BACKGROUND AND OBJECTIVE: To study the outcome of therapeutic penetrating kera toplasty in eyes with microbial keratitis. PATIENTS AND METHODS: A prospective d atabase on 134 therapeutic cornea transplants in 134 pati...BACKGROUND AND OBJECTIVE: To study the outcome of therapeutic penetrating kera toplasty in eyes with microbial keratitis. PATIENTS AND METHODS: A prospective d atabase on 134 therapeutic cornea transplants in 134 patients recorded demograph ic details on age and gender of the patient, indication for surgery, size of the donor and recipient bed, graft clarity, complications, and residualmorbidity. P atients included in this analysis had a minimum follow-up of 1 year. All patien ts underwent therapeutic penetrating keratoplasty by a similar method that invol ved a donor button that was oversized by 0.5 mm and 16 bites of interrupted sutu res. RESULTS: Most of the 134 ulcers needing therapeutic grafts were bacterial ( n=54) or fungal (n=54). One hundred eighteen eyes had perforation at presentatio n. One hundred six (90%) of the therapeutic grafts achieved anatomical success. The most common complication of glaucoma occurred in 22%of eyes with presurgic al perforated ulcers and 1%of nonperforated ulcers. Persistent epithelial defec ts were significantly more frequent in grafts of 9 mm or more (P=.05). CONCLUSIO NS: Our results con-firm that therapeutic penetrating keratoplasty for infectio ns is successful in restoring anatomic integrity in most eyes.展开更多
文摘BACKGROUND AND OBJECTIVE: To study the outcome of therapeutic penetrating kera toplasty in eyes with microbial keratitis. PATIENTS AND METHODS: A prospective d atabase on 134 therapeutic cornea transplants in 134 patients recorded demograph ic details on age and gender of the patient, indication for surgery, size of the donor and recipient bed, graft clarity, complications, and residualmorbidity. P atients included in this analysis had a minimum follow-up of 1 year. All patien ts underwent therapeutic penetrating keratoplasty by a similar method that invol ved a donor button that was oversized by 0.5 mm and 16 bites of interrupted sutu res. RESULTS: Most of the 134 ulcers needing therapeutic grafts were bacterial ( n=54) or fungal (n=54). One hundred eighteen eyes had perforation at presentatio n. One hundred six (90%) of the therapeutic grafts achieved anatomical success. The most common complication of glaucoma occurred in 22%of eyes with presurgic al perforated ulcers and 1%of nonperforated ulcers. Persistent epithelial defec ts were significantly more frequent in grafts of 9 mm or more (P=.05). CONCLUSIO NS: Our results con-firm that therapeutic penetrating keratoplasty for infectio ns is successful in restoring anatomic integrity in most eyes.
