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基于TRIZ原理的灭活疫苗中抗原空间表位的创新应用 被引量:2
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作者 张琳 丁雅苓 +1 位作者 武军 徐敏丽 《科技创新与应用》 2015年第15期19-20,共2页
TRIZ是技术和产品创新一种重要方法,已在农机装备、农业金融、农产品加工等农业领域成功的进行了应用,但兽医领域尚未尝试。本研究基于TRIZ原理,应用系统分析、三轴分析和矛盾分析对灭活疫苗生产过程中病原蛋白质的破坏问题进行了剖析,... TRIZ是技术和产品创新一种重要方法,已在农机装备、农业金融、农产品加工等农业领域成功的进行了应用,但兽医领域尚未尝试。本研究基于TRIZ原理,应用系统分析、三轴分析和矛盾分析对灭活疫苗生产过程中病原蛋白质的破坏问题进行了剖析,创新性提出了利用抗原空间表位建立灭活疫苗安全性检验的新方法,反向指示疫苗是否安全的新思路。研究结果证实,TRIZ理论完全可以在兽医领域中应用,能够为技术难题提供新思路和方案。 展开更多
关键词 TRIZ原理 灭活疫苗 抗原空间表位
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甲型H1N1流感病毒HA蛋白结构模建与构象表位分析 被引量:6
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作者 流感研究上海协作组 吴迪 +30 位作者 徐天磊 孙静 戴建新 丁国徽 何云刚 周正峰 熊慧 董辉 金维荣 边超 金力 王红艳 王小宁 杨忠 钟扬 王皓 车小燕 黄忠 蓝柯 孙兵 吴凡 袁政安 张曦 周晓农 周佳海 马志永 童光志 郭亚军 赵国屏 李亦学 曹志伟 《科学通报》 EI CAS CSCD 北大核心 2009年第12期1642-1644,共3页
最近几个月来,一种新型流感病毒H1N1在全球流行.本文运用生物信息技术,从NCBI发布的新型AH1N1流感病毒基因序列出发,通过同源模建方法构建了HA蛋白三维结构,利用自主开发的蛋白抗原空间表位预测程序SEPPA预测了HA蛋白潜在空间表位氨基酸... 最近几个月来,一种新型流感病毒H1N1在全球流行.本文运用生物信息技术,从NCBI发布的新型AH1N1流感病毒基因序列出发,通过同源模建方法构建了HA蛋白三维结构,利用自主开发的蛋白抗原空间表位预测程序SEPPA预测了HA蛋白潜在空间表位氨基酸,并与以往流感病毒HA蛋白潜在构象表位进行了比较.结果发现HA蛋白中58个氨基酸残基具有较强的免疫原性,大部分在HA蛋白球状头部表面上聚集成簇,构成空间抗原表位.与以往流感病毒HA蛋白潜在空间表位相比,虽然坐落位置相似,但新的抗原表位在静电势性质上明显不同于以往流感病毒HA蛋白抗原表位. 展开更多
关键词 甲型H1N1流感病毒HA蛋白 空间表位 生物信息学
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REMARKS ON THE REPRESENTATION THEOREM FOR RIESZ SPACES POSSESSING WEAK UNITS
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作者 熊洪允 《Transactions of Tianjin University》 EI CAS 1995年第1期10+6-10,共6页
The author obtains an algebraic version of the main result from his previous paper 'A characterization of Riesz spaces which are Riesz isomorphic to C(X) for some completely regular space X', and also studies... The author obtains an algebraic version of the main result from his previous paper 'A characterization of Riesz spaces which are Riesz isomorphic to C(X) for some completely regular space X', and also studies the relations among some conditions used therein. 展开更多
关键词 Riesz space weak unit REPRESENTATION
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Spatial differentiation in stable isotope compositions of surface waters and its environmental significance in the Issyk-Kul Lake region of Central Asia 被引量:2
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作者 MA Long JILILI Abuduwaili LI Yao-ming 《Journal of Mountain Science》 SCIE CSCD 2018年第2期254-263,共10页
Stable isotope values of oxygen (180) and hydrogen (2H) of surface waters were used to study the origin and environmental significanees in the Issyk-Kul basin of Kyrgyzstan in Central Asia, which is the most impor... Stable isotope values of oxygen (180) and hydrogen (2H) of surface waters were used to study the origin and environmental significanees in the Issyk-Kul basin of Kyrgyzstan in Central Asia, which is the most important intermountain basin in the modern Tien Shan orogen. This study is the first analysis of hydrochemical spatial differentiation in the stable isotopes of surface waters in this watershed. 75 samples were collected from rivers, springs, lakes, rain and snow during the rainy season in July and August of 2o16. Stable isotopes of 180 and 2H were studied for all samples, and cation ratios (Sr/Ca and Mg/Ca) were also determined for lake water samples. Stable isotope values from precipitation scattered around the Local Meteoric Water Line (determined from Urumqi Station of the global network of isotopes in precipitation (GNIP)), together with values of the Deuterium excess parameter (d) from 15.3‰ to 30.5‰, with an average of 19.8‰, indicating that the moisture sources are primarily from regions with low relative humidity. The 8180 and 52H values were significantly different between the river and lake samples, indicating that regional evaporation caused the isotopic enrichment of lake water. Geospatial autocorrelation, measured by Moran's I coefficient, indicated weak spatial autocorrelation within stable isotopes of oxygen and hydrogen in the surface waters of the studied area, which is primarily an effect of climate during the water chemistry evolution. The cation ratios Sr/Ca and Mg/Ca in lake water samples were not correlated with the concentration of total dissolved solids, but did show correlation with stable isotopic values, which is significant for paleoenvironmental reconstruction. 展开更多
关键词 Spatial differentiation Stable isotope Moisture Sources Geospatial autocorrelation IssykKul Lake Central Asia
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Flotation of kaolinite with dodecyl tertiary amines 被引量:1
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作者 曹学锋 刘长淼 胡岳华 《Journal of Central South University》 SCIE EI CAS 2009年第5期749-752,共4页
The flotation of kaolinite using a series of tertiary amines (N,N-dimethyl-dodecyl amine (DRN), N,N-diethyl-dodecyl amine (DEN), N,N-dipropyl-dodecyl amine (DPN) and N,N-dibenzyl-bodecyl amine (DBN)) was inv... The flotation of kaolinite using a series of tertiary amines (N,N-dimethyl-dodecyl amine (DRN), N,N-diethyl-dodecyl amine (DEN), N,N-dipropyl-dodecyl amine (DPN) and N,N-dibenzyl-bodecyl amine (DBN)) was investigated. The results show that the maximum recoveries of kaolinite for DEN, DPN and DRN are 93%, 88% and 84%, respectively, but that of DBN is very low. On the basis of zeta potential and FT-IR spectra, the ionization of surface hydroxyl and isomorphic exchange of surface ions account for the charging mechanisms of kaolinite surface. The adsorption mechanism of tertiary amines on kaolinite surface is mainly electrostatic. The isoelectric point (IEP) of kaolinite increases from 3.4 to some more positive points after the interaction of kaolinite with the four tertiary amines. The FT-IR spectra of kaolinite change with the presence of some new sharp shapes belonging to the tertiary amines. The inductive electronic effects and space-steric effects of -CH3, -C2H5, -C3H7 and -C7H7 bonding to N atom result in different collecting power of the four tertiary amines. 展开更多
关键词 KAOLINITE tertiary amine FLOTATION electrostatic effect inductive electronic effect space-steric effect RECOVERY
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Hamlet's Mobled Queen: The Displacement of the Figure in Contemporary Discourse, Communication, and Art
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作者 Ewa Bobrowska 《Sociology Study》 2017年第3期160-167,共8页
The paper will focus on communication through the figures of discourse. The problem of the entanglement of the visual and the semantic is discussed extensively by lean-Francois Lyotard, in his notable Discourse, Figur... The paper will focus on communication through the figures of discourse. The problem of the entanglement of the visual and the semantic is discussed extensively by lean-Francois Lyotard, in his notable Discourse, Figure, in relation to the perception and representation of space and the role and form of the sign. According to this philosopher, the figure dominates the communication process by deconstructing the text. Both the topography of the figure and art is the result of repression processes and the subsequent discharge of libidinal energy. Art in particular is a formalism of the death drive, according to Lyotard. The figure of "the mobled queen", the expression of a possible slip of the tongue in Hamlet, becomes a symbol of the distorted relationship of the visual, the semantic, the ethical, and the critical role of this in art and communication. In addition to Lyotard's model, the possible figures of globalization will be discussed in relation to Peter Sloterdik's Globes. Spheres II. 展开更多
关键词 HAMLET mobled queen the figure Lyotard contemporary philosophy contemporary art
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An Improved Method for Modeling Spatial Distribution of δD in Surface Snow over Antarctic Ice Sheet
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作者 WANG Yetang HOU Shugui +1 位作者 Bjom GRIGHOLM SONG Linlin 《Chinese Geographical Science》 SCIE CSCD 2009年第2期120-125,共6页
Using the recent compilation of the isotopic composition data of surface snow of Antarctic ice sheet, we proposed an improved interpolation method of δD, which utilizes geographical factors (i.e., latitude and altit... Using the recent compilation of the isotopic composition data of surface snow of Antarctic ice sheet, we proposed an improved interpolation method of δD, which utilizes geographical factors (i.e., latitude and altitude) as the primary predictors and incorporates inverse distance weighting (IDW) technique. The method was applied to a high-resolution digital elevation model (DEM) to produce a grid map of multi-year mean δD values with lkm spatial resolution for Antarctica. The mean absolute deviation between observed and estimated data in the map is about 5.4‰, and the standard deviation is 9‰. The resulting δD pattern resembles well known characteristics such as the depletion of the heavy isotopes with increasing latitude and distance from coast line, but also reveals the complex topographic effects. 展开更多
关键词 δD surface snow ice sheet ANTARCTICA
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