日本顺天堂大学医学部免疫学教授奥村康和真贝洋一、理化学研究所国际研究新领域系统研究员泷尾扩士等合作,首次在世界上精制了 T 杀伤细胞和天然杀伤细胞担负杀伤靶细胞任务的穿孔蛋白(或穿孔素,Perforin),并以此成果为基础,克隆了 cDN...日本顺天堂大学医学部免疫学教授奥村康和真贝洋一、理化学研究所国际研究新领域系统研究员泷尾扩士等合作,首次在世界上精制了 T 杀伤细胞和天然杀伤细胞担负杀伤靶细胞任务的穿孔蛋白(或穿孔素,Perforin),并以此成果为基础,克隆了 cDNA。这项研究是与住友电工公司共同进行的。已由公司申请了专利。这项成果除已在《Na-展开更多
We analysed data of 96 infants (under 1 year of age) with haemophagocytic lymp hohistiocytosis (HLH) from the registry of an HLH study conducted during 1986-2 002 in Japan. The cases were classified into five groups. ...We analysed data of 96 infants (under 1 year of age) with haemophagocytic lymp hohistiocytosis (HLH) from the registry of an HLH study conducted during 1986-2 002 in Japan. The cases were classified into five groups. The diagnosis of famil ial HLH (FHL) as group 1 (n =27) wasmade with positive family history and/or rec ent molecular test for perforin and Munc13-4 mutations. Neonatal enterovirus-o r herpes simplex virus-associated HLH as group 2a (n =7), Epstein-Barr virus- associated HLH (n =12) as group 2b, adenovirus-or cytomegalovirus-associated H LH as group 3 (n =9)were mostly diagnosed by viral isolation or by the detection of viral genome. Juvenile rheumatoid arthritis-associated macrophage activatio n syndrome was classified as group 4 (n =4) and the remaining without known trig gers as group 5 (n =37). The peak onset age was 1-2 months for group 1, 1-2 we eks for group 2a, 12 months for group 2b, none for group 3, 9 months for group 4 and 2 months for group 5. Future novel diagnostic measures are required to defi ne the precise nature of HLH in group 5. Conclusion:These data may provide usefu l information for neonatologists/ paediatricians in the differential diagnosis o f haemophagocytic lymphohistiocytosis in early infancy.展开更多
We report a case of a 63-year-old male who experienced an iatrogenic sigmoid perforation repaired combining three endoscopic techniques.The lesion was large and irregular with three discrete perforations,therefore,we ...We report a case of a 63-year-old male who experienced an iatrogenic sigmoid perforation repaired combining three endoscopic techniques.The lesion was large and irregular with three discrete perforations,therefore,we decided to close it by placing one clip per perforation,and then connecting all the clips with two endoloops.Finally we chose to use a fibrin glue injection to obtain a complete sealing.Four days after the colonoscopy the patient underwent a laparoscopic right hemicolectomy due to evidence of a large polyp of the caecum with high grade dysplasia and focal carcinoma in situ.Inspection of the sigma showed complete repair of the perforation.This report underlines how a conservative approach,together with a combination of various endoscopic techniques,can resolve complicated iatrogenic perforations of the colon.展开更多
文摘日本顺天堂大学医学部免疫学教授奥村康和真贝洋一、理化学研究所国际研究新领域系统研究员泷尾扩士等合作,首次在世界上精制了 T 杀伤细胞和天然杀伤细胞担负杀伤靶细胞任务的穿孔蛋白(或穿孔素,Perforin),并以此成果为基础,克隆了 cDNA。这项研究是与住友电工公司共同进行的。已由公司申请了专利。这项成果除已在《Na-
文摘We analysed data of 96 infants (under 1 year of age) with haemophagocytic lymp hohistiocytosis (HLH) from the registry of an HLH study conducted during 1986-2 002 in Japan. The cases were classified into five groups. The diagnosis of famil ial HLH (FHL) as group 1 (n =27) wasmade with positive family history and/or rec ent molecular test for perforin and Munc13-4 mutations. Neonatal enterovirus-o r herpes simplex virus-associated HLH as group 2a (n =7), Epstein-Barr virus- associated HLH (n =12) as group 2b, adenovirus-or cytomegalovirus-associated H LH as group 3 (n =9)were mostly diagnosed by viral isolation or by the detection of viral genome. Juvenile rheumatoid arthritis-associated macrophage activatio n syndrome was classified as group 4 (n =4) and the remaining without known trig gers as group 5 (n =37). The peak onset age was 1-2 months for group 1, 1-2 we eks for group 2a, 12 months for group 2b, none for group 3, 9 months for group 4 and 2 months for group 5. Future novel diagnostic measures are required to defi ne the precise nature of HLH in group 5. Conclusion:These data may provide usefu l information for neonatologists/ paediatricians in the differential diagnosis o f haemophagocytic lymphohistiocytosis in early infancy.
文摘We report a case of a 63-year-old male who experienced an iatrogenic sigmoid perforation repaired combining three endoscopic techniques.The lesion was large and irregular with three discrete perforations,therefore,we decided to close it by placing one clip per perforation,and then connecting all the clips with two endoloops.Finally we chose to use a fibrin glue injection to obtain a complete sealing.Four days after the colonoscopy the patient underwent a laparoscopic right hemicolectomy due to evidence of a large polyp of the caecum with high grade dysplasia and focal carcinoma in situ.Inspection of the sigma showed complete repair of the perforation.This report underlines how a conservative approach,together with a combination of various endoscopic techniques,can resolve complicated iatrogenic perforations of the colon.
