抑郁症严重危害人类身心健康。目前,抗抑郁药物存在初始治疗有效率低、起效慢、无法快速缓解抑郁症患者的痛苦等缺陷。研究发现,氯胺酮对难治型抑郁症患者有快速抗抑郁作用。动物模型的分子生物学和细胞学研究表明,氯胺酮通过激活哺乳...抑郁症严重危害人类身心健康。目前,抗抑郁药物存在初始治疗有效率低、起效慢、无法快速缓解抑郁症患者的痛苦等缺陷。研究发现,氯胺酮对难治型抑郁症患者有快速抗抑郁作用。动物模型的分子生物学和细胞学研究表明,氯胺酮通过激活哺乳动物西罗莫司靶蛋白(mammalian target of rapamycin,m TOR)信号通路来激发哺乳动物西罗莫司靶蛋白及其下游分子的翻译起始过程,从而增加前额叶皮层棘突突触的成熟度和数量,达到抑郁症治疗的目的。这些研究提示哺乳动物西罗莫司靶蛋白信号通路在氯胺酮快速抗抑郁作用中发挥重要作用,其在探索新型高效抗抑郁药物中具有巨大的潜力。展开更多
Since Caenorhabditis elegans was chosen as a model organism by Sydney Brenner in 1960's, genetic studies in this organism have been instrumental in discovering the function of genes and in deciphering molecular si...Since Caenorhabditis elegans was chosen as a model organism by Sydney Brenner in 1960's, genetic studies in this organism have been instrumental in discovering the function of genes and in deciphering molecular signaling network. The small size of the organism and the simple nervous system enable the complete reconstruction of the first connectome. The stereotypic developmental program and the anatomical reproducibility of synaptic connections provide a blueprint to dissect the mechanisms underlying synapse formation. Recent technological innovation using laser surgery of single axons and in vivo imaging has also made C. elegans a new model for axon regeneration. Importantly, genes regulating synaptogenesis and axon regeneration are highly conserved in function across animal phyla. This mini-review will summarize the main approaches and the key findings in understanding the mechanisms underlying the development and maintenance of the nervous system. The impact of such findings underscores the awesome power of C. elegans genetics.展开更多
Erratum to:SCIENCE CHINA Life Sciences,November 2015 Vol.58 No.11:1084–1088doi:10.1007/s11427-015-4962-9In the first paragraph of the manuscript,the name of Charles Harrington was printed in error,should be Charles S...Erratum to:SCIENCE CHINA Life Sciences,November 2015 Vol.58 No.11:1084–1088doi:10.1007/s11427-015-4962-9In the first paragraph of the manuscript,the name of Charles Harrington was printed in error,should be Charles Sherrington.展开更多
文摘抑郁症严重危害人类身心健康。目前,抗抑郁药物存在初始治疗有效率低、起效慢、无法快速缓解抑郁症患者的痛苦等缺陷。研究发现,氯胺酮对难治型抑郁症患者有快速抗抑郁作用。动物模型的分子生物学和细胞学研究表明,氯胺酮通过激活哺乳动物西罗莫司靶蛋白(mammalian target of rapamycin,m TOR)信号通路来激发哺乳动物西罗莫司靶蛋白及其下游分子的翻译起始过程,从而增加前额叶皮层棘突突触的成熟度和数量,达到抑郁症治疗的目的。这些研究提示哺乳动物西罗莫司靶蛋白信号通路在氯胺酮快速抗抑郁作用中发挥重要作用,其在探索新型高效抗抑郁药物中具有巨大的潜力。
基金supported by National Basic Research Development Program of China(No.2010CB912002)the Natural ScienceFoundation of Zhejiang Province,China(No.LY12C09001)Fundamental Research Funds for the Central Universities of China(No.2012QNA7007)
基金support from the National Institute of Healththe Howard Hughes Medical Institute of the United States of America
文摘Since Caenorhabditis elegans was chosen as a model organism by Sydney Brenner in 1960's, genetic studies in this organism have been instrumental in discovering the function of genes and in deciphering molecular signaling network. The small size of the organism and the simple nervous system enable the complete reconstruction of the first connectome. The stereotypic developmental program and the anatomical reproducibility of synaptic connections provide a blueprint to dissect the mechanisms underlying synapse formation. Recent technological innovation using laser surgery of single axons and in vivo imaging has also made C. elegans a new model for axon regeneration. Importantly, genes regulating synaptogenesis and axon regeneration are highly conserved in function across animal phyla. This mini-review will summarize the main approaches and the key findings in understanding the mechanisms underlying the development and maintenance of the nervous system. The impact of such findings underscores the awesome power of C. elegans genetics.
文摘Erratum to:SCIENCE CHINA Life Sciences,November 2015 Vol.58 No.11:1084–1088doi:10.1007/s11427-015-4962-9In the first paragraph of the manuscript,the name of Charles Harrington was printed in error,should be Charles Sherrington.
