超体质量、肥胖及黑棘皮病与空腹指血血糖相关性调查

目的通过对超体质量、肥胖及黑棘皮病的儿童青少年空腹末梢指血血糖的测定,进一步探讨超体质量、肥胖及黑棘皮病对儿童青少年血糖的影响。方法对19 112例北京市在读6-18岁中小学生进行临床查体,包括皮肤黑棘皮病及身高、体质量等,测定空腹末梢指血血糖。结果超体质量、肥胖和黑棘皮病儿童青少年检出率分别为21.38%、9.7%和2.43%。在空腹末梢指血血糖≥5.6 mmol/L和≥6.1 mmol/L 2组,超体质量、肥胖儿童青少年阳性率分别显著高于空腹末梢指血血糖〈5.6mmol/L和〈6.1 mmol/L 2组,本调查还发现在空腹末梢指血血糖≥5.6 mmol/L组黑棘皮病儿童青少年阳性率显著高于空腹末梢指血血糖〈5.6 mmol/L组。5.6 mmol/L和6.1 mmol/L两界值比较,后者并没有显示出优势。结论6-18岁超体质量、肥胖及黑棘皮病学龄儿童青少年出现空腹末梢指血血糖≥5.6 mmol/L几率显著增高。超体质量、肥胖及黑棘皮病学龄儿童青少年应作为糖尿病的高危人群进行早期筛查,建议空腹末梢指血血糖分界值为5.6 mmol/L。

糖尿病家族史与儿童青少年空腹指血血糖关系的调查

目的探讨糖尿病家族史与儿童青少年指血血糖的关系。方法以北京市全体中小学生为研究对象,于2004年4-10月对北京全体中小学生(6～18岁)通过整群抽样,共19112例在读中小学生(男9522名,女9590名)进行统计分析。采用统一设计的调查问卷(包括人口统计学特征、疾病史和家族史等)。问卷由家长和学生在调查人员帮助下共同填写,并对所有调查对象进行指微量血糖检测。结果在6～18岁空腹末梢指血血糖≥5.6mmol/L组,家族中一级亲属患糖尿病阳性率明显高于空腹末梢指血血糖<5.6mmol/L组,差异具有统计学意义(P=0.0002)。在空腹指血血糖≥5.6mmol/L组,父亲和母亲患糖尿病构成比无明显差异(P=0.509),不支持母系遗传的优势。父亲和母亲患糖尿病对不同性别子代血糖影响亦无明显差异(P=0.056)。结论父母患糖尿病的家族史对子女患糖尿病的意义尤为重要,即有一级亲属阳性家族史的子女更易出现血糖异常,应早期监测血糖。

Retrospective study of Traditional Chinese Medicine treatment of type 2 diabetes mellitus

OBJECTIVE: To provide clinical evidence in support of Dahuang Huanglian Xiexin decoction(DHXD) to treat type 2 diabetes mellitus(T2DM) and to introduce a new treatment option for clinicians.METHODS: Retrospective analysis was used to evaluate DHXD for the treatment of T2DM by analyzing clinical records of 183 cases. Patients with T2DM who met the inclusion criteria between January 1,2013 and January 1, 2014 were enrolled. The effects of the treatment were evaluated by the changes in fasting blood-glucose(FBG), postprandial blood sugar(PBG), hemoglobin A1c(Hb Alc), blood lipid profiles and body mass index(BMI) at 1, 2, 3 and 6 months. The changes in main symptoms were alsoevaluated. The dosage of Huanglian(Rhizoma Coptidis) and related factors were analyzed.RESULTS: There was a significant improvement in mean Hb A1C at 3 and 6 months after DHXD treatment compared with the baseline level(P < 0.01).There were also significant improvements in FBG,PBG, blood lipid series and BMI. DHXD also improved the main symptoms of stomach and intestine excessive heat syndrome in patients with obese T2DM. Huanglian(Rhizoma Coptidis) was the most frequently used in 678 clinical visits, the dosage of Huanglian(Rhizoma Coptidis) was related to age, BMI, DM duration, the level of blood glucose,and use of Western hypoglycemic drugs.CONCLUSION: This study suggests that DHXD could decrease blood glucose and improve T2DM symptoms and reduce body weight. The use of DHXD may indicate a new optional treatment for T2 DM.