Acute myeloid leukemia(AML) is a clonal disorder characterized by the accumulation of complex genomic alterations that define the disease pathophysiology and overall outcome. Recent advances in sequencing technologies...Acute myeloid leukemia(AML) is a clonal disorder characterized by the accumulation of complex genomic alterations that define the disease pathophysiology and overall outcome. Recent advances in sequencing technologies have described the molecular landscape of AML and identified several somatic alterations that impact overall survival. Despite all these advancement, several challenges remain in translating this information into effective therapy. Herein we will review the molecular landscape of AML and discuss the impact of the most common somatic mutations on disease biology and outcome.展开更多
A brief review of the former studies on the mechanisms of soil rheology and microstructure is presented. Then a microstructure model and a set of rheological constitutive relations for sott clays, which describe how t...A brief review of the former studies on the mechanisms of soil rheology and microstructure is presented. Then a microstructure model and a set of rheological constitutive relations for sott clays, which describe how the rheological consolidation settlement develops, are established in the framework of the catastrophe theory. The validity of this model is verified by a series of rheological consolidation experiments with different loading rates. The experimental data show that creep deformation can be clearly observed in these tests, and the consolidation settlement is loading rate dependent. The characteristics of the deformation can be explained and reproduced successfully using the model. It can be concluded that only the biggest set of voids would collapse for one load increment. Parameters in the model, k and η, are gained by curve fitting. With only two free parameters, good fits of the data are achieved.展开更多
文摘Acute myeloid leukemia(AML) is a clonal disorder characterized by the accumulation of complex genomic alterations that define the disease pathophysiology and overall outcome. Recent advances in sequencing technologies have described the molecular landscape of AML and identified several somatic alterations that impact overall survival. Despite all these advancement, several challenges remain in translating this information into effective therapy. Herein we will review the molecular landscape of AML and discuss the impact of the most common somatic mutations on disease biology and outcome.
基金Project(51079126) supported by the National Natural Science Foundation of ChinaProject(Y1090971) supported by the Natural Science Foundation of Zhejiang Province, China
文摘A brief review of the former studies on the mechanisms of soil rheology and microstructure is presented. Then a microstructure model and a set of rheological constitutive relations for sott clays, which describe how the rheological consolidation settlement develops, are established in the framework of the catastrophe theory. The validity of this model is verified by a series of rheological consolidation experiments with different loading rates. The experimental data show that creep deformation can be clearly observed in these tests, and the consolidation settlement is loading rate dependent. The characteristics of the deformation can be explained and reproduced successfully using the model. It can be concluded that only the biggest set of voids would collapse for one load increment. Parameters in the model, k and η, are gained by curve fitting. With only two free parameters, good fits of the data are achieved.
