To solve aircraft arrival sequencing and scheduling problems,and improve the typical predatory search algorithm（PSA）,an innovative PSA is developed.The new PSA uses variable constraints of local search and global se...To solve aircraft arrival sequencing and scheduling problems,and improve the typical predatory search algorithm（PSA）,an innovative PSA is developed.The new PSA uses variable constraints of local search and global search to avoid falling into local optimal solutions and the degeneration of solutions.To test the performance of new PSA,a case study with ten arriving flights and two runways is performed.Test results show that the new PSA performs much better than typical PSA and genetic algorithm（GA）in the aspects of the rate of gaining optimal solutions and the computational time.展开更多
Endothelial cells(ECs)not only serve as a barrier between blood and extravascular space to modulate the exchange of fluid,macromolecules and cells,but also play a critical role in regulation of vascular homeostasis an...Endothelial cells(ECs)not only serve as a barrier between blood and extravascular space to modulate the exchange of fluid,macromolecules and cells,but also play a critical role in regulation of vascular homeostasis and adaptation under mechanical stimulus via intrinsic mechanotransduction.Recently,with the dissection of microdomains responsible for cellular responsiveness to mechanical stimulus,a lot of mechanosensing molecules(mechanosensors)and pathways have been identified in ECs.In addition,there is growing evidence that endothelial mechanosensors not only serve as key vascular gatekeepers,but also contribute to the pathogenesis of various vascular disorders.This review focuses on recent findings in endothelial mechanosensors in subcellular microdomains and their roles in regulation of physiological and pathological functions under mechanical stress.展开更多
文摘To solve aircraft arrival sequencing and scheduling problems,and improve the typical predatory search algorithm（PSA）,an innovative PSA is developed.The new PSA uses variable constraints of local search and global search to avoid falling into local optimal solutions and the degeneration of solutions.To test the performance of new PSA,a case study with ten arriving flights and two runways is performed.Test results show that the new PSA performs much better than typical PSA and genetic algorithm（GA）in the aspects of the rate of gaining optimal solutions and the computational time.
基金supported by the National Natural Science Foundation of China(91339111,31221002)National Basic Research Program of China(2012CB945100)to Luo JinCai
文摘Endothelial cells(ECs)not only serve as a barrier between blood and extravascular space to modulate the exchange of fluid,macromolecules and cells,but also play a critical role in regulation of vascular homeostasis and adaptation under mechanical stimulus via intrinsic mechanotransduction.Recently,with the dissection of microdomains responsible for cellular responsiveness to mechanical stimulus,a lot of mechanosensing molecules(mechanosensors)and pathways have been identified in ECs.In addition,there is growing evidence that endothelial mechanosensors not only serve as key vascular gatekeepers,but also contribute to the pathogenesis of various vascular disorders.This review focuses on recent findings in endothelial mechanosensors in subcellular microdomains and their roles in regulation of physiological and pathological functions under mechanical stress.
