For the diagnosis of glaucoma,optical coherence tomography(OCT)is a noninvasive imaging technique for the assessment of retinal layers.To accurately segment intraretinal layers in an optic nerve head(ONH)region,we pro...For the diagnosis of glaucoma,optical coherence tomography(OCT)is a noninvasive imaging technique for the assessment of retinal layers.To accurately segment intraretinal layers in an optic nerve head(ONH)region,we proposed an automatic method for the segmentation of three intraretinal layers in eye OCT scans centered on ONH.The internal limiting membrane,inner segment and outer segment,Bruch’s membrane surfaces under vascular shadows,and interaction of multiple high-reflectivity regions in the OCT image can be accurately segmented through this method.Then,we constructed a novel spatial-gradient continuity constraint,termed spatial-gradient continuity constraint,for the correction of discontinuity between adjacent image segmentation results.In our experiment,we randomly selected 20 B-scans,each annotated three retinal layers by experts.Signed distance errors of?0.80μm obtained through this method are lower than those obtained through the state-of-art method(?1.43μm).Meanwhile,the segmentation results can be used as bases for the diagnosis of glaucoma.展开更多
This paper presents a trust region algorithm with null space technique fornonlinear equality constrained optimization. Considering in the null space methods that,the convergent rate of range space step is faster than ...This paper presents a trust region algorithm with null space technique fornonlinear equality constrained optimization. Considering in the null space methods that,the convergent rate of range space step is faster than the null space step for the most cases,the proposed algorithm computes null steps more often than range space step. Moreover,the new algorithm is based on the reduced Hessian SQP method. Global convergence ofthe proposed algorithm is proved. The effectiveness of the method is demonstrated bysome numerical examples.展开更多
基金Projects(61672542,61573380)supported by the National Natural Science Foundation of China
文摘For the diagnosis of glaucoma,optical coherence tomography(OCT)is a noninvasive imaging technique for the assessment of retinal layers.To accurately segment intraretinal layers in an optic nerve head(ONH)region,we proposed an automatic method for the segmentation of three intraretinal layers in eye OCT scans centered on ONH.The internal limiting membrane,inner segment and outer segment,Bruch’s membrane surfaces under vascular shadows,and interaction of multiple high-reflectivity regions in the OCT image can be accurately segmented through this method.Then,we constructed a novel spatial-gradient continuity constraint,termed spatial-gradient continuity constraint,for the correction of discontinuity between adjacent image segmentation results.In our experiment,we randomly selected 20 B-scans,each annotated three retinal layers by experts.Signed distance errors of?0.80μm obtained through this method are lower than those obtained through the state-of-art method(?1.43μm).Meanwhile,the segmentation results can be used as bases for the diagnosis of glaucoma.
基金This research is partly supported by the Hunan Provincial Natural Science Foundtion of China and Hunan Provincial Education Foundation of China 02B021
文摘This paper presents a trust region algorithm with null space technique fornonlinear equality constrained optimization. Considering in the null space methods that,the convergent rate of range space step is faster than the null space step for the most cases,the proposed algorithm computes null steps more often than range space step. Moreover,the new algorithm is based on the reduced Hessian SQP method. Global convergence ofthe proposed algorithm is proved. The effectiveness of the method is demonstrated bysome numerical examples.
