径构建:求同 究异 悟道——统编教材“民俗”大单元教学探微

大单元整体教学可采用群文阅读的教学形式,这不仅符合教材编者的设计意图,更能切实实现学生阅读素养的提升。其中,“确定议题”“选择文本”“设计问题”是群文阅读的三个命题。以期通过“求同—究异—悟道”之路径,让学生到达群文阅读的美好彼岸。

CATGUT EMBEDDING FOR TREATMENT OF SIMPLE OBESITY COMPLICATED WITH ABNORMAL BLOOD FAT

Objective To compare the therapeutic effect of catgut embedding combined with diet plus exercise with that of diet plus exercise in treating simple obesity complicated with abnormal blood fat. Methods A prescription of diet plus exercise was given to the patients in a control group, and catgut embedding was added to the prescription in a treatment group. It was given once every 15 days for the 1st three treatments, and once every month for the 2^nd three treatments. Six treatments constituted a therapeutic course. Body weight and blood fat were measured before and half a year since treatment. Results After treatment, BMI, TO, TG and LDL were very significantly improved in the treatment group （P〈0.01）, and BMI and TG were very significantly （P〈0.01） and TO and LDL were significantly （P〈0.05） improved in the control group. HDL was not obviously improved in both groups （P〉0.05）. The improvement of TO, TG and LDL in the treatment group was significantly more than that in the control group （P〈0.01）, but no difference in improvement of BMI and HDL was found between the two groups （P〉0.05）. Conclusion The therapy of diet plus exercise was effective in body weight reduction and lowering blood fat in patients with simple obesity complicated with abnormal blood fat, and catgut embedding used in combination was even better in lowering blood fat.

Thinking differences and language output： Lexical problems arising from non-English majored graduate writing

Non-English majored learners are poor in language out. It is pointed out the widespread problem reflected in their writing is that the learners are lack of the consciousness of the thinking differences between Chinese and English, and a negative Chinese transfer brings about expressing barriers. Five main lexical problems are presented to illustrate. It is suggested that the learners＇ awareness of the thinking differences be raised so as to improve language output.

A Velocity Map Ion-imaging Study on Ketene Photodissociation at 218 nm

Photodissociation dynamics of ketene at 218 nm has been investigated using the velocity map ion-imaging method. Both angular and translational energy distributions for the CO products at different rotational and vibrational states have been obtained. The 2＋1 REMPI spectrum of CO products is also obtained. The results are as bellow： （i） CO products in the first two vibrational states （ v＂=0 and v＂=1 ） exhibit significant rotational excitation. Furthermore the rotational excitation of CO at the v＂=0 level is noticeably higher than that at the v＂=1 level. （ii） It was found that the major photodissociation pathway of ketene at 218 nm is the CH2（ǎ^1A1）＋CO（X^1∑^＋） channel, while the CH2（b^1B1）＋CO（X^1∑^＋） channel and the CH2（X^3B1）＋CO（X^1E^＋） channel are also likely present, （iii） The anisotropy parameters β of CO different rovibronic states all appear to be larger than zero. No significant difference is observed at the two vibrational states,

EXPERIMENT AND RESEARCH ON DEVELOPMENT AND CHARACTERIZATIONS OF ANODIC ALUMINA MEMBR-ANE FOR USE IN HEMODIALYSIS

Objective The correlation between various formative conditions and the pore characterizationsof the anodic alumina membrane is investigated to seek the optimal conditions for the formation of anodic aluminamembrane. Methods High purity aluminum foils are used as the starting materials. The anodization is conduc-ted in three types of electrolytes, 3% sulfuric acid, 5% sulfuric acid and 2. 7% oxalic acid, respectively, with dif-ferent voltages at for 48h. The characterizations of the pore size, the effective porosity and the pore porosity areobserved and determined by scanning electron microscopy. The hydraulic conductances of the membranes are meas-ured to confirm that the pores are open and evaluate the permselectivity of the membranes. Results The experi-mental result shows that the ordered pore arrays are obtained for oxidation under our experimental conditions. Withthe increasing of the voltage, the pore size and pore porosity increased significantly (P <0.05) , while the effectiveporosity decreased significantly (P <0.05) with the same electrolyte. The pore size formed in 3% sulfuric acid or5% sulfuric acid is much smaller than in 2. 7% oxalic acid as an electrolyte. The hydraulic conductance of anodicalumina membrane that formed under our experimental condition is higher than those of the membranes are availablecurrently used in clinical. Conclusion The results suggest that the optimal conditions for the formation of anodicalumina membrane that used in hemodialysis are in 3% or 5% sulfuric acid with 12. 5V to 17. 5V at for 48h.

Numerical Investigation of Transmission of Low Frequency Sound Through a Smooth Air-water Interface

It is the traditional belief that sound transmission from water to the air is very weak due to a large contrast between air and water impedances. Recently, the enhanced sound transmission and anomalous transparency of air-water interface have been introduced. Anomalous transparency of air-water interface states that the sound generated by a submerged shallow depth monopole point source localized at depths less than 1/10 sound wavelength, can be transmitted into the air with omni-directional pattern. The generated sound has 35 times higher power compared to the classical ray theory prediction. In this paper, sound transmission through air-water interface for a localized underwater shallow depth source is examined. To accomplish this, two-phase coupled Helmholtz wave equations in two-phase media of air-water are solved by the commercial finite element based COMSOL Multiphysics software. Ratios of pressure amplitudes of different sound sources in two different underwater and air coordinates are computed and analyzed against non-dimensional ratio of the source depth （D） to the sound wavelength （λ）. The obtained results are compared with the experimental data and good agreement is displayed.

The Kinetic Study on the Anionic Polymerization of Isoprene

The kinetic study of the anionic polymerization of isoprene is carried out in tetrahy-drofuran(THF), using n-BuLi as initiator. Kinetic parameters are obtained, which comprise chain propagation rate constant, kp, and partial rate constants, k3 and k4 + k5, propagation orders with respect to monomer and active species concentrations, α and β, real activation energy, E, as well as partial activation energies, E3 and E4+5 and so on. The relationship between the microstruc-ture of polyisoprene and the ratio of [THF]/[n-BuLi] has been investigated. On the basis of the studies mentioned above, a reasonable mechanism of the anionic polymerization of isoprene in THF is proposed.

TWO-YEAR OBSERVATION OF A RANDOMIZED TRIAL ON TACROLIMUS-BASED THERAPY WITH WITHDRAWAL OF STEROIDS OR MYCOPHENOLATE MOFETIL AFTER RENAL TRANSPLANTATION

Objective To evaluate the safety and feasibility of steroid or mycophenolate mofetil （MMF） withdrawal from tacrolimus-based immunosuppressant regimen in renal allograft recipients. Methods A cohort of 45 patients following cadaveric renal allograft transplantation were randomly divided into 3 groups based on the regimen of combination of tacrolimus, steroid, and MMF： triple therapy group, steroid withdrawal group, and MMF withdrawal group. During 2 years, survival of patients and allografts, clinical acute rejection, adverse events, hepatic and renal allograft function, and blood lipids were monitored to evaluate the safety and feasibility of steroid or MMF withdrawal after renal transplantation. Results During two-year observation, steroid or MMF was successfully withdrawn from immunosuppressant regimen based on tacrolimus without any clinical acute rejection renal allografts kept excellent function. Some adverse events among groups. Patient and graft survival rates were 100% and all the occurred and there were no significant differences Conclusion Withdrawal of steroid or MMF in low-immunological-risk renal allografts treated with tacrolimus-based immunosuppressant regimen can be achieved with no increased risk of acute rejection.

Effects of Sex Differences and Problem-Solving Strategies on Digital Game Performance

Problem-solving strategy i,,; a critical skill in inquiry-based learning. Several studies have investigated how to use learning games to improve inquiry abilities. However, not every learner favors this kind of approach. Thus, we need to examine how human factors affect learners＇ reactions to the use of a digital game to support inquiry-based learning. This study addressed this issue by developing a digital game, ＂Baking Town＂, and using the game to examine the effects of two central human factors, sex differences and problem-solving strategies, on students＇ performance. The results demonstrate that students＇ inquiry abilities were significantly improved after they participated in the digital game. The results also demonstrate that the digital game may be a feasible way to reduce differences between boys and girls in this domain. Finally, we used the findings to develop a framework that can be used to enhance our understanding of sex differences and the use of problem-solving strategies in the context of digital games.

Tree Rings Tell Moisture Variability on Tibetan Plateau

Tibetan Plateau（TP）is known as＂Asia’s Water Tower＂,but it remains an interesting question whether the water supply to the north of the plateau is the same with that to the south.Dr.ZHANG Qibin and coworkers from the State Key Laboratory of Vegetation and Environmental Change.CAS Institute of Botany recently tried to answer it from their studies of tree rings.They found evidences for different moisture conditions on the north and south of the plateau during the past five and a half centuries,and particularly,

Clinical research on treatment of advanced androgen independent prostate cancer with Docetaxel and Thalidomide

Objective:To evaluate the clinical effects and adverse reactions of Docetaxel and Thalidomide in treating advanced androgen independent prostate cancer(AIPC).Methods:12 cases of advanced AIPC were given a combined treatment of Docetaxel and Thalidomide, with Docetaxel 75 mg/m2 on day 1 and Thalidomide 100 mg per day as initial dose and 300 mg as terminal dose by an increase of 50 mg every week.Results:The post-treatment values of prostate specific antigen(PSA) were normal(< 4 ng/L) in 10 patients, less than 50% of pretreatment value in one patient, and no significant change in one patient.The median survival time was 14 months and period of the median symptoms reduction was 16.3 months.Common adverse reactions were tolerable, including nausea, vomiting, leukopenia, anemia and thrombocytopenia.Conclusion:The regimen of Docetaxel combined with Thalidomide was effective and tolerable in the treatment of advanced AIPC.

Experimental research for specific down-regulated expression of p53 gene by individual antisense RNA in vitro

Objective： To investigate the specific blockage effect of individual antisense RNA on mutant p53 gene in vitro. Methods： The single strand antisense transcription system containing mt-p53 exon 8 sequence （pGEM3zf（＋/-）p53exon8） was constructed. The ligation of antisense RNAwith mt-p53 gene was confirmed by in situ hybridization; MDA-MB-231 human breast cancer cells were transfected with ASp53exon8＇RNA cotionic liposome-mediated. Expression of mt-p53 protein was examined by immunocytochemical staining and Western blot. Cell proliferation was evaluated by MTT assay; Cell cycle distribution was determined by flow cytometry （FCM）; Apoptosis was observed by TUNEL. Results： In transfected MDA-MB-231 cells, hybridization signals were observed in cytoplasm. ASp53exon8＇RNA transfection induced inhibition of cell proliferation, G2/M phase arrest and increasing apoptotic rates. In addition, expression of p53 protein was down-regulated. Conclusion： pGEM3zf（＋/-）p53exon8 was well constructed and ASp53exon8＇RNA can block mt-p53 gene expression specifically and then inhibit MDA-MB-231 cell proliferation in vitro, which may serve as therapeutic means for human malignancy.

A City between Metamorphosis and Mutation from 19th to 21st Century

Constantine is a big city, particular because of its site and history. But it is especially a city that currently polarizes a huge interest from public authorities, researchers, as well as citizens represented by associations that are militating to safeguard and promote the city. Making Constantine ＂a regional capital, a metropolis＂ is the ambitious urban project of this city authorities. It is a prestigious project, but at the same time, a double-edged sword. With the emergence of this project, a new conception of the city and its image is induced, the one that conjures new canons of urban modernity, with the whole discourse that sustains it and indicators that materialize it. A new attitude toward the current city of Constantine has emerged, from both the authorities and citizens. The inhabitants are continuing in spite of all to invest their city and do not accept that the natural process of appropriation of space may be stopped indefinitely. The author will try to expose the conflict situationof a changing city inside numerous and varied issues, as well as stakes and challenges.

顾广圻与《文选》学研究

本文论述了清代著名校勘学家顾广圻与《文选》学研究的关系。顾氏校勘的李善注《文选》,为《选》学研究作出了重要的贡献,具有划时代的意义,至今仍是我们学习和研究《文选》的重要版本。

Design,synthesis and bioevaluation of isoflavone derivative as a novel CLR/RAMP1 antagonist

CGRP receptor（CLR） is a B class GPCR that functions only when combined with RAMPs. CLR/RAMP1 has been regarded as a promising target for migraine treatment, as its antagonists have been proved to be effective recently. In the present study we designed and synthesized small molecular antagonists against CLR/RAMP1, resulting in a novel type of structure with acceptable high potency. The molecules were designed via virtual screening. Afterwards, a series of modification were conducted on the hit compounds, resulting in compound 8 as the best scored compound in docking, which was further validated in vitro by cell-based functional assay.

Study on the body surface temperature variation patterns of the meridian acupoints related to the physiological status of the uterus

Objective:By observing the body surface temperature changes of different meridian acupoints located at the same or adjacent spinal segments of the uterus during the whole storing and releasing process of the uterus under normal physiological condition by the infrared thermal imaging technology,to explore the specific patterns that the functions of Zang-fu organs are reflected on the biophysical characteristics of acupoints,and to enrich the functional specificity theory of the meridian acupoints,thus to provide a reference for discussing the biophysical characteristics of meridian acupoints associated with the menstrual cycle in healthy female college students.Methods:Ninety healthy subjects were included.Infrared thermal imaging device was used to detect the body surface temperature of the Yuan-Primary points,the Xi-Cleft points,the crossing points,the non-specific points,the unrelated meridian acupoints and the non-meridian non-acupoint points of the three yin meridians of foot located at the same or adjacent spinal cord segment with uterus,during the menstrual phase,the follicular phase,the ovulation phase and the luteal phase.The absolute skin temperature difference between the left and right acupoints with the same name was used as the main outcome indicator.Results:The temperature difference between left and right Diji(SP 8,the Xi-Cleft point of the Spleen Meridian)during the ovulation phase was significantly higher than that during the other 3 phases(all P<0.05).There was no statistically significant difference in the temperature difference between the other meridian acupoints and non-meridian non-acupoint points during the 4 phases(all P>0.05);the absolute temperature difference value of each meridian acupoint was not statistically different from each other in the same phase(all P>0.05).Conclusion:The temperature of Diji(SP 8)specifically reflected the onset of ovulation,and the thermal characteristics of Diji(SP 8)specifically reflected the physiological changes of uterus.The meridian acupoints reflecting the performance of Zang-fu function is not only associated with the spinal cord segment innervating the acupoints,but also associated with the characteristics of the acupoints and the meridians to which the acupoints belong.

Study on metabolic intensity value changes of points on the face using thermal chromatography technology

Objective： To observe the changes of metabolic intensity value of points on the face before and after needling bilateral Hegu （LI 4） in healthy people and provide scientific basis for association between Hegu （LI 4） and face/mouth. Methods： A total of 45 healthy college students were selected in this study. Using medical thermography and Pennes bio-heat transfer model, the infrared thermograph images on the face before and after needling bilateral Hegu （LI 4） were collected to observe the distribution of metabolic intensity value on the face before acupuncture and changes in these values after needling bilateral Hegu （LI 4）. Results： Before acupuncture, Cuanzhu （BL 2） had the maximal metabolic intensity value. Its mean value was （0.71±0.23） W. Quanliao （SI 28） had the minimal metabolic intensity value. There were no left-right statistical significances in metabolic intensity values. After needling bilateral Hegu （LI 4）, the metabolic intensity values of most points on the face were increased. Kouheliao （LI 19） obtained the maximal increase： 0.35 W on average; and Yangbai （GB 24） obtained the minimal increase： 0.08 W on average. Conclusion： Points on both sides in healthy people have good symmetry in metabolic intensity value. After needling bilateral Hegu （LI 4）, the metabolic intensity values of points on the face were increased, especially points around the lips, which accords with the pathway of the Large Intestine Meridian on the head and face. This provided some scientific foundation for the association between Hegu （LI 4） and face/mouth.

Nucleation field,reversal mechanism and coercivity paradox in two-phased magnetic nanosystem

The magnetic reversal mechanism has been determined within a micromagnetic model reliably for a two-phased magnetic nanosystem, with the formulae for nucleation fields derived analytically. It is found that the nucleation field HN decreases uni- formly as the size of the soft phase Ls increases whereas it increases with the size of the hard phase Lh. The analysis shows that whilst the effect of Lh could be ignored in most cases, where the nucleation field is dominated by the Ls and the calculation could be significantly simplified, the overly simple inverse square law between Hu and the soft layer thickness Ls adopted by the previous researchers is not a good approximation. While nucleation is the beginning of the magnetic reversal, pinning is the dominant coercivity mechanism in both two-phased and single-phased magnetic materials, where the crystalline defects exist. Comparison with the experimental data confirms this conclusion, indicating that Brown＇s paradox results from the much lower effective anisotropy in both single-phased and composite materials, as speculated in the literature.

Overview of researches on central action mechanism of needling Zusanli(ST 36)

The contents about the central action mechanisms of needling Zusanli（ST 36） were sorted by summarizing the relevant literatures published in the past 10 years, and it was found that： by comparing acupuncture at Zusanli（ST 36）, other acupoints or sham points, most studies showed that Zusanli（ST 36） had relatively specific characteristics in the brain function response; studies on the central action mechanisms of Zusanli（ST 36） were mainly focused on sequelae of cerebral apoplexy, pain, gastrointestinal diseases, weight loss and drug addiction withdrawal and so on; acupuncture manipulations, stimulation methods, individual differences, stimulation quantity, and stimulation duration, etc. could also induce different brain function responses; acupuncture at Zusanli（ST 36） had an after-working effect, also called long-term effect, but with poor repeatability. So, it was suggested that the future studies should focus on the factors that affect the clinical efficacies and experimental results, including the compatibility effects of the acupoints, reproducibility of research results, sample size, acupuncture methods, long-term effects and disease entities.

Study on the acupoints belonging to the three yin meridians of foot reflecting the variation pattern of uterine qi and blood in women with moderate constitution

Objective:To observe the blood perfusion volume variation pattern in the body surface microcirculation at the Yuan-Primary and the Xi-Cleft points during the menstrual cycle in female college students with moderate constitution under normal physiological state of the uterus;to explore the specific laws of the body surface microcirculation at the Yuan-Primary and Xi-Cleft points in response to the uterine qi and blood changes under normal physiological conditions,and to provide the experimental basis for the specificity of acupoints reflecting the uterine function.Methods:Forty-three healthy and moderate constitution female college students with regular menstrual cycles,without dysmenorrhea and not yet giving birth were recruited.Bilateral Yuan-Primary points[Taichong(LR 3),Taibai(SP 3)and Taixi(KI 3)]and Xi-Cleft points[Zhongdu(LR 6),Diji(SP 8)and Shuiquan(KI 5)],belonging to the three yin meridians of foot and adjacent to the spinal cord segment of the uterus,were selected as the detection acupoints;the crossing point of the three yin meridians of foot[Sanyinjiao(SP 6)],the uterus-related meridian acupoint[Xuehai(SP 10)],the uterus-non-related meridian acupoint[Xuanzhong(GB 39)],and the non-meridian non-acupoint point were selected as the control points.The laser speckle blood flow imaging technique was used to monitor the blood perfusion volume in skin microcirculation at the above points at the menstrual,follicular,ovulatory,and luteal phases of the subjects.Results:The blood perfusion volume in the body surface microcirculation at the right Zhongdu(LR 6)at the ovulatory phase was higher than that at the menstrual,follicular and luteal phases(all P<0.05);there was no significant difference in the microcirculation blood perfusion volume at the other points among different phases(all P>0.05).Conclusion:The blood perfusion volume in the body surface microcirculation at Zhongdu(LR 6),the Xi-Cleft point of the Liver Meridian,shows a specific response to qi and blood changes in the uterus of women with moderate constitution.