Aim To prepare and characterize solid dispersions of silymarin with the intention of improving their dissolution properties. Methods The solid dispersions were prepared by the fusion method with polyethylene glycol ...Aim To prepare and characterize solid dispersions of silymarin with the intention of improving their dissolution properties. Methods The solid dispersions were prepared by the fusion method with polyethylene glycol 6000(PEG 6000) as the carrier. Evaluation of the properties of the dispersions was performed using dissolution studies, X ray powder diffraction and Fourier transform infrared (FT IR) spectroscopy. Results The rate of dissolution of silymarin was considerably improved as compared with pure silymarin when formulated in solid dispersions with PEG 6000. The data of the X ray diffraction showed some changes in the parameters of lattice spacing [ d ], peak position and relative intensities. FT IR together with those from X ray diffraction showed the absence of well defined drug polymer interactions. Conclusion The dissolution improvement of poorly soluble silymarin could be illuminated by the changes of the lattice parameters of PEG 6000 and the drug.展开更多
Additive manufacturing(AM),also known as 3D-printing(3DP)technology,is an advanced manufacturing technology that has developed rapidly in the past 40 years.However,the ceramic material printing is still challenging be...Additive manufacturing(AM),also known as 3D-printing(3DP)technology,is an advanced manufacturing technology that has developed rapidly in the past 40 years.However,the ceramic material printing is still challenging because of the issue of cracking.Indirect 3D printing has been designed and drawn attention because of its high manufacturing speed and low cost.Indirect 3D printing separates the one-step forming process of direct 3D printing into binding and material sintering,avoiding the internal stress caused by rapid cooling,making it possible to realize the highquality ceramic component with complex shape.This paper presents the research progress of leading indirect 3D printing technologies,including binder jetting(BJ),stereolithography(SLA),and fused deposition modeling(FDM).At present,the additive manufacturing of ceramic materials is mainly achieved through indirect 3D printing technology,and these materials include silicon nitride,hydroxyapatite functional ceramics,silicon carbide structural ceramics.展开更多
Collisions between hot H atoms and CO2 molecules were studied experimentally by time resolved Fourier transform infrared emission spectroscopy. H atoms with three translational energies, 174.7, 241.0 and 306.2 k J/mol...Collisions between hot H atoms and CO2 molecules were studied experimentally by time resolved Fourier transform infrared emission spectroscopy. H atoms with three translational energies, 174.7, 241.0 and 306.2 k J/mol respectively, were generated by UV laser photolysis to initiate a chemical reaction of H+CO2→OH+CO. Vibrationally excited CO (v≤2) was observed in the spectrum, where CO was the product of the reaction. The highly efficient T-V energy transfer fro,n the hot H atoms to the CO2 was verified too. The highest vibrational level of v=4 in CO2 (va) was found. Rate ratio of the chemical reaction to the energy transfer was estimated as 10.展开更多
This paper investigates in detail the dynamics of the modified KdV equation with self-consistent sources, including characteristics of one-soliton, scattering conditions and phase shifts of two solitons, degenerate ca...This paper investigates in detail the dynamics of the modified KdV equation with self-consistent sources, including characteristics of one-soliton, scattering conditions and phase shifts of two solitons, degenerate case of two solitons and "ghost" solitons, etc. Co-moving coordinate frames are employed in asymptotic analysis.展开更多
AIM: To evaluate the efficacy and complications of stereotactic body radiotherapy in localized paraaortic lymph node recurrence from colorectal cancer. METHODS: From 2003 to 2009, 7 patients with paraaortic lymph no...AIM: To evaluate the efficacy and complications of stereotactic body radiotherapy in localized paraaortic lymph node recurrence from colorectal cancer. METHODS: From 2003 to 2009, 7 patients with paraaortic lymph node recurrence (1-3 lesions) from colorectal cancer were treated with stereotactic body radiotherapy. Total gross tumor volumes ranged from 4 to 40 mL. The doses were escalated from 36 Gy/patient to 51 Gy/patient and were delivered in 3 fractions. RESULTS: One and 3 year overall survival rates were 100% and 71.4%, respectively, and median survival was 37 mo. Grade IV intestinal obstruction was reported in 1 of 7 patients. This patient received 48 Gy in 3 fractions with a maximum point dose to the intestine of 53 Gy and V45Gy = 3.6 mL. However, 6 patients received an intestinal maximum point dose of 〈 51 Gy and V45Gy of 〈 1 mL, and did not develop any severe complications. CONCLUSION: This pilot study suggests selected paraaortic lymph node recurrence (1-3 closed lesions) that failed to respond to chemotherapy can be potentially salvaged by stereotactic body radiotherapy.展开更多
Lymph node (LN) metastases from hepatocellular carcinoma (HCC) are considered uncommon. We describe the surgical resection of a solitary para-aortic LN metastasis from HCC. A 65-year-old Japanese man with B-type liver...Lymph node (LN) metastases from hepatocellular carcinoma (HCC) are considered uncommon. We describe the surgical resection of a solitary para-aortic LN metastasis from HCC. A 65-year-old Japanese man with B-type liver cirrhosis was admitted for the evaluation of a liver tumor. He had already undergone radiofrequency ablation, transcatheter arterial chemoembolization, and percutaneous ethanol injection therapy for HCC. Despite treatment, viable regions remained in segments 4 and 8. We performed a right paramedian sectionectomy with partial resection of the left paramedian section of the liver. Six months later, serum concentrations of alpha-fetoprotein (189 ng/mL) and PIVKA-2 (507 mAU/mL) increased. Enhanced com- puted tomography of the abdomen revealed a tumor (20 mm in diameter) on the right side of the abdominal aorta. Fluorine-18 fluorodeoxyglucose positron emission tomography revealed an increased standard uptake value. There was no evidence of recurrence in other regions. Esophagogastroduodenoscopy and colonoscopy revealed no malignant tumor in the gastrointestinal tract. Para-aortic LN metastasis from HCC was thus diagnosed. We performed lymphadenectomy. Histopathological examination revealed that the tumor was largely necrotic, with poorly differentiated HCC on its surface, which confirmed the suspected diagnosis. After 6 mo tumor marker levels were normal, with no evidence of recurrence. Our experience suggests that a solitary para-aortic LN metastasis from HCC can be treated surgically.展开更多
One of the basic problems about the inverse scattering transform for solving a completely integrable nonlinear evolutions equation is to demonstrate that the Jost solutions obtained from the inverse scattering equatio...One of the basic problems about the inverse scattering transform for solving a completely integrable nonlinear evolutions equation is to demonstrate that the Jost solutions obtained from the inverse scattering equations of Cauchy integral satisfy the Lax equations. Such a basic problem still exists in the procedure of deriving the dark soliton solutions of the NLS equation in normal dispersion with non-vanishing boundary conditions through the inverse scattering transform. In this paper, a pair of Jost solutions with same analytic properties are composed to be a 2 × 2 matrix and then another pair are introduced to be its right inverse confirmed by the Liouville theorem. As they are both 2 × 2 matrices, the right inverse should be the left inverse too, based upon which it is not difficult to show that these Jost solutions satisfy both the first and second Lax equations. As a result of compatibility condition, the dark soliton solutions definitely satisfy the NLS equation in normal dispersion with non-vanishing boundary conditions.展开更多
This paper investigates the wave attenuation properties of the double trapezoidal submerged breakwaters on the flat-bed by conducting physical experiments subjected to linear and cnoidal incident waves.The method of G...This paper investigates the wave attenuation properties of the double trapezoidal submerged breakwaters on the flat-bed by conducting physical experiments subjected to linear and cnoidal incident waves.The method of Goda's two points is used to separate the heights of incident,reflected and transmitted waves based on the experimental data.The possible factors affecting the wave attenuation properties of the double trapezoidal submerged breakwaters(i.e.,the relative submerged water depth,relative breakwater spacing,wave steepness and relative wave height) are investigated with respect to the reflection and transmission coefficients.The results show that there is a range,within which the breakwater spacing has little impact on the reflection coefficient,and the transmission coefficient tends to be a constant.The influence of the wave steepness is reduced while the breakwater spacing is too large or too small.Within the range of the relative wave height tested in this study,the reflection and transmission coefficients increase and decrease with the relative wave height,respectively.The double trapezoidal submerged breakwaters model indicates a good attenuation effect for larger wave steepness,big relative wave height and within the range of the relative breakwater spacing between 12.5 and 14 according to linear and cnoidal waves.The changes of wave energy spectra between the double submerged breakwaters on the flat-bed are investigated by the fast Fourier transform(FFT) method,showing that wave energy dissipation can be reached more effectively when the relative breakwater spacing is 12.5.展开更多
Objective: The senile lung adenocarcinoma patients harboring an activating epidermal growth factor receptor (EGFR) mutation shows good and rapid response to EGFR tyrosine kinase inhibitors (TKIs). Whether gefitin...Objective: The senile lung adenocarcinoma patients harboring an activating epidermal growth factor receptor (EGFR) mutation shows good and rapid response to EGFR tyrosine kinase inhibitors (TKIs). Whether gefitinib combined with y-ray stereotactic body radiation therapy has better efficacy than gefitinib alone for senile lung adenocarcinoma patients with EGFR mutations as first-line regimen is still under investigation. Methods: The 42 senile lung adenocarcinoma patients with EGFR mutations were divided into 2 groups according to the therapy method. Group A was the 22 patients treated with gefitinib combined with y-ray stereotactic body radiation therapy (SBRT). Group B was the 20 patients treated with gefitinib alone. All of the patients received gefitinib of 250 mg/d from the first day until disease progression or other reasons. The patients of Group A were treated with y-ray stereotactic body radiation therapy from the second day. Radiation fields included the primary lesions and the integration of lymph nodes. Dose curve of this group was 50%-80%. Encircled dose was 4.0-6.5 Gy per fraction and the range of total dose was 40-52 Gy. We treated the patients 8-12 times and treated five times every week. Results: All the patients were examined by enhanced double helix CT at the second month. The tumor response rate (RR) of group A was 81.8% (18/22). Disease control rate (DCR) was 90.9% (20/22). The median overall survival (OS) was 24.2 months (range 8-58 months ) and the progression-free survival (PFS) was 18.6 months. The overall 1-year survival rate was 72.3% (16/22) and 2-year survival rate was 54.5% (12/22). The main side effects included skin rash and diarrhea. The RR of group B was 50.0 % (10/20). DCR was 75.0% (15/20). OS was 17.4 months (range 6-32 months ) and PFS was 12.1 months. The overall 1-year survival rate was 60.0% (12/20) and 2-year survival rate was 40.0% (8/20). The main side effects included skin rash and diarrhea. The group A who were treated with gefitinib combined with y-ray stereotactic body radiation therapy had a higher short term therapeutic effects (RR) and long term therapeutic effects (OS) than group B who were treated with gefitinib alone respectively (81.8% vs 50.0%, P = 0.029 〈 0.05, x2 = 4.773 and 24.2 vs 17.4, P = 0.024 〈 0.05, X2 = 5.098). Conclu. sion: Gefitinib combined with y-ray stereotactic body radiation therapy has better efficacy than gefitinib alone for senile lung adenocarcinoma patients with EGFR mutations as first-line regimen. The side affects are acceptable.展开更多
Brain metastasis is a major cause of poor prognosis and high mortality for non-small cell lung cancer patients. The prognosis of non-small-cell lung cancer(NSCLC) patients with brain metastasis is generally poor and m...Brain metastasis is a major cause of poor prognosis and high mortality for non-small cell lung cancer patients. The prognosis of non-small-cell lung cancer(NSCLC) patients with brain metastasis is generally poor and more effective treatment is required to improve their prognosis. Whole-brain radiotherapy, surgery, stereotactic radiosurgery, chemotherapy and targeted therapy are the main treatment for brain metastasis. This review focuses on the five therapeutic strategy and in particular, on targeted therapy.展开更多
OBJECTIVE To investigate the clinical efficacy and toxic effect of the 3-dimensional conformal radiation therapy (3DCRT) for non- small cell lung cancer (NSCLC). METHODS Fifty-two patients with the Stage-I and IV ...OBJECTIVE To investigate the clinical efficacy and toxic effect of the 3-dimensional conformal radiation therapy (3DCRT) for non- small cell lung cancer (NSCLC). METHODS Fifty-two patients with the Stage-I and IV NSCLC were treated with 3DCRT. Cross analysis of the clinical data was conducted in the comparison between the 52 cases with 3DCRT and the other 50 cases with the conventional radiation therapy (CRT). In the 3DCRT group, only the primary tumor and positive lymph-node draining area were included in the clinical target area, setting 4 to 6 coplanar or non-coplanar irradiation fields, with 2 Gy or 3 Gy/fraction, 1 fraction a day and 5 fractions per week. The total dose ranged from a test dose (DT) of 66 Gy to 72 Gy. In the CRT group, the field area contained the primary tumor plus the homolateral hilum of the lung, the mediastinum superior or hol-mediastinum, and opposed anteroposterior irradiation. When the dosage reached DT 36-40 Gy, an oblique portal administered radiation was conducted in order to avoid injuring the spinal cord. The DT was 1.8-2.0 Gy/fraction, 1 fraction a day, 5 fractions per week, with a total dose of 60 Gy to 70 Gy. RESULTS The therapeutic effect (CR + PR) was 90.4% in the 3DCRT group, and was 72% in the CRT group. There was statistically significant difference between the two groups, P 〈 0.01. There was a clinical symptom improvement attained by 96.5% and 86.4% respectively in the two groups, and there was a statistically significant difference between the groups, P 〈 0.01. The 6-month, 1 and 2-year overall survival rates were 92.3%, 75.0% and 42.3% in the 3DCRT group, and 76%, 60% and 30% in the CRT group, respectively. There was a significant difference in the 6-month overall survival rate between the groups, P 〈 0.05. There was no obvious significant difference in the 1 and 2-year overall survival rates between the two groups, P 〉 0.05. The toxic reaction was 12.5% and 23.7% respectively in the 3DCRT and CRT groups. Acute radioactive esophagitis and leucopenia were markedly lower in the 3DCRT group than in the CRT group. There was a statistically significant difference between the groups, P 〈 0.05. No toxic reaction of Stage-III and over was found in the 3DCRT group during radiation therapy. CONCLUSION The 3DCRT method has a satisfactory shortterm efficacy and improvement of clinical symptoms in treating NSCLC, with a mild toxic reaction and good tolerance in patients. It can be used for enhancing the tumor-control rate and bettering the quality of life.展开更多
A recent study has revealed a full 3-dimentional reactive scattering picture of the reaction CI+CHD3(v1=1) as the C1 atoms attack CHD3 from various directions respective to the C-H stretching bond. The reported pol...A recent study has revealed a full 3-dimentional reactive scattering picture of the reaction CI+CHD3(v1=1) as the C1 atoms attack CHD3 from various directions respective to the C-H stretching bond. The reported polarization-dependent differential cross sections provide the most detailed characterization of the influences of reagent alignments on reactivity. To convey the stereo-specific information more accessible to general chemists, we show here, by proper symmetry considerations, how to retrieve from the measurements the relative integral and differential cross sections of two most common collision geometries: the end-on versus side-on attacks. The results, albeit coarse-grained, provide an appealing picture that not only reinforces our intuition about chemical reactivity, but also sheds more light on the conventional (unpolarized) attributes.展开更多
Lung cancer is the leading cause of death due to cancer in China. In recent years, great progress has been made in radiotherapy for lung cancer patients in China. The main advance- ments include the following aspects...Lung cancer is the leading cause of death due to cancer in China. In recent years, great progress has been made in radiotherapy for lung cancer patients in China. The main advance- ments include the following aspects: (1) stereotactic ablative radiotherapy for early stage non- small cell lung cancer (NSCLC), (2) post-operative radiotherapy for NSCLC, (3) combined chemotherapy and radiotherapy for locally advanced NSCLC, (4) improved radiotherapy for advancedNSCLC, and 5) orediction of radiation-induced luna toxicitv.展开更多
In this paper, the approximate expressions of the solitary wave solutions for a class of nonlinear disturbed long-wave system are constructed using the homotopie mapping method.
A 3D stereotomography algorithm, which is derived from the 3D Cartesian coordinate, is applied for the first time to the deep-sea data acquired in the LH area, South China Sea, to invert a macro velocity model for pre...A 3D stereotomography algorithm, which is derived from the 3D Cartesian coordinate, is applied for the first time to the deep-sea data acquired in the LH area, South China Sea, to invert a macro velocity model for pre-stack depth migration. The successful implementation of stereotomography is highly dependent on the correct extraction of slowness components and the proper application of regularization terms. With the help of the structure tensor algorithm, a high-quality 3D stereotomography data space is achieved in a very efficient manner. Then, considering that the horizontal slowness in cross-line direction is usually unavailable for 3D narrow-azimuth data, the regularization terms must be enhanced to guarantee a stable convergence of the presented algorithm. The inverted model serves as a good model for the 3D pre-stack depth migration. The synthetic and real data examples demonstrated the robustness and effectiveness of the presented algorithm and the related schemes.展开更多
文摘Aim To prepare and characterize solid dispersions of silymarin with the intention of improving their dissolution properties. Methods The solid dispersions were prepared by the fusion method with polyethylene glycol 6000(PEG 6000) as the carrier. Evaluation of the properties of the dispersions was performed using dissolution studies, X ray powder diffraction and Fourier transform infrared (FT IR) spectroscopy. Results The rate of dissolution of silymarin was considerably improved as compared with pure silymarin when formulated in solid dispersions with PEG 6000. The data of the X ray diffraction showed some changes in the parameters of lattice spacing [ d ], peak position and relative intensities. FT IR together with those from X ray diffraction showed the absence of well defined drug polymer interactions. Conclusion The dissolution improvement of poorly soluble silymarin could be illuminated by the changes of the lattice parameters of PEG 6000 and the drug.
基金Project(51901020)supported by the National Natural Science Foundation of ChinaProject(2019JZZY010327)supported by Shandong Key Research and Development Plan,China+1 种基金Project(201942074001)supported by Aeronautical Science Foundation of ChinaProject(FRF-IP-20-05)supported by the Fundamental Research Funds for the Central Universities,China。
文摘Additive manufacturing(AM),also known as 3D-printing(3DP)technology,is an advanced manufacturing technology that has developed rapidly in the past 40 years.However,the ceramic material printing is still challenging because of the issue of cracking.Indirect 3D printing has been designed and drawn attention because of its high manufacturing speed and low cost.Indirect 3D printing separates the one-step forming process of direct 3D printing into binding and material sintering,avoiding the internal stress caused by rapid cooling,making it possible to realize the highquality ceramic component with complex shape.This paper presents the research progress of leading indirect 3D printing technologies,including binder jetting(BJ),stereolithography(SLA),and fused deposition modeling(FDM).At present,the additive manufacturing of ceramic materials is mainly achieved through indirect 3D printing technology,and these materials include silicon nitride,hydroxyapatite functional ceramics,silicon carbide structural ceramics.
基金supported by the National Natural Science Foundation of China and the National Basic Research Program of China(973 Program).
文摘Collisions between hot H atoms and CO2 molecules were studied experimentally by time resolved Fourier transform infrared emission spectroscopy. H atoms with three translational energies, 174.7, 241.0 and 306.2 k J/mol respectively, were generated by UV laser photolysis to initiate a chemical reaction of H+CO2→OH+CO. Vibrationally excited CO (v≤2) was observed in the spectrum, where CO was the product of the reaction. The highly efficient T-V energy transfer fro,n the hot H atoms to the CO2 was verified too. The highest vibrational level of v=4 in CO2 (va) was found. Rate ratio of the chemical reaction to the energy transfer was estimated as 10.
基金The project supported by National Natural Science Foundation of China under Grant Nos.10371070 and 10671121the Foundation of Shanghai Education Committee for Shanghai Prospective Excellent Young Teachers
文摘This paper investigates in detail the dynamics of the modified KdV equation with self-consistent sources, including characteristics of one-soliton, scattering conditions and phase shifts of two solitons, degenerate case of two solitons and "ghost" solitons, etc. Co-moving coordinate frames are employed in asymptotic analysis.
基金Supported by The National Nuclear Research and Development Program of the Ministry of Education,Science and Technology,South Korea
文摘AIM: To evaluate the efficacy and complications of stereotactic body radiotherapy in localized paraaortic lymph node recurrence from colorectal cancer. METHODS: From 2003 to 2009, 7 patients with paraaortic lymph node recurrence (1-3 lesions) from colorectal cancer were treated with stereotactic body radiotherapy. Total gross tumor volumes ranged from 4 to 40 mL. The doses were escalated from 36 Gy/patient to 51 Gy/patient and were delivered in 3 fractions. RESULTS: One and 3 year overall survival rates were 100% and 71.4%, respectively, and median survival was 37 mo. Grade IV intestinal obstruction was reported in 1 of 7 patients. This patient received 48 Gy in 3 fractions with a maximum point dose to the intestine of 53 Gy and V45Gy = 3.6 mL. However, 6 patients received an intestinal maximum point dose of 〈 51 Gy and V45Gy of 〈 1 mL, and did not develop any severe complications. CONCLUSION: This pilot study suggests selected paraaortic lymph node recurrence (1-3 closed lesions) that failed to respond to chemotherapy can be potentially salvaged by stereotactic body radiotherapy.
文摘Lymph node (LN) metastases from hepatocellular carcinoma (HCC) are considered uncommon. We describe the surgical resection of a solitary para-aortic LN metastasis from HCC. A 65-year-old Japanese man with B-type liver cirrhosis was admitted for the evaluation of a liver tumor. He had already undergone radiofrequency ablation, transcatheter arterial chemoembolization, and percutaneous ethanol injection therapy for HCC. Despite treatment, viable regions remained in segments 4 and 8. We performed a right paramedian sectionectomy with partial resection of the left paramedian section of the liver. Six months later, serum concentrations of alpha-fetoprotein (189 ng/mL) and PIVKA-2 (507 mAU/mL) increased. Enhanced com- puted tomography of the abdomen revealed a tumor (20 mm in diameter) on the right side of the abdominal aorta. Fluorine-18 fluorodeoxyglucose positron emission tomography revealed an increased standard uptake value. There was no evidence of recurrence in other regions. Esophagogastroduodenoscopy and colonoscopy revealed no malignant tumor in the gastrointestinal tract. Para-aortic LN metastasis from HCC was thus diagnosed. We performed lymphadenectomy. Histopathological examination revealed that the tumor was largely necrotic, with poorly differentiated HCC on its surface, which confirmed the suspected diagnosis. After 6 mo tumor marker levels were normal, with no evidence of recurrence. Our experience suggests that a solitary para-aortic LN metastasis from HCC can be treated surgically.
基金The project supported by National Natural Science Foundation of China under Grant Nos. 10474076 and 10375041
文摘One of the basic problems about the inverse scattering transform for solving a completely integrable nonlinear evolutions equation is to demonstrate that the Jost solutions obtained from the inverse scattering equations of Cauchy integral satisfy the Lax equations. Such a basic problem still exists in the procedure of deriving the dark soliton solutions of the NLS equation in normal dispersion with non-vanishing boundary conditions through the inverse scattering transform. In this paper, a pair of Jost solutions with same analytic properties are composed to be a 2 × 2 matrix and then another pair are introduced to be its right inverse confirmed by the Liouville theorem. As they are both 2 × 2 matrices, the right inverse should be the left inverse too, based upon which it is not difficult to show that these Jost solutions satisfy both the first and second Lax equations. As a result of compatibility condition, the dark soliton solutions definitely satisfy the NLS equation in normal dispersion with non-vanishing boundary conditions.
基金Supported by the General Program of National Natural Science Foundation of China(No.50979066 and No.50979008)Ph.D.Programs Foundation of Ministry of Education of China(No.20094316110002)Scientific Research Fund of Department of Education, Hunan Province(No.10A006)
文摘This paper investigates the wave attenuation properties of the double trapezoidal submerged breakwaters on the flat-bed by conducting physical experiments subjected to linear and cnoidal incident waves.The method of Goda's two points is used to separate the heights of incident,reflected and transmitted waves based on the experimental data.The possible factors affecting the wave attenuation properties of the double trapezoidal submerged breakwaters(i.e.,the relative submerged water depth,relative breakwater spacing,wave steepness and relative wave height) are investigated with respect to the reflection and transmission coefficients.The results show that there is a range,within which the breakwater spacing has little impact on the reflection coefficient,and the transmission coefficient tends to be a constant.The influence of the wave steepness is reduced while the breakwater spacing is too large or too small.Within the range of the relative wave height tested in this study,the reflection and transmission coefficients increase and decrease with the relative wave height,respectively.The double trapezoidal submerged breakwaters model indicates a good attenuation effect for larger wave steepness,big relative wave height and within the range of the relative breakwater spacing between 12.5 and 14 according to linear and cnoidal waves.The changes of wave energy spectra between the double submerged breakwaters on the flat-bed are investigated by the fast Fourier transform(FFT) method,showing that wave energy dissipation can be reached more effectively when the relative breakwater spacing is 12.5.
基金Supported by a grant from the Clinical Medicine Sciences Foundation of Jiangsu University(No.JLY20080085)
文摘Objective: The senile lung adenocarcinoma patients harboring an activating epidermal growth factor receptor (EGFR) mutation shows good and rapid response to EGFR tyrosine kinase inhibitors (TKIs). Whether gefitinib combined with y-ray stereotactic body radiation therapy has better efficacy than gefitinib alone for senile lung adenocarcinoma patients with EGFR mutations as first-line regimen is still under investigation. Methods: The 42 senile lung adenocarcinoma patients with EGFR mutations were divided into 2 groups according to the therapy method. Group A was the 22 patients treated with gefitinib combined with y-ray stereotactic body radiation therapy (SBRT). Group B was the 20 patients treated with gefitinib alone. All of the patients received gefitinib of 250 mg/d from the first day until disease progression or other reasons. The patients of Group A were treated with y-ray stereotactic body radiation therapy from the second day. Radiation fields included the primary lesions and the integration of lymph nodes. Dose curve of this group was 50%-80%. Encircled dose was 4.0-6.5 Gy per fraction and the range of total dose was 40-52 Gy. We treated the patients 8-12 times and treated five times every week. Results: All the patients were examined by enhanced double helix CT at the second month. The tumor response rate (RR) of group A was 81.8% (18/22). Disease control rate (DCR) was 90.9% (20/22). The median overall survival (OS) was 24.2 months (range 8-58 months ) and the progression-free survival (PFS) was 18.6 months. The overall 1-year survival rate was 72.3% (16/22) and 2-year survival rate was 54.5% (12/22). The main side effects included skin rash and diarrhea. The RR of group B was 50.0 % (10/20). DCR was 75.0% (15/20). OS was 17.4 months (range 6-32 months ) and PFS was 12.1 months. The overall 1-year survival rate was 60.0% (12/20) and 2-year survival rate was 40.0% (8/20). The main side effects included skin rash and diarrhea. The group A who were treated with gefitinib combined with y-ray stereotactic body radiation therapy had a higher short term therapeutic effects (RR) and long term therapeutic effects (OS) than group B who were treated with gefitinib alone respectively (81.8% vs 50.0%, P = 0.029 〈 0.05, x2 = 4.773 and 24.2 vs 17.4, P = 0.024 〈 0.05, X2 = 5.098). Conclu. sion: Gefitinib combined with y-ray stereotactic body radiation therapy has better efficacy than gefitinib alone for senile lung adenocarcinoma patients with EGFR mutations as first-line regimen. The side affects are acceptable.
文摘Brain metastasis is a major cause of poor prognosis and high mortality for non-small cell lung cancer patients. The prognosis of non-small-cell lung cancer(NSCLC) patients with brain metastasis is generally poor and more effective treatment is required to improve their prognosis. Whole-brain radiotherapy, surgery, stereotactic radiosurgery, chemotherapy and targeted therapy are the main treatment for brain metastasis. This review focuses on the five therapeutic strategy and in particular, on targeted therapy.
基金supported by a grant from the Natural Science Foundation of Ningxia Hui Autonomous Region,China(No.NZ0680)
文摘OBJECTIVE To investigate the clinical efficacy and toxic effect of the 3-dimensional conformal radiation therapy (3DCRT) for non- small cell lung cancer (NSCLC). METHODS Fifty-two patients with the Stage-I and IV NSCLC were treated with 3DCRT. Cross analysis of the clinical data was conducted in the comparison between the 52 cases with 3DCRT and the other 50 cases with the conventional radiation therapy (CRT). In the 3DCRT group, only the primary tumor and positive lymph-node draining area were included in the clinical target area, setting 4 to 6 coplanar or non-coplanar irradiation fields, with 2 Gy or 3 Gy/fraction, 1 fraction a day and 5 fractions per week. The total dose ranged from a test dose (DT) of 66 Gy to 72 Gy. In the CRT group, the field area contained the primary tumor plus the homolateral hilum of the lung, the mediastinum superior or hol-mediastinum, and opposed anteroposterior irradiation. When the dosage reached DT 36-40 Gy, an oblique portal administered radiation was conducted in order to avoid injuring the spinal cord. The DT was 1.8-2.0 Gy/fraction, 1 fraction a day, 5 fractions per week, with a total dose of 60 Gy to 70 Gy. RESULTS The therapeutic effect (CR + PR) was 90.4% in the 3DCRT group, and was 72% in the CRT group. There was statistically significant difference between the two groups, P 〈 0.01. There was a clinical symptom improvement attained by 96.5% and 86.4% respectively in the two groups, and there was a statistically significant difference between the groups, P 〈 0.01. The 6-month, 1 and 2-year overall survival rates were 92.3%, 75.0% and 42.3% in the 3DCRT group, and 76%, 60% and 30% in the CRT group, respectively. There was a significant difference in the 6-month overall survival rate between the groups, P 〈 0.05. There was no obvious significant difference in the 1 and 2-year overall survival rates between the two groups, P 〉 0.05. The toxic reaction was 12.5% and 23.7% respectively in the 3DCRT and CRT groups. Acute radioactive esophagitis and leucopenia were markedly lower in the 3DCRT group than in the CRT group. There was a statistically significant difference between the groups, P 〈 0.05. No toxic reaction of Stage-III and over was found in the 3DCRT group during radiation therapy. CONCLUSION The 3DCRT method has a satisfactory shortterm efficacy and improvement of clinical symptoms in treating NSCLC, with a mild toxic reaction and good tolerance in patients. It can be used for enhancing the tumor-control rate and bettering the quality of life.
文摘A recent study has revealed a full 3-dimentional reactive scattering picture of the reaction CI+CHD3(v1=1) as the C1 atoms attack CHD3 from various directions respective to the C-H stretching bond. The reported polarization-dependent differential cross sections provide the most detailed characterization of the influences of reagent alignments on reactivity. To convey the stereo-specific information more accessible to general chemists, we show here, by proper symmetry considerations, how to retrieve from the measurements the relative integral and differential cross sections of two most common collision geometries: the end-on versus side-on attacks. The results, albeit coarse-grained, provide an appealing picture that not only reinforces our intuition about chemical reactivity, but also sheds more light on the conventional (unpolarized) attributes.
文摘Lung cancer is the leading cause of death due to cancer in China. In recent years, great progress has been made in radiotherapy for lung cancer patients in China. The main advance- ments include the following aspects: (1) stereotactic ablative radiotherapy for early stage non- small cell lung cancer (NSCLC), (2) post-operative radiotherapy for NSCLC, (3) combined chemotherapy and radiotherapy for locally advanced NSCLC, (4) improved radiotherapy for advancedNSCLC, and 5) orediction of radiation-induced luna toxicitv.
基金Supported by the National Natural Science Foundation of China under Grant No.40876010the Main Direction Program of the Knowledge Innovation Project of Chinese Academy of Sciences under Grant No.KZCX2-YW-Q03-08+2 种基金the LASG State Key Laboratory Special Fundthe Foundation of Shanghai Municipal Education Commission under Grant No.E03004the Natural Science Foundation of Zhejiang Province under Grant No.Y6090164
文摘In this paper, the approximate expressions of the solitary wave solutions for a class of nonlinear disturbed long-wave system are constructed using the homotopie mapping method.
基金funded by China Natural Science Foundation(Nos.41574098 and 41630964)China key specialized project(No.2016ZX05026-001-03)
文摘A 3D stereotomography algorithm, which is derived from the 3D Cartesian coordinate, is applied for the first time to the deep-sea data acquired in the LH area, South China Sea, to invert a macro velocity model for pre-stack depth migration. The successful implementation of stereotomography is highly dependent on the correct extraction of slowness components and the proper application of regularization terms. With the help of the structure tensor algorithm, a high-quality 3D stereotomography data space is achieved in a very efficient manner. Then, considering that the horizontal slowness in cross-line direction is usually unavailable for 3D narrow-azimuth data, the regularization terms must be enhanced to guarantee a stable convergence of the presented algorithm. The inverted model serves as a good model for the 3D pre-stack depth migration. The synthetic and real data examples demonstrated the robustness and effectiveness of the presented algorithm and the related schemes.